Médecine et Maladies Infectieuses Formation最新文献

{"title":"Infections fongiques invasives chez les patients transplantés d’organe solide en 2026","authors":"Shaindel Minkowski ,&nbsp;Alexandra Serris ,&nbsp;Julie Toubiana ,&nbsp;Cléa Melenotte","doi":"10.1016/j.mmifmc.2026.01.003","DOIUrl":"10.1016/j.mmifmc.2026.01.003","url":null,"abstract":"<div><div>In 2023, more than 170,000 solid organ transplants were performed worldwide, representing a 9.5% increase compared to 2022. Infections are common complications in solid organ transplant (SOT) patients. Among these, 8% are invasive fungal infections (IFIs). The morbidity and mortality associated with IFIs in SOT patients have decreased overall in recent decades, thanks to improved diagnostic tools. However, mortality related to IFIs in SOT patients varies depending on the fungal agent involved and remains significant. It is estimated at nearly 10% for cryptococcal infections and more than 60% for <em>Mucorales</em> spp. infections. We present here a review of the literature on IFIs in SOT patients, addressing epidemiology, clinical presentation, diagnosis, and treatment options.</div></div>","PeriodicalId":100906,"journal":{"name":"Médecine et Maladies Infectieuses Formation","volume":"5 1","pages":"Pages 4-21"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147427386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Résultat du concours du meilleur cas clinique 2025","authors":"","doi":"10.1016/S2772-7432(26)00035-8","DOIUrl":"10.1016/S2772-7432(26)00035-8","url":null,"abstract":"","PeriodicalId":100906,"journal":{"name":"Médecine et Maladies Infectieuses Formation","volume":"5 1","pages":"Page 1"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147427389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Médecine du voyage pour les transplantés d’organes (pour les gens du Nord qui vont dans le Sud)","authors":"","doi":"10.1016/j.mmifmc.2025.11.001","DOIUrl":"10.1016/j.mmifmc.2025.11.001","url":null,"abstract":"","PeriodicalId":100906,"journal":{"name":"Médecine et Maladies Infectieuses Formation","volume":"5 1","pages":"Pages 88-89"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147427378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-infection cutanée à Cryptococcus neoformans et Alternaria alternata chez un patient greffé rénal","authors":"Dana Charif ,&nbsp;Laurène Tardieu ,&nbsp;Lara Meyer ,&nbsp;Juliette Châtelain ,&nbsp;Sébastien Bertout ,&nbsp;Donika Krasteva ,&nbsp;Virginie Bellet ,&nbsp;Thomas Huron ,&nbsp;Nathalie Pansu ,&nbsp;Vincent Le Moing ,&nbsp;Grégoire Pasquier","doi":"10.1016/j.mmifmc.2025.10.002","DOIUrl":"10.1016/j.mmifmc.2025.10.002","url":null,"abstract":"<div><div>A 63-year-old kidney transplant patient presented a meningeal and cutaneous cryptococcosis. Mycological examination of the skin biopsy revealed <em>Cryptococcus neoformans</em> as well as a phaeohyphomycete, <em>Alternaria alternata</em>. This rare co-infection was successfully treated with surgery and appropriate antifungal treatment.</div></div>","PeriodicalId":100906,"journal":{"name":"Médecine et Maladies Infectieuses Formation","volume":"5 1","pages":"Pages 94-98"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Régime alimentaire des transplantés de cellule souche CSH au cours des 100 premiers jours post-greffe","authors":"","doi":"10.1016/j.mmifmc.2025.09.003","DOIUrl":"10.1016/j.mmifmc.2025.09.003","url":null,"abstract":"","PeriodicalId":100906,"journal":{"name":"Médecine et Maladies Infectieuses Formation","volume":"5 1","pages":"Pages 78-87"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myiases du scalp chez un enfant : un cas inhabituel aux urgences","authors":"Yassine Zarouali,&nbsp;Layla Bendaoud,&nbsp;Maryem Aboudourib,&nbsp;Ouafa Hocar,&nbsp;Said Amal","doi":"10.1016/j.mmifmc.2025.11.002","DOIUrl":"10.1016/j.mmifmc.2025.11.002","url":null,"abstract":"<div><div>Cutaneous myiasis is a parasitic disease linked to the development of fly larvae in human tissue. We report the case of an 11-year-old girl, living in a rural area of Marrakech, who presented to the paediatric emergency department with lesions on her scalp suggestive of multiple boils. Clinical examination revealed three ulcerations measuring 3 cm, 1.5 cm and 1 cm in diameter, surrounded by an erythematous margin, revealing numerous whitish larvae. A diagnosis of cutaneous myiasis was made. Treatment consisted of complete mechanical extraction of the larvae using sterile forceps. The outcome was favorable after two weeks, with complete healing of the lesions.</div></div>","PeriodicalId":100906,"journal":{"name":"Médecine et Maladies Infectieuses Formation","volume":"5 1","pages":"Pages 99-102"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147427380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Le risque infectieux en transplantation hépatique : recommandations cliniques actuelles et expérience récente de la Côte d’Ivoire","authors":"Michèle Beniey,&nbsp;Elie Keli","doi":"10.1016/j.mmifmc.2025.12.001","DOIUrl":"10.1016/j.mmifmc.2025.12.001","url":null,"abstract":"<div><div>About two-thirds of liver transplant recipients develop an infection during their life time, the majority of them being bacterial. Despite the difficulty to precisely determine the infectious risk in the peritransplantation period, this risk can be minimised by meticulously screening for predisposing risk factors and actively treating both latent and active infections in both the donor and recipient. Three globally renowned societies have published clinical guidelines for the management of liver transplant candidates, including infectiology recommendations. These guidelines partially overlap and complement each other on many points. Currently, there is no pan-African society for liver transplantation management, and only a few detailed guidelines specific to tropical infections. In Côte d’Ivoire, we performed the first liver transplant in West Africa reported in the scientific literature. Our recent experience demonstrates the complexity of the challenges associated with infectious risk in scientific, health infrastructural, financial, cultural, sociopolitical, and human resources.