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Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease 肠大肠杆菌产生的耶尔希尼abactin促进克罗恩病中巨噬细胞的纤维化
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-18 DOI: 10.1016/j.chom.2024.11.012
Ju-Hyun Ahn, Marlus da Silva Pedrosa, Lacey R. Lopez, Taylor N. Tibbs, Joanna N. Jeyachandran, Emily E. Vignieri, Aaron Rothemich, Ian Cumming, Alexander D. Irmscher, Corey J. Haswell, William C. Zamboni, Yen-Rei A. Yu, Melissa Ellermann, Lee A. Denson, Janelle C. Arthur
{"title":"Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease","authors":"Ju-Hyun Ahn, Marlus da Silva Pedrosa, Lacey R. Lopez, Taylor N. Tibbs, Joanna N. Jeyachandran, Emily E. Vignieri, Aaron Rothemich, Ian Cumming, Alexander D. Irmscher, Corey J. Haswell, William C. Zamboni, Yen-Rei A. Yu, Melissa Ellermann, Lee A. Denson, Janelle C. Arthur","doi":"10.1016/j.chom.2024.11.012","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.012","url":null,"abstract":"Inflammatory bowel disease (IBD)-associated fibrosis causes significant morbidity. Mechanisms are poorly understood but implicate the microbiota, especially adherent-invasive <em>Escherichia coli</em> (AIEC). We previously demonstrated that AIEC producing the metallophore yersiniabactin (Ybt) promotes intestinal fibrosis in an IBD mouse model. Since macrophages interpret microbial signals and influence inflammation/tissue remodeling, we hypothesized that Ybt metal sequestration disrupts this process. Here, we show that macrophages are abundant in human IBD-fibrosis tissue and mouse fibrotic lesions, where they co-localize with AIEC. Ybt induces profibrotic gene expression in macrophages via stabilization and nuclear translocation of hypoxia-inducible factor 1-alpha (HIF-1α), a metal-dependent immune regulator. Importantly, Ybt-producing AIEC deplete macrophage intracellular zinc and stabilize HIF-1α through inhibition of zinc-dependent HIF-1α hydroxylation. HIF-1α+ macrophages localize to sites of disease activity in human IBD-fibrosis strictures and mouse fibrotic lesions, highlighting their physiological relevance. Our findings reveal microbiota-mediated metal sequestration as a profibrotic trigger targeting macrophages in the inflamed intestine.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"256 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungal-bacterial endosymbiosis: Recreating an ancient symbiotic relationship 真菌-细菌内共生：重建古老的共生关系
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.10.018
Paola Bonfante
{"title":"Fungal-bacterial endosymbiosis: Recreating an ancient symbiotic relationship","authors":"Paola Bonfante","doi":"10.1016/j.chom.2024.10.018","DOIUrl":"https://doi.org/10.1016/j.chom.2024.10.018","url":null,"abstract":"Fungal-bacterial endosymbioses, the most intimate typology of symbioses, have been described in different taxa of Mucoromycota, an early diverging group of Fungi. In a recent issue of <em>Nature</em>, Giger and colleagues describe how they implanted a Burkolderia-related microbe inside a Mucoromycota fungus, giving rise to a functional and stable endosymbiosis.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"12 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selenium nanoboosting of plant-beneficial microbiome 硒对植物有益微生物群的纳米促进作用
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.11.004
Miaomiao Ding, Ivie Sonia Osayande, Kenichi Tsuda
{"title":"Selenium nanoboosting of plant-beneficial microbiome","authors":"Miaomiao Ding, Ivie Sonia Osayande, Kenichi Tsuda","doi":"10.1016/j.chom.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.004","url":null,"abstract":"In the dynamic theater of plant-microbe interactions, a new conductor has emerged: selenium nanoparticles. As unveiled by Sun et al. in this issue of <em>Cell Host &amp; Microbe</em>, these microbially synthesized nanoparticles recruit plant growth-promoting microbes, orchestrating a synergy between plants and the rhizosphere microbiome.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"2020 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guilds as guides for health vs. disease 公会作为健康与疾病的指南
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.11.010
Antonio L.C. Gomes, Robert R. Jenq
