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Decoding WEEV’s host adaptation 解码WEEV的宿主适应
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-05-14 DOI: 10.1016/j.chom.2025.04.006
Yinong Qiu, Lei Sun
{"title":"Decoding WEEV’s host adaptation","authors":"Yinong Qiu, Lei Sun","doi":"10.1016/j.chom.2025.04.006","DOIUrl":"https://doi.org/10.1016/j.chom.2025.04.006","url":null,"abstract":"The Western equine encephalitis virus (WEEV), an alphavirus causing severe neurological disease, exhibits fluctuating epidemic patterns and enigmatic host adaptability. Recent studies by Raju et al. and Fan et al. in <em>Cell</em> reveal glycoprotein modifications enabling receptor switching, explaining its reduced human pathogenicity while underscoring re-emergence risks.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"4 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis 通过二十烷类细胞-免疫-微生物群轴的肠道炎症解决的年龄相关损伤
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-05-14 DOI: 10.1016/j.chom.2025.04.014
Marie Goepp, Jemma V. Milburn, Birong Zhang, Yijia Dong, Victoria Tyrrell, Xiaozhong Zheng, Jennifer M. Marshall, Silvia Bolsega, Marijana Basic, Laura Glendinning, Gwo-Tzer Ho, Jack Satsangi, Richard M. Breyer, Shuh Narumiya, Henry J. McSorley, Jürgen K.J. Schwarze, Christopher J. Anderson, David H. Dockrell, Adriano G. Rossi, André Bleich, Chengcan Yao
{"title":"Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis","authors":"Marie Goepp, Jemma V. Milburn, Birong Zhang, Yijia Dong, Victoria Tyrrell, Xiaozhong Zheng, Jennifer M. Marshall, Silvia Bolsega, Marijana Basic, Laura Glendinning, Gwo-Tzer Ho, Jack Satsangi, Richard M. Breyer, Shuh Narumiya, Henry J. McSorley, Jürgen K.J. Schwarze, Christopher J. Anderson, David H. Dockrell, Adriano G. Rossi, André Bleich, Chengcan Yao","doi":"10.1016/j.chom.2025.04.014","DOIUrl":"https://doi.org/10.1016/j.chom.2025.04.014","url":null,"abstract":"Aging manifests a decline of immune function, induces microbiome dysbiosis, drives organ inflammation, and impedes the resolution of inflammation. However, the mechanisms underlying age-related intestinal inflammation remain poorly described. Here, we find that the resolution of T cell-initiated intestinal inflammation is impaired with aging. This impairment is mediated by disrupting the immune-microbiota interplay, controlled by intestinal eicosanoid metabolism. Pharmacologically inhibiting eicosanoid biosynthesis, blocking the prostaglandin E receptor subtype 4 (EP4), or genetically ablating EP4 diminishes age-related impairment of intestinal inflammation resolution. Mechanistically, mononuclear phagocyte-intrinsic eicosanoid-EP4 signaling impedes the resolution of intestinal inflammation through fostering gut microbial dysbiosis and, more importantly, interrupting segmented filamentous bacterial adhesion to the intestinal epithelium. Colonization with EP4-ablated mouse microbiota or segmented filamentous bacteria improves the resolution of intestinal inflammation. These findings reveal that eicosanoid-dependent immune-microbiota interactions impair inflammation resolution in the aged intestine, highlighting potential intervention strategies for improving age-related gut health.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"43 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotics fire up inflammation to cool vaccine responsiveness 抗生素会引发炎症，从而降低疫苗的反应性
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-05-14 DOI: 10.1016/j.chom.2025.04.015
James G. Kublin
{"title":"Antibiotics fire up inflammation to cool vaccine responsiveness","authors":"James G. Kublin","doi":"10.1016/j.chom.2025.04.015","DOIUrl":"https://doi.org/10.1016/j.chom.2025.04.015","url":null,"abstract":"In this issue of <em>Cell Host &amp; Microbe</em>, Feng et al. find that broad-spectrum antibiotics perturbed the ecology of the gut microbiome in individuals receiving a rabies vaccine, resulting in systemic inflammatory responses. Such inflammation is hypothesized to alter immune homeostasis with consequences for immunological responsiveness to vaccination.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"55 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predator-prey interplay: When chemical conversation turns deadly 捕食者与猎物的相互作用：当化学对话变成致命的时候
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-05-14 DOI: 10.1016/j.chom.2025.04.012
