Cell host & microbe最新文献_第10页

Multi-omics signatures reveal genomic and functional heterogeneity of Cutibacterium acnes in normal and diseased skin 多组学特征揭示正常和患病皮肤中痤疮杆菌的基因组和功能异质性

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-06-26 DOI: 10.1016/j.chom.2024.06.002

Tianze Yu, Xiaoqiang Xu, Yang Liu, Xiaokai Wang, Shi Wu, Zhuoqiong Qiu, Xiaochun Liu, Xiaoyu Pan, Chaoying Gu, Shangshang Wang, Lixin Dong, Wei Li, Xu Yao

{"title":"Multi-omics signatures reveal genomic and functional heterogeneity of Cutibacterium acnes in normal and diseased skin","authors":"Tianze Yu, Xiaoqiang Xu, Yang Liu, Xiaokai Wang, Shi Wu, Zhuoqiong Qiu, Xiaochun Liu, Xiaoyu Pan, Chaoying Gu, Shangshang Wang, Lixin Dong, Wei Li, Xu Yao","doi":"10.1016/j.chom.2024.06.002","DOIUrl":"https://doi.org/10.1016/j.chom.2024.06.002","url":null,"abstract":"Cutibacterium acnes is the most abundant bacterium of the human skin microbiome since adolescence, participating in both skin homeostasis and diseases. Here, we demonstrate individual and niche heterogeneity of C. acnes from 1,234 isolate genomes. Skin disease (atopic dermatitis and acne) and body site shape genomic differences of C. acnes, stemming from horizontal gene transfer and selection pressure. C. acnes harbors characteristic metabolic functions, fewer antibiotic resistance genes and virulence factors, and a more stable genome compared with Staphylococcus epidermidis. Integrated genome, transcriptome, and metabolome analysis at the strain level unveils the functional characteristics of C. acnes. Consistent with the transcriptome signature, C. acnes in a sebum-rich environment induces toxic and pro-inflammatory effects on keratinocytes. L-carnosine, an anti-oxidative stress metabolite, is up-regulated in the C. acnes metabolome from atopic dermatitis and attenuates skin inflammation. Collectively, our study reveals the joint impact of genes and the microenvironment on C. acnes function.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"85 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of disease-adapted bacterial lineages in inflammatory bowel diseases 发现炎症性肠病中与疾病相适应的细菌谱系

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-06-24 DOI: 10.1016/j.chom.2024.05.022

Adarsh Kumbhari, Thomas N.H. Cheng, Ashwin N. Ananthakrishnan, Bharati Kochar, Kristin E. Burke, Kevin Shannon, Helena Lau, Ramnik J. Xavier, Christopher S. Smillie

{"title":"Discovery of disease-adapted bacterial lineages in inflammatory bowel diseases","authors":"Adarsh Kumbhari, Thomas N.H. Cheng, Ashwin N. Ananthakrishnan, Bharati Kochar, Kristin E. Burke, Kevin Shannon, Helena Lau, Ramnik J. Xavier, Christopher S. Smillie","doi":"10.1016/j.chom.2024.05.022","DOIUrl":"https://doi.org/10.1016/j.chom.2024.05.022","url":null,"abstract":"Gut bacteria are implicated in inflammatory bowel disease (IBD), but the strains driving these associations are unknown. Large-scale studies of microbiome evolution could reveal the imprint of disease on gut bacteria, thus pinpointing the strains and genes that may underlie inflammation. Here, we use stool metagenomes of thousands of IBD patients and healthy controls to reconstruct 140,000 strain genotypes, revealing hundreds of lineages enriched in IBD. We demonstrate that these strains are ancient, taxonomically diverse, and ubiquitous in humans. Moreover, disease-associated strains outcompete their healthy counterparts during inflammation, implying long-term adaptation to disease. Strain genetic differences map onto known axes of inflammation, including oxidative stress, nutrient biosynthesis, and immune evasion. Lastly, the loss of health-associated strains of Eggerthella lenta was predictive of fecal calprotectin, a biomarker of disease severity. Our work identifies reservoirs of strain diversity that may impact inflammatory disease and can be extended to other microbiome-associated diseases.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"82 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141444995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion 大规模 I 型 CBASS 抗噬菌体筛选确定噬菌体蛋白头蛋白酶是免疫激活和规避的关键决定因素

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-06-24 DOI: 10.1016/j.chom.2024.05.021

