Cell host & microbe最新文献_第5页

Uncovering fungal pathogens and skin microbiota in rural Malaysia 发现马来西亚农村地区的真菌病原体和皮肤微生物群

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.07.007

William S. Owens, Emilia D. Lim, Y. Erin Chen

引用次数: 0

Lactobacillus acidophilus promotes cognitive function recovery via regulating microglial peroxisomal function in cerebral ischemia 嗜酸乳杆菌通过调节脑缺血小胶质过氧化物酶体功能促进认知功能恢复

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.07.018

Yimin Huang, Xincheng Zhang, Chenxuan Yu, Yuan Liu, Huayu Kang, Yanchao Liu, Yu Ni, Yuze Xia, Zhengqiao Jiang, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Jianzhi Wang, Ting Lei, Chao Gan, Huaqiu Zhang

{"title":"Lactobacillus acidophilus promotes cognitive function recovery via regulating microglial peroxisomal function in cerebral ischemia","authors":"Yimin Huang, Xincheng Zhang, Chenxuan Yu, Yuan Liu, Huayu Kang, Yanchao Liu, Yu Ni, Yuze Xia, Zhengqiao Jiang, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Jianzhi Wang, Ting Lei, Chao Gan, Huaqiu Zhang","doi":"10.1016/j.chom.2025.07.018","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.018","url":null,"abstract":"Cerebral ischemia causes significant mortality and is accompanied by inflammatory reactions that exacerbate damage. While the gut microbiota is linked to clinical outcomes, specific treatments and mechanisms remain unclear. Our metagenomics linked low Lactobacillus abundance to cognitive decline in patients with cerebral ischemia. L. acidophilus supplementation alleviated post-ischemic deficits in murine middle cerebral artery occlusion and bilateral carotid artery stenosis models. The neuroprotective effects of L. acidophilus were driven by enhanced gut absorption of linoleic acid (LinA). L. acidophilus-induced LinA activates peroxisomes in microglia, triggering microglial reprogramming to an anti-inflammatory state via reactive oxygen species (ROS) scavenging and β-oxidation-mediated epigenetic changes. These L. acidophilus-driven effects are lost upon dietary deficits in LinA, microglia depletion, or peroxisome disruption. A randomized clinical trial showed that L. acidophilus improved cognition and cerebral blood flow in ischemic patients. This study was registered at ClinicalTrials.gov<svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg> (NCT05845983). Collectively, these findings reveal a therapeutic axis whereby L. acidophilus drives microglial reprogramming, providing a basis for microbiome-targeted neurotherapies.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"12 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charting a phage genome atlas 绘制噬菌体基因组图谱

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.07.001

Shelby E. Andersen, Breck A. Duerkop

引用次数: 0

One bacterium’s trash is another’s treasure 一种细菌的垃圾是另一种细菌的宝藏

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.07.017

Samuel C. Syberg, Lauren J. Rajakovich

引用次数: 0

Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system 假单胞菌通过一个单一的调节系统协调对病毒和细菌的先天防御

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-08-13 DOI: 10.1016/j.chom.2025.07.016

David M. Brinkley, Savannah K. Bertolli, Larry A. Gallagher, Yongjun Tan, Minola Motha de Silva, Ainsley Brockman, Dapeng Zhang, S. Brook Peterson, Joseph D. Mougous

{"title":"Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system","authors":"David M. Brinkley, Savannah K. Bertolli, Larry A. Gallagher, Yongjun Tan, Minola Motha de Silva, Ainsley Brockman, Dapeng Zhang, S. Brook Peterson, Joseph D. Mougous","doi":"10.1016/j.chom.2025.07.016","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.016","url":null,"abstract":"Bacterial cells live under constant existential threats imposed by other bacteria and viruses. Mechanisms for contending with these threats are well documented; however, the regulation of these diverse defense elements remains poorly understood. Here, we describe a genome-wide, coordinated, and highly effective immune response, termed Gac/Rsm-regulated unified antagonism response and defense (GUARD), that protects against bacterial and viral threats using a single regulatory pathway. Bioinformatic analyses reveal a Pseudomonas-wide form of the Gac/Rsm regulatory pathway (GRP), an established danger-sensing system in P. aeruginosa. Proteomic studies of diverse Pseudomonas species show that the pathway regulates a large and variable suite of factors implicated in defense against both bacterial and phage threats. Focusing on P. protegens, we identify profound phenotypic consequences of these factors against multiple forms of bacterial antagonism and several phages. Together, our results reveal that bacteria, like multicellular eukaryotes, couple danger sensing to the activation of an immune response with antibacterial and antiviral arms.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"37 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudomonas infections persisting after CFTR modulators are widespread throughout the lungs and drive lung inflammation 假单胞菌感染持续后CFTR调节剂广泛存在于整个肺部和驱动肺部炎症

