细胞内寄生原生生物的营养获取

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-06-11 DOI:10.1016/j.chom.2025.05.016

Giel G. van Dooren, Malcolm J. McConville

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引用次数: 0

摘要

属于顶复合体和锥虫科的寄生原生生物是人类重要疾病和终身慢性感染的原因。这些寄生虫中的一些在哺乳动物宿主的细胞内生态位内复制，包括专门的液泡，以及内溶酶体腔室或感染细胞的细胞质。这些寄生虫高度依赖于养分回收途径，以满足其复杂的营养需求，并维持不同的生长和代谢状态。在这篇综述中，我们概述了不同的细胞内寄生虫从宿主那里获取营养的常见策略和物种特异性策略，强调了这些寄生虫使用的不同生长策略与养分回收之间的联系。

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Nutrient acquisition by intracellular parasitic protists

Parasitic protists belonging to the Apicomplexa and Trypanosomatidae are the cause of important diseases and life-long chronic infections in humans. Several of these parasites replicate within intracellular niches in their mammalian host, including specialized vacuoles, as well as endo-lysosomal compartments or the cytosol of infected cells. These parasites are highly dependent on nutrient salvage pathways in order to satisfy their complex nutrient requirements as well as to maintain different growth and metabolic states. In this review, we provide an overview of common as well as species-specific strategies used by different intracellular parasites to acquire nutrients from their host, emphasizing the link between nutrient salvage and different growth strategies used by these parasites.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.