Cell host & microbe最新文献_第4页

Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering 微生物群的代谢生态学：营养竞争、宿主利益和群落工程

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.013

Erik Bakkeren, Vit Piskovsky, Kevin R. Foster

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Intra-phage immunity: Set a (pro)phage to catch a phage 噬菌体内免疫：设置一个（前）噬菌体来捕获一个噬菌体

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.012

Franklin L. Nobrega

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Human milk as a microbial pacemaker 母乳作为微生物起搏器

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.018

Liat Shenhav, Meghan B. Azad, Michael A. Silverman

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Unlocking the power of human milk and infant feeding: Understanding how nutrition and early microbiota interaction shapes health programming 释放母乳和婴儿喂养的力量：了解营养和早期微生物群的相互作用如何影响健康规划

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.014

Alexandra Zhernakova, Moran Yassour, Lindsay J. Hall, Maria Carmen Collado

{"title":"Unlocking the power of human milk and infant feeding: Understanding how nutrition and early microbiota interaction shapes health programming","authors":"Alexandra Zhernakova, Moran Yassour, Lindsay J. Hall, Maria Carmen Collado","doi":"10.1016/j.chom.2025.05.014","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.014","url":null,"abstract":"Human milk represents a highly evolved bioactive system that promotes colonization by infant microbial pioneers, supports immune maturation, and fosters infant development. Beyond providing nutrition, human milk contains key bioactive components, such as microbes, metabolites, human milk oligosaccharides, immunoglobulins, lactoferrin, and antimicrobial peptides. These factors influence colonization of the infant gut microbiome and facilitate immune development and metabolic health, with implications for health outcomes and risk of non-communicable diseases. In this review, we highlight the impact of infant feeding, human milk constituents (especially bioactive compounds), and weaning on infant microbial trajectories. By understanding how early-life nutrition influences microbial colonization and nutrient sensing, i.e., “how we feed our microbes,” we can develop targeted interventions and personalized diets to support proper gut maturation and disease prevention from infancy to adulthood, as well as explore the therapeutic potential of human milk bioactives beyond infancy, offering new strategies for disease prevention and treatment.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"585 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Nutrient acquisition by intracellular parasitic protists 细胞内寄生原生生物的营养获取

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-06-11 DOI: 10.1016/j.chom.2025.05.016

Giel G. van Dooren, Malcolm J. McConville

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Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism 干扰素-epsilon是一种雌激素诱导的I型干扰素，是淋病奈瑟菌通过影响唾液酸代谢而独特利用的干扰素

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-06-09 DOI: 10.1016/j.chom.2025.05.015

Evelyn A. Kurt-Jones, Sunita Gulati, Michael King, Rosane B. de Oliveira, Peter A. Rice, Bo Zheng, Jutamas Shaughnessy, Jennifer L. Edwards, Paul J. Hertzog, Sanjay Ram, Douglas T. Golenbock

{"title":"Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism","authors":"Evelyn A. Kurt-Jones, Sunita Gulati, Michael King, Rosane B. de Oliveira, Peter A. Rice, Bo Zheng, Jutamas Shaughnessy, Jennifer L. Edwards, Paul J. Hertzog, Sanjay Ram, Douglas T. Golenbock","doi":"10.1016/j.chom.2025.05.015","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.015","url":null,"abstract":"The female genital mucosa expresses the hormone-dependent type I interferon (IFN), IFN-epsilon (IFN-ε), which protects against chlamydia and herpes infection. Surprisingly, we found that IFN-ε knockout (Ifnε−/−) mice and type I IFN receptor knockout (Ifnar1−/−) mice exhibited enhanced clearance of Neisseria gonorrhoeae (Ng). This result was phenocopied using blocking anti-IFNAR monoclonal antibody (mAb). Ng colonization of the Ifnε−/− urogenital tract was restored by exogenous recombinant IFN-ε or IFN-β. Clearance of Ng in anti-IFNAR-treated mice required the expression of the cathelicidin mCRAMP. Ng deploys a unique mechanism to evade cathelicidins and other innate defenses by sialylating its lipooligosaccharide (LOS) using host-derived cytidine-5'-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac or CMP-sialic acid). Ifnε−/− mice expressed reduced levels of CMP-sialic acid synthetase mRNA in genital tissues. Accordingly, Ng recovered from IFN-deficient mice were hyposialylated. In conclusion, Ng exploits type I IFNs to obtain CMP-sialic acid for LOS sialylation, resulting in innate immune evasion and enhanced colonization.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"69 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway 鞘脂类拟杆菌通过甲羟戊酸途径促进抗炎反应

