Ana Flavia S Lima, Rayane M Botelho, Marilene B T Fragoso, Miguel L Silva, Jadriane A Xavier, Alexandre U Borbely, Marilia O F Goulart
{"title":"病毒通过胎盘垂直传播：天然产物作为治疗和预防抗病毒药物的潜力。","authors":"Ana Flavia S Lima, Rayane M Botelho, Marilene B T Fragoso, Miguel L Silva, Jadriane A Xavier, Alexandre U Borbely, Marilia O F Goulart","doi":"10.2174/0115680266366044250901094542","DOIUrl":null,"url":null,"abstract":"<p><p>Pregnant women are among the most vulnerable groups in human populations. The human placenta, consisting of fetal chorionic villi and maternal basal decidua, is a specialized and transient organ crucial for supporting pregnancy and ensuring the well-being of both the mother and the fetus. Although the placenta has a developed, robust defense system, some pathogens can overcome it and cause a fetal infection that may be lethal. This review examines the defense mechanisms in the placenta against viral infections, how microorganisms bypass these defense barriers to cause illness, and the potential use of natural products in treating viral infections during pregnancy. Research on natural products has shown their promise to serve as an alternative to antiviral therapy, particularly for pregnant women.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Viral Vertical Transmission through the Placenta: The Potential of Natural Products as Therapeutic and Prophylactic Antiviral Agents.\",\"authors\":\"Ana Flavia S Lima, Rayane M Botelho, Marilene B T Fragoso, Miguel L Silva, Jadriane A Xavier, Alexandre U Borbely, Marilia O F Goulart\",\"doi\":\"10.2174/0115680266366044250901094542\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pregnant women are among the most vulnerable groups in human populations. The human placenta, consisting of fetal chorionic villi and maternal basal decidua, is a specialized and transient organ crucial for supporting pregnancy and ensuring the well-being of both the mother and the fetus. Although the placenta has a developed, robust defense system, some pathogens can overcome it and cause a fetal infection that may be lethal. This review examines the defense mechanisms in the placenta against viral infections, how microorganisms bypass these defense barriers to cause illness, and the potential use of natural products in treating viral infections during pregnancy. Research on natural products has shown their promise to serve as an alternative to antiviral therapy, particularly for pregnant women.</p>\",\"PeriodicalId\":11076,\"journal\":{\"name\":\"Current topics in medicinal chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current topics in medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0115680266366044250901094542\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266366044250901094542","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Viral Vertical Transmission through the Placenta: The Potential of Natural Products as Therapeutic and Prophylactic Antiviral Agents.
Pregnant women are among the most vulnerable groups in human populations. The human placenta, consisting of fetal chorionic villi and maternal basal decidua, is a specialized and transient organ crucial for supporting pregnancy and ensuring the well-being of both the mother and the fetus. Although the placenta has a developed, robust defense system, some pathogens can overcome it and cause a fetal infection that may be lethal. This review examines the defense mechanisms in the placenta against viral infections, how microorganisms bypass these defense barriers to cause illness, and the potential use of natural products in treating viral infections during pregnancy. Research on natural products has shown their promise to serve as an alternative to antiviral therapy, particularly for pregnant women.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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