{"title":"Guilds as guides for health vs. disease","authors":"Antonio L.C. Gomes, Robert R. Jenq","doi":"10.1016/j.chom.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.010","url":null,"abstract":"In a recent <em>Cell</em> paper, Wu et al. identified microbiome guilds based on bacterial co-occurrence among type 2 diabetes patients. Two competing guilds, associated with high-fiber vs. control diets, correlated with healthy biomarkers. The potential of this approach was further verified across 15 diseases in 26 studies.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"119 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HAMpering infection: Helicase ratcheting emerges as a phage-sensing mechanism 阻碍感染：解旋酶棘轮作为噬菌体感应机制出现
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.11.009
Zhifeng Zeng, Wenyuan Han
{"title":"HAMpering infection: Helicase ratcheting emerges as a phage-sensing mechanism","authors":"Zhifeng Zeng, Wenyuan Han","doi":"10.1016/j.chom.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.009","url":null,"abstract":"The sensing of pathogens is the first step for any immune response. A recent paper in <em>Cell</em> reveals that the bacterial Hachiman anti-phage defense system deploys a helicase subunit to sense phage invasion via 3′ DNA recognition and subsequent domain rotation to enable nuclease activation.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"111 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The bad neighbor: Prophage competition in Salmonella during macrophage infection 坏邻居：巨噬细胞感染时沙门氏菌的前噬菌体竞争
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.11.011
Zoe Netter
{"title":"The bad neighbor: Prophage competition in Salmonella during macrophage infection","authors":"Zoe Netter","doi":"10.1016/j.chom.2024.11.011","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.011","url":null,"abstract":"Sargen and Helaine discover a prophage competition element in <em>Salmonella</em> that inhibits the lytic cycle of co-resident prophages by cleaving a subset of cellular tRNAs. During <em>Salmonella</em> pathogenesis in macrophages, a persister subset experiences prophage induction and competition, reducing release of immunogenic cellular components and altering macrophage response to infection.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"9 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the early life gut microbiome with MAGIC 用MAGIC探索生命早期肠道微生物群
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-11 DOI: 10.1016/j.chom.2024.10.019
Edoardo Pasolli
{"title":"Exploring the early life gut microbiome with MAGIC","authors":"Edoardo Pasolli","doi":"10.1016/j.chom.2024.10.019","DOIUrl":"https://doi.org/10.1016/j.chom.2024.10.019","url":null,"abstract":"In this issue of <em>Cell Host &amp; Microbe</em>, Peng et al. provide the MAGIC catalog as a resource for studying bacterial and viral diversity of the global gut microbiome in early life. By addressing gaps in geographic and age representation, this database enhances our understanding of early microbiome dynamics.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"1 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation I型ifn介导的NET释放促进结核分枝杆菌复制并与肉芽肿干酪化有关
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-04 DOI: 10.1016/j.chom.2024.11.008
Chanchal Sur Chowdhury, Rachel L. Kinsella, Michael E. McNehlan, Sumanta K. Naik, Daniel S. Lane, Priyanka Talukdar, Asya Smirnov, Neha Dubey, Ananda N. Rankin, Samuel R. McKee, Reilly Woodson, Abigail Hii, Sthefany M. Chavez, Darren Kreamalmeyer, Wandy Beatty, Joshua T. Mattila, Christina L. Stallings
{"title":"Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation","authors":"Chanchal Sur Chowdhury, Rachel L. Kinsella, Michael E. McNehlan, Sumanta K. Naik, Daniel S. Lane, Priyanka Talukdar, Asya Smirnov, Neha Dubey, Ananda N. Rankin, Samuel R. McKee, Reilly Woodson, Abigail Hii, Sthefany M. Chavez, Darren Kreamalmeyer, Wandy Beatty, Joshua T. Mattila, Christina L. Stallings","doi":"10.1016/j.chom.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.008","url":null,"abstract":"Neutrophils are the most abundant cell type in the airways of tuberculosis patients. <em>Mycobacterium tuberculosis</em> (<em>Mtb</em>) infection induces the release of neutrophil extracellular traps (NETs); however, the molecular regulation and impact of NET release on <em>Mtb</em> pathogenesis are unknown. We find that during <em>Mtb</em> infection in neutrophils, PAD4 citrullinates histones to decondense chromatin that gets released as NETs in a manner that can maintain neutrophil viability and promote <em>Mtb</em> replication. Type I interferon promotes the formation of chromatin-containing vesicles that allow NET release without compromising plasma membrane integrity. Analysis of nonhuman primate granulomas supports a model where neutrophils are exposed to type I interferon from macrophages as they migrate into the granuloma, thereby enabling the release of NETs associated with necrosis and caseation. Our data reveal NET release as a promising target to inhibit <em>Mtb</em> pathogenesis.