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-05-30 DOI: 10.1016/j.chom.2025.05.007

Eric M. Brown, Emily R. Temple, Sarah Jeanfavre, Julian Avila-Pacheco, Noel Taylor, Kai Liu, Phuong N.U. Nguyen, Ahmed M.T. Mohamed, Panhasith Ung, Rebecca A. Walker, Daniel B. Graham, Clary B. Clish, Ramnik J. Xavier

{"title":"Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway","authors":"Eric M. Brown, Emily R. Temple, Sarah Jeanfavre, Julian Avila-Pacheco, Noel Taylor, Kai Liu, Phuong N.U. Nguyen, Ahmed M.T. Mohamed, Panhasith Ung, Rebecca A. Walker, Daniel B. Graham, Clary B. Clish, Ramnik J. Xavier","doi":"10.1016/j.chom.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.007","url":null,"abstract":"Sphingolipids derived from Bacteroides species are associated with changes in host inflammation and metabolic syndrome; however, the signaling mechanisms within host cells are unknown. We utilize outer membrane vesicles (OMVs) from wild-type and sphingolipid-deficient Bacteroides strains to understand how these lipids modulate host inflammation. Characterization of the lipidome of B. thetaiotaomicron OMVs revealed enrichment of dihydroceramide phosphoethanolamine (CerPE). OMVs deliver bacterial sphingolipids into host dendritic and epithelial cells, where a subset of lipids, including CerPE, stably persist. Similarly, B. thetaiotaomicron colonization results in sphingolipid persistence in murine tissues and host lipidome alterations that are not observed with the sphingolipid-deficient strain. OMVs induce a potent, sphingolipid-dependent interleukin-10 (IL-10) anti-inflammatory response in dendritic cells, which depends on mevalonate pathway activation. Adding a CerPE fraction to sphingolipid-deficient OMVs rescued IL-10 secretion, similarly dependent on mevalonate pathway activation. These data highlight the essential roles of sphingolipids in stimulating anti-inflammatory responses mediated by mevalonate pathway induction.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"36 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-tooth resolved, whole-mouth prediction of early childhood caries via spatiotemporal variations of plaque microbiota 通过牙菌斑微生物群的时空变化来预测单齿、全口早期儿童龋病

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-05-30 DOI: 10.1016/j.chom.2025.05.006

Fang Yang, Fei Teng, Yufeng Zhang, Yanfei Sun, Jian Xu, Shi Huang

{"title":"Single-tooth resolved, whole-mouth prediction of early childhood caries via spatiotemporal variations of plaque microbiota","authors":"Fang Yang, Fei Teng, Yufeng Zhang, Yanfei Sun, Jian Xu, Shi Huang","doi":"10.1016/j.chom.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.006","url":null,"abstract":"Early childhood caries (ECC) exhibits tooth specificity, highlighting the need for single-tooth-level prevention. We profiled 2,504 dental plaque microbiota samples from 89 preschoolers across two cohorts, tracking compositional changes with imputed functional trends at a single-tooth resolution over 11 months. In healthy children, dental microbiota exhibited an anterior-to-posterior ecological gradient on maxillary teeth and strong bilateral symmetry. These patterns were disrupted in caries-affected children due to caries-driven microbial reorganization. Leveraging tooth-specific disease-associated taxa and spatially related clinical/microbial features, we developed spatial microbial indicators of caries (spatial-MiC or sMiC) using machine-learning techniques. sMiC achieves 98% accuracy in diagnosing ECC at a single-tooth resolution and 93% accuracy in predicting new caries 2 months in advance in perceived-healthy teeth. This high-resolution spatiotemporal microbial atlas of ECC development disentangles the microbial etiology at the single-tooth level, identifies a characteristic microbial signature for each tooth, and provides a foundation for tooth-specific ECC prevention strategies.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"16 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity 脆弱拟杆菌促进结直肠癌的化疗耐药，通过噬菌体VA7消除其可恢复化疗敏感性

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-05-29 DOI: 10.1016/j.chom.2025.05.004

