Cell host & microbe最新文献_第10页

Carving out the microbiota of Earth’s largest biomass reservoir 雕刻出地球上最大的生物资源库的微生物群

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-10-08 DOI: 10.1016/j.chom.2025.09.008

Moshe Alon, Omri M. Finkel

引用次数: 0

Metabolic clash of Cryptosporidium and its host 隐孢子虫及其宿主的代谢冲突

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-10-08 DOI: 10.1016/j.chom.2025.09.011

Simona Seizova, Christopher J. Tonkin

引用次数: 0

The HY5-NPR1 module governs light-dependent virulence of a plant bacterial pathogen HY5-NPR1模块控制植物细菌病原体的光依赖性毒力

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-10-07 DOI: 10.1016/j.chom.2025.09.016

Pengtao Liu, Zhao Zhao, Yaqi Tang, Yangyang Zhou, Jie Liu, Kaiqi Xu, Yaxin Chen, Xiaoting Li, Yaru Tang, Li Yang

引用次数: 0

Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation 肠道微生物源性尸胺对巨噬细胞的免疫代谢重编程控制结肠炎症

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-09-30 DOI: 10.1016/j.chom.2025.09.009

Rodrigo de Oliveira Formiga, Qing Li, Yining Zhao, Márcio Augusto Campos Ribeiro, Perle Guarino-Vignon, Rand Fatouh, Leonard Dubois, Laura Creusot, Virginie Puchois, Salomé Amouyal, Iria Alonso Salgueiro, Marius Bredon, Loïc Chollet, Tatiana Ledent, Cyril Scandola, Jean-Philippe Auger, Camille Danne, Gerhard Krönke, Emma Tkacz, Patrick Emond, Harry Sokol

{"title":"Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation","authors":"Rodrigo de Oliveira Formiga, Qing Li, Yining Zhao, Márcio Augusto Campos Ribeiro, Perle Guarino-Vignon, Rand Fatouh, Leonard Dubois, Laura Creusot, Virginie Puchois, Salomé Amouyal, Iria Alonso Salgueiro, Marius Bredon, Loïc Chollet, Tatiana Ledent, Cyril Scandola, Jean-Philippe Auger, Camille Danne, Gerhard Krönke, Emma Tkacz, Patrick Emond, Harry Sokol","doi":"10.1016/j.chom.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.chom.2025.09.009","url":null,"abstract":"Cadaverine is a polyamine produced by the gut microbiota with links to health and disease, notably inflammatory bowel disease (IBD). Here, we show that cadaverine shapes monocyte-macrophage immunometabolism in a context- and concentration-dependent fashion to impact macrophage functionality. At baseline, cadaverine is taken up via L-lysine transporters and activates the thioredoxin system, while during inflammation, cadaverine signals through aconitate decarboxylase 1 (Acod1)-itaconate. Both pathways induce activation of transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2), which supports mitochondrial respiration and promotes immunoregulatory macrophage polarization. Conversely, under higher concentrations, cadaverine acts via histamine 4 receptor, leading to glycolysis-driven inflammation and pro-inflammatory functions in macrophages. Likewise, cadaverine exhibits paradoxical effects in experimental colitis, either protective or detrimental, evoking opposite fates on macrophages depending on levels dictated by Enterobacteriaceae. In IBD patients, elevated cadaverine correlated with higher flare risk. Our findings implicate cadaverine as a microbiota-derived metabolite manipulating macrophage energy metabolism with consequences in intestinal inflammation and implications for IBD pathogenesis.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"2 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bacterial signal coordinates plant-microbe fitness trade-off to enhance sulfur deficiency tolerance in plants 细菌信号协调植物与微生物的适应度权衡，以增强植物的硫缺乏耐受性

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-09-26 DOI: 10.1016/j.chom.2025.09.007

Arijit Mukherjee, Mrinmoy Mazumder, Arun Verma, Hitesh Tikariha, Raktim Bhattacharya, Qi En Ooi, Sanjay Swarup