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"199 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142763488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cas10 relieves host growth arrest to facilitate spacer retention during type III-A CRISPR-Cas immunity 在III-A型CRISPR-Cas免疫过程中，Cas10缓解宿主生长停滞，促进间隔物保留
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-02 DOI: 10.1016/j.chom.2024.11.005
Naama Aviram, Amanda K. Shilton, Nia G. Lyn, Bernardo S. Reis, Amir Brivanlou, Luciano A. Marraffini
{"title":"Cas10 relieves host growth arrest to facilitate spacer retention during type III-A CRISPR-Cas immunity","authors":"Naama Aviram, Amanda K. Shilton, Nia G. Lyn, Bernardo S. Reis, Amir Brivanlou, Luciano A. Marraffini","doi":"10.1016/j.chom.2024.11.005","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.005","url":null,"abstract":"Cells from all kingdoms of life can enter growth arrest in unfavorable environmental conditions. Key to this process are mechanisms enabling recovery from this state. Staphylococcal type III-A CRISPR-Cas loci encode the Cas10 complex that uses a guide RNA to locate complementary viral transcripts and start an immune response. When the target sequence is expressed late in the viral lytic cycle, defense requires the activity of Csm6, a non-specific RNase that inhibits the growth of the infected cell. How Csm6 protects from infection and whether growth can be restored is not known. Here, we show that growth arrest provides immunity at the population level, preventing viral replication and allowing uninfected cells to propagate. In addition, the ssDNase activity of Cas10 is required for the regrowth of a subset of the arrested cells and the recovery of the infected host, presumably ending the immune response through degradation of the viral DNA.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"12 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis 空肠弯曲杆菌衍生的细胞致死膨胀毒素促进结直肠癌转移
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2024-12-02 DOI: 10.1016/j.chom.2024.11.006
Zhen He, Jing Yu, Junli Gong, Jinjie Wu, Xuan Zong, Zhanhao Luo, Xiaowen He, Wai Ming Cheng, Yugeng Liu, Chen Liu, Qiang Zhang, Lei Dai, Tao Ding, Beile Gao, Raad Z. Gharaibeh, Jinlin Huang, Christian Jobin, Ping Lan
{"title":"Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis","authors":"Zhen He, Jing Yu, Junli Gong, Jinjie Wu, Xuan Zong, Zhanhao Luo, Xiaowen He, Wai Ming Cheng, Yugeng Liu, Chen Liu, Qiang Zhang, Lei Dai, Tao Ding, Beile Gao, Raad Z. Gharaibeh, Jinlin Huang, Christian Jobin, Ping Lan","doi":"10.1016/j.chom.2024.11.006","DOIUrl":"https://doi.org/10.1016/j.chom.2024.11.006","url":null,"abstract":"Various forms of solid tumors harbor intracellular bacteria, but the physiological consequences of these microorganisms are poorly understood. We show that <em>Campylobacter</em> is significantly enriched in primary colorectal cancer (CRC) lesions from patients with metastasis. <em>Campylobacter</em> <em>jejuni</em>-derived cytolethal distending toxin (CDT) promotes CRC metastasis through JAK2-STAT3-MMP9 signaling in liver or pulmonary metastatic mice models, as confirmed in <em>C. jejuni</em>-infected human colonic tissue and CDT-treated colonic tumoroids from patients. Genetic deletion of <em>cdtB</em> (<em>ΔcdtB</em>) or purified CdtB protein demonstrates that the genotoxin is essential for <em>C. jejuni’s</em> pro-metastatic property. In <em>C.-jejuni</em>-colonized mice, increased translocation of CDT-producing <em>C. jejuni</em> to extraintestinal implanted tumors potentially leads to accelerated metastasis of these tumors. Overall, these findings demonstrate that an intratumor-bacteria-derived genotoxin accelerates tumor metastasis, potentially opening a new diagnostic and therapeutic avenue for cancer management.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"17 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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