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A necrotizing toxin enables Pseudomonas syringae infection across evolutionarily divergent plants 一种坏死毒素可使假单胞菌感染不同进化植物
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-19 DOI: 10.1016/j.chom.2024.11.014
Kristina Grenz, Khong-Sam Chia, Emma K. Turley, Alexa S. Tyszka, Rebecca E. Atkinson, Jacob Reeves, Martin Vickers, Martin Rejzek, Joseph F. Walker, Philip Carella
{"title":"A necrotizing toxin enables Pseudomonas syringae infection across evolutionarily divergent plants","authors":"Kristina Grenz, Khong-Sam Chia, Emma K. Turley, Alexa S. Tyszka, Rebecca E. Atkinson, Jacob Reeves, Martin Vickers, Martin Rejzek, Joseph F. Walker, Philip Carella","doi":"10.1016/j.chom.2024.11.014","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.014","url":null,"abstract":"The <em>Pseudomonas syringae</em> species complex harbors a diverse range of pathogenic bacteria that can infect hosts across the plant kingdom. However, much of our current understanding of <em>P. syringae</em> is centered on its infection of flowering plants. We took a comparative approach to understand how <em>P. syringae</em> infects evolutionarily divergent plants. We identified <em>P. syringae</em> isolates causing disease in the liverwort <em>Marchantia polymorpha</em>, the fern <em>Ceratopteris richardii</em>, and the flowering plant <em>Nicotiana benthamiana</em>, which last shared a common ancestor &gt;500 million years ago. Phytotoxin-enriched phylogroup (PG) 2 isolates of <em>P. syringae</em> are virulent in non-flowering plants, relying on type-3 effectors and the lipopeptide phytotoxin syringomycin. Ectopic syringomycin promotes tissue necrosis, activates conserved stress-related genes, and enhances <em>in planta</em> bacterial growth of toxin-deficient PGs in <em>Marchantia</em>. Collectively, our research reveals a key role for syringomycin in promoting <em>Pseudomonas</em> colonization, which works alongside effectors to antagonize an exceptionally wide spectrum of land plants.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"262 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roseburia intestinalis-derived butyrate alleviates neuropathic pain 源自蔷薇肠的丁酸盐可减轻神经性疼痛
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-19 DOI: 10.1016/j.chom.2024.11.013
Yanjun Jiang, Ziheng Huang, Wuping Sun, Jiabin Huang, Yunlong Xu, Yuliang Liao, Tingting Jin, Qing Li, Idy Hiu Ting Ho, Yidan Zou, Wenyi Zhu, Qian Li, Fenfen Qin, Xinyi Zhang, Shuqi Shi, Na Zhang, Shaomin Yang, Wenhui Xie, Songbin Wu, Likai Tan, Xiaodong Liu
{"title":"Roseburia intestinalis-derived butyrate alleviates neuropathic pain","authors":"Yanjun Jiang, Ziheng Huang, Wuping Sun, Jiabin Huang, Yunlong Xu, Yuliang Liao, Tingting Jin, Qing Li, Idy Hiu Ting Ho, Yidan Zou, Wenyi Zhu, Qian Li, Fenfen Qin, Xinyi Zhang, Shuqi Shi, Na Zhang, Shaomin Yang, Wenhui Xie, Songbin Wu, Likai Tan, Xiaodong Liu","doi":"10.1016/j.chom.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.013","url":null,"abstract":"Approximately 20% of patients with shingles develop postherpetic neuralgia (PHN). We investigated the role of gut microbiota in shingle- and PHN-related pain. Patients with shingles or PHN exhibited significant alterations in their gut microbiota with microbial markers predicting PHN development among patients with shingles. Functionally, fecal microbiota transplantation from patients with PHN to mice heightened pain sensitivity. Administration of <em>Roseburia intestinalis</em>, a bacterium both depleted in patients with shingles and PHN, alleviated peripheral nerve injury-induced pain in mice. <em>R. intestinalis</em> enhanced vagal neurotransmission to the nucleus tractus solitarius (NTS) to suppress the central amygdala (CeA), a brain region involved in pain perception. <em>R. intestinalis-</em>generated butyrate activated vagal neurons through the receptor, G protein-coupled receptor 41 (GPR41). Vagal knockout of <em>Gpr41</em> abolished the effects of <em>R. intestinalis</em> on the NTS-CeA circuit and reduced pain behaviors. Overall, we established a microbiota-based model for PHN risk assessment and identified <em>R. intestinalis</em> as a potential pain-alleviating probiotic.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"40 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-18 DOI: 10.1016/j.chom.2024.11.012
