Current topics in medicinal chemistry最新文献_第3页

Signaling Pathways (TNF-α-NF-κB, TLR2-TLR4 as well as ROS-MDA) and Cardiac Damages during Cardiac Surgeries (Coronary stenting, Permanent Pacemaker Implantations, Radiofrequency Ablations). 信号通路（TNF-α-NF-κB、TLR2-TLR4 以及 ROS-MDA）和心脏手术（冠状动脉支架植入术、永久起搏器植入术、射频消融术）期间的心脏损伤。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-09-27 DOI: 10.2174/0115680266314899240919081451

Xia Li, Yongjuan Zhao, Hualan Zhou, Youdong Hu, Ying Chen, Dianxuan Guo

{"title":"Signaling Pathways (TNF-α-NF-κB, TLR2-TLR4 as well as ROS-MDA) and Cardiac Damages during Cardiac Surgeries (Coronary stenting, Permanent Pacemaker Implantations, Radiofrequency Ablations).","authors":"Xia Li, Yongjuan Zhao, Hualan Zhou, Youdong Hu, Ying Chen, Dianxuan Guo","doi":"10.2174/0115680266314899240919081451","DOIUrl":"https://doi.org/10.2174/0115680266314899240919081451","url":null,"abstract":"Introduction: The mutual activations of multiple signaling pathways are the key factors in the development and progression of myocardial cell injuries.Objective: This research aimed to compare the different degrees of myocardial injury after coronary stenting, permanent pacemaker implantations, or cardiac radiofrequency ablation and to investigate the effects of the mutual activation of TNF-α/NF-κB, TLR2/TLR4, and ROS/MDA signaling pathways on myocardial injury in elderly patients after coronary stents or permanent pacemakers or radiofrequency ablation.Methods: We determined reactive oxygen species (ROS), malondialdehyde (MDA), toll-like receptor 2 (TLR2), toll-like receptor 4 (TLR4), nuclear factor kappa B (NF-κB), tumor necrosis factor- α (TNF-α) and high-sensitive cardiac troponin T (hs-cTnT) as a marker of myocardial injury in patients.Results: The levels of ROS, MDA, TLR2, TLR4, NF-κB, TNF-α, and hs-cTnT were increased in patients with permanent pacemaker implantations when compared to patients with cardiac radiofrequency ablation (P < 0.01) at 6 months and were further increased in patients with coronary stenting compared to patients with cardiac radiofrequency ablation and permanent pacemaker implantations at 6 months, respectively (P < 0.01). This research confirmed that ROS, MDA, TLR2, TLR4, NF-κB, and TNF-α predicted myocardial injury severity.Conclusion: Oxidative stress (ROS/MDA signaling pathway) may be linked to immune response (TLR2/TLR4 signaling pathway) and pro-inflammatory response (TNF-α/NF-κB signaling pathway) in myocardial injury, and ROS/MDA signaling may play a dominant role.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioassay Guided Isolation and α-Glucosidase Inhibition Studies of a New Sesquiterpene from Ochradenus aucheri. 生物测定指导下从 Ochradenus aucheri 中分离和抑制 α-葡萄糖苷酶的研究。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-09-27 DOI: 10.2174/0115680266318007240924174634

Hamida K M Al Rabani, Ajmal Khan, Tania Shamim Rizvi, Liaqat Ali, Javid Hussain, Fazal Mabood, Sobia Ahsan Halim, Asaad Khalid, Ahmed Al-Harrasi

