Current topics in medicinal chemistry最新文献

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Benzoxathiolone-Thiazolidinone Hybrids: A New Class in the Search for Anticancer Agents. 苯并恶硫龙-噻唑烷酮杂合体:一类新的抗癌药物。
IF 2.9 4区 医学
Current topics in medicinal chemistry Pub Date : 2025-06-16 DOI: 10.2174/0115680266366285250528005320
Eliza de Lucas Chazin, Ligia Souza da Silveira Pinto, Victor Facchinetti, Paula de Aquino Soeiro Portilho, Breno de Souza Bernardes, Claudia Regina Brandão Gomes, Emerson Lucena da Silva, Luina Benevides Lima, Felipe Pantoja Mesquita, Pedro Filho Noronha de Souza, Raquel Carvalho Montenegro, Marcus Vinicius Nora De Souza, Thatyana Rocha Alves Vasconcelos
{"title":"Benzoxathiolone-Thiazolidinone Hybrids: A New Class in the Search for Anticancer Agents.","authors":"Eliza de Lucas Chazin, Ligia Souza da Silveira Pinto, Victor Facchinetti, Paula de Aquino Soeiro Portilho, Breno de Souza Bernardes, Claudia Regina Brandão Gomes, Emerson Lucena da Silva, Luina Benevides Lima, Felipe Pantoja Mesquita, Pedro Filho Noronha de Souza, Raquel Carvalho Montenegro, Marcus Vinicius Nora De Souza, Thatyana Rocha Alves Vasconcelos","doi":"10.2174/0115680266366285250528005320","DOIUrl":"https://doi.org/10.2174/0115680266366285250528005320","url":null,"abstract":"<p><strong>Background: </strong>Cancer continues to be a significant public health issue and one of the leading causes of death globally. In this context, developing new, potent, and more specific treatments against this disease is urgent.</p><p><strong>Methods: </strong>A total of 15 benzoxathiolone-thiazolidinones hybrids were synthesized in a 5-step route and tested for their cytotoxicity against five human cancer cell lines: AGP-01 (gastric), SKMEL- 103 (melanoma), HCT-116 (colon), CAL27 (tongue), and K562 (leukemia), as well as a nontumoral cell line MRC-5.</p><p><strong>Results: </strong>Compounds 3-(6-hydroxy-2-oxobenzo[d][1,3]oxathiol-5-yl)-2-(4-nitrophenyl)thiazolidin- 4-one and 2-(2,4-dichlorophenyl)-3-(6-hydroxy-2-oxobenzo[d][1,3]oxathiol-5-yl)thiazolidin-4-one exhibited good activity against the K562 leukemia cell line, with IC50 values of 4.0 μM and 5.3 μM, respectively. Docking studies demonstrated that these compounds likely bind to the BCRABL1 kinase, a key protein in the pathogenesis of chronic myeloid leukemia (CML).</p><p><strong>Conclusion: </strong>The study suggests these benzoxathiolone-thiazolidinone hybrids could be promising lead compounds for developing new anticancer agents targeting leukemia.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histone Deacetylase Inhibition in Alzheimer's Disease: Molecular Mechanisms, Therapeutic Potential, and Future Perspectives. 阿尔茨海默病的组蛋白去乙酰化酶抑制:分子机制、治疗潜力和未来展望。
IF 2.9 4区 医学
Current topics in medicinal chemistry Pub Date : 2025-06-16 DOI: 10.2174/0115680266360664250606110220
Nachiket Joshi, Prachee Khadse, Shivani Jadhav, RajaSekhar Reddy Alavala
{"title":"Histone Deacetylase Inhibition in Alzheimer's Disease: Molecular Mechanisms, Therapeutic Potential, and Future Perspectives.","authors":"Nachiket Joshi, Prachee Khadse, Shivani Jadhav, RajaSekhar Reddy Alavala","doi":"10.2174/0115680266360664250606110220","DOIUrl":"https://doi.org/10.2174/0115680266360664250606110220","url":null,"abstract":"<p><p>Alzheimer's disease (AD) remains a formidable challenge in modern medicine, with limited therapeutic options available to combat its progressive cognitive decline. Histone acetylation is a key epigenetic mechanism responsible for gene expression, cell growth, and differentiation. HDAC is a group of enzymes that can reverse the acetylation of cells. These enzymes have been evidenced to be involved in the pathophysiology of AD. Hence, inhibition of this enzyme was postulated to exhibit pronounced benefits in AD concerning memory, learning, and cognition. Pan-HDAC inhibitors