Cell host & microbe最新文献_第8页

Intratumoral bacterium Enterocloster bolteae promotes hepatocellular carcinoma progression by directly binding tumor cells 瘤内细菌肠闭杆菌通过直接结合肿瘤细胞促进肝细胞癌的进展

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-02-24 DOI: 10.1016/j.chom.2026.01.020

Xuxin Ren, Gaomin Zheng, Yuyao Liu, Shangru Li, Shimao Liu, Yixi Wen, Ying Zhang, Yutong Zhao, Huayu Guan, Xinning Wang, Yuting Yang, Qiaoyi Chen, Youmei Kang, Yihang Xu, Liting Peng, Sui Peng, Lixia Xu, Jianting Long, Xuezhen Zeng, Shixian Hu, Ming Kuang

{"title":"Intratumoral bacterium Enterocloster bolteae promotes hepatocellular carcinoma progression by directly binding tumor cells","authors":"Xuxin Ren, Gaomin Zheng, Yuyao Liu, Shangru Li, Shimao Liu, Yixi Wen, Ying Zhang, Yutong Zhao, Huayu Guan, Xinning Wang, Yuting Yang, Qiaoyi Chen, Youmei Kang, Yihang Xu, Liting Peng, Sui Peng, Lixia Xu, Jianting Long, Xuezhen Zeng, Shixian Hu, Ming Kuang","doi":"10.1016/j.chom.2026.01.020","DOIUrl":"https://doi.org/10.1016/j.chom.2026.01.020","url":null,"abstract":"The gut microbiota regulates systemic metabolism, inflammation, and immunity, with evidence linking microbiota translocation through the gut-liver axis to hepatocellular carcinoma (HCC) progression. However, the specific bacteria and underlying mechanisms driving tumor progression remain unexplored. We identify that E. bolteae is enriched in the feces of HCC patients and is associated with poor prognosis. E. bolteae disrupts intestinal barrier integrity, translocates to the liver, and promotes tumor proliferation. Mechanistically, we show that E. bolteae’s surface protein, penicillin-binding transpeptidase domain-containing protein (PbpT), directly interacts with the tumor cell receptor desmoglein 1 (DSG1), facilitating bacterial adhesion and attenuating DSG1’s tumor-suppressive function. Additionally, this interaction activates the mitogen-activated protein kinase (MAPK) signaling pathway to accelerate HCC progression. Blockade of PbpT abrogates E. bolteae attachment and its role in promoting HCC progression. These findings identify the PbpT-DSG1-MAPK axis as a critical driver of HCC progression. Targeting PbpT may be a promising therapeutic strategy for HCC.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"13 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147279378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commensal enteric virome regulates intestinal carbohydrate digestion and absorption 共生肠道病毒调节肠道碳水化合物的消化和吸收

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-02-23 DOI: 10.1016/j.chom.2026.01.019

Fengqing Lin, Lianglan Li, Yuanpeng He, Shujie Xu, Qiufen Mo, Wangsen Cao, Aikun Fu, Weiqin Li

{"title":"Commensal enteric virome regulates intestinal carbohydrate digestion and absorption","authors":"Fengqing Lin, Lianglan Li, Yuanpeng He, Shujie Xu, Qiufen Mo, Wangsen Cao, Aikun Fu, Weiqin Li","doi":"10.1016/j.chom.2026.01.019","DOIUrl":"https://doi.org/10.1016/j.chom.2026.01.019","url":null,"abstract":"The enteric microbiome and nutrient sensing within the small intestine play critical roles in maintaining host metabolic homeostasis. Although various bacteria and some fungi have established functions in nutrient metabolism, the role of the enteric virome remains poorly understood. Here, we demonstrate that the enteric virome significantly influences carbohydrate digestion and absorption independently of the bacteriome. Furthermore, the virome elicits distinct responses across different intestinal cell types. Specifically, it activates programs for carbohydrate digestion and absorption in intestinal epithelial cells while simultaneously stimulating antigen-presenting cells―Th17 cells―to produce interleukin-22, a cytokine that curbs excessive carbohydrate uptake. The virome’s effect on carbohydrate digestion and absorption—whether suppressive or stimulatory—depends on the presence or absence of immune surveillance. This intricate interplay between metabolic and immune pathways establishes the enteric virome as a pivotal regulator of metabolism and reveals the virome’s intrinsic capacity to autonomously modulate vertebrate intestinal physiology.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"97 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147279377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An image-based transcriptomics atlas reveals the regional and microbiota-dependent molecular, cellular, and spatial structure of the murine gut 基于图像的转录组图谱揭示了小鼠肠道的区域和微生物依赖的分子，细胞和空间结构

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-02-19 DOI: 10.1016/j.chom.2026.01.018

Rosalind J. Xu, Hao Zhang, Paolo Cadinu, Phillip B. Nicol, Uli S. Herrmann, Tyrone Lee, Ludwig Geistlinger, Rafael A. Irizarry, Jeffrey R. Moffitt