Desmond Richmond-Buccola, Samuel J. Hobbs, Jasmine M. Garcia, Hunter Toyoda, Jingjing Gao, Sichen Shao, Amy S.Y. Lee, Philip J. Kranzusch

{"title":"A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion","authors":"Desmond Richmond-Buccola, Samuel J. Hobbs, Jasmine M. Garcia, Hunter Toyoda, Jingjing Gao, Sichen Shao, Amy S.Y. Lee, Philip J. Kranzusch","doi":"10.1016/j.chom.2024.05.021","DOIUrl":"https://doi.org/10.1016/j.chom.2024.05.021","url":null,"abstract":"Cyclic oligonucleotide-based signaling system (CBASS) is an antiviral system that protects bacteria from phage infection and is evolutionarily related to human cGAS-STING immunity. cGAS-STING signaling is initiated by the recognition of viral DNA, but the molecular cues activating CBASS are incompletely understood. Using a screen of 975 type I CBASS operon-phage challenges, we show that operons with distinct cGAS/DncV-like nucleotidyltransferases (CD-NTases) and CD-NTase-associated protein (Cap) effectors exhibit marked patterns of phage restriction. We find that some type I CD-NTase enzymes require a C-terminal AGS-C immunoglobulin (Ig)-like fold domain for defense against select phages. Escaper phages evade CBASS via protein-coding mutations in virion assembly proteins, and acquired resistance is largely operon specific. We demonstrate that the phage Bas13 prohead protease interacts with the CD-NTase EcCdnD12 and can induce CBASS-dependent growth arrest in cells. Our results define phage virion assembly as a determinant of type I CBASS immune evasion and support viral protein recognition as a putative mechanism of cGAS-like enzyme activation.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"21 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice Anaerostipes caccae 和乳糖的合成益生菌可预防和治疗小鼠食物过敏症

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-06-20 DOI: 10.1016/j.chom.2024.05.019

Lauren A. Hesser, Armando A. Puente, Jack Arnold, Edward Ionescu, Anjali Mirmira, Nidhi Talasani, Jacqueline Lopez, Lisa Maccio-Maretto, Mark Mimee, Cathryn R. Nagler

{"title":"A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice","authors":"Lauren A. Hesser, Armando A. Puente, Jack Arnold, Edward Ionescu, Anjali Mirmira, Nidhi Talasani, Jacqueline Lopez, Lisa Maccio-Maretto, Mark Mimee, Cathryn R. Nagler","doi":"10.1016/j.chom.2024.05.019","DOIUrl":"https://doi.org/10.1016/j.chom.2024.05.019","url":null,"abstract":"Depletion of beneficial microbes by modern lifestyle factors correlates with the rising prevalence of food allergies. Re-introduction of allergy-protective bacteria may be an effective treatment strategy. We characterized the fecal microbiota of healthy and food-allergic infants and found that the anaerobe Anaerostipes caccae (A. caccae) was representative of the protective capacity of the healthy microbiota. We isolated a strain of A. caccae from the feces of a healthy infant and identified lactulose as a prebiotic to optimize butyrate production by A. caccae in vitro. Administration of a synbiotic composed of our isolated A. caccae strain and lactulose increased luminal butyrate in gnotobiotic mice colonized with feces from an allergic infant and in antibiotic-treated specific pathogen-free (SPF) mice, and prevented or treated an anaphylactic response to allergen challenge. The synbiotic’s efficacy in two models and microbial contexts suggests that it may be a promising approach for the treatment of food allergy.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"38 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141430646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

H19 influenza A virus exhibits species-specific MHC class II receptor usage H19 甲型流感病毒显示出物种特异性的 MHC II 类受体使用情况

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-06-17 DOI: 10.1016/j.chom.2024.05.018

Umut Karakus, Ignacio Mena, Jithesh Kottur, Sara S. El Zahed, Rocío Seoane, Soner Yildiz, Leanne Chen, Magdalena Plancarte, LeAnn Lindsay, Rebecca Halpin, Timothy B. Stockwell, David E. Wentworth, Geert-Jan Boons, Florian Krammer, Silke Stertz, Walter Boyce, Robert P. de Vries, Aneel K. Aggarwal, Adolfo García-Sastre