inhibited multiple HDAC isoforms but were associated with certain side effects. Hence, class-specific and isoform-specific inhibitors were discovered, revealing great potencies and proving efficacious. This review article comprehensively explores the evolving landscape of research avenues targeting HDAC inhibitors against AD. Beginning with the molecular mechanisms underlying AD pathology, we delve into the intricate roles of HDACs in neurodegeneration and synaptic dysfunction. Subsequently, we scrutinize preclinical studies investigating various HDAC inhibitors, elucidating their promising neuroprotective effects, modulation of epigenetic mechanisms, and potential for disease modification. Furthermore, we highlight the translational challenges and therapeutic opportunities in advancing HDAC inhibitors toward clinical applications for AD. By summarizing current research findings, this review aims to provide valuable insights into the burgeoning field of HDAC inhibition as a promising therapeutic strategy for combating AD, paving the way for future research directions and drug development endeavors.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibody-aptamer Complementation: Advancing Biosensing for Disease Monitoring. 抗体-适体互补:推进疾病监测的生物传感。
IF 2.9 4区 医学
Current topics in medicinal chemistry Pub Date : 2025-06-16 DOI: 10.2174/0115680266372074250603091350
Thangavel Lakshmipriya, Subash C B Gopinath
{"title":"Antibody-aptamer Complementation: Advancing Biosensing for Disease Monitoring.","authors":"Thangavel Lakshmipriya, Subash C B Gopinath","doi":"10.2174/0115680266372074250603091350","DOIUrl":"https://doi.org/10.2174/0115680266372074250603091350","url":null,"abstract":"<p><p>A biosensor is a biological device designed to convert biological responses into an electrical signal, which has diverse applications across various fields, including diagnostics, environmental monitoring, food safety, and drug discovery. Among these, biosensing technology has achieved remarkable success in medical diagnostics. To detect target molecules for various probe molecules, such as nucleic acids, peptides, antibodies, and proteins are widely used. Of these, antibodies are well-established as remarkable molecules for detecting and monitoring a broad range of analytes. Recently, a novel class of molecules known as aptamers, often referred to as \"artificial antibodies,\" has gained significant attention from researchers for numerous biomedical applications, particularly in biosensing. Aptamers are synthetic molecules generated through a method called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Since aptamer and antibody have different bindings for target molecules, various biosensing techniques are utilized by using the combination of aptamer and antibody to enhance the biosensor. This combination possesses a unique and beneficial feature and holds the potential to drive significant advancements in sensing technology. Applying these combinations in biosensing technologies has some limitations due to the aptamer generation for some particular targets. This review explores recent applications of antibodies, aptamers, and their combined use in enhancing biosensing technologies and their limitations.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Qi Yin San Liang San Decoction Relieves Gefitinib-Induced Diarrhea via the Modulation of Chemokines and Innate Immune Responses. 气阴三良散汤通过调节趋化因子和先天免疫反应缓解吉非替尼所致腹泻。
IF 2.9 4区 医学
Current topics in medicinal chemistry Pub Date : 2025-06-13 DOI: 10.2174/0115680266393963250611142026
Ke Yan, Qian Hua, Pengxiang Guo, Luyao Chen, Yufeng Chen, Haiyan Li, Xu Wang, Ya-Li Zhang, Yan Tan