Natália Carolina Drebes Dörr, Cristina Elisa Alvarez-Martinez
{"title":"Predator-prey interplay: When chemical conversation turns deadly","authors":"Natália Carolina Drebes Dörr, Cristina Elisa Alvarez-Martinez","doi":"10.1016/j.chom.2025.04.012","DOIUrl":"https://doi.org/10.1016/j.chom.2025.04.012","url":null,"abstract":"Bacteria deploy many distinct mechanisms to resist protist predation in natural environments. In a recent study published in <em>Cell</em>, Zhang et al. discover a chemical radar used by the plant pathogen <em>Pseudomonas syringae</em> to sense and kill an amoeba predator.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"29 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The amazing impact of gut microbes on lifelong metabolic health 肠道微生物对终生代谢健康的惊人影响
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-05-14 DOI: 10.1016/j.chom.2025.04.007
M.B. Geuking, C.A. Thomson
{"title":"The amazing impact of gut microbes on lifelong metabolic health","authors":"M.B. Geuking, C.A. Thomson","doi":"10.1016/j.chom.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.chom.2025.04.007","url":null,"abstract":"A new study published in <em>Science</em><span><span><sup>1</sup></span></span> reveals a crucial connection between our neonatal gut microbiota composition and the long-term health of our pancreas, specifically focusing on β-cell development and the subsequent lifelong impact microbe-induced β-cell expansion has on metabolic health, including prevention of, and even potential reversal of, diabetes.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"122 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling strain-level dynamics in the human skin microbiome 揭示人类皮肤微生物组的菌株水平动态
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-05-14 DOI: 10.1016/j.chom.2025.03.014
Zhiming Li, Jingjing Xia, Jiucun Wang
{"title":"Unveiling strain-level dynamics in the human skin microbiome","authors":"Zhiming Li, Jingjing Xia, Jiucun Wang","doi":"10.1016/j.chom.2025.03.014","DOIUrl":"https://doi.org/10.1016/j.chom.2025.03.014","url":null,"abstract":"Species-level uniformity on the skin surface masks substantial strain-level diversity modulated by ecological dynamics. In this issue of <em>Cell Host &amp; Microbe</em>, Jacob et al. uncover dynamic intraspecies behaviors, revealing different patterns of colonization and persistence for two important skin commensals.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"123 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RBRL co-opts NINJA for plant defense RBRL采用NINJA进行植物防御
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-05-14 DOI: 10.1016/j.chom.2025.04.004
Fangfang Ma, Zhilong Bao
{"title":"RBRL co-opts NINJA for plant defense","authors":"Fangfang Ma, Zhilong Bao","doi":"10.1016/j.chom.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.chom.2025.04.004","url":null,"abstract":"Antiviral defense requires signal transmission that connects the perception of viral infection to activation of plant immunity. Findings in <em>Nature</em> by Huang et al. describe key players whereby RING1-IBR-RING2-type ubiquitin ligase (RBRL) recognizes viral coat proteins to release NINJA3-mediated suppression of jasmonate signaling and initiate broad-spectrum antiviral responses in rice.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"52 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic keys to microbial gut colonization 微生物肠道定植的遗传关键
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-05-14 DOI: 10.1016/j.chom.2025.04.016
Karthik Anantharaman, Cody Martin
{"title":"Genetic keys to microbial gut colonization","authors":"Karthik Anantharaman, Cody Martin","doi":"10.1016/j.chom.2025.04.016","DOIUrl":"https://doi.org/10.1016/j.chom.2025.04.016","url":null,"abstract":"What enables certain microbes to successfully colonize the mammalian gut? In a recent issue of <em>Cell</em>, Liu et al. present a microbial cross-species genomic framework that identifies conserved genetic determinants of gut residency. This study provides a roadmap for developing more effective microbiome-based therapeutics, advancing our understanding of host-microbe interactions.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"10 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Salmonella subset exploits erythrophagocytosis to subvert SLC11A1-imposed iron deprivation 沙门氏菌亚群利用红细胞吞噬作用破坏slc11a1施加的铁剥夺
