Thiazolidine Derivatives: An Up-to-Date Review of Synthesis and Biological Activity.

Introduction: Over the past decade, thiazolidine derivatives have become promising heterocyclic compounds in medicinal chemistry, and much research work has been devoted to this ring due to their diverse biological activities, therapeutic potential, and heterocyclic ring-like structure. Several studies have shown that certain thiazolidine derivatives exhibit superior activity compared to standard drugs and hold potential for future pharmaceutical applications. This review comprehensively summarizes the key synthetic strategies for thiazolidine derivatives and highlights their biological activities.

Methods: The present study is based on the most recent and extensive research on the Thiazolidine structure in the fields of organic synthesis and biological activities from 2015 to 2024, as well as the most widely used methodologies in recent years.

Results: The three methods described in this review for the synthesis of thioazolidine derivatives are the most commonly used in recent decades and have given rise to interesting biological activities and the promotion of compounds with chemical and biological significance.

Discussions: The synthesis of compounds with a thiazolidine skeleton plays a vital and interesting role in organic chemistry, with methods that are becoming increasingly sophisticated and easy to use, making it possible to obtain derivatives of biological and pharmacological importance, and a basis for future research.

Conclusion: The thiazolidine scaffold provides an efficient synthetic route for constructing complex molecular structures with significant biological activities. Their versatile reactivity makes them particularly interesting in organic chemistry, as well as biochemistry and pharmacology.