Cell host & microbe最新文献_第3页

Bacteria exploit viral dormancy to establish CRISPR-Cas immunity

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-02-25 DOI: 10.1016/j.chom.2025.02.001

Nicholas C. Keith, Rhett A. Snyder, Chad W. Euler, Joshua W. Modell

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Colonization island directs L. plantarum to its niche

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-02-12 DOI: 10.1016/j.chom.2025.01.005

Aryan Rahimi-Midani, Igor Iatsenko

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A brief history of human infections with H5Ny avian influenza viruses

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-02-12 DOI: 10.1016/j.chom.2025.01.010

Liang Wang, George F. Gao

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Cysteines shape antibody battles for HIV-1 Env

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-02-12 DOI: 10.1016/j.chom.2025.01.003

Mingxi Li, Dapeng Li

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Skin-deep immune sensing

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-02-12 DOI: 10.1016/j.chom.2025.01.007

Nonhlanhla Lunjani, Liam O’Mahony

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Symbionts of predatory protists are widespread in the oceans and related to animal pathogens

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-02-12 DOI: 10.1016/j.chom.2025.01.009

Fabian Wittmers, Camille Poirier, Charles Bachy, Charlotte Eckmann, Olga Matantseva, Craig A. Carlson, Stephen J. Giovannoni, Ursula Goodenough, Alexandra Z. Worden

{"title":"Symbionts of predatory protists are widespread in the oceans and related to animal pathogens","authors":"Fabian Wittmers, Camille Poirier, Charles Bachy, Charlotte Eckmann, Olga Matantseva, Craig A. Carlson, Stephen J. Giovannoni, Ursula Goodenough, Alexandra Z. Worden","doi":"10.1016/j.chom.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.chom.2025.01.009","url":null,"abstract":"Protists are major predators of ocean microbial life, with an ancient history of entanglements with prokaryotes, but their delicate cell structures and recalcitrance to culturing hinder exploration of marine symbioses. We report that tiny oceanic protistan predators, specifically choanoflagellates—the closest living unicellular relatives of animals—and uncultivated MAST-3 form symbioses with four bacterial lineages related to animal symbionts. By targeting living phagotrophs on ship expeditions, we recovered genomes from physically associated uncultivated Legionellales and Rickettsiales. The evolutionary trajectories of Marinicoxiellaceae, Cosmosymbacterales, Simplirickettsiaceae, and previously named Gamibacteraceae vary, including host-engagement mechanisms unknown in marine bacteria, horizontally transferred genes that mediate pathogen-microbiome interactions, and nutritional pathways. These symbionts and hosts occur throughout subtropical and tropical oceans. Related bacteria were detected in public data from freshwater, fish, and human samples. Symbiont associations with animal-related protists, alongside relationships to animal pathogens, suggest an unexpectedly long history of shifting associations and possibilities for host expansion as environments change.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"22 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerating mammalian filovirus research with receptor binding blueprints

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-02-12 DOI: 10.1016/j.chom.2025.01.006

Xinglou Yang, Sandra Chiu

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A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-02-12 DOI: 10.1016/j.chom.2025.01.002

Moamen M. Elmassry, Kohei Sugihara, Pranatchareeya Chankhamjon, Yeji Kim, Francine R. Camacho, Shuo Wang, Yuki Sugimoto, Seema Chatterjee, Lea Ann Chen, Nobuhiko Kamada, Mohamed S. Donia

{"title":"A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules","authors":"Moamen M. Elmassry, Kohei Sugihara, Pranatchareeya Chankhamjon, Yeji Kim, Francine R. Camacho, Shuo Wang, Yuki Sugimoto, Seema Chatterjee, Lea Ann Chen, Nobuhiko Kamada, Mohamed S. Donia","doi":"10.1016/j.chom.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.chom.2025.01.002","url":null,"abstract":"Gut microbiome changes have been associated with several human diseases, but the molecular and functional details underlying these associations remain largely unknown. Here, we performed a meta-analysis of small molecule biosynthetic gene clusters (BGCs) in metagenomic samples of the gut microbiome from inflammatory bowel disease (IBD) patients and matched healthy subjects and identified two Clostridia-derived BGCs that are significantly associated with Crohn’s disease (CD), a main IBD type. Using synthetic biology, we discovered and solved the structures of six fatty acid amides as the products of the CD-enriched BGCs, which we subsequently detected in fecal samples from IBD patients. Finally, we show that the discovered molecules disrupt gut permeability and exacerbate disease in chemically or genetically susceptible mouse models of colitis. These findings suggest that microbiome-derived small molecules may play a role in the etiology of IBD and represent a generalizable approach for discovering molecular mediators of disease-relevant microbiome-host interactions.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"129 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-02-04 DOI: 10.1016/j.chom.2025.01.008