Ju-Hyun Ahn, Marlus da Silva Pedrosa, Lacey R. Lopez, Taylor N. Tibbs, Joanna N. Jeyachandran, Emily E. Vignieri, Aaron Rothemich, Ian Cumming, Alexander D. Irmscher, Corey J. Haswell, William C. Zamboni, Yen-Rei A. Yu, Melissa Ellermann, Lee A. Denson, Janelle C. Arthur
{"title":"Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease","authors":"Ju-Hyun Ahn, Marlus da Silva Pedrosa, Lacey R. Lopez, Taylor N. Tibbs, Joanna N. Jeyachandran, Emily E. Vignieri, Aaron Rothemich, Ian Cumming, Alexander D. Irmscher, Corey J. Haswell, William C. Zamboni, Yen-Rei A. Yu, Melissa Ellermann, Lee A. Denson, Janelle C. Arthur","doi":"10.1016/j.chom.2024.11.012","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.012","url":null,"abstract":"Inflammatory bowel disease (IBD)-associated fibrosis causes significant morbidity. Mechanisms are poorly understood but implicate the microbiota, especially adherent-invasive <em>Escherichia coli</em> (AIEC). We previously demonstrated that AIEC producing the metallophore yersiniabactin (Ybt) promotes intestinal fibrosis in an IBD mouse model. Since macrophages interpret microbial signals and influence inflammation/tissue remodeling, we hypothesized that Ybt metal sequestration disrupts this process. Here, we show that macrophages are abundant in human IBD-fibrosis tissue and mouse fibrotic lesions, where they co-localize with AIEC. Ybt induces profibrotic gene expression in macrophages via stabilization and nuclear translocation of hypoxia-inducible factor 1-alpha (HIF-1α), a metal-dependent immune regulator. Importantly, Ybt-producing AIEC deplete macrophage intracellular zinc and stabilize HIF-1α through inhibition of zinc-dependent HIF-1α hydroxylation. HIF-1α+ macrophages localize to sites of disease activity in human IBD-fibrosis strictures and mouse fibrotic lesions, highlighting their physiological relevance. Our findings reveal microbiota-mediated metal sequestration as a profibrotic trigger targeting macrophages in the inflamed intestine.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"256 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungal-bacterial endosymbiosis: Recreating an ancient symbiotic relationship
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.10.018
Paola Bonfante
{"title":"Fungal-bacterial endosymbiosis: Recreating an ancient symbiotic relationship","authors":"Paola Bonfante","doi":"10.1016/j.chom.2024.10.018","DOIUrl":"https://doi.org/10.1016/j.chom.2024.10.018","url":null,"abstract":"Fungal-bacterial endosymbioses, the most intimate typology of symbioses, have been described in different taxa of Mucoromycota, an early diverging group of Fungi. In a recent issue of <em>Nature</em>, Giger and colleagues describe how they implanted a Burkolderia-related microbe inside a Mucoromycota fungus, giving rise to a functional and stable endosymbiosis.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"12 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selenium nanoboosting of plant-beneficial microbiome
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.11.004
Miaomiao Ding, Ivie Sonia Osayande, Kenichi Tsuda
{"title":"Selenium nanoboosting of plant-beneficial microbiome","authors":"Miaomiao Ding, Ivie Sonia Osayande, Kenichi Tsuda","doi":"10.1016/j.chom.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.004","url":null,"abstract":"In the dynamic theater of plant-microbe interactions, a new conductor has emerged: selenium nanoparticles. As unveiled by Sun et al. in this issue of <em>Cell Host &amp; Microbe</em>, these microbially synthesized nanoparticles recruit plant growth-promoting microbes, orchestrating a synergy between plants and the rhizosphere microbiome.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"2020 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guilds as guides for health vs. disease
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.11.010
Antonio L.C. Gomes, Robert R. Jenq
{"title":"Guilds as guides for health vs. disease","authors":"Antonio L.C. Gomes, Robert R. Jenq","doi":"10.1016/j.chom.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.010","url":null,"abstract":"In a recent <em>Cell</em> paper, Wu et al. identified microbiome guilds based on bacterial co-occurrence among type 2 diabetes patients. Two competing guilds, associated with high-fiber vs. control diets, correlated with healthy biomarkers. The potential of this approach was further verified across 15 diseases in 26 studies.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"119 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HAMpering infection: Helicase ratcheting emerges as a phage-sensing mechanism
