{"title":"利用纳米银进行治疗创新的综述：对医学应用、安全性和未来方向的综合综述。","authors":"Muhammad Raza, Hyang Yeol Lee","doi":"10.2174/0115680266405632250929122554","DOIUrl":null,"url":null,"abstract":"<p><p>A novel class of nanomaterials known as silver nanoparticles (AgNPs) changes the potential in modern medicine. AgNPs are rapidly gaining significance in therapeutic applications ranging from tissue engineering to drug delivery systems due to their strong antibacterial, anticancer, anti-inflammatory, and wound-healing properties. This review presents a comprehensive analysis of the biomedical potential of AgNPs, physical, chemical and biological features that allow for regulated release mechanisms, improved bioavailability, and selective cellular targeting. Considering their obvious promise, there are significant challenges due to concerns about longterm exposure, toxicity, and regulatory uncertainty. We cover new developments, clinical studies, and safety evaluations, providing a balanced perspective of the advantages and disadvantages of AgNP or drug-based therapies. This review proposes a framework for scientists, physicians, and legislators to harness the full therapeutic power of silver nanoparticles while directing associated risks.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Review on Harnessing Silver Nanoparticles for Therapeutic Innovations: A Comprehensive Review on Medical Applications, Safety, and Future Directions.\",\"authors\":\"Muhammad Raza, Hyang Yeol Lee\",\"doi\":\"10.2174/0115680266405632250929122554\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A novel class of nanomaterials known as silver nanoparticles (AgNPs) changes the potential in modern medicine. AgNPs are rapidly gaining significance in therapeutic applications ranging from tissue engineering to drug delivery systems due to their strong antibacterial, anticancer, anti-inflammatory, and wound-healing properties. This review presents a comprehensive analysis of the biomedical potential of AgNPs, physical, chemical and biological features that allow for regulated release mechanisms, improved bioavailability, and selective cellular targeting. Considering their obvious promise, there are significant challenges due to concerns about longterm exposure, toxicity, and regulatory uncertainty. We cover new developments, clinical studies, and safety evaluations, providing a balanced perspective of the advantages and disadvantages of AgNP or drug-based therapies. This review proposes a framework for scientists, physicians, and legislators to harness the full therapeutic power of silver nanoparticles while directing associated risks.</p>\",\"PeriodicalId\":11076,\"journal\":{\"name\":\"Current topics in medicinal chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current topics in medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0115680266405632250929122554\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266405632250929122554","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Review on Harnessing Silver Nanoparticles for Therapeutic Innovations: A Comprehensive Review on Medical Applications, Safety, and Future Directions.
A novel class of nanomaterials known as silver nanoparticles (AgNPs) changes the potential in modern medicine. AgNPs are rapidly gaining significance in therapeutic applications ranging from tissue engineering to drug delivery systems due to their strong antibacterial, anticancer, anti-inflammatory, and wound-healing properties. This review presents a comprehensive analysis of the biomedical potential of AgNPs, physical, chemical and biological features that allow for regulated release mechanisms, improved bioavailability, and selective cellular targeting. Considering their obvious promise, there are significant challenges due to concerns about longterm exposure, toxicity, and regulatory uncertainty. We cover new developments, clinical studies, and safety evaluations, providing a balanced perspective of the advantages and disadvantages of AgNP or drug-based therapies. This review proposes a framework for scientists, physicians, and legislators to harness the full therapeutic power of silver nanoparticles while directing associated risks.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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