{"title":"H19 influenza A virus exhibits species-specific MHC class II receptor usage","authors":"Umut Karakus, Ignacio Mena, Jithesh Kottur, Sara S. El Zahed, Rocío Seoane, Soner Yildiz, Leanne Chen, Magdalena Plancarte, LeAnn Lindsay, Rebecca Halpin, Timothy B. Stockwell, David E. Wentworth, Geert-Jan Boons, Florian Krammer, Silke Stertz, Walter Boyce, Robert P. de Vries, Aneel K. Aggarwal, Adolfo García-Sastre","doi":"10.1016/j.chom.2024.05.018","DOIUrl":"https://doi.org/10.1016/j.chom.2024.05.018","url":null,"abstract":"Avian influenza A virus (IAV) surveillance in Northern California, USA, revealed unique IAV hemagglutinin (HA) genome sequences in cloacal swabs from lesser scaups. We found two closely related HA sequences in the same duck species in 2010 and 2013. Phylogenetic analyses suggest that both sequences belong to the recently discovered H19 subtype, which thus far has remained uncharacterized. We demonstrate that H19 does not bind the canonical IAV receptor sialic acid (Sia). Instead, H19 binds to the major histocompatibility complex class II (MHC class II), which facilitates viral entry. Unlike the broad MHC class II specificity of H17 and H18 from bat IAV, H19 exhibits a species-specific MHC class II usage that suggests a limited host range and zoonotic potential. Using cell lines overexpressing MHC class II, we rescued recombinant H19 IAV. We solved the H19 crystal structure and identified residues within the putative Sia receptor binding site (RBS) that impede Sia-dependent entry.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"45 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141333896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropilin invites reoviruses into neurons 神经蛋白酶吸引再病毒进入神经元

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-06-12 DOI: 10.1016/j.chom.2024.05.013

Tom Gallagher

引用次数: 0

Going viral: The role of mobile genetic elements in bacterial immunity 病毒移动遗传因子在细菌免疫中的作用

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-06-12 DOI: 10.1016/j.chom.2024.05.017

Beatriz Beamud, Fabienne Benz, David Bikard

引用次数: 0

Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year 出生方式和环境决定的微生物群传播动态与第一年的母乳喂养相辅相成

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-06-12 DOI: 10.1016/j.chom.2024.05.005

Marta Selma-Royo, Léonard Dubois, Serena Manara, Federica Armanini, Raúl Cabrera-Rubio, Mireia Valles-Colomer, Sonia González, Anna Parra-Llorca, Ramon Escuriet, Lars Bode, Cecilia Martínez-Costa, Nicola Segata, Maria Carmen Collado

{"title":"Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year","authors":"Marta Selma-Royo, Léonard Dubois, Serena Manara, Federica Armanini, Raúl Cabrera-Rubio, Mireia Valles-Colomer, Sonia González, Anna Parra-Llorca, Ramon Escuriet, Lars Bode, Cecilia Martínez-Costa, Nicola Segata, Maria Carmen Collado","doi":"10.1016/j.chom.2024.05.005","DOIUrl":"https://doi.org/10.1016/j.chom.2024.05.005","url":null,"abstract":"The composition and maturation of the early-life microbiota are modulated by a number of perinatal factors, whose interplay in relation to microbial vertical transmission remains inadequately elucidated. Using recent strain-tracking methodologies, we analyzed mother-to-infant microbiota transmission in two different birth environments: hospital-born (vaginal/cesarean) and home-born (vaginal) infants and their mothers. While delivery mode primarily explains initial compositional differences, place of birth impacts transmission timing—being early in homebirths and delayed in cesarean deliveries. Transmission patterns vary greatly across species and birth groups, yet certain species, like Bifidobacterium longum, are consistently vertically transmitted regardless of delivery setting. Strain-level analysis of B. longum highlights relevant and consistent subspecies replacement patterns mainly explained by breastfeeding practices, which drive changes in human milk oligosaccharide (HMO) degrading capabilities. Our findings highlight how delivery setting, breastfeeding duration, and other lifestyle preferences collectively shape vertical transmission, impacting infant gut colonization during early life.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"59 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tactical terminase: How a Salmonella prophage navigates oxidative stress 战术终结酶沙门氏菌噬菌体如何应对氧化应激

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-06-12 DOI: 10.1016/j.chom.2024.05.010

引用次数: 0

Nutrient acquisition strategies by gut microbes 肠道微生物的营养获取策略

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-06-12 DOI: 10.1016/j.chom.2024.05.011

Matthew K. Muramatsu, Sebastian E. Winter

引用次数: 0