{"title":"Bioassay Guided Isolation and α-Glucosidase Inhibition Studies of a New Sesquiterpene from Ochradenus aucheri.","authors":"Hamida K M Al Rabani, Ajmal Khan, Tania Shamim Rizvi, Liaqat Ali, Javid Hussain, Fazal Mabood, Sobia Ahsan Halim, Asaad Khalid, Ahmed Al-Harrasi","doi":"10.2174/0115680266318007240924174634","DOIUrl":"https://doi.org/10.2174/0115680266318007240924174634","url":null,"abstract":"Aims: The aim of the current study was to explore the anti-diabetic potential of Ochradenus aucheri Boiss (O. aucheri).Method: All the fractions of O. aucheri were evaluated for α-glucosidase inhibition, followed by bioassay-guided isolation which resulted in a new sesquiterpenoid, as a potential α-glucosidase inhibitor.Results: The preliminary screening showed that all the fractions including n-hexane (38.0 ± 1.38 μg/mL), dichloromethane (92.6 ± 6.18 μg/mL), ethyl acetate (29.2 ± 0.51 μg/mL) and n-butanol (361.8 ± 5.80 μg/mL) displayed significant α-glucosidase inhibitory activity. The activity-directed fractionation and purification of ethyl acetate fraction led to the isolation of one new sesquiterpenoid, Jardenol (1), and two known metabolites: β-stitosterol-3-O-β-D-glucopyranoside (2) and β-Sitosterol (3). To the best of our knowledge, these metabolites have not been isolated from this plant previously. The structure of the new metabolite 1 was confirmed through 1D and 2D NMR spectroscopy, and MS analysis. Compound 1 showed significant α-glucosidase inhibition with an IC50 value of 138.2 ± 2.43 μg/mL as compared to positive control acarbose (IC50 = 942.0 ± 0.60 μg/mL). Additionally, in-silico docking was employed to predict the binding mechanism of compound 1 in the active site of the target enzyme, α-glucosidase. The docking results suggested that the compound forms strong interactions at the catalytic site of α-glucosidase.Conclusion: The results of the present study indicated that the newly purified secondary metabolite, Jardenol, can be a promising anti-diabetic compound.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterocyclic Phytochemicals as Anticancer Agents. 作为抗癌剂的杂环植物化学物质。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-09-27 DOI: 10.2174/0115680266314693240914070250

M Amin Mir, Bimal Krishna Banik

{"title":"Heterocyclic Phytochemicals as Anticancer Agents.","authors":"M Amin Mir, Bimal Krishna Banik","doi":"10.2174/0115680266314693240914070250","DOIUrl":"https://doi.org/10.2174/0115680266314693240914070250","url":null,"abstract":"Cancer continues to be a major global health challenge, driving the need for the discovery of novel therapeutic agents. Among these, heterocyclic phytochemicals have gained significant attention for their potential as anticancer agents. This review offers a detailed analysis of various classes of heterocyclic compounds with proven anticancer properties, shedding light on their mechanisms of action. The study draws from a diverse array of natural product sources, detailing the chemical structures and bioactivities of these compounds. Key heterocyclic classes such as alkaloids, flavonoids, coumarins, and terpenoids are emphasized due to their potent anticancer effects. Heterocyclic phytochemicals exhibit diverse anticancer mechanisms, including the modulation of cellular pathways like apoptosis, angiogenesis, and cell cycle progression. The combination of heterocyclic phytochemicals with conventional cancer therapies has shown promising synergistic effects, enhanced treatment efficacy and reducing side effects. The review systematically evaluates both preclinical and clinical studies, revealing the efficacy, safety profiles, and pharmacokinetics of selected heterocyclic compounds. The promising outcomes highlighted in this review underscore the critical need for ongoing research to fully realize the therapeutic potential of heterocyclic phytochemicals in cancer treatment.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Therapeutic Potential of Glycyrrhiza Compounds in Alzheimer's Disease: A Comprehensive Review. 探索甘草化合物对阿尔茨海默病的治疗潜力：全面综述。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-09-25 DOI: 10.2174/0115680266322320240911194626

Xiaona Song, Xiaotang Wang, Yao Gao, Guoqiang Xu, Xiaoru Yan, Zhaoyang Chen, Guohua Song

{"title":"Exploring the Therapeutic Potential of Glycyrrhiza Compounds in Alzheimer's Disease: A Comprehensive Review.","authors":"Xiaona Song, Xiaotang Wang, Yao Gao, Guoqiang Xu, Xiaoru Yan, Zhaoyang Chen, Guohua Song","doi":"10.2174/0115680266322320240911194626","DOIUrl":"https://doi.org/10.2174/0115680266322320240911194626","url":null,"abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Research shows that the development of AD is linked to neuroinflammation, endoplasmic reticulum stress, mitochondrial dysfunction, cell death, and abnormal cholinergic signaling. Glycyrrhiza compounds contain active ingredients and extracts that offer multiple benefits, including targeting various pathways, high efficacy with low toxicity, and long-lasting therapeutic effects. These benefits highlight the significant potential of Glycyrrhiza compounds for preventing and treating AD. This review summarizes recent advancements in Glycyrrhiza compounds for preventing and treating AD. It focuses on their inhibitory effects on key signaling pathways, such as Toll-like receptor 4 (TLR4), nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and cholinergic signaling. This study aims to establish a scientific framework for using Glycyrrhiza compounds in the clinical prevention and treatment of AD and to support the development of new therapeutic interventions.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Nature to Drug: Overview and CADD Approach of Anacardic Acid to Propose their Biological Potential. 从自然到药物：概述心绞痛酸并采用 CADD 方法提出其生物潜力。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-09-18 DOI: 10.2174/0115680266319575240905164313