{"title":"Qi Yin San Liang San Decoction Relieves Gefitinib-Induced Diarrhea via the Modulation of Chemokines and Innate Immune Responses.","authors":"Ke Yan, Qian Hua, Pengxiang Guo, Luyao Chen, Yufeng Chen, Haiyan Li, Xu Wang, Ya-Li Zhang, Yan Tan","doi":"10.2174/0115680266393963250611142026","DOIUrl":"https://doi.org/10.2174/0115680266393963250611142026","url":null,"abstract":"<p><strong>Background: </strong>Gefitinib is associated with various adverse reactions, with diarrhea being prevalent. It is mainly managed through lifestyle changes and symptomatic pharmacological interventions, but these approaches have limited effectiveness and frequent recurrence. Qi Yin San Liang San Decoction (QYSLS) shows promise in relieving gefitinib-induced diarrhea, but its mechanisms are unclear.</p><p><strong>Objective: </strong>This study aims to explore the pathological mechanisms underlying gefitinib-induced diarrhea and to elucidate the molecular pathways through which QYSLS mediates its therapeutic effects.</p><p><strong>Methods: </strong>RNA-seq identified differentially expressed genes (DEGs) in colon samples from control and gefitinib-induced diarrhea rats. Network pharmacology was employed to predict the bioactive components and potential targets of QYSLS. A protein-protein interaction (PPI) network was utilized to explore the interactions among these targets, while GO, KEGG, and GSEA enrichment analyses were conducted to reveal the signaling pathways associated with these targets. RNA-seq was used to detect DEGs in QYSLS-mediated relieving of gefitinib-induced diarrhea; the intersection with potential targets was further analyzed to identify key genes. The expression of hub genes was validated through immunohistochemistry and RT-qPCR.</p><p><strong>Results: </strong>RNA-seq and network pharmacology identified 103 bioactive components of QYSLS, with 84 potential targets in QYSLS relieving gefitinib-induced diarrhea. The DEGs in QYSLS relieving gefitinib-induced diarrhea and 84 potential targets were intersected, resulting in the identification of 26 key genes. Further analysis highlighted three central hub genes (CCL20, CCL25, NOS2), which were enriched in pathways related to innate immune response. Furthermore, immunohistochemistry and RT-qPCR confirmed that the expression of CCL25 was reduced by QYSLS in gefitinib-induced diarrhea rats.</p><p><strong>Conclusion: </strong>These results indicate that QYSLS may exert its therapeutic effect on gefitinibinduced diarrhea via the modulation of chemokines and innate immune responses.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Green Synthesis of Cu Nanoparticles and Investigation of the Antibacterial Properties and Cytotoxicity on Multidrug-Resistant E. coli. 铜纳米颗粒的绿色合成及其对多重耐药大肠杆菌的抗菌性能和细胞毒性研究。
IF 2.9 4区 医学
Current topics in medicinal chemistry Pub Date : 2025-06-13 DOI: 10.2174/0115680266379834250605135159
XiaoFeng Yuan, Yu Wang
{"title":"The Green Synthesis of Cu Nanoparticles and Investigation of the Antibacterial Properties and Cytotoxicity on Multidrug-Resistant E. coli.","authors":"XiaoFeng Yuan, Yu Wang","doi":"10.2174/0115680266379834250605135159","DOIUrl":"https://doi.org/10.2174/0115680266379834250605135159","url":null,"abstract":"<p><strong>Introduction: </strong>Although E. coli is considered a normal human microbiota, it may cause life-threatening infections such as septicemia, urinary tract infections, and enteric infections. Moreover, multidrug-resistant strains are a serious challenge in the clinic due to high mortality rates and the limited number of therapeutic options. Hence, the current study aimed to benefit from pink rose petals as a source of green synthesis of copper nanoparticles (Cu-NPs), to investigate the antibacterial features against multidrug-resistant E. coli, and to measure the cytotoxicity of Cu-NPs.