{"title":"Exploring the Medicinal and Nutraceutical Frontiers of Tinospora Cordifolia in Stress and Cancer Management.","authors":"Akansha Jaiswal, Kulbhushan Thakur, Atika Chandra, Tejveer Singh, Bilal Ahmad Mir, Shailendra Goel, Rajesh Tandon, Vijay Rani Rajpal","doi":"10.2174/0115680266347636250505063601","DOIUrl":null,"url":null,"abstract":"<p><p>Tinospora cordifolia, commonly known as Guduchi, Giloy, or Amrita, has been a cornerstone of traditional medicine for centuries and is renowned for its diverse nutraceutical and medicinal potential. The plant exhibits immunomodulatory, antioxidant, anti-inflammatory, and anti-viral activities due to its rich array of bioactive compounds, including alkaloids, diterpenoid lactones, polysaccharides, and others. These properties make Giloy a promising candidate for a variety of therapeutic applications. Further, as oxidative damage contributes to chronic diseases by affecting essential biomolecules, the antioxidant phytochemicals found in T. cordifolia counter the free radicals and offer significant health benefits. This comprehensive review delves into the health benefits and therapeutic efficacy of Giloy, with a particular focus on its mechanisms for mitigating stress and combating cancer. The preclinical and clinical studies have demonstrated Giloy's ability to enhance antioxidant defences and induce apoptosis in cancerous cells. Additionally, it has shown potential in adjunct therapy to improve the quality of life for cancer patients by reducing the side effects associated with conventional cancer therapies. By exploring the multifaceted potential of T. cordifolia in modern medicine, this review aims to bridge the gap between traditional knowledge and contemporary scientific insights by addressing the underutilization of ancient herbal remedies in evidence-based healthcare. It also discusses future research directions and probable applications of Giloy in clinical practice, highlighting the importance of this ancient remedy in the context of modern healthcare practices, especially in cancer and stress management.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266347636250505063601","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Tinospora cordifolia, commonly known as Guduchi, Giloy, or Amrita, has been a cornerstone of traditional medicine for centuries and is renowned for its diverse nutraceutical and medicinal potential. The plant exhibits immunomodulatory, antioxidant, anti-inflammatory, and anti-viral activities due to its rich array of bioactive compounds, including alkaloids, diterpenoid lactones, polysaccharides, and others. These properties make Giloy a promising candidate for a variety of therapeutic applications. Further, as oxidative damage contributes to chronic diseases by affecting essential biomolecules, the antioxidant phytochemicals found in T. cordifolia counter the free radicals and offer significant health benefits. This comprehensive review delves into the health benefits and therapeutic efficacy of Giloy, with a particular focus on its mechanisms for mitigating stress and combating cancer. The preclinical and clinical studies have demonstrated Giloy's ability to enhance antioxidant defences and induce apoptosis in cancerous cells. Additionally, it has shown potential in adjunct therapy to improve the quality of life for cancer patients by reducing the side effects associated with conventional cancer therapies. By exploring the multifaceted potential of T. cordifolia in modern medicine, this review aims to bridge the gap between traditional knowledge and contemporary scientific insights by addressing the underutilization of ancient herbal remedies in evidence-based healthcare. It also discusses future research directions and probable applications of Giloy in clinical practice, highlighting the importance of this ancient remedy in the context of modern healthcare practices, especially in cancer and stress management.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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