Magna Maria Lima Araújo, Maria Lorena de Oliveira Andrade, Genil Dantas de Oliveira, Igor José Dos Santos Nascimento, Samuel Paulo Cibulski, Harley da Silva Alves

{"title":"From Nature to Drug: Overview and CADD Approach of Anacardic Acid to Propose their Biological Potential.","authors":"Magna Maria Lima Araújo, Maria Lorena de Oliveira Andrade, Genil Dantas de Oliveira, Igor José Dos Santos Nascimento, Samuel Paulo Cibulski, Harley da Silva Alves","doi":"10.2174/0115680266319575240905164313","DOIUrl":"https://doi.org/10.2174/0115680266319575240905164313","url":null,"abstract":"Anacardic acids are natural compounds found in various plant families, such as Anacardiaceae, Geraniaceae, Ginkgoaceae, and Myristicaceae, among others. Several activities have been reported regarding these compounds, including antibacterial, antioxidant, anticancer, anti-inflammatory, and antiviral activities, showing the potential therapeutic applicability of these compounds. From a chemical point of view, they are structurally made up of salicylic acids substituted by an alkyl chain containing unsaturated bonds, which can vary in number and position, determining their bioactivity and differentiating them from the various existing forms. Our work aimed to explore the potential of anacardic acids, based on studies that address the bioactivity of these compounds, as well as to establish a greater understanding of the structure-activity relationship of these compounds through in silico methods, with a focus on the elucidation of a possible drug target through the application of computer-aided drug design, CADD.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mentha spicata Mediated Formulation of Iron Oxide Nanoparticles Exhibit Superior Antimicrobial, Antioxidant, and Photodegradation Propensity Compared to Chemically Formulated Counterparts. 薄荷介导的氧化铁纳米粒子配方与化学配方相比具有更强的抗菌、抗氧化和光降解能力。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-09-18 DOI: 10.2174/0115680266332330240910100638

Lipsa Leena Panigrahi, Shashank Shekhar, Ashirdbad Sarangi, Siddharth Satpathy, Ankita Parmanik, Anindya Bose, Debapriya Bhattacharya, Manoranjan Arakha

{"title":"Mentha spicata Mediated Formulation of Iron Oxide Nanoparticles Exhibit Superior Antimicrobial, Antioxidant, and Photodegradation Propensity Compared to Chemically Formulated Counterparts.","authors":"Lipsa Leena Panigrahi, Shashank Shekhar, Ashirdbad Sarangi, Siddharth Satpathy, Ankita Parmanik, Anindya Bose, Debapriya Bhattacharya, Manoranjan Arakha","doi":"10.2174/0115680266332330240910100638","DOIUrl":"https://doi.org/10.2174/0115680266332330240910100638","url":null,"abstract":"Introduction: Iron oxide nanoparticles demonstrate tremendous potential in preserving the ecological balance of the environment since they act as antimicrobial agents and efficient photocatalysts. However, environmental sustainability has challenged the synthesis protocols of nanomaterials.Method: This study compares the green synthesis method with the scalable chemical synthesis method. In this work, Iron oxide nanoparticles were fabricated via the green chemistry technique utilizing the leaf extract of Mentha spicata (M-IONP) and also via the chemical co-precipitation method (C-IONP). The synthesized IONPs were analyzed by different characterization methods such as XRD, FTIR, SEM analysis, ZETA potential measurements, and DLS spectroscopy analysis.Results: The biosynthesized and chemically synthesized IONPs were analyzed for their mechanistic action against different applications like antimicrobial, antioxidant, and degradation of harmful dyes. Interestingly, the biosynthesized IONPs (M-IONP) exhibited more effective antimicrobial efficacy towards Gram-positive and Gram-negative organisms than chemically synthesized IONPs.Conclusion: The green synthesized M-IONP also showed significant antioxidant propensity similar to that of the standards taken. Additionally, green-synthesized M-IONP exhibited enhanced degradation efficacies against Methylene blue, chromium, and sulphamethoxazole in comparison to chemically synthesized IONP.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solar Light-Induced Synthesis of Biologically Active Compounds. 太阳光诱导生物活性化合物的合成。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-09-18 DOI: 10.2174/0115680266318635240906102108

