Inter-kingdom lipid messengers sustain gut harmony

IF 18.7 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-10-08 DOI:10.1016/j.chom.2025.09.003

Jinglin Hou, Xinyang Song

引用次数: 0

Abstract

In this issue of Cell Host & Microbe, Czauderna et al. reveal that unsaturated long-chain fatty acids (uLCFAs) accumulate in the gut during immune activation, yet are toxic to commensals, notably Blautia producta. Symbiont-encoded oleate hydratase converts uLCFAs into non-toxic hydroxy FAs that suppress pro-inflammatory T cells, thereby regulating immunostasis.

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王国间脂质信使维持肠道和谐

在这一期的《细胞宿主与微生物》中，Czauderna等人揭示了不饱和长链脂肪酸（uLCFAs）在免疫激活过程中在肠道中积累，但对共生菌有毒，尤其是蓝藻产品。共生体编码的油酸水合酶将uLCFAs转化为无毒的羟基FAs，抑制促炎T细胞，从而调节免疫停滞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.