{"title":"A Comprehensive Review on Flavone Scaffolds: Examining their Structural Modifications and Biological Activities.","authors":"Ramalakshmi N, Dibenthiran S, Arunkumar S, Amuthalakshmi S, Indrakumar S, Nalini Cn","doi":"10.2174/0115680266385536250822095825","DOIUrl":null,"url":null,"abstract":"<p><p>Flavones, an important subgroup of flavonoids, demonstrate a wide range of biological activities. A comprehensive review of the literature on the flavone scaffold elucidates its synthetic methodologies and therapeutic potential in various disease states and demonstrates how structural modifications of the flavone moiety result in high-affinity lead candidates for diverse biological targets. The objective of this review is the systematic examination of the alternative synthetic methods of flavones over the traditional method and their medicinal properties, with brief consideration of their structure-activity relationships (SAR). This structural framework presents opportunities for the discovery of novel, improved, efficacious, and well-tolerated biological agents. This review aimed to provide insights that will aid researchers in the systematic design and synthesis of flavone derivatives, potentially leading to the development of novel therapeutic agents.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266385536250822095825","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Flavones, an important subgroup of flavonoids, demonstrate a wide range of biological activities. A comprehensive review of the literature on the flavone scaffold elucidates its synthetic methodologies and therapeutic potential in various disease states and demonstrates how structural modifications of the flavone moiety result in high-affinity lead candidates for diverse biological targets. The objective of this review is the systematic examination of the alternative synthetic methods of flavones over the traditional method and their medicinal properties, with brief consideration of their structure-activity relationships (SAR). This structural framework presents opportunities for the discovery of novel, improved, efficacious, and well-tolerated biological agents. This review aimed to provide insights that will aid researchers in the systematic design and synthesis of flavone derivatives, potentially leading to the development of novel therapeutic agents.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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