Cell host & microbe最新文献_第9页

A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights 人类口腔微生物组的高质量基因组目录拓宽了其系统发育和临床见解

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-10-29 DOI: 10.1016/j.chom.2025.10.001

Jun Hyung Cha, Nayeon Kim, Junyeong Ma, Sungho Lee, Geon Koh, Sunmo Yang, Samuel Beck, Iksu Byeon, Byungwook Lee, Insuk Lee

引用次数: 0

Soil organic carbon mediates plant immunity-rhizosphere microbiome interactions and controls colonization resistance to microbial inoculants 土壤有机碳介导植物免疫-根际微生物组相互作用并控制对微生物接种剂的定植抗性

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-10-29 DOI: 10.1016/j.chom.2025.10.002

Yuxiao Huang, Shengyue Tang, Rumeng Liu, Pugang Yu, Ju Liu, Ting Xiao, Yong Zhang, Mingsheng Fan, Fusuo Zhang, Bin Ni

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Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation 肠道REG3凝集素通过减少粘膜相关微生物群和防止细菌易位来预防酒精性脂肪性肝炎

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-10-17 DOI: 10.1016/j.chom.2025.10.011

Lirui Wang, Derrick E. Fouts, Peter Stärkel, Phillipp Hartmann, Peng Chen, Cristina Llorente, Jessica DePew, Kelvin Moncera, Samuel B. Ho, David A. Brenner, Lora V. Hooper, Bernd Schnabl

引用次数: 0

Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline n2特异性种系对H5N1流感神经氨酸酶抗体交叉反应性的进化

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-10-17 DOI: 10.1016/j.chom.2025.09.015

Huibin Lv, Yang Wei Huan, Qi Wen Teo, Chunke Chen, Tossapol Pholcharee, Akshita B. Gopal, Madison R. Ardagh, Jessica J. Huang, Ruipeng Lei, Xin Chen, Yuanxin Sun, Yun Sang Tang, Arjun Mehta, Mateusz Szlembarski, Kevin J. Mao, Emily X. Ma, Lucas E. Wittenborn, Meixuan Tong, Lucia A. Rodriguez, Letianchu Wang, Nicholas C. Wu

{"title":"Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline","authors":"Huibin Lv, Yang Wei Huan, Qi Wen Teo, Chunke Chen, Tossapol Pholcharee, Akshita B. Gopal, Madison R. Ardagh, Jessica J. Huang, Ruipeng Lei, Xin Chen, Yuanxin Sun, Yun Sang Tang, Arjun Mehta, Mateusz Szlembarski, Kevin J. Mao, Emily X. Ma, Lucas E. Wittenborn, Meixuan Tong, Lucia A. Rodriguez, Letianchu Wang, Nicholas C. Wu","doi":"10.1016/j.chom.2025.09.015","DOIUrl":"https://doi.org/10.1016/j.chom.2025.09.015","url":null,"abstract":"The ongoing spread of highly pathogenic avian influenza H5N1 clade 2.3.4.4b virus in animals and its occasional spillover to humans have raised concerns about a potential H5N1 pandemic. Although recent studies have shown that pre-existing human antibodies can recognize H5N1 neuraminidase, the molecular basis of how this cross-reactivity develops remains poorly understood. In this study, we used a phage display antibody library derived from 245 healthy donors to isolate an antibody, HB420, that cross-reacts with neuraminidases of human H3N2 and avian H5N1 clade 2.3.4.4b viruses and confers protection in vivo. Cryogenic electron microscopy analysis reveals that HB420 targets the neuraminidase active site by mimicking sialic acid binding through a single Asp residue. Furthermore, the inferred germline of HB420 is N2 specific but acquires cross-reactivity to H5N1 neuraminidase through somatic hypermutation. Overall, our findings provide insights into how neuraminidase antibody evolves breadth, which has important implications for the development of broadly protective influenza vaccines.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"1 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A conserved adaptor orchestrates co-secretion of synergistic type VI effectors in gut Bacteroidota 在肠道拟杆菌群中，一个保守的接头协调协同VI型效应物的共同分泌

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-10-09 DOI: 10.1016/j.chom.2025.09.012

Weixun Li, Shuaining Zheng, Xiaoning Xu, Jing He, Xuyao Jiao, Mingyu Wang, Wei Hu, Shengying Li, Xianzhi Jiang, Bentley Lim, Feng Shao, Xiang Gao

{"title":"A conserved adaptor orchestrates co-secretion of synergistic type VI effectors in gut Bacteroidota","authors":"Weixun Li, Shuaining Zheng, Xiaoning Xu, Jing He, Xuyao Jiao, Mingyu Wang, Wei Hu, Shengying Li, Xianzhi Jiang, Bentley Lim, Feng Shao, Xiang Gao","doi":"10.1016/j.chom.2025.09.012","DOIUrl":"https://doi.org/10.1016/j.chom.2025.09.012","url":null,"abstract":"Interbacterial competition is crucial for shaping microbial communities and is often mediated by type VI secretion systems (T6SSs) that inject effectors into competing bacteria. T6SS effectors are released via structural proteins such as VgrG, but the secretion timing and coordination are unclear. Here, we report two effectors, BtpeA (Bacteroides T6SS phosphatase effector A) and BtaeB (Bacteroides T6SS amidase effector B), within the Bacteroidota T6SS that exert distinct cell-wall destructive activities critical for interspecies competition but whose secretion is interdependent. BtpeA and BtaeB co-secretion requires an adaptor protein, BtapC (Bacteroides T6SS adaptor protein C), that mediates the sequential assembly of the pre-firing complex, VgrG-BtpeA-BtaeB-BtapC. Structural analyses of this quaternary complex elucidate multi-cargo loading mechanisms with a conserved loop in BtaeB serving as a “checkpoint” to ensure BtpeA co-secretion. During mouse colonization, the combined activities of BtpeA and BtaeB significantly exceed the sum of the individual effectors. These findings unveil a T6SS-mediated co-delivery mechanism that ensures functional synergism of effectors, highlighting potential applications in modulating gut microbiota.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"26 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inter-kingdom lipid messengers sustain gut harmony 王国间脂质信使维持肠道和谐

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-10-08 DOI: 10.1016/j.chom.2025.09.003

Jinglin Hou, Xinyang Song

引用次数: 0

Deep learning helps fight against antibiotic resistance 深度学习有助于对抗抗生素耐药性

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-10-08 DOI: 10.1016/j.chom.2025.09.005

Antonio Lavecchia

引用次数: 0

Metabolic tug-of-war: Mitochondria starve Toxoplasma of folate 代谢拉锯战：线粒体使弓形虫缺乏叶酸