Uniting against enteric invaders: IgA meets its microbial ally

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-06-11 DOI:10.1016/j.chom.2025.05.009

Sophia Adlkirchner, Romana R. Gerner

引用次数: 0

Abstract

Gut colonization by opportunistic or pathogenic microbes is a critical step in infection, but strategies to displace these organisms without perturbing the commensal microbiota remain scarce. In a recent Science article, Lentsch et al. combine oral vaccination with a niche-competing strain to selectively eliminate Salmonella spp. and related Escherichia coli.

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联合起来对抗肠道入侵者：IgA遇到了它的微生物盟友

机会性或致病性微生物的肠道定植是感染的关键步骤，但在不干扰共生微生物群的情况下取代这些微生物的策略仍然很少。在最近的一篇科学文章中，Lentsch等人将口服疫苗接种与一种利基竞争菌株结合起来，选择性地消灭沙门氏菌和相关的大肠杆菌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.