FDA-Approved Fluorine-Containing Molecules in 2024: Significance, Synthesis, and Therapeutic Applications.

IF 3.3 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-09-23 DOI:10.2174/0115680266388061250917093142

Malla Reddy Gannarapu, Ravi Kumar Nagiri, Madhu Desagoni, Ganga Reddy Velma

引用次数: 0

Abstract

For the past 75 years, the development pipeline of fluorinated drugs has exemplified the strategic use of fluorine to enhance key pharmacological properties, including bioavailability, metabolic stability, and target affinity. Consequently, fluorine incorporation has become a cornerstone in drug design, inspiring continuous research and development efforts across both academic and industrial sectors. Each year, numerous reviews highlight the ongoing importance of fluorinated drugs and aim to keep the field updated on emerging advancements. This review provides a comprehensive evaluation of the structural and functional benefits of fluorine in medicinal chemistry, presenting an extensive analysis of FDA-approved fluorine-containing drugs from 2015 to 2024. Special attention is paid to the latest approvals from 2024, with a focus on their mechanisms of action and detailed synthetic methodologies.

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fda批准的2024含氟分子：意义、合成和治疗应用。

在过去的75年里，含氟药物的开发管道已经证明了氟的战略性使用，以提高关键的药理学特性，包括生物利用度、代谢稳定性和靶点亲和力。因此，含氟已成为药物设计的基石，激励着学术界和工业界不断开展研究和开发工作。每年，许多评论都强调了氟化药物的持续重要性，并旨在使该领域保持最新的新进展。本综述对氟在药物化学中的结构和功能益处进行了全面评估，对2015年至2024年fda批准的含氟药物进行了广泛分析。特别关注2024年以来的最新批准，重点关注其作用机制和详细的合成方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.