Decoding WEEV’s host adaptation

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-05-14 DOI:10.1016/j.chom.2025.04.006

Yinong Qiu, Lei Sun

引用次数: 0

Abstract

The Western equine encephalitis virus (WEEV), an alphavirus causing severe neurological disease, exhibits fluctuating epidemic patterns and enigmatic host adaptability. Recent studies by Raju et al. and Fan et al. in Cell reveal glycoprotein modifications enabling receptor switching, explaining its reduced human pathogenicity while underscoring re-emergence risks.

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解码WEEV的宿主适应

西方马脑炎病毒（WEEV）是一种引起严重神经系统疾病的甲病毒，表现出波动的流行模式和神秘的宿主适应性。Raju等人和Fan等人最近在《细胞》杂志上的研究揭示了糖蛋白修饰使受体转换，解释了其降低人类致病性的同时强调了再次出现的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.