Cell host & microbe最新文献_第2页

Clec12a controls colitis by tempering inflammation and restricting expansion of specific commensals Clec12a通过缓和炎症和限制特定共生体的扩张来控制结肠炎

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-01-08 DOI: 10.1016/j.chom.2024.12.009

Tyson R. Chiaro, Morgan Greenewood, Kaylyn M. Bauer, Kyla S. Ost, Emmanuel Stephen-Victor, Michaela Murphy, Allison M. Weis, Morgan C. Nelson, Jennifer H. Hill, Rickesha Bell, Warren Voth, Taylor Jackson, Kendra A. Klag, Ryan M. O’Connell, W. Zac Stephens, June L. Round

{"title":"Clec12a controls colitis by tempering inflammation and restricting expansion of specific commensals","authors":"Tyson R. Chiaro, Morgan Greenewood, Kaylyn M. Bauer, Kyla S. Ost, Emmanuel Stephen-Victor, Michaela Murphy, Allison M. Weis, Morgan C. Nelson, Jennifer H. Hill, Rickesha Bell, Warren Voth, Taylor Jackson, Kendra A. Klag, Ryan M. O’Connell, W. Zac Stephens, June L. Round","doi":"10.1016/j.chom.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.chom.2024.12.009","url":null,"abstract":"Microbiota composition regulates colitis severity, yet the innate immune mechanisms that control commensal communities and prevent disease remain unclear. We show that the innate immune receptor, Clec12a, impacts colitis severity by regulating microbiota composition. Transplantation of microbiota from a Clec12a−/− animal is sufficient to worsen colitis in wild-type mice. Clec12a−/− mice have expanded Faecalibaculum rodentium, and treatment with F. rodentium similarly exacerbates disease. However, Clec12a−/− animals are resistant to colitis development when rederived into an 11-member community, underscoring the role of specific species. Colitis in Clec12a−/− mice is dependent on monocytes, and cytokine and sequencing analysis in Clec12a−/− macrophages and serum shows enhanced inflammation with a reduction in phagocytic genes. F. rodentium specifically binds to Clec12a, and Clec12a−/−-deficient macrophages are impaired in their ability to phagocytose F. rodentium. Thus, Clec12a contributes to an innate-immune-surveillance mechanism that controls the expansion of potentially harmful commensals while limiting inflammation.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"30 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142936085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pks+ E. coli adhesins—The fine line between good and evil pks+大肠杆菌黏附素——善与恶的界限

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-01-08 DOI: 10.1016/j.chom.2024.12.007

Chi Chun Wong, Jun Yu

引用次数: 0

Linking E. coli to fibrosis in Crohn’s disease 将大肠杆菌与克罗恩病纤维化联系起来

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-01-08 DOI: 10.1016/j.chom.2024.12.011

Ethan T. Dehantschutter, Cormac T. Taylor

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Bugs take the sting out 虫子把刺取出来

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-01-08 DOI: 10.1016/j.chom.2024.12.008

Arren J. Liu, Jonathan B. Lynch

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Identification of a broad-inhibition influenza neuraminidase antibody from pre-existing memory B cells 预先存在的记忆B细胞中广泛抑制流感神经氨酸酶抗体的鉴定

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-12-30 DOI: 10.1016/j.chom.2024.12.004

Xin Wang, Huihui Kong, Bingxin Chu, Qian Yang, Chaohui Lin, Rui Liu, Changxu Chen, Yang Gao, Guojun Wang, Dayan Wang, Chen Qin, Xiaohua Ye, Lifei Yu, Xiangfei Xu, Jie Jin, Ren Sun, Hualan Chen, Xudong Wu, Zeli Zhang

引用次数: 0

Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization 在艰难梭菌定植期间，共生病原体动力学结构疾病结果

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-12-27 DOI: 10.1016/j.chom.2024.12.002

Skye R.S. Fishbein, Anna L. DeVeaux, Sakshi Khanna, Aura L. Ferreiro, James Liao, Wesley Agee, Jie Ning, Bejan Mahmud, Miranda J. Wallace, Tiffany Hink, Kimberly A. Reske, Candice Cass, Janaki Guruge, Sidh Leekha, Sunaina Rengarajan, Erik R. Dubberke, Gautam Dantas

