发布求助
文献互助 智能选刊 最新文献

Cell host & microbe最新文献

筛选
英文 中文
RSV and rhinovirus increase pneumococcal carriage acquisition and density, whereas nasal inflammation is associated with bacterial shedding RSV 和鼻病毒会增加肺炎球菌的携带量和密度，而鼻腔炎症则与细菌脱落有关
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-08-23 DOI: 10.1016/j.chom.2024.07.024
Elena Mitsi, Elissavet Nikolaou, Andre Goncalves, Annie Blizard, Helen Hill, Madlen Farrar, Angela Hyder-Wright, Oluwasefunmi Akeju, Josh Hamilton, Ashleigh Howard, Filora Elterish, Carla Solorzano, Ryan Robinson, Jesus Reiné, Andrea M. Collins, Stephen B. Gordon, Richard E. Moxon, Jeffrey N. Weiser, Debby Bogaert, Daniela M. Ferreira
{"title":"RSV and rhinovirus increase pneumococcal carriage acquisition and density, whereas nasal inflammation is associated with bacterial shedding","authors":"Elena Mitsi, Elissavet Nikolaou, Andre Goncalves, Annie Blizard, Helen Hill, Madlen Farrar, Angela Hyder-Wright, Oluwasefunmi Akeju, Josh Hamilton, Ashleigh Howard, Filora Elterish, Carla Solorzano, Ryan Robinson, Jesus Reiné, Andrea M. Collins, Stephen B. Gordon, Richard E. Moxon, Jeffrey N. Weiser, Debby Bogaert, Daniela M. Ferreira","doi":"10.1016/j.chom.2024.07.024","DOIUrl":"https://doi.org/10.1016/j.chom.2024.07.024","url":null,"abstract":"<p>Epidemiological studies report the impact of co-infection with pneumococcus and respiratory viruses upon disease rates and outcomes, but their effect on pneumococcal carriage acquisition and bacterial load is scarcely described. Here, we assess this by combining natural viral infection with controlled human pneumococcal infection in 581 healthy adults screened for upper respiratory tract viral infection before intranasal pneumococcal challenge. Across all adults, respiratory syncytial virus (RSV) and rhinovirus asymptomatic infection confer a substantial increase in secondary infection with pneumococcus. RSV also has a major impact on pneumococcal density up to 9 days post challenge. We also study rates and kinetics of bacterial shedding through the nose and oral route in a subset. High levels of pneumococcal colonization density and nasal inflammation are strongly correlated with increased odds of nasal shedding as opposed to cough shedding. Protection against respiratory viral infections and control of pneumococcal density may contribute to preventing pneumococcal disease and reducing bacterial spread.</p>","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"15 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142043070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salmonella re-engineers the intestinal environment to break colonization resistance in the presence of a compositionally intact microbiota 沙门氏菌重新设计肠道环境，在微生物群组成完整的情况下打破定植阻力
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-08-23 DOI: 10.1016/j.chom.2024.07.025
Andrew W.L. Rogers, Lauren C. Radlinski, Henry Nguyen, Connor R. Tiffany, Thaynara Parente Carvalho, Hugo L.P. Masson, Michael L. Goodson, Lalita Bechtold, Kohei Yamazaki, Megan J. Liou, Brittany M. Miller, Scott P. Mahan, Briana M. Young, Aurore M. Demars, Sophie R. Gretler, Anaïs B. Larabi, Jee-Yon Lee, Derek J. Bays, Renee M. Tsolis, Andreas J. Bäumler
{"title":"Salmonella re-engineers the intestinal environment to break colonization resistance in the presence of a compositionally intact microbiota","authors":"Andrew W.L. Rogers, Lauren C. Radlinski, Henry Nguyen, Connor R. Tiffany, Thaynara Parente Carvalho, Hugo L.P. Masson, Michael L. Goodson, Lalita Bechtold, Kohei Yamazaki, Megan J. Liou, Brittany M. Miller, Scott P. Mahan, Briana M. Young, Aurore M. Demars, Sophie R. Gretler, Anaïs B. Larabi, Jee-Yon Lee, Derek J. Bays, Renee M. Tsolis, Andreas J. Bäumler","doi":"10.1016/j.chom.2024.07.025","DOIUrl":"https://doi.org/10.1016/j.chom.2024.07.025","url":null,"abstract":"<p>The gut microbiota prevents harmful microbes from entering the body, a function known as colonization resistance. The enteric pathogen <em>Salmonella enterica</em> serovar (<em>S</em>.) Typhimurium uses its virulence factors to break colonization resistance through unknown mechanisms. Using metabolite profiling and genetic analysis, we show that the initial rise in luminal pathogen abundance was powered by a combination of aerobic respiration and mixed acid fermentation of simple sugars, such as glucose, which resulted in their depletion from the metabolome. The initial rise in the abundance of the pathogen in the feces coincided with a reduction in the cecal concentrations of acetate and butyrate and an increase in epithelial oxygenation. Notably, these changes in the host environment preceded changes in the microbiota composition. We conclude that changes in the host environment can weaken colonization resistance even in the absence of overt compositional changes in the gut microbiota.</p>","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"4 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142043071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating beyond associations: Opportunities to establish causal relationships between the gut microbiome and colorectal carcinogenesis 超越关联：在肠道微生物组和结直肠癌发生之间建立因果关系的机会