{"title":"An image-based transcriptomics atlas reveals the regional and microbiota-dependent molecular, cellular, and spatial structure of the murine gut","authors":"Rosalind J. Xu, Hao Zhang, Paolo Cadinu, Phillip B. Nicol, Uli S. Herrmann, Tyrone Lee, Ludwig Geistlinger, Rafael A. Irizarry, Jeffrey R. Moffitt","doi":"10.1016/j.chom.2026.01.018","DOIUrl":"https://doi.org/10.1016/j.chom.2026.01.018","url":null,"abstract":"The gastrointestinal environment is home to a massive diversity of diet-, host-, and microbiota-derived small molecules, collectively sensed by a remarkable variety of cells. To explore the cellular and spatial organization of sensation, we use MERFISH to profile receptor expression across 2.1 million cells in multiple regions of the murine gut under specific-pathogen-free (SPF) and germ-free (GF) conditions. This atlas reveals expected and previously unidentified cell types—including a candidate murine homolog of human BEST4⁺ enterocytes—demonstrates cell-type regional specialization, discovers extensive location-dependent spatial fine-tuning in mucosal cell expression, and suggests cell-type-specific mediators of the effects of microbiota-derived small molecules. Additionally, this atlas reveals that, aside from immune cell abundance, many aspects of the murine gut are host-intrinsic and modified only modestly in the absence of a microbiota. Collectively, this atlas provides a valuable resource for understanding the cellular and spatial organization underlying small-molecule sensation in the gut.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"37 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146223317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A modular alliance: Probiotics and macrophages converge on glioblastoma 一个模块化的联盟：益生菌和巨噬细胞聚集在胶质母细胞瘤

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-02-11 DOI: 10.1016/j.chom.2026.01.005

Jiarui Zhao, Jian Chen

引用次数: 0

How a coral holobiont stays in sync in nature 珊瑚全息生物是如何在自然界中保持同步的

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-02-11 DOI: 10.1016/j.chom.2026.01.010

Cheong Xin Chan

引用次数: 0

Microbial communities in semi-mature oak trees are resilient to drought, nutrient limitation, and pathogen challenge 半成熟橡树的微生物群落对干旱、营养限制和病原体的挑战具有弹性

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-02-11 DOI: 10.1016/j.chom.2026.01.009

Usman Hussain, Marine C. Cambon, Bridget Crampton, Sunitha Subramaniam, Anparasy Kajamuhan, Alejandra Ordoñez, Jim Downie, Jasen Finch, Manfred Beckmann, Nathan Brown, Amy Elison, Carrie Brady, Elena Vanguelova, Sandra Denman, James E. McDonald

引用次数: 0

Outsmarting the wicked smart: Using chemistry to overcome bacterial anti-viral systems 智胜邪恶的聪明人：利用化学物质来克服细菌的抗病毒系统

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-02-11 DOI: 10.1016/j.chom.2026.01.015

Antonio Tinoco

引用次数: 0

Seeing the forest: Microbiome resilience in mature trees 观赏森林：成熟树木的微生物群弹性

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-02-11 DOI: 10.1016/j.chom.2026.01.014

Zahavah Rojer, Tory A. Hendry

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Protist predators engineer bacterial metabolic cooperation 原生捕食者设计细菌的代谢合作

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-02-11 DOI: 10.1016/j.chom.2026.01.011

Lu Ma, Longfei Shu

引用次数: 0

Gut DNA virome enterotype dictates inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn's disease 肠道DNA病毒组肠型通过调节克罗恩病中噬菌体-细菌-鞘氨醇-肠轴来指示炎症异质性

IF 30.3 1区医学

Cell host & microbe Pub Date : 2026-02-09 DOI: 10.1016/j.chom.2026.01.016

Weijie Wen, Runping Su, Yunyun Liu, Zhiyang Feng, Yancai Li, Jieli Li, Ziyu Huang, Fen Zhang, Shanshan Gao, Yingfei Ma, Qinghua Zhou, Emad M. El-Omar, Jeremy J. Barr, Tao Zuo

{"title":"Gut DNA virome enterotype dictates inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn's disease","authors":"Weijie Wen, Runping Su, Yunyun Liu, Zhiyang Feng, Yancai Li, Jieli Li, Ziyu Huang, Fen Zhang, Shanshan Gao, Yingfei Ma, Qinghua Zhou, Emad M. El-Omar, Jeremy J. Barr, Tao Zuo","doi":"10.1016/j.chom.2026.01.016","DOIUrl":"https://doi.org/10.1016/j.chom.2026.01.016","url":null,"abstract":"The human gut harbors a diverse virome, believed to play a crucial role in maintaining intestinal homeostasis. However, the magnitude of heterogeneity of the gut mucosal virome, and how it differentially regulates host inflammation phenotypes, such as those observed in Crohn’s disease (CD), remains unclear. Here, we identify two mucosal DNA virome enterotypes (E1 and E2) in humans, with E2 subjects exhibiting higher virome diversity and nuanced bacteriophage-bacteria correlations. Moreover, E2-enterotyped CD patients exhibited higher <ce:italic>Wulfhauvirus</ce:italic> abundance than healthy controls. The E2 virome is causally more proinflammatory in inducing intestinal inflammation in mice. Mechanistically, the novel E2-virome-enriched phage øBTZT001P (belonging to <ce:italic>Wulfhauvirus</ce:italic>) lysogenically infects <ce:italic>Bacteroides thetaiotaomicron</ce:italic>, increasing sphingosine production. Downstream, sphingosine suppresses the commensal bacterium <ce:italic>Blautia obeum</ce:italic> in the gut, leading to worsened intestinal inflammation. Our findings reveal that configurational differences in the gut virome may dictate disease outcome through a phage-bacteria-metabolite-intestine axis, highlighting the importance of gut phage-bacteria crosstalk in health.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"16 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0