醛糖还原酶抑制剂有机化合物的开发与探索综述。

IF 3.3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Bhanupriya Bhrigu, Shikha Sharma, Bimal Krishna Banik
{"title":"醛糖还原酶抑制剂有机化合物的开发与探索综述。","authors":"Bhanupriya Bhrigu, Shikha Sharma, Bimal Krishna Banik","doi":"10.2174/0115680266368117250826105101","DOIUrl":null,"url":null,"abstract":"<p><p>Changes in the body's natural glucose levels have been associated with the onset of diabetes mellitus. It is frequently accompanied by a number of long-term consequences, including cardiovascular disease, retinopathy, nephropathy, and cataracts. Aldose reductase (AR), an enzyme belonging to the aldoketo reductase superfamily, plays a crucial role in the polyol pathway of glucose metabolism by converting glucose into sorbitol. Aldose reductase inhibitors (ARIs), a key target for reducing sorbitol flow through the polyol pathway, may be a new target for treating significant diabetic complications. A variety of structural classes of ARIs have been developed. These include: i) derivatives of carboxylic acids (e.g., Epalrestat, Alrestatin, Zopalrestat, Zenarestat, Ponalrestat, Lidorestat, and Tolrestat); ii) derivatives of spirohydantoins and related cyclic amides (e.g., Sorbinil, Minalrestat, and Fidarestat); and iii) phenolic derivatives (e.g., related to Benzopyran- 4-one and Chalcone). The current review article provides concise details of the various chemical classes that aldose reductase inhibitors play in the treatment of diabetic complications. This also describes the advancements made in ARI research and possible applications by obtaining the required data. The process involves thoroughly searching multiple databases-such as PubMed, ScienceDirect, and SciFinder-for citations.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development and Exploration of Organic Compounds as Aldose Reductase Inhibitors: An Overview.\",\"authors\":\"Bhanupriya Bhrigu, Shikha Sharma, Bimal Krishna Banik\",\"doi\":\"10.2174/0115680266368117250826105101\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Changes in the body's natural glucose levels have been associated with the onset of diabetes mellitus. It is frequently accompanied by a number of long-term consequences, including cardiovascular disease, retinopathy, nephropathy, and cataracts. Aldose reductase (AR), an enzyme belonging to the aldoketo reductase superfamily, plays a crucial role in the polyol pathway of glucose metabolism by converting glucose into sorbitol. Aldose reductase inhibitors (ARIs), a key target for reducing sorbitol flow through the polyol pathway, may be a new target for treating significant diabetic complications. A variety of structural classes of ARIs have been developed. These include: i) derivatives of carboxylic acids (e.g., Epalrestat, Alrestatin, Zopalrestat, Zenarestat, Ponalrestat, Lidorestat, and Tolrestat); ii) derivatives of spirohydantoins and related cyclic amides (e.g., Sorbinil, Minalrestat, and Fidarestat); and iii) phenolic derivatives (e.g., related to Benzopyran- 4-one and Chalcone). The current review article provides concise details of the various chemical classes that aldose reductase inhibitors play in the treatment of diabetic complications. This also describes the advancements made in ARI research and possible applications by obtaining the required data. The process involves thoroughly searching multiple databases-such as PubMed, ScienceDirect, and SciFinder-for citations.</p>\",\"PeriodicalId\":11076,\"journal\":{\"name\":\"Current topics in medicinal chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current topics in medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0115680266368117250826105101\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266368117250826105101","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

摘要

人体天然葡萄糖水平的变化与糖尿病的发病有关。它经常伴有一些长期的后果,包括心血管疾病、视网膜病变、肾病和白内障。醛糖还原酶(AR)是醛酮还原酶超家族的一种酶,通过将葡萄糖转化为山梨醇,在葡萄糖代谢的多元醇途径中起着至关重要的作用。醛糖还原酶抑制剂(ARIs)是通过多元醇途径减少山梨醇流动的关键靶点,可能成为治疗糖尿病严重并发症的新靶点。ARIs的各种结构类已经被开发出来。这些包括:1)羧酸衍生物(如依帕司他、阿司他、佐帕司他、泽那司他、波那司他、利多司他和托尔司他);ii)螺酰肼和相关环酰胺衍生物(如山梨醇、米纳司他和非达司他);iii)酚类衍生物(例如,与苯并吡喃- 4-酮和查尔酮相关)。目前的综述文章提供了各种化学类醛糖还原酶抑制剂在糖尿病并发症的治疗中发挥的简明细节。本文还介绍了ARI研究方面取得的进展,以及通过获得所需数据而可能实现的应用。这个过程包括彻底搜索多个数据库——比如PubMed、ScienceDirect和scifinder——以获取引文。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development and Exploration of Organic Compounds as Aldose Reductase Inhibitors: An Overview.

Changes in the body's natural glucose levels have been associated with the onset of diabetes mellitus. It is frequently accompanied by a number of long-term consequences, including cardiovascular disease, retinopathy, nephropathy, and cataracts. Aldose reductase (AR), an enzyme belonging to the aldoketo reductase superfamily, plays a crucial role in the polyol pathway of glucose metabolism by converting glucose into sorbitol. Aldose reductase inhibitors (ARIs), a key target for reducing sorbitol flow through the polyol pathway, may be a new target for treating significant diabetic complications. A variety of structural classes of ARIs have been developed. These include: i) derivatives of carboxylic acids (e.g., Epalrestat, Alrestatin, Zopalrestat, Zenarestat, Ponalrestat, Lidorestat, and Tolrestat); ii) derivatives of spirohydantoins and related cyclic amides (e.g., Sorbinil, Minalrestat, and Fidarestat); and iii) phenolic derivatives (e.g., related to Benzopyran- 4-one and Chalcone). The current review article provides concise details of the various chemical classes that aldose reductase inhibitors play in the treatment of diabetic complications. This also describes the advancements made in ARI research and possible applications by obtaining the required data. The process involves thoroughly searching multiple databases-such as PubMed, ScienceDirect, and SciFinder-for citations.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信