代谢拉锯战：线粒体使弓形虫缺乏叶酸

IF 18.7 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-10-08 DOI:10.1016/j.chom.2025.09.002

Evie R. Hodgson, Diana Stojanovski

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引用次数: 0

摘要

在最近的一篇科学论文中，Medeiros等人描述了受感染的细胞如何利用线粒体作为代谢守护者，与弓形虫寄生虫竞争叶酸（DNA合成所必需的维生素）。这种代谢免疫策略将细胞的动力转化为积极的防御者，在新陈代谢的拔河中将营养物质从入侵者手中隔离开来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Metabolic tug-of-war: Mitochondria starve Toxoplasma of folate

In a recent Science paper, Medeiros et al. describe how infected cells use mitochondria as metabolic guardians, outcompeting Toxoplasma parasites for folate, an essential vitamin for DNA synthesis. This metabolic immunity strategy transforms the cell’s powerhouse to an active defender, sequestering nutrients away from invaders in a metabolic tug-of-war.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.