Cell host & microbe最新文献_第9页

If you can’t beat them, join them: Anti-CRISPR proteins derived from CRISPR-associated genes 如果你不能打败他们，那就加入他们吧：源自CRISPR相关基因的抗CRISPR蛋白

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-11-13 DOI: 10.1016/j.chom.2024.10.009

Charlie Y. Mo

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mRNA vaccines: A promising platform for safer, more effective next-generation Orthopoxvirus immunization mRNA 疫苗：更安全、更有效的下一代正畸病毒免疫平台前景广阔

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-11-13 DOI: 10.1016/j.chom.2024.10.014

Xiaonan Han, Qingrui Huang, Jinghua Yan

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Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn’s disease 微生物诱导的巨噬细胞犬尿氨酸代谢改变促使克罗恩病中爬行脂肪的形成

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-11-13 DOI: 10.1016/j.chom.2024.10.008

Jinjie Wu, Wanyi Zeng, Hongyu Xie, Mujia Cao, Jingyi Yang, Yanchun Xie, Zhanhao Luo, Zongjin Zhang, Haoyang Xu, Weidong Huang, Tingyue Zhou, Jinyu Tan, Xiaomin Wu, Zihuan Yang, Shu Zhu, Ren Mao, Zhen He, Ping Lan

{"title":"Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn’s disease","authors":"Jinjie Wu, Wanyi Zeng, Hongyu Xie, Mujia Cao, Jingyi Yang, Yanchun Xie, Zhanhao Luo, Zongjin Zhang, Haoyang Xu, Weidong Huang, Tingyue Zhou, Jinyu Tan, Xiaomin Wu, Zihuan Yang, Shu Zhu, Ren Mao, Zhen He, Ping Lan","doi":"10.1016/j.chom.2024.10.008","DOIUrl":"https://doi.org/10.1016/j.chom.2024.10.008","url":null,"abstract":"Hyperplasia of mesenteric tissues in Crohn’s disease, called creeping fat (CrF), is associated with surgical recurrence. Although microbiota translocation and colonization have been found in CrF, convincing mouse phenotypes and the underlying mechanisms of CrF formation remain unclear. Utilizing single-nucleus RNA (snRNA) sequencing of CrF and different mouse models, we demonstrate that the commensal Achromobacter pulmonis induces mesenteric adipogenesis through macrophage alteration. Targeted metabolome analysis reveals that L-kynurenine is the most enriched metabolite in CrF. Upregulation of indoleamine 2,3-dioxygenase 1 (IDO1) enhances kynurenine metabolism and drives mesenteric adipogenesis. Leveraging single-cell RNA (scRNA) sequencing of mouse mesenteric tissues and macrophage-specific IDO1 knockout mice, we verify the role of macrophage-sourced L-kynurenine in mesenteric adipogenesis. Mechanistically, L-kynurenine-induced adipogenesis is mediated by the aryl hydrocarbon receptors in adipocytes. Administration of an IDO1 inhibitor or bacteria engineered to degrade L-kynurenine alleviates mesenteric adipogenesis in mice. Collectively, our study demonstrates that microbiota-induced modulation of macrophage metabolism potentiates CrF formation.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"7 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Microbial alchemists unlock honeybee cognition 微生物炼金术士开启蜜蜂的认知能力

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-11-13 DOI: 10.1016/j.chom.2024.10.013

Huihui Sun, Guan-Hong Wang

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Beta-carbolines suppress vaginal inflammation β-碳酸氢盐抑制阴道炎症

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-11-13 DOI: 10.1016/j.chom.2024.10.005

Cancan Qi, Ri-hua Xie, Yan He, Muxuan Chen

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A prophage competition element protects Salmonella from lysis 噬菌体竞争元件保护沙门氏菌不被溶解

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-11-07 DOI: 10.1016/j.chom.2024.10.012