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-05-14 DOI: 10.1016/j.chom.2025.04.013
Béatrice Roche, Beatrice Claudi, Olivier Cunrath, Christopher K.E. Bleck, Minia Antelo-Varela, Jiagui Li, Dirk Bumann
{"title":"A Salmonella subset exploits erythrophagocytosis to subvert SLC11A1-imposed iron deprivation","authors":"Béatrice Roche, Beatrice Claudi, Olivier Cunrath, Christopher K.E. Bleck, Minia Antelo-Varela, Jiagui Li, Dirk Bumann","doi":"10.1016/j.chom.2025.04.013","DOIUrl":"https://doi.org/10.1016/j.chom.2025.04.013","url":null,"abstract":"Solute carrier family 11 member 1 (SLC11A1) is critical for host resistance to diverse intracellular pathogens. During infection, SLC11A1 limits <em>Salmonella</em>’s access to iron, zinc, and magnesium, but only magnesium deprivation significantly impairs <em>Salmonella</em> replication. To understand the unexpected minor impact of iron, we determined <em>Salmonella</em>’s iron access in infected SLC11A1-deficient and normal mice. Using reporter strains and mass spectrometry of <em>Salmonella</em> purified from the spleen, we found that SLC11A1 caused growth-restricting iron deprivation in a subset of <em>Salmonella</em>. Volume electron microscopy revealed that another <em>Salmonella</em> subset circumvented iron restriction by targeting iron-rich endosomes in macrophages degrading red blood cells (erythrophagocytosis). These iron-replete bacteria dominated overall <em>Salmonella</em> growth, masking the effects of the other <em>Salmonella</em> subset’s iron deprivation. Thus, SLC11A1 effectively sequesters iron, but heterogeneous <em>Salmonella</em> populations partially bypass this nutritional immunity by targeting iron-rich tissue microenvironments.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"122 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cohabitation facilitates microbiome shifts that promote isoflavone transformation to ameliorate liver injury 同居促进微生物组的转变，促进异黄酮的转化，以改善肝损伤
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-05-02 DOI: 10.1016/j.chom.2025.04.011
Yunong Zeng, Rong Wu, Yi He, Qian Zhang, Ze Wang, Ping Qin, Fangyuan Yang, Yingshi Han, Mingjing Hao, Yujian Zheng, Lei Gao, Xia Chen, Xiaoshan Zhao, Zhenhua Zeng, Zhe-Xiong Lian, Weidong Xiao, Zhanguo Liu, Zhi-Bin Zhao, Shenhai Gong
{"title":"Cohabitation facilitates microbiome shifts that promote isoflavone transformation to ameliorate liver injury","authors":"Yunong Zeng, Rong Wu, Yi He, Qian Zhang, Ze Wang, Ping Qin, Fangyuan Yang, Yingshi Han, Mingjing Hao, Yujian Zheng, Lei Gao, Xia Chen, Xiaoshan Zhao, Zhenhua Zeng, Zhe-Xiong Lian, Weidong Xiao, Zhanguo Liu, Zhi-Bin Zhao, Shenhai Gong","doi":"10.1016/j.chom.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.chom.2025.04.011","url":null,"abstract":"Acetaminophen overuse is a leading cause of acute liver injury (ALI). Although ALI is linked to inter-individual differences in microbiome composition, the mechanisms remain unclear. We demonstrate that horizontal transmission of gut microbiota between male and female mice impacts ALI and identify <em>Rikenella</em> <em>microfusus-</em>mediated isoflavone transformation as determinants of ALI severity. <em>R. microfusus</em> increases upon cohabitation with bacterial β-galactosidase enhancing intestinal absorption of isoflavone biochanin-A (Bio-A). <em>R. microfusus</em> mono-colonization reduced ALI severity following acetaminophen overdose. Genetic or chemical-mediated inhibition of β-galactosidase blocked Bio-A release and negated the hepatoprotective effects of <em>R. microfusus</em>. Bio-A directly binds to pyruvate carboxylase (PC) and propionyl-CoA carboxylase subunit alpha (PCCA), augmenting the tricarboxylic acid cycle and promoting protective glutathione synthesis in hepatocytes. Additionally, immunohistochemical analysis revealed reduced hepatic PC and PCCA expression in liver failure (LF) patients. These findings highlight the impacts of microbiome composition on ALI and the ability of microbial isoflavone absorption to mitigate ALI severity.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"26 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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