Aparna Das, Devalina Ray, Muhammad Waqar Ashraf, Bimal Krishna Banik

{"title":"Solar Light-Induced Synthesis of Biologically Active Compounds.","authors":"Aparna Das, Devalina Ray, Muhammad Waqar Ashraf, Bimal Krishna Banik","doi":"10.2174/0115680266318635240906102108","DOIUrl":"https://doi.org/10.2174/0115680266318635240906102108","url":null,"abstract":"Over the past few years, photocatalytic methods have shown great promise as low-cost, environmentally friendly, and sustainable technologies. During the development of photochemistry, a variety of sources of light were used, including sunlight, compact fluorescent lamps, lasers, and even light-emitting diodes. As a part of preparing diverse organic compounds, the photochemical approach was used, for instance, to form rings, arylated compounds, cycloaddition, functionalized compounds, dehalogenated compounds, oxidized compounds, reduced compounds, isomers, and sensitized compounds. Solar energy is a renewable resource that can be harvested from the sun and this light energy can be changed into chemical energy with the help of photocatalysts. During this green approach, electron-hole pairs are generated in photocatalysts in order to begin reactions by using solar light. It has been highlighted in this article that there have been impressive developments in the use of light, mainly the solar light, to promote important organic reactions, which would otherwise be unattainable under thermal conditions.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Therapeutic Potential of Traditional Medicinal Foods in Cancer Treatment: Molecular Evidence and Bioactivities 探索传统药用食品在癌症治疗中的治疗潜力：分子证据和生物活性

IF 3.4 4区医学

Current topics in medicinal chemistry Pub Date : 2024-09-10 DOI: 10.2174/0115680266328466240829045659

Kulbhushan Thakur, Tejveer Singh, Deepika Sharma, Nipun Padha, Bilal Ahmad Mir, Atika Chandra, Vijay Rani Rajpal

{"title":"Exploring the Therapeutic Potential of Traditional Medicinal Foods in Cancer Treatment: Molecular Evidence and Bioactivities","authors":"Kulbhushan Thakur, Tejveer Singh, Deepika Sharma, Nipun Padha, Bilal Ahmad Mir, Atika Chandra, Vijay Rani Rajpal","doi":"10.2174/0115680266328466240829045659","DOIUrl":"https://doi.org/10.2174/0115680266328466240829045659","url":null,"abstract":": Traditional medicinal foods derived from natural sources have gained increasing attention in recent years due to their perceived health benefits and potential therapeutic properties and are deeply rooted in cultural practices. This review aimed at understanding their potential health benefits, emphasizes the need to identify the key bioactive substances in traditional home medicine. We have discussed the bioactive properties, molecular targets, and anti-cancer effects of various compounds such as curcumin, genistein, berberine, resveratrol, and, quercetin present in traditional medicinal foods. Our study highlights the potential of traditional medicinal food in the prevention and management of various health conditions, including cardiovascular diseases, cancer and neurodegenerative disorders as evident from in vitro, in vivo and clinical trials. Additionally, our study explores the mechanistic action of various bioactive constituents of grapes, rosemary, barberry, turmeric and garlic that have been shown to interfere with cancer growth, proliferation, metastasis, angiogenesis, and induce apoptosis by targeting various pathways and the cell cycle. Additionally, a wide range of healing abilities of medicinal foods including their impact on cancer cells demonstrate their direct anti-tumor potential along with antioxidant and antiinflammatory properties. To summarize, the present review highlights that integrating the insights of contemporary science with the age-old wisdom of traditional medicine in a systematic way holds immense potential for developing alternate and effective approaches to cancer therapeutics and offering evidence-based dietary recommendations.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":"17 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and Verification of a Prognostic Risk Signature in Oral Squamous Cell Carcinoma. 口腔鳞状细胞癌预后风险特征的识别与验证