{"title":"A bacterial signal coordinates plant-microbe fitness trade-off to enhance sulfur deficiency tolerance in plants","authors":"Arijit Mukherjee, Mrinmoy Mazumder, Arun Verma, Hitesh Tikariha, Raktim Bhattacharya, Qi En Ooi, Sanjay Swarup","doi":"10.1016/j.chom.2025.09.007","DOIUrl":"https://doi.org/10.1016/j.chom.2025.09.007","url":null,"abstract":"Plant-associated microorganisms interact with each other and with host plants via intricate chemical signals, offering multiple benefits, including enhanced nutrition. We report a mechanism through which the rhizosphere microbiome improves plant growth under sulfur (S) deficiency. Disruption of plant S homeostasis caused a coordinated shift in the composition and S-metabolism of the rhizosphere microbiome. Leveraging this, we developed an 18-membered synthetic rhizosphere bacterial community (SynCom) that rescued the growth of Arabidopsis and a leafy Brassicaceae vegetable under S-deficiency. This beneficial trait is taxonomically widespread among SynCom members, with bacterial pairs providing both synergistic and neutral effects on host growth. Notably, stronger competitive interactions among SynCom members conferred greater fitness benefits to the host, suggesting a trans-kingdom (plant-microbe) fitness trade-off. Finally, guided chemical screening, deletion knockout mutants, and targeted metabolomics identified and validated microbially released glutathione (GSH) as the necessary bioactive signal that coordinates the trans-kingdom fitness trade-off and improves plant growth under sulfur limitation.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"18 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation 脆弱拟杆菌蛋白酶激活宿主PAR2诱导肠道疼痛和炎症

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-09-26 DOI: 10.1016/j.chom.2025.09.010

Markus Lakemeyer, Rocco Latorre, Kristyna Blazkova, Hannah M. Wood, Dane D. Jensen, Nayab Shakil, Scott C. Thomas, Deepak Saxena, Yatendra Mulpuri, David Poolman, Paz Duran, Laura J. Keller, David E. Reed, Brian L. Schmidt, Néstor N. Jiménez-Vargas, Fangxi Xu, Alan E. Lomax, Nigel W. Bunnett, Matthew Bogyo

{"title":"A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation","authors":"Markus Lakemeyer, Rocco Latorre, Kristyna Blazkova, Hannah M. Wood, Dane D. Jensen, Nayab Shakil, Scott C. Thomas, Deepak Saxena, Yatendra Mulpuri, David Poolman, Paz Duran, Laura J. Keller, David E. Reed, Brian L. Schmidt, Néstor N. Jiménez-Vargas, Fangxi Xu, Alan E. Lomax, Nigel W. Bunnett, Matthew Bogyo","doi":"10.1016/j.chom.2025.09.010","DOIUrl":"https://doi.org/10.1016/j.chom.2025.09.010","url":null,"abstract":"Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation, and pain. Upregulated intestinal proteolysis and PAR2 signaling are implicated in inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS), conditions often associated with gut microbiome alterations. To identify potential bacterial regulators of PAR2 activity, we developed a functional assay for PAR2 processing to screen a library of diverse gut microbes. We identify multiple bacteria that secrete proteases capable of cleaving host PAR2. Using chemoproteomic profiling with a covalent irreversible inhibitor, we uncovered a previously uncharacterized Bacteroides fragilis serine protease 1 (Bfp1) and show that it cleaves and activates PAR2 in multicellular and murine models. PAR2 cleavage by Bfp1 disrupts the intestinal barrier, sensitizes nociceptors, and triggers colonic inflammation and abdominal pain. Collectively, our findings uncover Bfp1-mediated PAR2 processing as an axis of host-commensal interaction in the gut that has the potential to be targeted for therapeutic intervention in IBD or IBS.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"100 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The microbiota extends the reproductive lifespan of mice by safeguarding the ovarian reserve 微生物群通过保护卵巢储备来延长小鼠的生殖寿命

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-09-25 DOI: 10.1016/j.chom.2025.09.006

Sarah K. Munyoki, Julie P. Goff, Amanda Reshke, Erin Wilderoter, Nyasha Mafarachisi, Antonija Kolobaric, Yi Sheng, Steven J. Mullett, Gabrielle E. King, Jacob D. DeSchepper, Richard J. Bookser, Carlos A. Castro, Stacy L. Gelhaus, Mayara Grizotte-Lake, Kathleen E. Morrison, Anthony J. Zeleznik, Timothy W. Hand, Miguel A. Brieño-Enriquez, Eldin Jašarević

