Targeting Cell Signalling Pathways with New Small Molecules in Inflammation and Cancer.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-05-12 DOI:10.2174/0115680266360926250509040743

Ritam Mondal, Kalpana Rahate, Sandhya Chaudhary

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Abstract

In the treatment of cancer and inflammation, small molecules become powerful therapeutic tools that provide new therapeutic approaches with improved efficacy and fewer side effects. This review offers a thorough summary of current developments in small-molecule drugs that target cancer and inflammatory pathways. Specifically, inhibition of phosphodiesterase-4 (PDE4) and COX receptors have demonstrated potential in the field of inflammation to help mitigate a variety of inflammatory disorders. We examine the structural design, mechanism of action, and therapeutic potential of innovative small compounds that inhibit or alter these pathways. Significant attention is placed on the dual anti-inflammatory and anti-cancer properties of these substances. The evaluation emphasizes preclinical and clinical data, revealing the most promising candidates under development. In summary, the precise manipulation of cellular signalling pathways by small compounds constitutes a dynamic domain with the capacity to revolutionize therapeutic approaches for inflammation and cancer. Ongoing investigation of these chemicals is essential for the advancement of safer and more efficacious therapies.

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在炎症和癌症中靶向细胞信号通路的新小分子。

在癌症和炎症的治疗中，小分子成为强有力的治疗工具，提供了新的治疗方法，提高了疗效，减少了副作用。本文综述了针对癌症和炎症途径的小分子药物的最新进展。具体来说，抑制磷酸二酯酶-4 （PDE4）和COX受体在炎症领域已被证明具有帮助减轻多种炎症疾病的潜力。我们研究了结构设计、作用机制和抑制或改变这些途径的创新小化合物的治疗潜力。值得注意的是，这些物质具有抗炎和抗癌的双重特性。评估强调临床前和临床数据，揭示正在开发的最有希望的候选药物。总之，小化合物对细胞信号通路的精确操纵构成了一个动态领域，具有彻底改变炎症和癌症治疗方法的能力。对这些化学物质的持续研究对于开发更安全、更有效的治疗方法至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.