Oroidins: Marine Pyrrole-Imidazole Alkaloids with Emerging Therapeutic Potential.

IF 3.3 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-09-17 DOI:10.2174/0115680266391437250909024350

Navin Kumar Tailor, Geeta Deswal, Ajmer Singh Grewal, Kumar Guarve

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引用次数: 0

Abstract

Introduction/objective: Oroidins are marine-derived alkaloids known for their structural complexity and a broad range of pharmacological activities. This review aims to explore their emerging role as promising scaffolds in medicinal chemistry, particularly focusing on their unique chemical structure, diverse biological effects, and recent synthetic advancements.

Methods: An extensive literature review was conducted to analyze peer-reviewed articles on the isolation, synthesis, structural characterization, and pharmacological evaluation of oroidins and their derivatives. The review highlights significant developments in synthetic strategies, including the incorporation of pyrrole carboxamide units, isotopic labeling approaches, and palladiumcatalyzed reactions.

Results: Oroidins exhibit a wide spectrum of biological activities, including antibacterial, antiviral, antimalarial, antiprotozoal, anticancer, anti-inflammatory, neurotropic, and antimuscarinic properties. Their characteristic pyrrole-imidazole core, containing a glycocyamidine moiety and azepinone ring, has been instrumental in targeting key biological pathways such as kinases, NF-κB, and the Raf/MEK-1/MAPK cascade. Structural modifications have led to enhanced potency and specificity of oroidin-based compounds.

Discussion: The findings emphasize the potential of oroidins as lead compounds in drug development. Their structural diversity, bioactivity profile, and ability to inhibit critical cellular targets position them as attractive templates for therapeutic design. However, further research is needed to optimize their pharmacokinetic properties and evaluate their clinical relevance.

Conclusion: Oroidins represent a valuable class of marine alkaloids with significant therapeutic promise. Advances in synthetic methodologies have expanded their applicability in drug discovery, supporting continued exploration of these compounds for the development of novel therapeutic agents.

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Oroidins：具有新兴治疗潜力的海洋吡咯-咪唑类生物碱。

简介/目的：鱼罗苷是一种海洋生物碱，以其结构复杂和广泛的药理活性而闻名。本文综述了其在药物化学领域的应用前景，重点介绍了其独特的化学结构、多样的生物效应以及近年来的合成进展。方法：广泛查阅文献，对经同行评议的羊甲苷及其衍生物的分离、合成、结构表征和药理评价等方面的文章进行分析。这篇综述强调了合成策略的重大进展，包括吡咯甲酰胺单元的结合、同位素标记方法和钯催化反应。结果：Oroidins具有广泛的生物活性，包括抗菌、抗病毒、抗疟、抗原虫、抗癌、抗炎、嗜神经和抗毒蕈碱。它们的特征是吡咯-咪唑核，包含一个糖氨基部分和氮平酮环，在靶向激酶、NF-κB和Raf/MEK-1/MAPK级联等关键生物通路中发挥了重要作用。结构上的修饰提高了羊藿苷类化合物的效力和特异性。讨论：这一发现强调了在药物开发中，鱼腥草素作为先导化合物的潜力。它们的结构多样性、生物活性特征和抑制关键细胞靶点的能力使它们成为治疗设计的有吸引力的模板。然而，需要进一步的研究来优化它们的药代动力学特性和评估它们的临床意义。结论：鱼腥草苷是一类有价值的海洋生物碱，具有广阔的治疗前景。合成方法的进步扩大了它们在药物发现中的适用性，支持继续探索这些化合物以开发新的治疗药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.