{"title":"The microbiota extends the reproductive lifespan of mice by safeguarding the ovarian reserve","authors":"Sarah K. Munyoki, Julie P. Goff, Amanda Reshke, Erin Wilderoter, Nyasha Mafarachisi, Antonija Kolobaric, Yi Sheng, Steven J. Mullett, Gabrielle E. King, Jacob D. DeSchepper, Richard J. Bookser, Carlos A. Castro, Stacy L. Gelhaus, Mayara Grizotte-Lake, Kathleen E. Morrison, Anthony J. Zeleznik, Timothy W. Hand, Miguel A. Brieño-Enriquez, Eldin Jašarević","doi":"10.1016/j.chom.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.chom.2025.09.006","url":null,"abstract":"Infertility affects one in six people, but the underlying mechanisms remain unclear. We show that the microbiota governs female reproductive longevity in mice. Germ-free mice have fewer primordial follicles, increased atresia, and ovarian fibrosis, leading to smaller litters, fewer offspring, and a shorter reproductive lifespan. Germ-free mice are born with a similar ovarian reserve but display excessive activation, impaired progression, and increased atresia during post-natal development. Microbiome colonization during a critical post-natal window rescues premature ovarian reserve loss by normalizing follicle kinetics and gene expression patterns. These changes parallel increased short-chain fatty acids (SCFAs), and SCFA administration mitigates ovarian dysfunction in germ-free mice. Similar oocyte dysfunction occurred in conventionally raised mice fed a high-fat diet, but additional dietary fiber helped preserve oocyte quality and embryo competence. Thus, host-microbe interactions shape female fertility, and microbiota-targeted interventions may offer strategies to address reproductive disorders.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"99 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-chain unsaturated fatty acids released during immune responses stimulate host-microbe trans-kingdom communication 免疫应答过程中释放的长链不饱和脂肪酸刺激宿主-微生物跨界交流

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-09-18 DOI: 10.1016/j.chom.2025.08.011

Aleksander Czauderna, Grishma Kulkarni, Niccolò Bianchi, Liqing Cheng, Marissa Sim, Nicola R. Realini, Joanna Gach, Aurelie Caillon, Joachim Kloehn, Gérard Lambeau, Annika Hausmann, Stefano Serra, Matthew T. Sorbara, Simone Becattini

{"title":"Long-chain unsaturated fatty acids released during immune responses stimulate host-microbe trans-kingdom communication","authors":"Aleksander Czauderna, Grishma Kulkarni, Niccolò Bianchi, Liqing Cheng, Marissa Sim, Nicola R. Realini, Joanna Gach, Aurelie Caillon, Joachim Kloehn, Gérard Lambeau, Annika Hausmann, Stefano Serra, Matthew T. Sorbara, Simone Becattini","doi":"10.1016/j.chom.2025.08.011","DOIUrl":"https://doi.org/10.1016/j.chom.2025.08.011","url":null,"abstract":"Immune responses can significantly alter the structure and function of the gut microbiota, leading to rapid transcriptional and metabolic shifts in commensal microbes. However, the host mediators involved in this process and their effects on bacteria remain poorly elucidated. Here, using a flagellin injection model to induce immune activation, we identified unsaturated long-chain fatty acids (uLCFAs) as broad modulators that are released into the gut lumen and alter bacterial gene expression. Luminal release of uLCFAs is partially mediated by host phospholipases, including PLA2G5. In response to uLCFAs, commensals such as Blautia trigger the expression of ohyA, encoding oleate hydratase, which converts toxic uLCFAs to non-toxic hydroxy fatty acids with immunomodulatory properties. Remarkably, oral administration of uLCFAs to mice replicates many of the bacterial transcriptional changes induced by flagellin. This molecular loop underscores the sophisticated interactions between host and microbiota and sheds light on how immune responses affect gut commensal functions.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"68 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145078378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal resistance in rice is restored by interfamily transfer of an evolutionarily lost co-receptor 水稻的真菌抗性是通过一种进化上丢失的共受体的家族间转移而恢复的

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-09-17 DOI: 10.1016/j.chom.2025.08.015