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.11.009
Zhifeng Zeng, Wenyuan Han
{"title":"HAMpering infection: Helicase ratcheting emerges as a phage-sensing mechanism","authors":"Zhifeng Zeng, Wenyuan Han","doi":"10.1016/j.chom.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.009","url":null,"abstract":"The sensing of pathogens is the first step for any immune response. A recent paper in <em>Cell</em> reveals that the bacterial Hachiman anti-phage defense system deploys a helicase subunit to sense phage invasion via 3′ DNA recognition and subsequent domain rotation to enable nuclease activation.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"111 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The bad neighbor: Prophage competition in Salmonella during macrophage infection
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.11.011
Zoe Netter
{"title":"The bad neighbor: Prophage competition in Salmonella during macrophage infection","authors":"Zoe Netter","doi":"10.1016/j.chom.2024.11.011","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.011","url":null,"abstract":"Sargen and Helaine discover a prophage competition element in <em>Salmonella</em> that inhibits the lytic cycle of co-resident prophages by cleaving a subset of cellular tRNAs. During <em>Salmonella</em> pathogenesis in macrophages, a persister subset experiences prophage induction and competition, reducing release of immunogenic cellular components and altering macrophage response to infection.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"9 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the early life gut microbiome with MAGIC
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.10.019
Edoardo Pasolli
{"title":"Exploring the early life gut microbiome with MAGIC","authors":"Edoardo Pasolli","doi":"10.1016/j.chom.2024.10.019","DOIUrl":"https://doi.org/10.1016/j.chom.2024.10.019","url":null,"abstract":"In this issue of <em>Cell Host &amp; Microbe</em>, Peng et al. provide the MAGIC catalog as a resource for studying bacterial and viral diversity of the global gut microbiome in early life. By addressing gaps in geographic and age representation, this database enhances our understanding of early microbiome dynamics.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"1 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-04 DOI: 10.1016/j.chom.2024.11.008
Chanchal Sur Chowdhury, Rachel L. Kinsella, Michael E. McNehlan, Sumanta K. Naik, Daniel S. Lane, Priyanka Talukdar, Asya Smirnov, Neha Dubey, Ananda N. Rankin, Samuel R. McKee, Reilly Woodson, Abigail Hii, Sthefany M. Chavez, Darren Kreamalmeyer, Wandy Beatty, Joshua T. Mattila, Christina L. Stallings
{"title":"Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation","authors":"Chanchal Sur Chowdhury, Rachel L. Kinsella, Michael E. McNehlan, Sumanta K. Naik, Daniel S. Lane, Priyanka Talukdar, Asya Smirnov, Neha Dubey, Ananda N. Rankin, Samuel R. McKee, Reilly Woodson, Abigail Hii, Sthefany M. Chavez, Darren Kreamalmeyer, Wandy Beatty, Joshua T. Mattila, Christina L. Stallings","doi":"10.1016/j.chom.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.008","url":null,"abstract":"Neutrophils are the most abundant cell type in the airways of tuberculosis patients. <em>Mycobacterium tuberculosis</em> (<em>Mtb</em>) infection induces the release of neutrophil extracellular traps (NETs); however, the molecular regulation and impact of NET release on <em>Mtb</em> pathogenesis are unknown. We find that during <em>Mtb</em> infection in neutrophils, PAD4 citrullinates histones to decondense chromatin that gets released as NETs in a manner that can maintain neutrophil viability and promote <em>Mtb</em> replication. Type I interferon promotes the formation of chromatin-containing vesicles that allow NET release without compromising plasma membrane integrity. Analysis of nonhuman primate granulomas supports a model where neutrophils are exposed to type I interferon from macrophages as they migrate into the granuloma, thereby enabling the release of NETs associated with necrosis and caseation. Our data reveal NET release as a promising target to inhibit <em>Mtb</em> pathogenesis.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"199 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142763488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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