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-08-14 DOI: 10.1016/j.chom.2024.07.008
{"title":"Navigating beyond associations: Opportunities to establish causal relationships between the gut microbiome and colorectal carcinogenesis","authors":"","doi":"10.1016/j.chom.2024.07.008","DOIUrl":"https://doi.org/10.1016/j.chom.2024.07.008","url":null,"abstract":"<p>The gut microbiota has been recognized as an important determinant in the initiation and progression of colorectal cancer (CRC), with recent studies shining light on the molecular mechanisms that may contribute to the interactions between microbes and the CRC microenvironment. Despite the increasing wealth of associations being established in the field, proving causality remains challenging. Obstacles include the high variability of the microbiome and its context, both across individuals and across time. Additionally, there is a lack of large and representative cohort studies with long-term follow-up and/or appropriate sampling methods for studying the mucosal microbiome. Finally, most studies focus on CRC, whereas interactions between host and bacteria in early events in carcinogenesis remain elusive, reinforced by the heterogeneity of CRC development. Here, we discuss these current most prominent obstacles, the recent developments, and research needs.</p>","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"19 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the mind-gut connection: Impact of human microbiome on cognition 解开心灵与肠道的联系：人类微生物群对认知的影响
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-08-14 DOI: 10.1016/j.chom.2024.07.019
{"title":"Unlocking the mind-gut connection: Impact of human microbiome on cognition","authors":"","doi":"10.1016/j.chom.2024.07.019","DOIUrl":"https://doi.org/10.1016/j.chom.2024.07.019","url":null,"abstract":"<p>This perspective explores the current understanding of the gut microbiota’s impact on cognitive function in apparently healthy humans and in individuals with metabolic disease. We discuss how alterations in gut microbiota can influence cognitive processes, focusing not only on bacterial composition but also on often overlooked components of the gut microbiota, such as bacteriophages and eukaryotes, as well as microbial functionality. We examine the mechanisms through which gut microbes might communicate with the central nervous system, highlighting the complexity of these interactions. We provide a comprehensive overview of the emerging field of microbiota-gut-brain interactions and its significance for cognitive health. Additionally, we summarize novel therapeutic strategies designed to promote cognitive resilience and reduce the risk of cognitive disorders, focusing on interventions that target the gut microbiota. An in-depth understanding of the microbiome-brain axis is imperative for developing innovative treatments aimed at improving cognitive health.</p>","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"9 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome 剖腹产期间母体使用抗生素预防对婴儿肠道微生物组的影响有限
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-08-14 DOI: 10.1016/j.chom.2024.07.010
{"title":"Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome","authors":"","doi":"10.1016/j.chom.2024.07.010","DOIUrl":"https://doi.org/10.1016/j.chom.2024.07.010","url":null,"abstract":"<p>Pregnant women undergoing a cesarean section (CS) typically receive antibiotics prior to skin incision to prevent infections. To investigate if the timing of antibiotics influences the infant gut microbiome, we conducted a randomized controlled trial (NCT06030713) in women delivering via a scheduled CS who received antibiotics either before skin incision or after umbilical cord clamping. We performed a longitudinal analysis on 172 samples from 28 infants at 8 post-birth time points and a cross-sectional analysis at 1 month in 79 infants from 3 cohorts. Although no significant associations with bacterial composition, metabolic pathways, short-chain fatty acids, and bile acids were found, we observed subtle differences between the groups at the bacterial strain level and in the load of antibiotic resistance genes. Rather, feeding mode was a predominant and defining factor impacting infant microbial composition. In conclusion, antibiotic administration during CS has only limited effects on the early-life gut microbiome.</p>","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"2 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lost in translation: Cesarean antibiotics and the infant microbiome 翻译中的迷失：剖腹产抗生素与婴儿微生物组
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-08-14 DOI: 10.1016/j.chom.2024.07.018