</p><p><strong>Methods: </strong>Pink rose petals were used as a reducing agent for Cu-NP synthesis, and then XRD, zeta potential, UV-Vis, FTIR, SEM, and DLS analyses were performed to characterize the synthesized NPs. Moreover, the MIC and zone of inhibition values of Cu-NPs were measured and compared to common antibiotics. Additionally, the MTT assay was performed to assess the cytotoxicity.</p><p><strong>Results: </strong>The green synthesized Cu-NPs were spherical and uniform with a size of ~200 nm. The MIC of Cu-NPs was 1024 μg/ml on the MDR strain of E. coli, representing the antibacterial activity comparable to levofloxacin (p-value>0.05) but less than imipenem and trimethoprim (pvalue< 0.001). Moreover, the CC50 of synthesized Cu-NPs was 731.2 μg/ml and significantly lower than the studied antibiotics (p-value<0.001).</p><p><strong>Conclusion: </strong>The findings may suggest Cu-NPs as a promising antibacterial strategy against MDR strains of E. coli, however, further studies are encouraged to clarify the safety of optimized doses.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Research from 2012 to 2024 on Pyrazole-based Anticancer Agents with SAR Study. 2012 - 2024年吡唑类抗癌药物SAR研究综述
IF 2.9 4区 医学
Current topics in medicinal chemistry Pub Date : 2025-06-10 DOI: 10.2174/0115680266370083250530180225
Deepali Wanode, Deweshri Nandurkar, Megha Ambatkar, Nilesh Rarokar, Pramod Khedekar
{"title":"A Review of Research from 2012 to 2024 on Pyrazole-based Anticancer Agents with SAR Study.","authors":"Deepali Wanode, Deweshri Nandurkar, Megha Ambatkar, Nilesh Rarokar, Pramod Khedekar","doi":"10.2174/0115680266370083250530180225","DOIUrl":"https://doi.org/10.2174/0115680266370083250530180225","url":null,"abstract":"<p><p>The field of cancer research has witnessed a surge in the exploration of novel therapeutic agents, with pyrazole derivatives emerging as promising candidates in the quest for effective anticancer treatments. This comprehensive review provides an in-depth analysis of the research landscape surrounding pyrazole derivatives as potential anticancer agents over the period from 2012 to 2024. Many synthetic pyrazole derivatives have been approved by the FDA and used as chemotherapeutic medicines, and some are under clinical trials, also reported in this article. The review aims to serve as a valuable resource for researchers, guiding future investigations and fostering the development of innovative pyrazole-based anticancer therapeutics.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traditional Medicinal Food for Stress and Cancer Intervention. 传统药膳对应激和癌症的干预。
IF 2.9 4区 医学
Current topics in medicinal chemistry Pub Date : 2025-06-10 DOI: 10.2174/0115680266413093250604073402
Vijay Rani Rajpal, Renu Wadhwa, Sunil Kaul
{"title":"Traditional Medicinal Food for Stress and Cancer Intervention.","authors":"Vijay Rani Rajpal, Renu Wadhwa, Sunil Kaul","doi":"10.2174/0115680266413093250604073402","DOIUrl":"https://doi.org/10.2174/0115680266413093250604073402","url":null,"abstract":"","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer-associated Fibroblasts (CAFs)-derived Exosomes Regulating Chemoresistance. 癌症相关成纤维细胞(CAFs)衍生的外泌体调节化学耐药。
IF 2.9 4区 医学
Current topics in medicinal chemistry Pub Date : 2025-06-05 DOI: 10.2174/0115680266384380250603112353
Gyas Khan, Md Sadique Hussain
{"title":"Cancer-associated Fibroblasts (CAFs)-derived Exosomes Regulating Chemoresistance.","authors":"Gyas Khan, Md Sadique Hussain","doi":"10.2174/0115680266384380250603112353","DOIUrl":"https://doi.org/10.2174/0115680266384380250603112353","url":null,"abstract":"","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurological Inflammation in Parkinsonism: Current Prognosticative Diagnostics and Pitfalls. 帕金森氏症的神经炎症:当前的预测诊断和陷阱。
IF 2.9 4区 医学
Current topics in medicinal chemistry Pub Date : 2025-06-04 DOI: 10.2174/0115680266365134250530063901
Thangavel Lakshmipriya, Subash C B Gopinath, Yeng Chen, Sreenivasan Sasidharan, Evan T Salim, Makram A Fakhri