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-08-05 DOI: 10.1016/j.chom.2025.07.009

Samantha L. Durfey, Siddhartha G. Kapnadak, Tahuanty Pena, Matthew M. Willmering, J. David Godwin, Mary E. Teresi, Sonya L. Heltshe, Anh T. Vo, Raul A. Villacreses, Ieva Aliukonyte, Linda Boyken, Mal R. Stroik, Sarah J. Morgan, Grace M. Wang, Hannah L. Betts, Shide Zhang, Christopher H. Goss, John P. Clancy, Moira L. Aitken, Chad Steele, Pradeep K. Singh

{"title":"Pseudomonas infections persisting after CFTR modulators are widespread throughout the lungs and drive lung inflammation","authors":"Samantha L. Durfey, Siddhartha G. Kapnadak, Tahuanty Pena, Matthew M. Willmering, J. David Godwin, Mary E. Teresi, Sonya L. Heltshe, Anh T. Vo, Raul A. Villacreses, Ieva Aliukonyte, Linda Boyken, Mal R. Stroik, Sarah J. Morgan, Grace M. Wang, Hannah L. Betts, Shide Zhang, Christopher H. Goss, John P. Clancy, Moira L. Aitken, Chad Steele, Pradeep K. Singh","doi":"10.1016/j.chom.2025.07.009","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.009","url":null,"abstract":"Cystic fibrosis transmembrane conductance regulator (CFTR) modulators improve the physiological defect causing cystic fibrosis, but the lungs of most people remain infected and inflamed. A leading hypothesis implicates damaged segments as the cause of persistent infection and predicts that mildly diseased segments within an individual's lungs will clear after treatment, whereas severely diseased segments will not. Our findings contradict this hypothesis. We used bronchoscopy to sample the least- and most-damaged lung segments in Pseudomonas aeruginosa (Pa)-infected individuals before modulators and returned to these same segments after 1.5 years. Surprisingly, we find an “all-or-none” infection clearance response: the most-diseased segments clear if any other lung segment in that person clears, and the least-diseased segments remain infected if others in that person do. Furthermore, neutrophilic inflammation completely resolves where Pa clears but remains elevated where Pa persists. These data indicate that post-modulator infections are not limited to severely diseased segments and that Pa infections drive persistent lung inflammation after modulators.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"29 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amino acid competition shapes Acinetobacter baumannii gut carriage 氨基酸竞争塑造鲍曼不动杆菌肠道运输

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-08-04 DOI: 10.1016/j.chom.2025.07.003

Xiaomei Ren, R. Mason Clark, Dziedzom A. Bansah, Elizabeth N. Varner, Connor R. Tiffany, Kanchan Jaswal, John H. Geary, Olivia A. Todd, Jonathan D. Winkelman, Elliot S. Friedman, Riley N. Jarrett, Babette S. Zemel, Gary D. Wu, Joseph P. Zackular, William H. DePas, Judith Behnsen, Lauren D. Palmer

{"title":"Amino acid competition shapes Acinetobacter baumannii gut carriage","authors":"Xiaomei Ren, R. Mason Clark, Dziedzom A. Bansah, Elizabeth N. Varner, Connor R. Tiffany, Kanchan Jaswal, John H. Geary, Olivia A. Todd, Jonathan D. Winkelman, Elliot S. Friedman, Riley N. Jarrett, Babette S. Zemel, Gary D. Wu, Joseph P. Zackular, William H. DePas, Judith Behnsen, Lauren D. Palmer","doi":"10.1016/j.chom.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.003","url":null,"abstract":"Asymptomatic colonization is often critical for persistence of antimicrobial-resistant pathogens, such as Acinetobacter baumannii, and can increase the risk of clinical infections. However, the ecological factors shaping A. baumannii gut colonization remain unclear. We show that A. baumannii and other pathogenic Acinetobacter evolved to utilize the amino acid ornithine, a non-preferred carbon source, to compete with resident microbiota and persist in the gut in mice. A. baumannii encodes ornithine succinyltransferase (AstO) necessary for catabolizing ornithine, especially in conditions of increased microbial diversity. Supplemental dietary ornithine promotes long-term fecal shedding of A. baumannii. By contrast, supplementation of preferred carbon sources—monosodium glutamate or histidine—abolishes the requirement for ornithine catabolism. Additionally, A. baumannii gut carriage is higher in formula-fed human infants, who generally consume higher levels of protein, revealing dietary impacts on Acinetobacter colonization. Together, these results reveal that ornithine catabolism facilitates A. baumannii colonization, providing a reservoir for pathogen spread.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"16 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144770007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic cross-feeding of a dietary antioxidant enhances anaerobic energy metabolism by human gut bacteria 饲粮中抗氧化剂的代谢交叉喂养促进了人体肠道细菌的厌氧能量代谢

