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Lab to field: Challenges and opportunities for plant biology 从实验室到野外：植物生物学的挑战与机遇
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.05.027
Derek S. Lundberg, Joy Bergelson, Fabrice Roux, Detlef Weigel, Talia L. Karasov
{"title":"Lab to field: Challenges and opportunities for plant biology","authors":"Derek S. Lundberg, Joy Bergelson, Fabrice Roux, Detlef Weigel, Talia L. Karasov","doi":"10.1016/j.chom.2025.05.027","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.027","url":null,"abstract":"Plant-microbe research offers many choices of model and strain and whether a field-first or lab-first approach is best. However, differences between laboratory studies, offering control and repeatability, versus field experiments, revealing ecological relevance and environmental effects, should not be seen as failure but motivate further inquiry and allow complementary discovery.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"6 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144824908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Active on demand: A precision prodrug strategy against drug-resistant Gram-negative pathogens 主动按需：针对耐药革兰氏阴性病原体的精确前药策略
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.07.013
Seyed Majed Modaresi, Melis N. Anahtar, Aarti Krishnan
{"title":"Active on demand: A precision prodrug strategy against drug-resistant Gram-negative pathogens","authors":"Seyed Majed Modaresi, Melis N. Anahtar, Aarti Krishnan","doi":"10.1016/j.chom.2025.07.013","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.013","url":null,"abstract":"In a recent issue of <em>Science Translational Medicine</em>, Xie et al. introduce a host defense peptide-mimicking prodrug that activates selectively at acidic infection sites, clearing Gram-negative pathogens and biofilms without inducing resistance—advancing precision antibiotic therapy.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"103 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth-defense trade-off in plants: From hypothesis to principle to paradigm 植物生长与防御的权衡：从假设到原则再到范式
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.05.022
Menglu Hou, Guoyong Xu
{"title":"Growth-defense trade-off in plants: From hypothesis to principle to paradigm","authors":"Menglu Hou, Guoyong Xu","doi":"10.1016/j.chom.2025.05.022","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.022","url":null,"abstract":"The growth-defense trade-off describes a prevalent pattern where developing resistance traits compromises growth. In this Forum, we highlight the importance of inducible and specific resistance to safeguard growth in wild plant evolution and elite crop breeding, while discussing how the relationship between defense and growth extends beyond a simple trade-off.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"107 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Networks of the symbiosis-immunity continuum in plants 植物共生-免疫连续体的网络
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.06.009
Xiaowei Zhang, Xinhang Tan, Ertao Wang
{"title":"Networks of the symbiosis-immunity continuum in plants","authors":"Xiaowei Zhang, Xinhang Tan, Ertao Wang","doi":"10.1016/j.chom.2025.06.009","DOIUrl":"https://doi.org/10.1016/j.chom.2025.06.009","url":null,"abstract":"Plants continuously interact with diverse microbes. Forming essential symbiotic relationships promotes plant growth, while defending against harmful microbes prevents disease. Plants resist pathogens by detecting molecules released from microbes. Beneficial microbes distinguish themselves from harmful pathogens before establishing symbiosis by releasing molecules and suppressing plant defenses during the infection and colonization stages. Despite their distinct outcomes, symbiotic and immune responses lie on a continuum and share key features, including dynamic cellular remodeling, metabolite rearrangement, and the maintenance of defenses against pathogens. This review explores the regulatory networks governing these processes, highlighting the shared and unique molecular mechanisms underlying symbiotic and immune responses. Understanding how plants integrate environmental signals to balance symbiotic compatibility and defense will provide valuable insights into optimizing plant health and productivity in changing ecosystems.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"26 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plant-microbe interactions amid global change 全球变化中植物与微生物的相互作用
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.05.028
Francisco Dini-Andreote
{"title":"Plant-microbe interactions amid global change","authors":"Francisco Dini-Andreote","doi":"10.1016/j.chom.2025.05.028","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.028","url":null,"abstract":"Terrestrial plants have ancient evolutionary relationships with microbes. Global change alters these interactions, with impacts on natural and agricultural ecosystems. This commentary outlines an overview of plant-microbe interactions and provides perspectives for advancing research directions toward effectively harnessing plant-microbe interactions to promote plant and ecosystem tolerance amid global change scenarios.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"291 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of plant receptor-like kinases in sensing extrinsic and host-derived signals and shaping the microbiome 植物受体样激酶在感知外来和宿主来源信号和塑造微生物组中的作用
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.07.012
Aditi Bhat, Cara H. Haney
{"title":"The role of plant receptor-like kinases in sensing extrinsic and host-derived signals and shaping the microbiome","authors":"Aditi Bhat, Cara H. Haney","doi":"10.1016/j.chom.2025.07.012","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.012","url":null,"abstract":"Microbiota provide diverse benefits to their hosts, including nutrient acquisition, stress tolerance, and disease resistance. However, the mechanisms by which plants coordinate intrinsic and extrinsic cues to shape microbial communities remain poorly understood. Receptor-like kinases (RLKs), one of the largest gene families in plants, are central to the perception of both exogenous and endogenous signals, including pathogens, mutualists, and plant physiology. Indeed, recent evidence has identified RLKs that regulate microbiome structure and function. This minireview focuses on how their quantity and ability to transduce diverse signals make RLKs strong candidates to coordinate plant physiology and immunity with the microbiome.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"16 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial Makeover: Skin microbiome reset after stem cell transplantation 微生物改造：干细胞移植后皮肤微生物组重置