Molly R. Sargen, Sophie Helaine

{"title":"A prophage competition element protects Salmonella from lysis","authors":"Molly R. Sargen, Sophie Helaine","doi":"10.1016/j.chom.2024.10.012","DOIUrl":"https://doi.org/10.1016/j.chom.2024.10.012","url":null,"abstract":"Most bacteria are polylysogens that carry multiple prophages integrated into the chromosome. These prophages confer advantages to their bacterial host, yet also pose a lethal threat as they can reactivate and enter a lytic cycle. DNA damage of the bacterial host is a common trigger of prophage lytic cycles. Because DNA damage is frequently experienced by bacterial pathogens exposed to host immune defenses, prophage activation may be common during infection. Investigating the consequences of prophage induction in Salmonella, we discover a prophage competition element in the Gifsy-1 prophage that we name ribonuclease effector module with ATPase, inhibitor, and nuclease (RemAIN) because it blocks the lytic cycles and release of viral particles of co-resident prophages. Intramacrophage Salmonella persisters, a subpopulation that incurs DNA damage, experience prophage reactivation and subsequent RemAIN activation, which influences Salmonella persisters and macrophage response to infection. Our findings reveal a multi-layered host-pathogen arms race in which prophage-prophage competition influences bacterial persistence and the mammalian immune response.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"64 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients 抗 PD-1 治疗期间肠道微生物群的纵向分析揭示了黑色素瘤患者反应的稳定微生物特征

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-10-30 DOI: 10.1016/j.chom.2024.10.006

Angeli D.G. Macandog, Carlotta Catozzi, Mariaelena Capone, Amir Nabinejad, Padma P. Nanaware, Shujing Liu, Smita Vinjamuri, Johanna A. Stunnenberg, Serena Galiè, Maria Giovanna Jodice, Francesca Montani, Federica Armanini, Ester Cassano, Gabriele Madonna, Domenico Mallardo, Benedetta Mazzi, Salvatore Pece, Maria Tagliamonte, Vito Vanella, Massimo Barberis, Luigi Nezi

{"title":"Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients","authors":"Angeli D.G. Macandog, Carlotta Catozzi, Mariaelena Capone, Amir Nabinejad, Padma P. Nanaware, Shujing Liu, Smita Vinjamuri, Johanna A. Stunnenberg, Serena Galiè, Maria Giovanna Jodice, Francesca Montani, Federica Armanini, Ester Cassano, Gabriele Madonna, Domenico Mallardo, Benedetta Mazzi, Salvatore Pece, Maria Tagliamonte, Vito Vanella, Massimo Barberis, Luigi Nezi","doi":"10.1016/j.chom.2024.10.006","DOIUrl":"https://doi.org/10.1016/j.chom.2024.10.006","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) improve outcomes in advanced melanoma, but many patients are refractory or experience relapse. The gut microbiota modulates antitumor responses. However, inconsistent baseline predictors point to heterogeneity in responses and inadequacy of cross-sectional data. We followed patients with unresectable melanoma from baseline and during anti-PD-1 therapy, collecting fecal and blood samples that were surveyed for changes in the gut microbiota and immune markers. Varying patient responses were linked to different gut microbiota dynamics during ICI treatment. We select complete responders by their stable microbiota functions and validate them using multiple external cohorts and experimentally. We identify major histocompatibility complex class I (MHC class I)-restricted peptides derived from flagellin-related genes of Lachnospiraceae (FLach) as structural homologs of tumor-associated antigens, detect FLach-reactive CD8+ T cells in complete responders before ICI therapy, and demonstrate that FLach peptides improve antitumor immunity. These findings highlight the prognostic value of microbial functions and therapeutic potential of tumor-mimicking microbial peptides.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"62 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive analysis of Mycobacterium tuberculosis genomes reveals genetic variations in bacterial virulence 结核分枝杆菌基因组综合分析揭示了细菌毒力的遗传变异

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-10-28 DOI: 10.1016/j.chom.2024.10.004

Wittawin Worakitchanon, Hideki Yanai, Pundharika Piboonsiri, Reiko Miyahara, Supalert Nedsuwan, Worarat Imsanguan, Boonchai Chaiyasirinroje, Waritta Sawaengdee, Sukanya Wattanapokayakit, Nuanjan Wichukchinda, Yosuke Omae, Prasit Palittapongarnpim, Katsushi Tokunaga, Surakameth Mahasirimongkol, Akihiro Fujimoto