Xiao Ding, Nick Lung-Ngai Ting, Chi Chun Wong, Pingmei Huang, Lanping Jiang, Chuanfa Liu, Yufeng Lin, Shiyu Li, Yujie Liu, Mingxu Xie, Weixin Liu, Kai Yuan, Luyao Wang, Xinyue Zhang, Yanqiang Ding, Qing Li, Yang Sun, Yinglei Miao, Lanqing Ma, Xiang Gao, Jun Yu

{"title":"Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity","authors":"Xiao Ding, Nick Lung-Ngai Ting, Chi Chun Wong, Pingmei Huang, Lanping Jiang, Chuanfa Liu, Yufeng Lin, Shiyu Li, Yujie Liu, Mingxu Xie, Weixin Liu, Kai Yuan, Luyao Wang, Xinyue Zhang, Yanqiang Ding, Qing Li, Yang Sun, Yinglei Miao, Lanqing Ma, Xiang Gao, Jun Yu","doi":"10.1016/j.chom.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.004","url":null,"abstract":"Chemoresistance is a main cause of colorectal cancer (CRC) treatment failure. We identified that Bacteroides fragilis is enriched in patients with CRC resistant to chemotherapy in two independent cohorts, and its abundance is associated with poor survival. Consistently, administration of B. fragilis to CRC xenografts and ApcMin/+- and AOM/DSS-induced CRC mice all significantly attenuated the antitumor efficacy of 5-FU and OXA. Mechanistically, B. fragilis colonized colon tumors and mediated its effect via its surface protein SusD/RagB binding to the Notch1 receptor in CRC cells, leading to activation of the Notch1 signaling pathway and the induction of epithelial-to-mesenchymal transition (EMT)/stemness to suppress chemotherapy-induced apoptosis. Either deletion of SusD/RagB or blockade of Notch1 signaling abrogated B. fragilis-mediated chemoresistance. Finally, B. fragilis-targeting phage VA7 selectively suppressed B. fragilis and restored chemosensitivity in preclinical CRC mouse models. Our findings have offered insights into the potential of precise gut microbiota manipulation for the clinical management of CRC.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"58 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drought-induced plant microbiome and metabolic enrichments improve drought resistance 干旱诱导的植物微生物组和代谢丰富可提高抗旱性

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-05-29 DOI: 10.1016/j.chom.2025.05.002

Jiayu Li, Hongwei Liu, Juntao Wang, Catriona A. Macdonald, Pankaj Singh, Vu Thanh Cong, Marcus Klein, Manuel Delgado-Baquerizo, Brajesh K. Singh

{"title":"Drought-induced plant microbiome and metabolic enrichments improve drought resistance","authors":"Jiayu Li, Hongwei Liu, Juntao Wang, Catriona A. Macdonald, Pankaj Singh, Vu Thanh Cong, Marcus Klein, Manuel Delgado-Baquerizo, Brajesh K. Singh","doi":"10.1016/j.chom.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.002","url":null,"abstract":"Plant-microbiome interactions are crucial in maintaining plant health and productivity under stress; however, little is known about these interactions under drought. Here, using wheat as a model, we combine genomics and culture-dependent methods to investigate the interactions between the soil, root, and rhizosphere microbiomes with rhizosphere metabolomes and plant phenotypes. We find that drought conditions promote microbial colonization in plant microbiomes, enriching Streptomyces coeruleorubidus and Leifsonia shinshuensis, while also increasing 4-oxoproline levels in the rhizosphere, potentially attracting S. coeruleorubidus. Consistently, genes facilitating microbial responses to drought, including the N-terminal acetyltransferase rimJ, are enriched, while S. coeruleorubidus and L. shinshuensis reintroduction promotes host drought resistance. Drought-legacy-effect experiments further support these benefits, with increased plant biomass and yield in the subsequent growth cycle under drought. Collectively, this study informs how drought-induced microbial and metabolite enrichments improve plant adaptation to abiotic stresses, potentially informing development of bio-based tools to mitigate drought effects.<h3>Video abstract</h3><video controls=\"\" crossorigin=\"anonymous\" poster=\"https://ars.els-cdn.com/content/image/1-s2.0-S1931312825001817-mmc5.jpg\" preload=\"auto\" style=\"width:100%\"><source src=\"https://ars.els-cdn.com/content/image/1-s2.0-S1931312825001817-mmc5.mp4\" type=\"video/mp4\"/></video>Download: Download video (4MB)","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"22 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0