祸不单行：微生物代谢物与心力衰竭和慢性肾病有关

IF 18.7 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-10-08 DOI:10.1016/j.chom.2025.09.001

Jingyuan Fu, Nine V.A.M. Knoers

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引用次数: 0

摘要

心力衰竭是危及生命的，在慢性肾脏疾病患者中很常见。1 Zheng等人在本期报道了产毒大肠杆菌色氨酸代谢诱导心肌凋亡，增加心衰合并肾功能不全的风险。作者表明，益生菌产品在临床前和临床环境中降低了这种风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Misfortunes never come singly: Microbial metabolites link heart failure and chronic kidney disease

Heart failure is life threatening and common in chronic kidney disease patients. In this issue,¹ Zheng et al. report that toxin-generating E. coli tryptophan metabolism induces myocardial apoptosis, contributing to heart failure risk with kidney dysfunction. The authors show that a probiotic product reduces this risk in preclinical and clinical settings.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.