{"title":"Traditional Design and Modification of \"Celastrol\" Nano-Delivery Systems for Cancer: A Review.","authors":"Siu Kan Law, Sze Wing Ng, Yanping Wang, Xiao Xiao Wu","doi":"10.2174/0115680266418981250929223913","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Cancer is a prevalent public health issue and a significant global problem. Patients receive different treatments, including Western Medicine (WM) and Traditional Chinese Medicine (TCM). This review article aims to discuss a Traditional Chinese Medicine (TCM), \"Celastrol,\" its traditional design, modification, and nano-drug delivery systems for the treatment of cancer.</p><p><strong>Methods: </strong>Nine electronic databases, such as WanFang Data, PubMed, ScienceDirect, Scopus, Web of Science, SpringerLink, SciFinder, and China National Knowledge Infrastructure (CNKI), were used to find relevant information from the past twenty years, with searched keywords including \"celastrol,\" \"cancer,\" and \"nano-drug delivery system,\" etc., without language restrictions.</p><p><strong>Results: </strong>Celastrol is a therapeutic agent with anticancer properties against liver and breast cancers, ovarian cancer, multiple myeloma, and glioma. PI3K/Akt/mTOR, Bcl-2/Bax-caspases, EGFR, ROS/JNK, NF-κB, STAT3, JNK/Nrf2/HO-1, VEGF, AR/miR-101, HSF1-LKB1-AMPKα-YAP, Wnt/β-catenin, and CIP2A/c-MYC signaling pathways are the possible mechanisms by which celastrol acts against cancer.</p><p><strong>Conclusion: </strong>A naturally occurring bioactive substance, \"celastrol,\" is extracted from the root of Tripterygium wilfordii Hook F. Its effectiveness can be enhanced with the support of nanotechnology to overcome its limitations in cancer treatment. However, the toxicity, dosage, and safety assessments of celastrol and nanocelastrol in cancer applications must be further investigated.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266418981250929223913","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Cancer is a prevalent public health issue and a significant global problem. Patients receive different treatments, including Western Medicine (WM) and Traditional Chinese Medicine (TCM). This review article aims to discuss a Traditional Chinese Medicine (TCM), "Celastrol," its traditional design, modification, and nano-drug delivery systems for the treatment of cancer.
Methods: Nine electronic databases, such as WanFang Data, PubMed, ScienceDirect, Scopus, Web of Science, SpringerLink, SciFinder, and China National Knowledge Infrastructure (CNKI), were used to find relevant information from the past twenty years, with searched keywords including "celastrol," "cancer," and "nano-drug delivery system," etc., without language restrictions.
Results: Celastrol is a therapeutic agent with anticancer properties against liver and breast cancers, ovarian cancer, multiple myeloma, and glioma. PI3K/Akt/mTOR, Bcl-2/Bax-caspases, EGFR, ROS/JNK, NF-κB, STAT3, JNK/Nrf2/HO-1, VEGF, AR/miR-101, HSF1-LKB1-AMPKα-YAP, Wnt/β-catenin, and CIP2A/c-MYC signaling pathways are the possible mechanisms by which celastrol acts against cancer.
Conclusion: A naturally occurring bioactive substance, "celastrol," is extracted from the root of Tripterygium wilfordii Hook F. Its effectiveness can be enhanced with the support of nanotechnology to overcome its limitations in cancer treatment. However, the toxicity, dosage, and safety assessments of celastrol and nanocelastrol in cancer applications must be further investigated.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