{"title":"Lost in translation: Cesarean antibiotics and the infant microbiome","authors":"","doi":"10.1016/j.chom.2024.07.018","DOIUrl":"https://doi.org/10.1016/j.chom.2024.07.018","url":null,"abstract":"<p>In this issue of <em>Cell Host &amp; Microbe</em>, Sinha et al. describe their randomized trial assessing whether antibiotics given for maternal benefit prior to Cesarean disrupted the infants’ microbiomes. Despite pre-incision antibiotics reaching the neonate, there was no meaningful alteration to the infant microbiome—especially when compared with breastmilk feeding.</p>","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"21 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteroides acidifaciens drives a liver detox program 酸性乳杆菌推动肝脏排毒计划
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-08-14 DOI: 10.1016/j.chom.2024.07.011
{"title":"Bacteroides acidifaciens drives a liver detox program","authors":"","doi":"10.1016/j.chom.2024.07.011","DOIUrl":"https://doi.org/10.1016/j.chom.2024.07.011","url":null,"abstract":"<p>Alcohol-associated liver disease is a leading cause of chronic liver conditions, yet there are limited effective therapies. In this issue of <em>Cell Host &amp; Microbe</em>, Shen et al. demonstrate that soluble dietary fiber enhances intestinal <em>Bacteroides acidifaciens,</em> which ameliorates alcohol-associated liver injury in mice by activating hepatic ornithine aminotransferase.</p>","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"35 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141980992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial metabolome in septic shock: Bridging bench to bedside 脓毒性休克中的微生物代谢组：从工作台到床边的桥梁
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-08-14 DOI: 10.1016/j.chom.2024.07.009
{"title":"Microbial metabolome in septic shock: Bridging bench to bedside","authors":"","doi":"10.1016/j.chom.2024.07.009","DOIUrl":"https://doi.org/10.1016/j.chom.2024.07.009","url":null,"abstract":"Due to its enormous incidence and mortality, sepsis is a huge health priority. In the latest issue of Cell, an innovative approach is provided that ad…","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"11 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141980999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The central role of the gut microbiota in the pathophysiology and management of type 2 diabetes 肠道微生物群在 2 型糖尿病的病理生理学和治疗中的核心作用
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-08-14 DOI: 10.1016/j.chom.2024.07.017
{"title":"The central role of the gut microbiota in the pathophysiology and management of type 2 diabetes","authors":"","doi":"10.1016/j.chom.2024.07.017","DOIUrl":"https://doi.org/10.1016/j.chom.2024.07.017","url":null,"abstract":"<p>The inhabitants of our intestines, collectively called the gut microbiome, comprise fungi, viruses, and bacterial strains. These microorganisms are involved in the fermentation of dietary compounds and the regulation of our adaptive and innate immune systems. Less known is the reciprocal interaction between the gut microbiota and type 2 diabetes mellitus (T2DM), as well as their role in modifying therapies to reduce associated morbidity and mortality. In this review, we aim to discuss the existing literature on gut microbial strains and their diet-derived metabolites involved in T2DM. We also explore the potential diagnostics and therapeutic avenues the gut microbiota presents for targeted T2DM management. Personalized treatment plans, driven by diet and medication based on the patient’s microbiome and clinical markers, could optimize therapy.</p>","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"6 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commensal microbe regulation of skin cells in disease 疾病中皮肤细胞的共生微生物调控
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-08-14 DOI: 10.1016/j.chom.2024.07.020
{"title":"Commensal microbe regulation of skin cells in disease","authors":"","doi":"10.1016/j.chom.2024.07.020","DOIUrl":"https://doi.org/10.1016/j.chom.2024.07.020","url":null,"abstract":"<p>Human skin is the host to various commensal microbes that constitute a substantial microbial community. The reciprocal communication between these microbial inhabitants and host cells upholds both the morphological and functional attributes of the skin layers, contributing indispensably to microenvironmental and tissue homeostasis. Thus, disruption of the skin barrier or imbalances in the microbial communities can exert profound effects on the behavior of host cells. This influence, mediated by the microbes themselves or their metabolites, manifests in diverse outcomes. In this review, we examine existing knowledge to provide insight into the nuanced behavior exhibited by the microbiota on skin cells in health and disease states. These interactions provide insight into potential cellular targets for future microbiota-based therapies to prevent and treat skin disease.</p>","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"141 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141980998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信