An Overview of Novel Indole Scaffolds with Structural Aspects and Receptor Inhibition for Cancer Treatment.

IF 3.3 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-09-19 DOI:10.2174/0115680266393974250912071544

Neha Sharma, Anurag Chaudhary

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引用次数: 0

Abstract

Cancer has consistently posed a concern on a worldwide scale. Numerous studies were conducted to establish the best and most efficient treatment for this illness. We attempted to determine the function and mechanism of indole analogs as molecularly targeted anticancer treatment in this review. These indole analogs target various molecules, influencing the development, growth, and spread of tumors. Target anticancer medications function cytostatically and are typically made to accomplish specific goals, in contrast to traditional chemotherapeutics, which act cytotoxically. Small molecules and macromolecules are a novel class of targeted drugs that resulted from this approach. Certain receptor-targeted drugs are superior to macromolecule medicines in terms of improved patient care. Various receptor inhibitors and tyrosine protein kinase receptors that are currently being targeted by anticancer drugs are studied in this review. The different indole analogs target all of these receptors to identify a successful cancer treatment. The Structural Relationship (SAR) between several indole analogs with anticancer action is also highlighted in the present work.

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新型吲哚支架的结构和受体抑制在癌症治疗中的应用综述。

癌症一直是全世界关注的问题。为了确定这种疾病的最佳和最有效的治疗方法，进行了大量的研究。本文旨在探讨吲哚类似物作为分子靶向抗癌药物的作用和机制。这些吲哚类似物靶向各种分子，影响肿瘤的发育、生长和扩散。靶向抗癌药物的作用是细胞静止的，通常是为了实现特定的目标，与传统的化疗药物不同，后者的作用是细胞毒性的。小分子和大分子是由这种方法产生的一类新的靶向药物。某些受体靶向药物在改善患者护理方面优于大分子药物。本文对目前抗癌药物靶向的各种受体抑制剂和酪氨酸蛋白激酶受体进行了综述。不同的吲哚类似物靶向所有这些受体，以确定成功的癌症治疗方法。几种具有抗癌作用的吲哚类似物之间的结构关系（SAR）也在本工作中得到了强调。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.