Bentley Lim, Jinghua Xu, Igor H. Wierzbicki, Carlos G. Gonzalez, Zhe Chen, David J. Gonzalez, Xiang Gao, Andrew L. Goodman

{"title":"A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability","authors":"Bentley Lim, Jinghua Xu, Igor H. Wierzbicki, Carlos G. Gonzalez, Zhe Chen, David J. Gonzalez, Xiang Gao, Andrew L. Goodman","doi":"10.1016/j.chom.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.chom.2025.01.008","url":null,"abstract":"Antagonistic interactions play a key role in determining microbial community dynamics. Here, we report that one of the most widespread contact-dependent effectors in human gut microbiomes, Bte1, directly targets the PpiD-YfgM periplasmic chaperone complex in related microbes. Structural, biochemical, and genetic characterization of this interaction reveals that Bte1 reverses the activity of the chaperone complex, promoting substrate aggregation and toxicity. Using <em>Bacteroides</em>, we show that Bte1 is active in the mammalian gut, conferring a fitness advantage to expressing strains. Recipient cells targeted by Bte1 exhibit sensitivity to membrane-compromising conditions, and human gut microbes can use this effector to exploit pathogen-induced inflammation in the gut. Further, Bte1 allelic variation in gut metagenomes provides evidence for an arms race between Bte1-encoding and immunity-encoding strains in humans. Together, these studies demonstrate that human gut microbes alter the protein-folding capacity of neighboring cells and suggest strategies for manipulating community dynamics.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"39 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-02-04 DOI: 10.1016/j.chom.2025.01.004

Maria C. Hesselman, Marius Zeeb, Peter Rusert, Chloé Pasin, Jennifer Mamrosh, Samuel Kariuki, Ian Pichler, Michèle Sickmann, Masako M. Kaufmann, Daniel Schmidt, Nikolas Friedrich, Karin J. Metzner, Audrey Rindler, Herbert Kuster, Craig Adams, Ruwayhida Thebus, Michael Huber, Sabine Yerly, Karoline Leuzinger, Matthieu Perreau, Alexandra Trkola

{"title":"Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development","authors":"Maria C. Hesselman, Marius Zeeb, Peter Rusert, Chloé Pasin, Jennifer Mamrosh, Samuel Kariuki, Ian Pichler, Michèle Sickmann, Masako M. Kaufmann, Daniel Schmidt, Nikolas Friedrich, Karin J. Metzner, Audrey Rindler, Herbert Kuster, Craig Adams, Ruwayhida Thebus, Michael Huber, Sabine Yerly, Karoline Leuzinger, Matthieu Perreau, Alexandra Trkola","doi":"10.1016/j.chom.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.chom.2025.01.004","url":null,"abstract":"Identifying HIV-1 envelope (Env) traits associated with neutralization cross-reactivity is crucial for vaccine design. Variable loops 1 and 2 (V1V2), positioned at the Env trimer apex, are key regions linked to neutralization. We describe non-canonical cysteine (Cys) residues in V1 that are enriched in individuals with elite neutralization breadth. Analyzing over 65,000 V1 sequences from the CATNAP database, AMP trials, and longitudinal HIV-1 cohorts (SHCS, ZPHI, and CAPRISA), we found that Env variants with extra V1 Cys are present at low levels and fluctuate over time. Extra V1 Cys associate with elite plasma neutralization, and two additional Cys are preferred, suggesting stabilization through disulfide bonds. Among 34 broadly neutralizing antibody (bnAb)-inducer Envs, 17.6% had elongated V1 regions with extra Cys. These extra Cys moderately increased neutralization resistance and altered bnAb epitope accessibility. Collectively, altering epitope exposure alongside Env stabilization renders the V1 twin Cys motif a promising feature for HIV-1 bnAb immunogens.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"19 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0