Current topics in medicinal chemistry最新文献

{"title":"Antiproliferative Activity, DNA/HSA Interactions and Human Topoisomerase Inhibition Evaluations of Indole-Thiazolidinone Derivatives: Are Two Indole Rings Better than One?","authors":"Maksuelly Libanio de Lima, Rafael David Souto de Azevedo, Fernanda Carvalho Manito Ferreira, Josival Emanuel Ferreira Alves, Elizabeth Almeida Lafayette, Jessica Celerino Dos Santos, Gleyton Leonel Silva Sousa, Maria do Carmo Alves de Lima, Sinara Mônica Vitalino de Almeida","doi":"10.2174/0115680266457267260721075824","DOIUrl":"https://doi.org/10.2174/0115680266457267260721075824","url":null,"abstract":"<p><strong>Introduction: </strong>Indole derivatives are promising candidates for anticancer drug discovery due to their occurrence in biologically active molecules and their ability to modulate cellular targets. This study aimed to evaluate the antiproliferative effects, biomolecular interactions, and topoisomerase inhibition potential of four indole-thiazolidinone derivatives.</p><p><strong>Methods: </strong>DNA and HSA binding were investigated by UV-Vis absorption, fluorescence spectroscopy, and molecular docking. Topoisomerase inhibition was evaluated in vitro. Antiproliferative activity and effects on cell migration were assessed in human cancer cell lines using the sulforhodamine B (SRB) and wound healing assays, respectively.</p><p><strong>Results: </strong>The bis-indole derivative (4a) showed the strongest affinity for DNA (Kb = 1.34 × 10⁶ M⁻¹) and HSA (Kb = 1.30 × 10⁶ M⁻¹), altering the IIA hydrophobic microenvironment. In vitro, 4a displayed potent antiproliferative activity against MCF-7 breast cancer cells (GI₅₀ = 4.53 μM) and inhibited cell migration by 11.65% at 1 μM. No significant inhibition of topoisomerase I and II was observed at 10 and 50 μM.</p><p><strong>Discussion: </strong>The findings suggest that the cytotoxic activity of compound 4a is more closely associated with its interaction with DNA than with topoisomerase inhibition. Spectroscopic and computational analyses indicated the occurrence of multiple binding modes with DNA and HSA, supporting its favourable interaction profile. Furthermore, the high affinity for HSA may contribute to compound transport and distribution in biological systems, while the observed reduction in cell migration indicates a potential effect on tumour progression.</p><p><strong>Conclusion: </strong>Compound 4a is the most active in the series, representing a significant starting point for the development of new derivatives with potential anti-tumour activity.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycogen Synthase Kinase-3β in Alzheimer's Disease: Targets for Therapy and Imaging.","authors":"Jianhua Jia","doi":"10.2174/0115680266497019260720045602","DOIUrl":"https://doi.org/10.2174/0115680266497019260720045602","url":null,"abstract":"<p><p>Glycogen synthase kinase-3β (GSK-3β) is a key regulator of the pathogenesis of Alzheimer's disease (AD), capable of simultaneously modulating core pathological processes such as amyloid-β (Aβ) deposition, tau protein hyperphosphorylation, synaptic damage, and neuroinflammation. Therefore, it has become one of the core druggable molecular nodes for AD intervention. This review is mainly divided into two parts. The first part focuses on the GSK-3β inhibitors that have been validated in AD-related cell and animal models. These inhibitors are specifically classified into four categories: metal ion-based compounds, adenosine triphosphate (ATP)-competitive inhibitors, non-ATP-competitive inhibitors, and multi-target inhibitors. The second part focuses on GSK-3β-specific positron emission tomography (PET) radioligands, which can non-invasively monitor GSK-3β enzyme activity in vivo, providing quantitative in vivo molecular imaging tracers for the study of AD pathogenesis and quantitative assessment of treatment effects. This review systematically summarizes GSK-3β-related inhibitors and PET radioligands in AD, thereby providing key references for the rational design of next-generation AD therapeutic drugs and diagnostic agents.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Heterocyclic Derivatives for Aromatase Inhibition in Hormone-Dependent Breast Cancer.","authors":"Harsimran Kaur, Kawalpreet Kaur, Gurdeep Singh","doi":"10.2174/0115680266452626260702092804","DOIUrl":"https://doi.org/10.2174/0115680266452626260702092804","url":null,"abstract":"<p><p>Breast cancer is one of the most common causes of cancer death among women in the world, and the number of tumors that depend on hormones occupies a significant percentage of cases that are diagnosed. The estrogen factor is central to the development of these cancers; hence, aromatase, the central enzyme involved in estrogen production, is a critical therapeutic target. Aromatase Inhibitors (AIs), in particular, have emerged to play an important role in endocrine therapy in postmenopausal