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.07.014
John E. Common, Rebecca P. Payne
{"title":"Microbial Makeover: Skin microbiome reset after stem cell transplantation","authors":"John E. Common, Rebecca P. Payne","doi":"10.1016/j.chom.2025.07.014","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.014","url":null,"abstract":"Inborn errors of immunity disrupt host-microbe interactions. In this issue of <em>Cell Host &amp; Microbe</em>, Che et al.<span><span><sup>1</sup></span></span> examine DOCK8-deficient individuals undergoing stem cell transplantation and show that immune reconstitution rebalances the skin microbiome, underscoring the central role of immunity in shaping cutaneous microbial ecology.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"15 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomolecular condensates in plant immunity 植物免疫中的生物分子凝聚物
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.06.014
Shuai Huang, Xinnian Dong
{"title":"Biomolecular condensates in plant immunity","authors":"Shuai Huang, Xinnian Dong","doi":"10.1016/j.chom.2025.06.014","DOIUrl":"https://doi.org/10.1016/j.chom.2025.06.014","url":null,"abstract":"Plant defense against microbial pathogens relies on coordinated regulation of diverse molecular processes. Although much has been learned about these processes through traditional and modern approaches, recent findings indicate that they are orchestrated through membraneless biomolecular condensates formed via liquid-liquid phase separation and related phase transitions. The principle of subcellular compartmentalization is especially important for plants, as they lack specialized immune cells, requiring them to coordinate defense responses with other physiological functions. As a result, the dynamic spatiotemporal organization of immune-related molecules becomes a critical layer of regulation that has only recently become a research frontier. Here, we discuss the emerging roles of biomolecular condensates in plant immunity, identify critical questions for future research, and propose a framework for moving forward. By incorporating condensate biology into the study of plant defense, we suggest novel strategies for enhancing crop resilience and advancing sustainable agriculture.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"18 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pangenomic context reveals the extent of intraspecific plant NLR evolution 泛基因组背景揭示了种内植物NLR进化的程度
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.07.011
Luisa C. Teasdale, Kevin D. Murray, Max Collenberg, Adrian Contreras-Garrido, Theresa Schlegel, Leon van Ess, Justina Jüttner, Christa Lanz, Oliver Deusch, Joffrey Fitz, Regina Mencia, Rosanne van Velthoven, Hajk-Georg Drost, Detlef Weigel, Gautam Shirsekar
{"title":"Pangenomic context reveals the extent of intraspecific plant NLR evolution","authors":"Luisa C. Teasdale, Kevin D. Murray, Max Collenberg, Adrian Contreras-Garrido, Theresa Schlegel, Leon van Ess, Justina Jüttner, Christa Lanz, Oliver Deusch, Joffrey Fitz, Regina Mencia, Rosanne van Velthoven, Hajk-Georg Drost, Detlef Weigel, Gautam Shirsekar","doi":"10.1016/j.chom.2025.07.011","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.011","url":null,"abstract":"Nucleotide-binding leucine-rich repeat (NLR) proteins are major components of the plant immune system, recognizing pathogen effectors and triggering defense responses. Because of the diversity of pathogen effector repertoires, NLRs have extraordinary sequence, structural, and regulatory variability. Although processes contributing to NLR diversity have been identified, the precise evolution of NLRs in their genomic context and along the multiple axes of diversity has been difficult to trace. We integrate genome-specific full-length transcript, homology, and transposable element information to annotate 3,789 NLRs in 17 diverse <em>Arabidopsis thaliana</em> accessions. We define 121 pangenomic NLR neighborhoods, which vary greatly in size, content, and complexity. NLRs are diverse across many axes, and multiple metrics are required to fully capture NLR variation. Based on these findings, we propose that diversity in diversity generation is fundamental to maintaining a functionally “adaptive” immune system in plants and that mechanistic studies should consider multiple axes of immune system diversity.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"20 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subspecies of the human gut microbiota carry implicit information for in-depth microbiome research 人类肠道微生物群的亚种为深入的微生物组研究提供了隐含的信息
IF 30.3 1区 医学
Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.07.015
Matija Tričković, Silas Kieser, Evgeny M. Zdobnov, Mirko Trajkovski
{"title":"Subspecies of the human gut microbiota carry implicit information for in-depth microbiome research","authors":"Matija Tričković, Silas Kieser, Evgeny M. Zdobnov, Mirko Trajkovski","doi":"10.1016/j.chom.2025.07.015","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.015","url":null,"abstract":"Microbial strains within a single species can exhibit distinct functional characteristics due to variations in gene content and often show individual specificity, which can obscure unbiased associations and hinder deductive research. Here, we comprehensively define the human gut microbiota at a consistently annotated operational subspecies unit (OSU) resolution in an unbiased, cohort-independent manner, demonstrating that this approach can generalize across diverse global populations while maintaining specificity and improving interstudy reproducibility. We develop panhashome—a sketching-based method for rapid subspecies and species quantification and identification of genes that drive intraspecies variations—and show that subspecies carry implicit information undetectable at the species level. We identify subspecies associated with colorectal cancer (CRC) whose sibling subspecies or species are not, while a machine-learning CRC diagnostic algorithm based on subspecies outperformed species-level methods. This subspecies catalog allows identification of genes that drive functional differences between subspecies as a fundamental step in mechanistically understanding microbiome-phenotype interactions.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"185 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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