{"title":"Comprehensive analysis of Mycobacterium tuberculosis genomes reveals genetic variations in bacterial virulence","authors":"Wittawin Worakitchanon, Hideki Yanai, Pundharika Piboonsiri, Reiko Miyahara, Supalert Nedsuwan, Worarat Imsanguan, Boonchai Chaiyasirinroje, Waritta Sawaengdee, Sukanya Wattanapokayakit, Nuanjan Wichukchinda, Yosuke Omae, Prasit Palittapongarnpim, Katsushi Tokunaga, Surakameth Mahasirimongkol, Akihiro Fujimoto","doi":"10.1016/j.chom.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.chom.2024.10.004","url":null,"abstract":"Tuberculosis, a disease caused by Mycobacterium tuberculosis (Mtb), is a significant health problem worldwide. Here, we developed a method to detect large insertions and deletions (indels), which have been generally understudied. Leveraging this framework, we performed a comprehensive analysis of single nucleotide variants and small and large indels across 1,960 Mtb clinical isolates. Comparing the distribution of variants demonstrated that gene disruptive variants are underrepresented in genes essential for bacterial survival. An evolutionary analysis revealed that Mtb genomes are enriched in partially deleterious mutations. Genome-wide association studies identified small and large deletions in eccB2 significantly associated with patient prognosis. Additionally, we unveil significant associations with antibiotic resistance in 23 non-canonical genes. Among these, large indels are primarily found in genetic regions of Rv1216c, Rv1217c, fadD11, and ctpD. This study provides a comprehensive catalog of genetic variations and highlights their potential impact for the future treatment and risk prediction of tuberculosis.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"35 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme 元转录组学指导下的多酚代谢肠道微生物酶的发现与表征

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-10-28 DOI: 10.1016/j.chom.2024.10.002

Minwoo Bae, Chi Le, Raaj S. Mehta, Xueyang Dong, Lindsey M. Pieper, Lorenzo Ramirez, Margaret Alexander, Sina Kiamehr, Peter J. Turnbaugh, Curtis Huttenhower, Andrew T. Chan, Emily P. Balskus

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Exclusive enteral nutrition initiates individual protective microbiome changes to induce remission in pediatric Crohn’s disease 纯肠内营养启动个体保护性微生物组变化，诱导小儿克罗恩病病情缓解

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-10-25 DOI: 10.1016/j.chom.2024.10.001

Deborah Häcker, Kolja Siebert, Byron J. Smith, Nikolai Köhler, Alessandra Riva, Aritra Mahapatra, Helena Heimes, Jiatong Nie, Amira Metwaly, Hannes Hölz, Quirin Manz, Federica De Zen, Jeannine Heetmeyer, Katharina Socas, Giang Le Thi, Chen Meng, Karin Kleigrewe, Josch K. Pauling, Klaus Neuhaus, Markus List, Dirk Haller

{"title":"Exclusive enteral nutrition initiates individual protective microbiome changes to induce remission in pediatric Crohn’s disease","authors":"Deborah Häcker, Kolja Siebert, Byron J. Smith, Nikolai Köhler, Alessandra Riva, Aritra Mahapatra, Helena Heimes, Jiatong Nie, Amira Metwaly, Hannes Hölz, Quirin Manz, Federica De Zen, Jeannine Heetmeyer, Katharina Socas, Giang Le Thi, Chen Meng, Karin Kleigrewe, Josch K. Pauling, Klaus Neuhaus, Markus List, Dirk Haller","doi":"10.1016/j.chom.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.chom.2024.10.001","url":null,"abstract":"Exclusive enteral nutrition (EEN) is a first-line therapy for pediatric Crohn’s disease (CD), but protective mechanisms remain unknown. We established a prospective pediatric cohort to characterize the function of fecal microbiota and metabolite changes of treatment-naive CD patients in response to EEN (German Clinical Trials DRKS00013306). Integrated multi-omics analysis identified network clusters from individually variable microbiome profiles, with Lachnospiraceae and medium-chain fatty acids as protective features. Bioorthogonal non-canonical amino acid tagging selectively identified bacterial species in response to medium-chain fatty acids. Metagenomic analysis identified high strain-level dynamics in response to EEN. Functional changes in diet-exposed fecal microbiota were further validated using gut chemostat cultures and microbiota transfer into germ-free Il10-deficient mice. Dietary model conditions induced individual patient-specific strain signatures to prevent or cause inflammatory bowel disease (IBD)-like inflammation in gnotobiotic mice. Hence, we provide evidence that EEN therapy operates through explicit functional changes of temporally and individually variable microbiome profiles.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"97 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0