Ellagic Acid as a Therapeutic Agent for Blood-Brain Barrier Restoration in Neurodegenerative Diseases.

IF 3.3 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-10-10 DOI:10.2174/0115680266411446250926102553

Mazen M Jamil Al-Obaidi, Tanweer Al Zuhaibi, Hoor Al Wahshi

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Abstract

The Blood-Brain Barrier (BBB) plays a crucial role in maintaining the stability of the Central Nervous System (CNS) by regulating what enters and protecting the brain from inflammation and damage caused by harmful molecules. The disruption of the BBB is a characteristic feature of several neurodegenerative disorders and is intimately linked to oxidative stress, inflammation, and apoptosis. Ellagic Acid (EA), a polyphenolic molecule present in several fruits and nuts, has attracted interest due to its significant antioxidant, anti-inflammatory, and neuroprotective characteristics. This review examine recent findings on how EA might help keep the BBB healthy and reduce brain damage. EA works by increasing the levels of tight junction proteins, boosting antioxidant processes, and managing cell death pathways. The review also discusses EA's limited bioavailability and emphasises the therapeutic potential of its gut-derived metabolites, urolithins, which demonstrate enhanced stability and cellular transport. Although EA has considerable potential as a neuroprotective drug, its translational use necessitates more research into its pharmacokinetics, delivery mechanisms, and therapeutic effectiveness. A comprehensive understanding of EA's molecular processes, especially in brain microvascular endothelial cells, may provide innovative therapeutic approaches for safeguarding the BBB and addressing neurodegenerative disorders.

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鞣花酸作为神经退行性疾病血脑屏障修复的治疗剂。

血脑屏障（BBB）在维持中枢神经系统（CNS）的稳定中起着至关重要的作用，它通过调节进入大脑的物质，保护大脑免受有害分子引起的炎症和损伤。血脑屏障的破坏是几种神经退行性疾病的特征，与氧化应激、炎症和细胞凋亡密切相关。鞣花酸（EA）是一种存在于多种水果和坚果中的多酚分子，由于其显著的抗氧化、抗炎和神经保护特性而引起了人们的兴趣。这篇综述研究了最近关于EA如何帮助保持血脑屏障健康和减少脑损伤的发现。EA的工作原理是增加紧密连接蛋白的水平，促进抗氧化过程，并管理细胞死亡途径。该综述还讨论了EA有限的生物利用度，并强调了其肠源代谢物尿石素的治疗潜力，尿石素显示出增强的稳定性和细胞运输。虽然EA作为一种神经保护药物具有相当大的潜力，但其转化应用需要对其药代动力学、传递机制和治疗效果进行更多的研究。全面了解EA的分子过程，特别是在脑微血管内皮细胞中，可能为保护血脑屏障和治疗神经退行性疾病提供创新的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.