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-08-04 DOI: 10.1016/j.chom.2025.07.008

Zhe Zhou, Angela Jiang, Xiaofang Jiang, Stavroula K. Hatzios

{"title":"Metabolic cross-feeding of a dietary antioxidant enhances anaerobic energy metabolism by human gut bacteria","authors":"Zhe Zhou, Angela Jiang, Xiaofang Jiang, Stavroula K. Hatzios","doi":"10.1016/j.chom.2025.07.008","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.008","url":null,"abstract":"The degradation of complex carbohydrates and other macromolecules by human gut bacteria generates metabolites that are used by neighboring microbes for anaerobic respiration. However, it is largely unknown whether cross-feeding of other dietary compounds can drive energy-yielding redox reactions in the gut. We show that gut bacteria from different phyla cross-feed a common dietary antioxidant to produce energy under anaerobic conditions. Clostridium symbiosum encodes ergothionases that transform ergothioneine, a mushroom-derived antioxidant, into the electron acceptor thiourocanic acid (TUA). TUA is reduced by Bacteroides xylanisolvens, increasing bacterial ATP synthesis and growth. Furthermore, TUA is selectively produced and consumed by certain human fecal microbial communities. Consistent with emerging links between intestinal ergothioneine homeostasis and colorectal cancer, ergothionase is significantly enriched in fecal metagenomes from colorectal cancer patients. Together, these results illustrate how commensalistic cross-feeding of an antioxidant nutrient enhances microbial energy metabolism, which may contribute to interpersonal differences in disease risk.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"58 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144770069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metagenomic selections reveal diverse antiphage defenses in human and environmental microbiomes 宏基因组选择揭示了人类和环境微生物组中不同的噬菌体防御

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-07-29 DOI: 10.1016/j.chom.2025.07.005

Luis Rodriguez-Rodriguez, James Pfister, Liam Schuck, Arabella E. Martin, Luis M. Mercado-Santiago, Vincent S. Tagliabracci, Kevin J. Forsberg

引用次数: 0

The prototypic crAssphage is a linear phage-plasmid 原噬菌体是一种线性噬菌体质粒

IF 30.3 1区医学

Cell host & microbe Pub Date : 2025-07-28 DOI: 10.1016/j.chom.2025.07.004

Danica T. Schmidtke, Angela S. Hickey, Jakob Wirbel, Jordan D. Lin, Ivan Liachko, Gavin Sherlock, Ami S. Bhatt

{"title":"The prototypic crAssphage is a linear phage-plasmid","authors":"Danica T. Schmidtke, Angela S. Hickey, Jakob Wirbel, Jordan D. Lin, Ivan Liachko, Gavin Sherlock, Ami S. Bhatt","doi":"10.1016/j.chom.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.004","url":null,"abstract":"The prototypic crAssphage (Carjivirus communis) is an abundant, prevalent, and persistent human gut bacteriophage, yet it remains uncultured and its lifestyle uncharacterized. C. communis does not readily plaque, suggesting a largely non-lytic lifestyle. Here, we find that C. communis is a linear phage-plasmid that stably persists extrachromosomally within its host. Plasmid and phage-related genes are transcribed, and multiple putative replication origins may initiate replication for multiple lifestyles and genome conformations, including both circular and linear formations. Leveraging these findings, we use a plaque-free culturing approach to measure C. communis replication on prevalent gut bacteria, notably Phocaeicola vulgatus, P. dorei, and Bacteroides stercoris, revealing a broad host range. C. communis persists without causing major cell lysis events or integrating into host chromosomes. Taken together, C. communis’ ability to switch between phage and plasmid lifestyles within a wide range of hosts may contribute to its widespread presence in human gut microbiomes.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"49 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0