breast cancer patients. Heterocyclic compounds, in particular, have also been receiving significant focus in the design of AI scaffolds, because they are structurally diverse and capable of binding the heme iron in the aromatase active site. This review provides extensive coverage of recent developments in heterocyclic aromatase inhibitors, including large classes such as azoles, indoles, quinolines, coumarins, benzofurans, and other fused heterocyclic systems. The focus is on trends in Structure-Activity Relationships (SAR), with emphasis on the patterns of substitution and pharmacophoric features that can modulate potency and selectivity. Mechanistic information from molecular docking and other computational studies is also presented to elucidate binding interactions and inform rational drug design. In addition, new approaches such as the development of hybrid molecules and multi-target-directed ligands are listed to illustrate emerging trends aimed at enhancing efficacy and pharmacokinetic properties. Together with heterocyclic structures, these frameworks are still offering viable and bright platforms on which next-generation aromatase inhibitors can be developed to treat breast cancer better.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotransformation-Driven Structural Remodeling of Natural Products by Ganoderma lucidum Fermentation: Mechanisms and Enhanced Bioactivities.","authors":"Yuchen Liu, Bing Liu, Ting Zhu, Ning Chen, Junyao Chu, Hongyue Wei, Wenlan Li","doi":"10.2174/0115680266461232260515094327","DOIUrl":"https://doi.org/10.2174/0115680266461232260515094327","url":null,"abstract":"<p><p>Ganoderma lucidum fermentation (GLF) serves as a sustainable biotransformation platform that precisely modulates the chemical profiles and bioactivities of natural products through enzymatic hydrolysis, microbial metabolic remodeling, and substrate-microbe crosstalk. This review systematically elucidates the GLF-driven structural modifications of key compounds- including polysaccharides, saponins, triterpenoids, flavonoids, and proteins. These structural optimizations synergistically enhance multiple bioactivities: the increased content of deglycosylated ginsenosides enhances antitumor activity, while the antioxidant and prebiotic effects of polysaccharides are potentiated through the regulation of gut microbiota and short-chain fatty acid (SCFA) production. The core mechanisms involve a sophisticated interplay of specific enzyme catalysis, fungal endogenous biosynthesis, and a dynamic \"substrate degradation-product synthesis\" metabolic cycle. Finally, we emphasize that integrating multi-omics and synthetic biology is crucial for achieving precision control of GLF and advancing its translation in functional foods and drug discovery.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupting Bacterial Quorum Sensing: A Review of Protein Families and Natural Inhibitors for Combating Resistance.","authors":"Asghar Ali, Andaleeb Zahra, Mohan Kamthan, Md Salik Noorani, Mohammad Abid","doi":"10.2174/0115680266385347250529040422","DOIUrl":"https://doi.org/10.2174/0115680266385347250529040422","url":null,"abstract":"<p><p>The Quorum Sensing (QS) system plays a central role in regulating several processes that influence bacterial physiology, communication, and pathogenesis. It governs the production of virulence factors, facilitates biofilm formation, and contributes to the development of antibiotic resistance, all of which are critical to bacterial survival and pathogenicity. QS enables both intraspecies and inter-species bacterial communication, operating through distinct pathways in Gram-positive and Gram-negative bacteria. This review provides a comprehensive overview of the major families of quorum-sensing proteins involved in the working of the signalling molecules. It examines the structural features, functional roles, and mechanisms of action of these proteins, highlighting their significance in bacterial behaviour. Furthermore, the study explores the potential of plant-derived secondary metabolites as natural inhibitors targeting QS systems to disrupt bacterial pathogenicity. Finally, it discusses the implications of exploiting these inhibitors as promising strategies to address the growing challenge of antibiotic resistance in bacterial infections.