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-09-05 DOI: 10.2174/0115680266335055240828061128

Rishou Chen, Junlin Duan, Yonglong Ye, Huan Xu, Yali Ding, Jun Liu

{"title":"Identification and Verification of a Prognostic Risk Signature in Oral Squamous Cell Carcinoma.","authors":"Rishou Chen, Junlin Duan, Yonglong Ye, Huan Xu, Yali Ding, Jun Liu","doi":"10.2174/0115680266335055240828061128","DOIUrl":"https://doi.org/10.2174/0115680266335055240828061128","url":null,"abstract":"Introduction: Oral squamous cell carcinoma (OSCC) is a prevalent malignant condition. This study aimed to investigate the role of mTORC1 signaling and develop a prognostic model for OSCC.Materials and methods: The single-sample gene set enrichment analysis (ssGSEA) algorithm was utilized to calculate the Z-Score of Hallmarks in OSCC, followed by univariate Cox regression analysis to identify processes associated with prognosis. Weighted gene co-expression network analysis (WGCNA) was performed using transcriptomic data from the cancer genome atlas (TCGA) cohort to identify genes correlated with mTORC1 signaling. A six-gene prognostic model was constructed using multifactorial Cox regression analysis and validated using an external dataset.Results: The study uncovered a strong linkage between mTORC1, glycolysis, hypoxia, and the prognosis of OSCC. mTORC1 signaling emerged as the most significant risk factor, negatively impacting patient survival. Additionally, a six-gene prognostic risk score model was developed which provided a quantitative measure of patients' survival probabilities. Interestingly, within the context of these findings, TP53 gene mutations were predominantly observed in the high-risk group, potentially underlining the genetic complexity of this patient subgroup. Additionally, differential immune cell infiltration and an integrated nomogram were also reported.Conclusion: This study highlights the importance of mTORC1 signaling in OSCC prognosis and presents a robust prognostic model for predicting patient outcomes.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Method for Predicting Allelic Variants of Single Nucleotide Polymorphisms. 预测单核苷酸多态性等位基因变异的方法。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-09-05 DOI: 10.2174/0115680266328330240828040922

Ekaterina Evgenyevna Tyagunova, Alexander Sergeevich Zakharov, Galina Valerievna Pavlova, Daria Alexandrovna Ogarkova, Natalia Alexandrovna Zhuchenko, Vladimir Alexeyevich Gushchin

{"title":"A Method for Predicting Allelic Variants of Single Nucleotide Polymorphisms.","authors":"Ekaterina Evgenyevna Tyagunova, Alexander Sergeevich Zakharov, Galina Valerievna Pavlova, Daria Alexandrovna Ogarkova, Natalia Alexandrovna Zhuchenko, Vladimir Alexeyevich Gushchin","doi":"10.2174/0115680266328330240828040922","DOIUrl":"https://doi.org/10.2174/0115680266328330240828040922","url":null,"abstract":"Introduction: Single nucleotide polymorphisms (SNPs) are pivotal in clinical genetics, serving to link genotypes with disease susceptibility and response to environmental factors, including pharmacogenetics. They also play a crucial role in population genetics for mapping the human genome and localizing genes. Despite their utility, challenges arise when molecular genetic studies yield insufficient or uninformative data, particularly for socially significant diseases. This study aims to address these gaps by proposing a method to predict allelic variants of SNPs.Method: Using quantitative PCR and analyzing body composition data from 150 patients with their voluntary informed consent, we employed IBM SPSS Statistics 29.0 for data analysis. Our prototype formula, exemplified by allelic variant ADRB2 (rs1042713) = 0.257 + 0.639 * allelic variant ADRB2 (rs1042714) - 0.314 * allelic variant ADRB3 (rs4994) + 0.191 * allelic variant PPARA (rs4253778) - 0.218 * allelic variant PPARD (rs2016520) + 0.027 * body weight + 0.00001 * body weight², demonstrates the feasibility of predicting SNP allelic variants.Results: This method holds promise for diverse diseases, including those of significant social impact, due to its potential to streamline and economize molecular genetic research. Its ability to stratify disease risk in the absence of complete SNP data makes it particularly compelling for clinical and laboratory geneticists.Conclusion: However, its translation into clinical practice necessitates the establishment of a comprehensive SNP database, especially for frequently analyzed SNPs within the implementing institution.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0