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The microbiome: An actor or stage for the beneficial action of probiotics, prebiotics, synbiotics, and postbiotics? 微生物群：益生菌、益生元、合成菌和后益生菌有益作用的演员或舞台？
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.04.017
Mary Ellen Sanders, Colin Hill
{"title":"The microbiome: An actor or stage for the beneficial action of probiotics, prebiotics, synbiotics, and postbiotics?","authors":"Mary Ellen Sanders, Colin Hill","doi":"10.1016/j.chom.2025.04.017","DOIUrl":"https://doi.org/10.1016/j.chom.2025.04.017","url":null,"abstract":"Probiotics, prebiotics, synbiotics, and postbiotics are required, by definition, to confer a health benefit on the host. It is often presumed the host microbiome plays a central role in the mechanism of action of these substances, collectively referred to here as “biotics.” However, the definitions of both probiotics and postbiotics do not include an associated mechanism nor the involvement of the microbiome. The definitions of prebiotics and synbiotics require evidence of selective utilization by the host microbiome, but do not state that confirmatory evidence must be provided that this utilization causes the associated health benefit. In this perspective, we discuss evidence supporting a role for the microbiome in delivering these health benefits and whether or not measuring microbiome alterations can serve as important readouts of efficacy. We also discuss the possibility of expanding the biotics family with substances such as bacteriophage, fermented foods, and live dietary microbes.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"41 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiome-facilitated plant nutrient acquisition 微生物促进植物养分获取
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.005
Brajesh K. Singh, Hang-Wei Hu, Catriona A. Macdonald, Chao Xiong
{"title":"Microbiome-facilitated plant nutrient acquisition","authors":"Brajesh K. Singh, Hang-Wei Hu, Catriona A. Macdonald, Chao Xiong","doi":"10.1016/j.chom.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.005","url":null,"abstract":"Plants and microbiomes have co-evolved for millennia. Through this co-evolution, microbiomes have become essential for plant nutrient acquisition, which involves plant signaling, microbial sensing, and acquiring and sharing nutrients. In this review, we synthesize recent advancements in the complex associations of molecular, physiological, and eco-evolutionary mechanisms that underpin microbe-facilitated plant nutrient uptake. Focusing on emerging insights in plant-microbial communication and metabolic pathways, we evaluate potential opportunities to harness plant microbiomes to sustainably supply nutrients in agricultural and natural ecosystems. However, further progress is constrained by key knowledge gaps. We propose an amended conceptual framework for advancement that includes a holistic understanding of eco-evolutionary relationships with explicit consideration of signaling and sensing mechanisms. Finally, we argue that advancing fundamental science by utilizing emerging analytical approaches in an integrated way is critical to develop effective microbiome-informed tools that can enhance plant nutrient acquisition and promote long-term food security and environmental sustainability.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"26 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Origins and functions of microbiome rhythms 微生物组节律的起源和功能
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.017
Silke Kiessling, Shuaitong Liu, Dirk Haller, Christoph A. Thaiss
{"title":"Origins and functions of microbiome rhythms","authors":"Silke Kiessling, Shuaitong Liu, Dirk Haller, Christoph A. Thaiss","doi":"10.1016/j.chom.2025.05.017","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.017","url":null,"abstract":"Daily oscillations in microbiota composition and function are emerging as an important element in host-microbiota interactions. Here, we summarize features of the microbiota that undergo diurnal rhythms, their development, their impact on the biology of the host, and their relevance to human health and disease. In particular, we focus on the intrinsic and extrinsic factors that regulate microbiota oscillations and the multifaceted roles that microbiota rhythmicity plays in host physiology, immunity, and metabolism. Given the pervasive impact of intestinal microorganisms on host health, understanding the origins and functions of microbiota rhythms is a critical aspect of the circadian biology of the meta-organism.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"6 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Here, we grow 在这里，我们成长
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.021
Ella Hinson
{"title":"Here, we grow","authors":"Ella Hinson","doi":"10.1016/j.chom.2025.05.021","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.021","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Main text</h2>A microbiologist’s lexicon is filled with words focused on the life cycle of their favorite microorganism, such as growth, replication, and fitness. Researchers log hours at the bench counting PFUs, CFUs, titers, and plotting growth curves and survival. These metrics are key to understanding microbes and how these tiny inhabitants interact with their environments, whether it be a plant root, human gut, insect salivary gland, or another microbe. While perhaps trivial to calculate, these growth</section></section>","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"254 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uniting against enteric invaders: IgA meets its microbial ally 联合起来对抗肠道入侵者：IgA遇到了它的微生物盟友
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.009
Sophia Adlkirchner, Romana R. Gerner