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic Potential of Garcinia atroviridis Griff: In Vitro and In Vivo Evaluation of Glucose Metabolism and Enzyme Inhibition.","authors":"Ibrahim Mahmood, Song Zhu, Douglas Law, Lunasmrita Saikia, Partha Pratim Dutta, Saikat Sen, Shazrul Fazry, Ahmed Najm","doi":"10.2174/0115680266449106260626205346","DOIUrl":"https://doi.org/10.2174/0115680266449106260626205346","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is characterized by hyperglycemia, insulin resistance, and pancreatic β-cell failure, necessitating novel treatments. Garcinia atroviridis, rich in hydroxy citric acid (HCA), flavonoids, and polyphenols, shows potential against diabetes. In vitro and in vivo studies assessed its effects on glucose absorption, enzyme inhibition, and glycemic control in diabetic rats. The extract exhibited significant total phenolic (10.09 ± 0.24 mg GAE/g) and flavonoid (9.44 ± 0.11 mg QE/g) content. It demonstrated moderate direct antioxidant activity (DPPH IC₅₀ 15.14 ± 0.55 mg/mL) and inhibited α-glucosidase, α-amylase, and DPP-4 (IC₅₀ 35.04 ± 0.22 mg/mL, 22.21 ± 0.13 mg/mL). Crucially, in L6 myoblast cells, it enhanced glucose absorption (165.25% at 62.5 µg/mL) without cytotoxicity (IC₅₀ 3.12 ± 0.027 mg/mL). In diabetic rats, G. atroviridis (400 mg/kg) significantly reduced fasting blood glucose (69.33 mg/dL by day 21) and improved glucose tolerance. The findings suggest that the antidiabetic potential of G. atroviridis is likely driven by a multi-mechanistic synergy between its moderate direct antioxidant capacity, enzyme inhibition, and, most notably, its potent ability to enhance cellular glucose uptake at low concentrations. This positions G. atroviridis as a promising natural adjunct for diabetes treatment, warranting further research into its active compounds and clinical applications.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on the Role of AMPK Signaling Pathway in the Regulation of Neural Injury.","authors":"JiaTai An, XiuHua Li, TangNa Zhao, Aiping Zheng, XinJian Yang, Liang Xu","doi":"10.2174/0115680266464264260627162948","DOIUrl":"https://doi.org/10.2174/0115680266464264260627162948","url":null,"abstract":"<p><strong>Introduction: </strong>Nerve Injury (NI) imposes a severe clinical burden involving energy failure, neuroinflammation, oxidative stress, and apoptosis. This review aims to systematically synthesize structural insights into AMP-activated protein kinase (AMPK), elucidate its multifaceted molecular mechanisms in NI, and evaluate AMPK-targeted pharmacological interventions.</p><p><strong>Methods: </strong>A comprehensive literature search across major databases (PubMed, Web of Science, Scopus, and Google Scholar) identified peer-reviewed in vitro and in vivo studies focusing on AMPK mechanisms, structural pharmacology, signaling networks (e.g., AMPK/mTOR, AMPK/SIRT1), and drug targeting in various neural injury models.</p><p><strong>Results: </strong>Upon cellular energy deficit, AMPK induces neuroprotective autophagy via the AMPK/mTOR/ULK1 axis and combats oxidative stress and neuroinflammation by promoting PGC-1α-mediated mitochondrial biogenesis and suppressing NF-κB. Conversely, AMPK dysregulation exacerbates neuronal death. Pharmacological agents demonstrate robust preclinical neuroprotection, though clinical application is hindered by off-target systemic toxicity and poor Blood-Brain Barrier (BBB) permeability.</p><p><strong>Discussion: </strong>The findings highlight AMPK as a pivotal modulator of interconnected metabolic stress response cascades. While pharmacological agents demonstrate robust preclinical neuroprotection, their clinical application is currently hindered by off-target systemic toxicity, lack of isoform specificity, and poor blood-brain barrier (BBB) permeability.</p><p><strong>Conclusion: </strong>AMPK represents a highly promising therapeutic target for mitigating NI. Translating preclinical successes into clinical practice demands rigorous Structure-Activity Relationship (SAR) optimization to develop CNS-penetrant, isoform-selective modulators, thereby maximizing targeted neuroprotection while minimizing adverse systemic effects.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cosmetic Products Containing Rutin: A Systematic Review of Patents from 2014 to 2024.","authors":"Maria Andréa da Silva, Valéria Regina de Souza Moraes, Raphael Amancio de Jesus, José Michael da Silva, Heloyza Stefanny de Jesus Correa, Lorena Cristina Santos Araújo","doi":"10.2174/0115680266414480251024071716","DOIUrl":"https://doi.org/10.2174/0115680266414480251024071716","url":null,"abstract":"<p><strong>Introduction: </strong>Rutin is a natural flavonoid with several validated benefits for cosmetic use and has been increasingly incorporated into cosmetic and dermocosmetic formulas, especially for its antioxidant potential.</p><p><strong>Methods: </strong>A search for patents on the use of rutin in cosmetics was conducted at the European Patent Office (EPO), the World Intellectual Property Organization (WIPO), and the National Institute of Intellectual Property (INPI-Brazil). The search strategy used (i) \"rutin\" AND (ii) \"Cosmetics\" OR \"Skin Cream\" OR \"Cosmeceuticals\" AND \"A61K8\" OR \"C07H17\".</p><p><strong>Results: </strong>A total of 38 patents were selected, 27 of which emphasized the anti-wrinkle and/or antiaging, sunscreen, and antioxidant effects of their formulations. Fifteen patents reported the botanical origin of the rutin used, highlighting the growing interest in developing new cosmetics from different plant sources.