{"title":"Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization","authors":"Skye R.S. Fishbein, Anna L. DeVeaux, Sakshi Khanna, Aura L. Ferreiro, James Liao, Wesley Agee, Jie Ning, Bejan Mahmud, Miranda J. Wallace, Tiffany Hink, Kimberly A. Reske, Candice Cass, Janaki Guruge, Sidh Leekha, Sunaina Rengarajan, Erik R. Dubberke, Gautam Dantas","doi":"10.1016/j.chom.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.chom.2024.12.002","url":null,"abstract":"Gastrointestinal colonization by Clostridioides difficile is common in healthcare settings and ranges in presentation from asymptomatic carriage to lethal C. difficile infection (CDI). We used a systems biology approach to investigate why patients colonized with C. difficile have a range of clinical outcomes. Microbiota humanization of germ-free mice with fecal samples from toxigenic C. difficile carriers revealed a spectrum of virulence among clinically prevalent clade 1 lineages and identified candidate taxa, including Blautia, as markers of stable colonization. Using gnotobiotic mice engrafted with defined human microbiota, we validated strain-specific CDI severity across clade 1 strains isolated from patients. Mice engrafted with a community broadly representative of colonized patients were protected from severe disease across all strains without suppression of C. difficile colonization. These results underline the capacity of gut community structure to attenuate a diversity of pathogenic strains without inhibiting colonization, providing insight into determinants of stable C. difficile carriage.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"31 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The blue-light receptor CRY1 serves as a switch to balance photosynthesis and plant defense 蓝光受体CRY1是平衡光合作用和植物防御的开关

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-12-27 DOI: 10.1016/j.chom.2024.12.003

Yuhan Hao, Zexian Zeng, Minhang Yuan, Hui Li, Shisong Guo, Yu Yang, Shushu Jiang, Eva Hawara, Jianxu Li, Peng Zhang, Jiawei Wang, Xiufang Xin, Wenbo Ma, Hongtao Liu

{"title":"The blue-light receptor CRY1 serves as a switch to balance photosynthesis and plant defense","authors":"Yuhan Hao, Zexian Zeng, Minhang Yuan, Hui Li, Shisong Guo, Yu Yang, Shushu Jiang, Eva Hawara, Jianxu Li, Peng Zhang, Jiawei Wang, Xiufang Xin, Wenbo Ma, Hongtao Liu","doi":"10.1016/j.chom.2024.12.003","DOIUrl":"https://doi.org/10.1016/j.chom.2024.12.003","url":null,"abstract":"Plant stomata open in response to blue light, allowing gas exchange and water transpiration. However, open stomata are potential entry points for pathogens. Whether plants can sense pathogens and mount defense responses upon stomatal opening and how blue-light cues are integrated to balance growth-defense trade-offs are poorly characterized. We show that the Arabidopsis blue-light photoreceptor CRYPTOCHROME 1 (CRY1) mediates various aspects of immunity, including pathogen-triggered stomatal closure as well as activation of plant immunity through a typical light-responsive protein LATE UPREGULATED IN RESPONSE TO HYALOPERONOSPORA PARASITICA (LURP1). LURP1 undergoes N-terminal palmitoylation in the presence of bacterial flagellin, prompting a change in subcellular localization from the cytoplasm to plasma membrane, where it enhances the activity of the receptor FLAGELLIN SENSING 2 (FLS2) to mediate plant defense. Collectively, these findings reveal that blue light regulates stomatal defense and highlight the dual functions of CRY1 in photosynthesis and immunity.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"305 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phocaeicola vulgatus shapes the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile 普通Phocaeicola vulgatus塑造了艰难梭菌的长期生长动态和进化适应

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-12-26 DOI: 10.1016/j.chom.2024.12.001

Jordy Evan Sulaiman, Jaron Thompson, Pak Lun Kevin Cheung, Yili Qian, Jericha Mill, Isabella James, Hanhyeok Im, Eugenio I. Vivas, Judith Simcox, Ophelia S. Venturelli

{"title":"Phocaeicola vulgatus shapes the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile","authors":"Jordy Evan Sulaiman, Jaron Thompson, Pak Lun Kevin Cheung, Yili Qian, Jericha Mill, Isabella James, Hanhyeok Im, Eugenio I. Vivas, Judith Simcox, Ophelia S. Venturelli","doi":"10.1016/j.chom.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.chom.2024.12.001","url":null,"abstract":"Clostridioides difficile can transiently or persistently colonize the human gut, posing a risk for infections. This colonization is influenced by complex molecular and ecological interactions with the human gut microbiota. By investigating C. difficile dynamics in human gut communities over hundreds of generations, we show patterns of stable coexistence, instability, or competitive exclusion. Lowering carbohydrate concentrations shifted a community containing C. difficile and the prevalent human gut symbiont Phocaeicola vulgatus from competitive exclusion to coexistence, facilitated by increased cross-feeding. In this environment, two key mutations in C. difficile altered its metabolic niche from proline to glucose utilization. These metabolic changes in C. difficile substantially impacted gut microbiota inter-species interactions and reduced disease severity in mice. In sum, interactions with P. vulgatus are crucial in shaping the long-term growth dynamics and evolutionary adaptations of C. difficile, offering key insights for developing anti-C. difficile strategies.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"23 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A necrotizing toxin enables Pseudomonas syringae infection across evolutionarily divergent plants 一种坏死毒素可使假单胞菌感染不同进化植物