Qian Zhang, Wenyue Zheng, Haoxiang Huang, Shuchen Wang, Sizhe Li, Kaixiang Wang, Haixia You, Hao Gong, Xiayan Pan, Zhongqiang Qi, Yan Du, Junjie Yu, Mina Yu, Huijuan Cao, Rongsheng Zhang, Yuanchao Wang, Daolong Dou, Zhenchuan Ma, Yongfeng Liu, Tianqiao Song

{"title":"Fungal resistance in rice is restored by interfamily transfer of an evolutionarily lost co-receptor","authors":"Qian Zhang, Wenyue Zheng, Haoxiang Huang, Shuchen Wang, Sizhe Li, Kaixiang Wang, Haixia You, Hao Gong, Xiayan Pan, Zhongqiang Qi, Yan Du, Junjie Yu, Mina Yu, Huijuan Cao, Rongsheng Zhang, Yuanchao Wang, Daolong Dou, Zhenchuan Ma, Yongfeng Liu, Tianqiao Song","doi":"10.1016/j.chom.2025.08.015","DOIUrl":"https://doi.org/10.1016/j.chom.2025.08.015","url":null,"abstract":"The interfamily transfer of pattern-recognition receptors (PRRs) offers a promising strategy to enhance plant immunity; however, factors causing functional limitations across species remain unknown. Here, we identify secreted TOM20 domain-containing protein (STOM), a previously uncharacterized fungal microbe-associated molecular pattern (MAMP) that triggers immunity in Nicotiana benthamiana but not in rice (Oryza sativa). We identify NbSTOMR as the receptor that recognizes and binds STOM, and NbSTOMRh as the co-receptor that, despite lacking ligand-binding ability, is essential through its extracellular interaction with NbSTOMR. Transferring NbSTOMR to rice fails to confer resistance, but NbSTOMRh alone enhances resistance to false smut and blast disease. Evolutionary analyses reveal that while STOMR is conserved, monocots have lost STOMRh due to transposon-mediated chromosomal separation of its extracellular domain. Although OsSTOMR binds STOM, OsSTOMRh is non-functional; however, NbSTOMRh promotes OsSTOMR-dependent STOM recognition. These findings highlight the critical role of co-receptors in overcoming taxonomic barriers and provide a strategy for reconstituting PRR-mediated immunity in monocot crops.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"52 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145072169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common mycorrhizal networks facilitate plant disease resistance by altering rhizosphere microbiome assembly 常见的菌根网络通过改变根际微生物群的组合来促进植物抗病

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-09-16 DOI: 10.1016/j.chom.2025.08.016

Xianhong Zhang, Xue Jin, Jiawei Li, Francisco Dini-Andreote, Hongyu Li, Muhammad Khashi u Rahman, Minmin Du, Fengzhi Wu, Zhong Wei, Xingang Zhou, Marcel G.A. van der Heijden, Matthias C. Rillig

{"title":"Common mycorrhizal networks facilitate plant disease resistance by altering rhizosphere microbiome assembly","authors":"Xianhong Zhang, Xue Jin, Jiawei Li, Francisco Dini-Andreote, Hongyu Li, Muhammad Khashi u Rahman, Minmin Du, Fengzhi Wu, Zhong Wei, Xingang Zhou, Marcel G.A. van der Heijden, Matthias C. Rillig","doi":"10.1016/j.chom.2025.08.016","DOIUrl":"https://doi.org/10.1016/j.chom.2025.08.016","url":null,"abstract":"Arbuscular mycorrhizal fungi can interconnect the roots of individual plants by forming common mycorrhizal networks (CMNs). These symbiotic structures can act as conduits for interplant communication. Despite their importance, the mechanisms of signal transfer via CMNs and their implications for plant community performance remain unknown. Here, we demonstrate that CMNs act as a pathway to elicit defense responses in healthy receiver plants connected to pathogen-infected donors. Specifically, we show that donor plants infected by the phytopathogen Botrytis cinerea transfer jasmonic acid via CMNs, which then act as a chemical signal in receiver plants. This signal transfer to receiver plants induces shifts in root exudates, promoting the recruitment of specific microbial taxa (Streptomyces and Actinoplanes) that are directly linked to the suppression of B. cinerea infection. Collectively, our study reveals that CMNs act as interplant chemical communication conduits, transferring signals that contribute to plant disease resistance via modulation of the rhizosphere microbiota.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"19 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0