</p><p><strong>Discussion: </strong>It has been observed that cosmetic compositions containing rutin can combine natural and synthetic active ingredients to achieve synergistic effects. The use of pharmaceutical technologies and structural modifications to the rutin molecule has been reported, including polyglycosylated rutin, troxerutin, and rutin hydroxycinnamate, to improve the molecule's physicochemical properties.</p><p><strong>Conclusion: </strong>Structural modifications to rutin can optimize its effects, and the main technologies described in the patents, such as microencapsulation and nanoliposomes, aim to improve the efficacy of the active ingredients, facilitating their application in cosmetic formulations in both cases. Considering this, we emphasize the potential of local flora as promising sources for cosmetic development and research.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of Immunotherapy in Lung Cancer: Present Landscape.","authors":"Sonia Singh, Pramod Kumar Singh, Manas Kumar Jha","doi":"10.2174/0115680266418486251118102503","DOIUrl":"https://doi.org/10.2174/0115680266418486251118102503","url":null,"abstract":"<p><p>Lung cancer remains the leading cause of cancer-related mortality in both women and men. It is broadly classified into two main types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC accounts for approximately 80-85% of all cases, while SCLC comprises the remainder. For decades, the prognosis and management of lung cancer have relied heavily on chemotherapy and radiation therapy, although these treatments often lead to significant adverse effects, including respiratory complications, cough, and dyspnoea. In recent years, major advances have positioned immunotherapy as a transformative treatment modality for NSCLC, substantially improving overall survival in patients with advanced disease. This review examines contemporary immunotherapeutic strategies, with a focus on targeted therapies directed at the most clinically relevant immune checkpoints in lung cancer, which have driven significant progress in the management of both NSCLC and SCLC. These approaches represent some of the most promising and effective treatment options currently available. Furthermore, immunotherapy is increasingly anticipated to serve as a valuable adjuvant treatment, including for individuals without motor impairments, offering a potential shift in the therapeutic landscape of lung cancer.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of a Novel Physicochemical Property Space for the Development of Antimalarial Drugs.","authors":"Phuong-Thuy T Phan, My-Vy N Tran, Tuan-Anh N Pham","doi":"10.2174/0115680266485526260618224057","DOIUrl":"https://doi.org/10.2174/0115680266485526260618224057","url":null,"abstract":"<p><strong>Introduction: </strong>Malaria remains a major global health burden, with rising resistance to artemisinin and most current therapies, alongside emerging parasite species and genetic mutations that undermine disease control efforts. Identifying drug candidates with favorable physicochemical profiles is crucial for improving success rates in antimalarial drug discovery.</p><p><strong>Methods: </strong>A comprehensive dataset comprising 52 approved and clinical-stage antimalarial drugs and 1,708 antimalarial research compounds was compiled. Their physicochemical properties were analyzed to characterize distribution patterns and identify parameters that distinguish successful drugs from research compounds.</p><p><strong>Results: </strong>Four key parameters-molecular weight (MW), calculated partition coefficient (cLogP), topological polar surface area (TPSA), and fraction of sp3-hybridized carbons (Fsp3)-showed significant differences between drugs and research compounds. These parameters enabled the definition of an antimalarial-specific physicochemical space described by 248.71 ≤ MW ≤ 535.51, 1.86 ≤ cLogP ≤ 5.21, 28.16 ≤ TPSA ≤ 100.52, and 0.11 ≤ Fsp3 ≤ 1. Approximately 75% of approved or clinical antimalarial drugs fall within this space, compared with 49% of research compounds and 46% of high-potency candidates.</p><p><strong>Discussion: </strong>These findings highlight a distinct and data-driven physicochemical profile associated with successful antimalarial agents, underscoring limitations of general drug-likeness rules such as Lipinski's Rule of Five (Ro5). The proposed space enhances compound prioritization by focusing on property ranges linked to clinical success. However, the analysis is constrained by available datasets and may not fully reflect emerging chemotypes or novel therapeutic modalities.</p><p><strong>Conclusion: </strong>This study defines an antimalarial-specific physicochemical space that can support compound prioritization and guide optimization efforts during antimalarial drug discovery.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}