</div></div>","PeriodicalId":100906,"journal":{"name":"Médecine et Maladies Infectieuses Formation","volume":"5 1","pages":"Pages 45-54"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147427381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VIH, grossesse et allaitement : mise en place pratique des nouvelles recommandations françaises","authors":"Laurent Mandelbrot","doi":"10.1016/j.mmifmc.2025.10.001","DOIUrl":"10.1016/j.mmifmc.2025.10.001","url":null,"abstract":"<div><div>Pregnancy in women living with HIV has become simpler in cases of virological success, which eliminates both sexual and mother-to-child transmission. However, even in the absence of adverse medical and/or psychosocial factors, pregnancy carries risks (viral escape, treatment complications, premature delivery). We therefore recommend a pre-conception consultation, followed by monthly obstetric, medical, and biological monitoring during pregnancy.</div><div>In the absence of known HIV status, screening must be prescribed at the first prenatal visit and, if not done, should be encouraged later, up to delivery. Pre-exposure prophylaxis (PrEP) should be offered if the woman or her partner is at risk.</div><div>The choice of antiretroviral drugs for pregnant women is evolving. A triple therapy based on integrase inhibitors—dolutegravir or raltegravir—is recommended as first-line treatment. A non-nucleoside inhibitor, rilpivirine, is an alternative. No current antiretroviral drugs are strictly contraindicated, but several are not recommended due to a lack of perinatal safety data or concerns about reduced plasma concentrations during pregnancy.</div><div>Breastfeeding is now possible under optimal conditions, where the mother has a viral load of less than 50 copies/mL for at least six months prior to delivery and every month during breastfeeding. Under these conditions, the risk of HIV transmission appears to be eliminated, pending confirmation from further data.</div><div>French experts recommend preventive treatment (usually nevirapine) for infants, serving as a second line of prevention in the event of breastfeeding complications or lapses in maternal treatment adherence. When maternal viral load is not controlled, breastfeeding remains contraindicated in France.</div><div>Research perspectives include the risks of antiretroviral toxicity for the exposed children and the safety of breastfeeding. A new mother-child cohort study (Viropreg) is starting in referral centers, and the Lactavih observatory enables monitoring of all breastfeeding cases among mothers living with HIV in all centers across the country (metropolitan France and overseas departments and regions).</div></div>","PeriodicalId":100906,"journal":{"name":"Médecine et Maladies Infectieuses Formation","volume":"5 1","pages":"Pages 55-63"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147427382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplantation en plein essor en zone Sud : maîtriser le défi infectieux","authors":"Corinne Akpovo ,&nbsp;Aristophane Tanon","doi":"10.1016/j.mmifmc.2026.01.001","DOIUrl":"10.1016/j.mmifmc.2026.01.001","url":null,"abstract":"","PeriodicalId":100906,"journal":{"name":"Médecine et Maladies Infectieuses Formation","volume":"5 1","pages":"Pages 2-3"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147427387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications infectieuses chez les greffés rénaux au cours de la première année post-greffe : expérience d’un centre tunisien","authors":"Meriem Ben Salem ,&nbsp;Adnene Toumi ,&nbsp;Nouha Ben Mahmoud ,&nbsp;Mouna Hamouda ,&nbsp;Ahmed Letaief ,&nbsp;Manel Ben Salah ,&nbsp;Sirine Bchir ,&nbsp;Khouloud Hafi ,&nbsp;Faten Ghabi ,&nbsp;Habib Skhiri","doi":"10.1016/j.mmifmc.2026.01.002","DOIUrl":"10.1016/j.mmifmc.2026.01.002","url":null,"abstract":"<div><div>Infectious complications are a major cause of morbidity and mortality after kidney transplantation (KT). The aim of this study is to determine the incidence of infectious complications during the first post-transplant year by characterizing the types of infections and the pathogens involved. We conducted a retrospective, descriptive, single-center cohort study including kidney transplant recipients (2005-2024) who were followed for at least one year after transplantation in the Nephrology Department of the University Hospital of Monastir (Tunisia). A total of 145 patients were included, with a mean age of 32.5 ± 8.3 years. An infectious complication occurred in 87 patients (60%), who experienced 175 infectious episodes, with a predominance of urinary tract infections (<em>n</em>=74, 42.3%). Infections were microbiologically documented in 134 cases (76.6%), and were mainly bacterial infections (<em>n</em>=71, 40.5%), particularly due to <em>Escherichia coli</em> (<em>n</em>=30, 42.2%). Viral infections were observed in 54 patients (30.8%), and were dominated by cytomegalovirus (<em>n</em>=38, 70.4%). In conclusion, infectious complications after KT remain a major concern. Understanding their epidemiology and identifying high-risk patients are crucial for optimizing therapeutic strategies.</div></div>","PeriodicalId":100906,"journal":{"name":"Médecine et Maladies Infectieuses Formation","volume":"5 1","pages":"Pages 30-35"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147427383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}