Cell host & microbe最新文献_第2页

A microbial signal rewires the adipose-ovary dialogue 一种微生物信号重新连接了脂肪与卵巢之间的对话

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-10-14 DOI: 10.1016/j.chom.2026.09.005

Huimin Zheng,Pan Li,Xia Chen

引用次数: 0

From blunt to precision: Engineering microbiome therapeutics against cancer 从生硬到精确：工程微生物组治疗癌症

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-10-14 DOI: 10.1016/j.chom.2026.08.008

Abigail E. Rose,Wenhan Zhu

引用次数: 0

Candidozyma auris turns skin immunity to its advantage 耳念珠菌使皮肤免疫发挥其优势

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-10-14 DOI: 10.1016/j.chom.2026.09.004

Guolei Zhao,Teresa R. O’Meara

引用次数: 0

Native pathogen-phage networks reveal multilayered defense and gut-active anti-phage immunity 天然病原体噬菌体网络显示多层防御和肠道活性抗噬菌体免疫

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-10-08 DOI: 10.1016/j.chom.2026.09.009

Benjamin X. Wang,Ramya Narasimhan,Aisling Brady,Nicolas Wenner,Blanca Perez Sepulveda,Kelly Hughes,Yogesh Hooda,Senjuti Saha,Jay C.D. Hinton,Denise M. Monack

{"title":"Native pathogen-phage networks reveal multilayered defense and gut-active anti-phage immunity","authors":"Benjamin X. Wang,Ramya Narasimhan,Aisling Brady,Nicolas Wenner,Blanca Perez Sepulveda,Kelly Hughes,Yogesh Hooda,Senjuti Saha,Jay C.D. Hinton,Denise M. Monack","doi":"10.1016/j.chom.2026.09.009","DOIUrl":"https://doi.org/10.1016/j.chom.2026.09.009","url":null,"abstract":"Bacteriophages drive pathogen evolution, yet the mechanisms governing phage susceptibility in native bacterial backgrounds, and their consequences within mammalian hosts, remain poorly understood. Here, we mapped >1,000 interactions between 20 diverse Salmonella isolates and 52 wild phages from global disease reservoirs, integrating genome-scale fitness profiling with comparative genomics. Receptor identity and surface phase variation, including Hin-mediated flagellar switching, explained ∼67% of phage susceptibility patterns, identifying cell-surface architecture as the major determinant of phage host range in Salmonella. Among resistance phenotypes not explained by surface features, we discovered anti-phage-packaging agent (AppA), a prophage-encoded defense factor that abrogates phage replication within its native host. AppA inhibits phage DNA packaging through functional mimicry of a terminase assembly interface, revealing a previously unrecognized mechanism of phage defense. AppA is expressed under conditions encountered during mammalian infection and suppresses phage expansion in the murine gut, demonstrating that prophage-encoded single-gene defenses can shape disease outcomes in vivo.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"9 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149124070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Within-host evolution and transmission of a human gut symbiont across ecological scales 宿主内人类肠道共生体在生态尺度上的进化和传播

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-10-01 DOI: 10.1016/j.chom.2026.09.002

Kimberly S. Vasquez,Daniel P.G.H. Wong,Kent Kotaka,Saria McKeithen-Mead,Miguel F. Pedro,Feiqiao Brian Yu,Sunit Jain,Xiandong Meng,Steven K. Higginbottom,Brian C. DeFelice,Norma Neff,Ami Bhatt,Carolina Tropini,Karina B. Xavier,Justin L. Sonnenburg,Benjamin H. Good,Kerwyn Casey Huang

引用次数: 0

An enzyme-responsive nanoplatform rewires host-microbe tryptophan metabolism for cancer immunotherapy 酶反应纳米平台重新连接宿主-微生物色氨酸代谢用于癌症免疫治疗

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-09-30 DOI: 10.1016/j.chom.2026.09.011

Chao Pan, Taotao Zhou, Liqin Ye, Canyu Yang, Qinyu Li, Hongyu Liu, Fenqing Tang, Gulixian Aili, Shidong Zhou, Yong Gan

{"title":"An enzyme-responsive nanoplatform rewires host-microbe tryptophan metabolism for cancer immunotherapy","authors":"Chao Pan, Taotao Zhou, Liqin Ye, Canyu Yang, Qinyu Li, Hongyu Liu, Fenqing Tang, Gulixian Aili, Shidong Zhou, Yong Gan","doi":"10.1016/j.chom.2026.09.011","DOIUrl":"https://doi.org/10.1016/j.chom.2026.09.011","url":null,"abstract":"Immunotherapy shows great promise against cancer, yet imbalanced tryptophan (Trp) metabolism drives tumor immune tolerance, severely limiting its efficacy. To address this, we advance a synergistic host-microbe metabolism-regulated strategy that concurrently amplifies microbial indole pathway while suppressing the host kynurenine (Kyn) pathway to correct metabolic and immune dysregulation, thereby enhancing antitumor immunity. To produce an oral co-delivery nanoparticle, mesoporous silica nanoparticles are loaded with Trp via ester bonds and coated with agar containing the metabolism inhibitor NLG919 (NLG). This design enables enzyme-responsive release of Trp and NLG in the large intestine, where microbiota and colorectal tumors coexist. Unlike conventional strategies that either block the Kyn pathway or non-selectively activate both pathways, this platform enhances Trp metabolism toward immunostimulatory microbial indole derivatives while suppressing the immunosuppressive Kyn pathway, thereby synergistically enhancing antitumor immunity and achieving potent efficacy with favorable biosafety, offering a promising metabolism-guided paradigm for safe and effective cancer immunotherapy.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"397 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149084660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A commensal-derived sugar protects against obesity by regulating immunometabolism 一种来自植物的糖通过调节免疫代谢来防止肥胖