{"title":"Neurological Inflammation in Parkinsonism: Current Prognosticative Diagnostics and Pitfalls.","authors":"Thangavel Lakshmipriya, Subash C B Gopinath, Yeng Chen, Sreenivasan Sasidharan, Evan T Salim, Makram A Fakhri","doi":"10.2174/0115680266365134250530063901","DOIUrl":"https://doi.org/10.2174/0115680266365134250530063901","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a persistent neurological degenerative condition that can significantly alter one's quality of life. This condition affects the substantia nigra, the region of the brain that contains dopamine-producing neurons. It is a disorder of the central nervous system that arises when nerve cells, or neurons, in this brain area are damaged or die. Norepinephrine, another chemical messenger that aids in controlling primary physiological processes, such as heart rate and blood pressure, is also deficient in PD patients. The symptoms of PD can interfere with daily activities and include fatigue, walking difficulties, limb rigidity, and loss of smell. Researchers are striving to identify a reliable biomarker for Parkinson's disease. Currently, the Food and Drug Administration has approved the radiotracer I-123-ioflupane injection followed by scanning (DATscan- SPECT) for precise analysis. To diagnose Parkinson's disease early, researchers are developing predictive diagnostic techniques using various biomarkers. The right biosensor can recommend the best personalized course of action to slow the progression of Parkinson's disease. This review highlights the strong performance of diagnostic biomarkers for Parkinson's disease and emphasizes the effectiveness of the common immuno-, apta- and DNA-sensors for their efficient implementations for different biomarkers. Further, it also discusses the potential advantages and drawbacks associated with detection methods for improving high-performance diagnostics.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Updated Review on Nipah Virus Infection with a Focus on Encephalitis, Vasculitis, and Therapeutic Approaches. 尼帕病毒感染的最新综述,重点是脑炎、血管炎和治疗方法。
IF 2.9 4区 医学
Current topics in medicinal chemistry Pub Date : 2025-06-04 DOI: 10.2174/0115680266347761250515082453
Pratibha Pandey, Prashant Chauhan, Shivam Pandey, Sorabh Lakhanpal, G Padmapriya, Shivang Mishra, Mandeep Kaur, Ayash Ashraf, M Ravi Kumar, Seema Ramniwas, Fahad Khan
{"title":"An Updated Review on Nipah Virus Infection with a Focus on Encephalitis, Vasculitis, and Therapeutic Approaches.","authors":"Pratibha Pandey, Prashant Chauhan, Shivam Pandey, Sorabh Lakhanpal, G Padmapriya, Shivang Mishra, Mandeep Kaur, Ayash Ashraf, M Ravi Kumar, Seema Ramniwas, Fahad Khan","doi":"10.2174/0115680266347761250515082453","DOIUrl":"https://doi.org/10.2174/0115680266347761250515082453","url":null,"abstract":"<p><p>Nipah virus (NiV), a member of the Paramyxoviridae family, has gained global attention owing to its high mortality rate and destructive potential. NiV has a Biosafety Level 4 (BSL-4) rating and has repeatedly precipitated devastating outbreaks associated with severe respiratory infections, often accompanied by encephalitis and systemic vasculitis. Several studies have been conducted to understand the mechanisms involved in its pathogenesis and to effectively produce new medications to treat this zoonotic virus. However, the cruelty of NiV and its propensity to elude existing treatments underscores the need to elucidate better therapeutics to manage NiV infection more effectively. Therefore, this review highlights the fundamental mechanisms involved in the etiology of NiV, specifically fatal encephalitis and systemic vasculitis. Furthermore, this study investigated promising therapeutic strategies to mitigate the clinical consequences of NiV infections.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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