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-12-19 DOI: 10.1016/j.chom.2024.11.014

Kristina Grenz, Khong-Sam Chia, Emma K. Turley, Alexa S. Tyszka, Rebecca E. Atkinson, Jacob Reeves, Martin Vickers, Martin Rejzek, Joseph F. Walker, Philip Carella

{"title":"A necrotizing toxin enables Pseudomonas syringae infection across evolutionarily divergent plants","authors":"Kristina Grenz, Khong-Sam Chia, Emma K. Turley, Alexa S. Tyszka, Rebecca E. Atkinson, Jacob Reeves, Martin Vickers, Martin Rejzek, Joseph F. Walker, Philip Carella","doi":"10.1016/j.chom.2024.11.014","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.014","url":null,"abstract":"The Pseudomonas syringae species complex harbors a diverse range of pathogenic bacteria that can infect hosts across the plant kingdom. However, much of our current understanding of P. syringae is centered on its infection of flowering plants. We took a comparative approach to understand how P. syringae infects evolutionarily divergent plants. We identified P. syringae isolates causing disease in the liverwort Marchantia polymorpha, the fern Ceratopteris richardii, and the flowering plant Nicotiana benthamiana, which last shared a common ancestor >500 million years ago. Phytotoxin-enriched phylogroup (PG) 2 isolates of P. syringae are virulent in non-flowering plants, relying on type-3 effectors and the lipopeptide phytotoxin syringomycin. Ectopic syringomycin promotes tissue necrosis, activates conserved stress-related genes, and enhances in planta bacterial growth of toxin-deficient PGs in Marchantia. Collectively, our research reveals a key role for syringomycin in promoting Pseudomonas colonization, which works alongside effectors to antagonize an exceptionally wide spectrum of land plants.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"262 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roseburia intestinalis-derived butyrate alleviates neuropathic pain 源自蔷薇肠的丁酸盐可减轻神经性疼痛

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-12-19 DOI: 10.1016/j.chom.2024.11.013

Yanjun Jiang, Ziheng Huang, Wuping Sun, Jiabin Huang, Yunlong Xu, Yuliang Liao, Tingting Jin, Qing Li, Idy Hiu Ting Ho, Yidan Zou, Wenyi Zhu, Qian Li, Fenfen Qin, Xinyi Zhang, Shuqi Shi, Na Zhang, Shaomin Yang, Wenhui Xie, Songbin Wu, Likai Tan, Xiaodong Liu

{"title":"Roseburia intestinalis-derived butyrate alleviates neuropathic pain","authors":"Yanjun Jiang, Ziheng Huang, Wuping Sun, Jiabin Huang, Yunlong Xu, Yuliang Liao, Tingting Jin, Qing Li, Idy Hiu Ting Ho, Yidan Zou, Wenyi Zhu, Qian Li, Fenfen Qin, Xinyi Zhang, Shuqi Shi, Na Zhang, Shaomin Yang, Wenhui Xie, Songbin Wu, Likai Tan, Xiaodong Liu","doi":"10.1016/j.chom.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.013","url":null,"abstract":"Approximately 20% of patients with shingles develop postherpetic neuralgia (PHN). We investigated the role of gut microbiota in shingle- and PHN-related pain. Patients with shingles or PHN exhibited significant alterations in their gut microbiota with microbial markers predicting PHN development among patients with shingles. Functionally, fecal microbiota transplantation from patients with PHN to mice heightened pain sensitivity. Administration of Roseburia intestinalis, a bacterium both depleted in patients with shingles and PHN, alleviated peripheral nerve injury-induced pain in mice. R. intestinalis enhanced vagal neurotransmission to the nucleus tractus solitarius (NTS) to suppress the central amygdala (CeA), a brain region involved in pain perception. R. intestinalis-generated butyrate activated vagal neurons through the receptor, G protein-coupled receptor 41 (GPR41). Vagal knockout of Gpr41 abolished the effects of R. intestinalis on the NTS-CeA circuit and reduced pain behaviors. Overall, we established a microbiota-based model for PHN risk assessment and identified R. intestinalis as a potential pain-alleviating probiotic.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"40 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0