Isatin Derivatives as Emerging Promising Anti-Alzheimer Agents: Focusing on Their Chemical Structure and Biological Targets.

IF 3.3 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-10-06 DOI:10.2174/0115680266394265250828164308

Yasaman Tamaddon-Abibigloo, Siavoush Dastmalchi, Fardin Mahdipanah, Elham Asadi, Sadegh Khezrpour, Pardis Valizadeh, Javid Shahbazi-Mojarrad

引用次数: 0

Abstract

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder with a complex pathology. Until now, there is no generally effective treatment for AD. Isatin is a natural alkaloid whose derivatives have shown a wide spectrum of biological activities. This molecule is also the basic scaffold for several compounds with useful biological properties against AD. In this review, for the first time, we focus on the anti-AD properties of isatin derivatives. We tried to present comprehensive data about their structure and mechanism of action. Results showed that indirubins, isatin Schiff Bases, and spiro derivatives of isatin were the most studied molecules. The most studied targets were the glycogen synthase kinase-3, cholinesterases, and amyloid beta aggregation. It was concluded that isatin could be considered an important scaffold for the development of new anti-AD compounds.

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Isatin衍生物作为新兴的抗阿尔茨海默病药物：关注它们的化学结构和生物学靶点。

阿尔茨海默病（AD）是一种具有复杂病理的进行性和不可逆的神经退行性疾病。到目前为止，对阿尔茨海默病还没有普遍有效的治疗方法。鸢尾素是一种天然生物碱，其衍生物具有广泛的生物活性。该分子也是几种具有抗阿尔茨海默病有用生物学特性的化合物的基本支架。本文首次对isatin衍生物的抗ad特性进行了综述。我们试图提供有关它们的结构和作用机制的全面数据。结果表明，靛红素、isatin希夫碱和isatin的螺旋衍生物是研究最多的分子。研究最多的目标是糖原合成酶激酶-3，胆碱酯酶和淀粉样蛋白聚集。结果表明，isatin可作为开发新型抗ad化合物的重要支架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.