{"title":"Uniting against enteric invaders: IgA meets its microbial ally","authors":"Sophia Adlkirchner, Romana R. Gerner","doi":"10.1016/j.chom.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.009","url":null,"abstract":"Gut colonization by opportunistic or pathogenic microbes is a critical step in infection, but strategies to displace these organisms without perturbing the commensal microbiota remain scarce. In a recent <em>Science</em> article, Lentsch et al. combine oral vaccination with a niche-competing strain to selectively eliminate <em>Salmonella</em> spp. and related <em>Escherichia coli</em>.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"217 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Root bacteria hack another plant hormone and affect yield 根细菌会分泌另一种植物激素，影响产量
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.010
Hugo R. Barajas, Derek S. Lundberg
{"title":"Root bacteria hack another plant hormone and affect yield","authors":"Hugo R. Barajas, Derek S. Lundberg","doi":"10.1016/j.chom.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.010","url":null,"abstract":"Plant hormone pathways can be regulated by microbes. In a recent issue of <em>Cell</em>, Zhang et al. demonstrate manipulation of rice strigolactone signaling by root bacteria in field conditions and reveal the molecular mechanism of rhizosphere microbiota that affect rice tillering and yield.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"41 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhizosphere microbes attenuate plant response to shade 根际微生物减弱植物对荫凉的反应
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.008
Jigang Li, Hongtao Liu
{"title":"Rhizosphere microbes attenuate plant response to shade","authors":"Jigang Li, Hongtao Liu","doi":"10.1016/j.chom.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.008","url":null,"abstract":"How plants respond to shade is crucial for optimizing crop yield under high-density planting. In this issue of <em>Cell Host &amp; Microbe</em>, Lu et al. revealed that rhizosphere microbes regulate shade avoidance response in <em>Arabidopsis</em> via the host FLS2/BAK1 immune complex and the MYC2/PIFs/HY5 transcription factors.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"24 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision nutrition and the gut microbiome: Harnessing AI to revolutionize cancer prevention and therapy 精准营养和肠道微生物组：利用人工智能彻底改变癌症预防和治疗
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.011
K. Leigh Greathouse, Ankan Choudhury
{"title":"Precision nutrition and the gut microbiome: Harnessing AI to revolutionize cancer prevention and therapy","authors":"K. Leigh Greathouse, Ankan Choudhury","doi":"10.1016/j.chom.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.011","url":null,"abstract":"The gut microbiome plays a pivotal role in human health, particularly in cancer prevention and treatment. Diet can significantly influence microbiome composition, but individual variability complicates intervention outcomes. We review the microbiome’s influence on cancer development and therapy outcomes and evaluate dietary strategies that modulate microbial composition and metabolites. To address these complexities, we propose the digital gut twin: an artificial intelligence (AI)-driven, dynamically updated simulation that integrates nutrient databases, multi-omic microbiome profiles, host genomics, and clinical data to predict personalized responses to dietary interventions. While significant data and regulatory challenges exist that currently limit clinical implementation, emerging solutions—including pre-trained microbiome models, mechanistic simulators, automated knowledge graphs, and privacy-preserving training—provide a promising pathway toward establishing personalized diet-microbiome modulation as a core component of precision oncology.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"100 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering 微生物群的代谢生态学：营养竞争、宿主利益和群落工程
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.013
Erik Bakkeren, Vit Piskovsky, Kevin R. Foster
{"title":"Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering","authors":"Erik Bakkeren, Vit Piskovsky, Kevin R. Foster","doi":"10.1016/j.chom.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.013","url":null,"abstract":"Many plants and animals, including humans, host diverse communities of microbes that provide many benefits. A key challenge in understanding microbiomes is that the species composition often differs among individuals, which can thwart generalization. Here, we argue that the key to identifying general principles for microbiome science lies in microbial metabolism. In the human microbiome and in other systems, every microbial species must find ways to harvest nutrients to thrive. The available nutrients in a microbiome interact with microbial metabolism to define which species have the potential to persist in a host. The resulting nutrient competition shapes other mechanisms, including bacterial warfare and cross-feeding, to define microbiome composition and properties. We discuss impacts on ecological stability, colonization resistance, nutrient provision for the host, and evolution. A focus on the metabolic ecology of microbiomes offers a powerful way to understand and engineer microbiomes in health, agriculture, and the environment.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"21 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intra-phage immunity: Set a (pro)phage to catch a phage 噬菌体内免疫：设置一个（前）噬菌体来捕获一个噬菌体
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.012
Franklin L. Nobrega
{"title":"Intra-phage immunity: Set a (pro)phage to catch a phage","authors":"Franklin L. Nobrega","doi":"10.1016/j.chom.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.012","url":null,"abstract":"In this issue, Brenes and Laub screen temperate phages for defenses against other temperate phages. This uncovers an array of prophage-encoded immune systems in <em>E. coli</em>. The work expands the concept of phage-phage conflict, reveals context dependency of defense, and highlights temperate phages as both targets and carriers of anti-phage immunity.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"140 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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