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-09-23 DOI: 10.1016/j.chom.2026.08.018

Chin Yee Tan,Yinghui Li,Danting Jiang,Barbara S. Theriot,Meghana V. Rao,Neeraj K. Surana

{"title":"A commensal-derived sugar protects against obesity by regulating immunometabolism","authors":"Chin Yee Tan,Yinghui Li,Danting Jiang,Barbara S. Theriot,Meghana V. Rao,Neeraj K. Surana","doi":"10.1016/j.chom.2026.08.018","DOIUrl":"https://doi.org/10.1016/j.chom.2026.08.018","url":null,"abstract":"Obesity is a worsening global epidemic that is partially regulated by the microbiota through unknown factors. We discovered a human commensal bacterium, Clostridium immunis, which prevents and treats obesity in mice by secreting a phosphocholine-modified exopolysaccharide. Loss- and gain-of-function bacterial mutants involving the phosphocholine biosynthesis locus (licABC) revealed that the phosphocholine moiety is required to protect against metabolic disease. This C. immunis exopolysaccharide decreases small-intestinal and visceral fat levels of IL-22, which increases metabolic activity specifically in visceral adipose tissue; C. immunis lacks activity against obesity when IL-22 or group 3 innate lymphoid cells, predominant secretors of IL-22, are absent. Importantly, phosphocholine biosynthesis genes are less abundant in humans with obesity or hypertriglyceridemia, suggesting conserved functions of bacterial phosphocholine. These results define a bacterial molecule—and its key structural motif—that provides immunometabolic control of obesity. More broadly, they highlight a clinically translatable strategy to reduce visceral fat.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"19 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary pectin remodels commensal bacterial surfaces to promote IgA-mediated protection from intestinal inflammation 膳食果胶重塑共生细菌表面，促进iga介导的肠道炎症保护

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-09-17 DOI: 10.1016/j.chom.2026.08.017

Wenjie Tang,Yuhao Wang,Siyuan Feng,Jiachen Li,Zhixiang Ni,Hongliang Tian,Jiangdi Mao,Yanfei Ma,Chang Liu,Xiaotong Lv,Xin M. Luo,Haifeng Wang

{"title":"Dietary pectin remodels commensal bacterial surfaces to promote IgA-mediated protection from intestinal inflammation","authors":"Wenjie Tang,Yuhao Wang,Siyuan Feng,Jiachen Li,Zhixiang Ni,Hongliang Tian,Jiangdi Mao,Yanfei Ma,Chang Liu,Xiaotong Lv,Xin M. Luo,Haifeng Wang","doi":"10.1016/j.chom.2026.08.017","DOIUrl":"https://doi.org/10.1016/j.chom.2026.08.017","url":null,"abstract":"Diet-microbe interactions shape mucosal immunity, yet how dietary cues drive strain-specific immunoglobulin A (IgA) responses remains poorly understood. Here, we show that dietary pectin induces a microbiota-dependent high-IgA phenotype in gnotobiotic mice mono-colonized with Bacteroides uniformis (B. uniformis). This effect is mediated by a pectin-responsive rcsC-associated regulatory program that remodels the bacterial surface. Comparative lipidomics identifies the glycosphingolipid HexCer (34:0) as a dominant feature of the remodeled bacterial surface. HexCer is recognized by the C-type lectin receptor CLEC4E on intestinal neutrophils, and CLEC4E deficiency abrogates IgA induction. Downstream of CLEC4E, neutrophil-derived APRIL (a proliferation-inducing ligand) promotes IgA class switching and enhances IgA coating of bacteria in vivo. This IgA response increases the mucosal association of B. uniformis and confers protection against colitis. Together, these findings uncover a diet-responsive bacterial program that generates an immunogenic glycosphingolipid signal to engage innate sensing and shape the mucosal IgA repertoire, thereby reinforcing mutualistic colonization.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"47 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148980625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Holding the granuloma together: Fibroblasts contain mycobacterial infection 将肉芽肿粘在一起：成纤维细胞含有分枝杆菌感染

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-09-09 DOI: 10.1016/j.chom.2026.08.014

Bibhuti B. Mishra

引用次数: 0

Swallowing the evidence: Oral microbes mark gut cancer 吞下证据：口腔微生物标志着肠道癌症

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-09-09 DOI: 10.1016/j.chom.2026.08.013

Wataru Suda,Lena Takayasu

引用次数: 0