Cell host & microbe最新文献_第6页

Clinical sequelae of gut microbiome development and disruption in hospitalized preterm infants 住院早产儿肠道微生物组的发展和破坏带来的临床后遗症

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-09-24 DOI: 10.1016/j.chom.2024.09.012

Robert Thänert, Drew J. Schwartz, Eric C. Keen, Carla Hall-Moore, Bin Wang, Nurmohammad Shaikh, Jie Ning, L. Colleen Rouggly-Nickless, Anna Thänert, Aura Ferreiro, Skye R.S. Fishbein, Janice E. Sullivan, Paula Radmacher, Marilyn Escobedo, Barbara B. Warner, Phillip I. Tarr, Gautam Dantas

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Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium 微生物群通过塑造肠上皮细胞中的 STAT1-NLRC5 轴来调节新生儿对病毒诱发的坏死性小肠结肠炎的疾病耐受性

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-09-17 DOI: 10.1016/j.chom.2024.08.013

Saravanan Subramanian, Hua Geng, Longtao Wu, Chao Du, Amy M. Peiper, Heng-Fu Bu, Pauline M. Chou, Xiao Wang, Stephanie C. Tan, Neha R. Iyer, Nazeer Hussain Khan, Ellen L. Zechner, James G. Fox, Rolf Breinbauer, Chao Qi, Bakhtiar Yamini, Jenny P. Ting, Isabelle G. De Plaen, Stephanie M. Karst, Xiao-Di Tan

{"title":"Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium","authors":"Saravanan Subramanian, Hua Geng, Longtao Wu, Chao Du, Amy M. Peiper, Heng-Fu Bu, Pauline M. Chou, Xiao Wang, Stephanie C. Tan, Neha R. Iyer, Nazeer Hussain Khan, Ellen L. Zechner, James G. Fox, Rolf Breinbauer, Chao Qi, Bakhtiar Yamini, Jenny P. Ting, Isabelle G. De Plaen, Stephanie M. Karst, Xiao-Di Tan","doi":"10.1016/j.chom.2024.08.013","DOIUrl":"https://doi.org/10.1016/j.chom.2024.08.013","url":null,"abstract":"Microbiota and feeding modes influence the susceptibility of premature newborns to necrotizing enterocolitis (NEC) through mechanisms that remain unknown. Here, we show that microbiota colonization facilitated by breastmilk feeding promotes NOD-like receptor family CARD domain containing 5 (Nlrc5) gene expression in mouse intestinal epithelial cells (IECs). Notably, inducible knockout of the Nlrc5 gene in IECs predisposes neonatal mice to NEC-like injury in the small intestine upon viral inflammation in an NK1.1+ cell-dependent manner. By contrast, formula feeding enhances neonatal gut colonization with environment-derived tilivalline-producing Klebsiella spp. Remarkably, tilivalline disrupts microbiota-activated STAT1 signaling that controls Nlrc5 gene expression in IECs through a PPAR-γ-mediated mechanism. Consequently, this dysregulation hinders the resistance of neonatal intestinal epithelium to self-NK1.1+ cell cytotoxicity upon virus infection/colonization, promoting NEC development. Together, we discover the underappreciated role of intestinal microbiota colonization in shaping a disease tolerance program to viral inflammation and elucidate the mechanisms impacting NEC development in neonates.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"2 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization 母乳微生物群网络与宿主基因组学、儿童哮喘和过敏致敏有关

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-09-17 DOI: 10.1016/j.chom.2024.08.014

Zhi Yi Fang, Sara A. Stickley, Amirthagowri Ambalavanan, Yang Zhang, Amanda M. Zacharias, Kelsey Fehr, Shirin Moossavi, Charisse Petersen, Kozeta Miliku, Piushkumar J. Mandhane, Elinor Simons, Theo J. Moraes, Malcolm R. Sears, Michael G. Surette, Padmaja Subbarao, Stuart E. Turvey, Meghan B. Azad, Qingling Duan

{"title":"Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization","authors":"Zhi Yi Fang, Sara A. Stickley, Amirthagowri Ambalavanan, Yang Zhang, Amanda M. Zacharias, Kelsey Fehr, Shirin Moossavi, Charisse Petersen, Kozeta Miliku, Piushkumar J. Mandhane, Elinor Simons, Theo J. Moraes, Malcolm R. Sears, Michael G. Surette, Padmaja Subbarao, Stuart E. Turvey, Meghan B. Azad, Qingling Duan","doi":"10.1016/j.chom.2024.08.014","DOIUrl":"https://doi.org/10.1016/j.chom.2024.08.014","url":null,"abstract":"The human milk microbiota (HMM) is thought to influence the long-term health of offspring. However, its role in asthma and atopy and the impact of host genomics on HMM composition remain unclear. Through the CHILD Cohort Study, we followed 885 pregnant mothers and their offspring from birth to 5 years and determined that HMM was associated with maternal genomics and prevalence of childhood asthma and allergic sensitization (atopy) among human milk-fed infants. Network analysis identified modules of correlated microbes in human milk that were associated with subsequent asthma and atopy in preschool-aged children. Moreover, reduced alpha-diversity and increased Lawsonella abundance in HMM were associated with increased prevalence of childhood atopy. Genome-wide association studies (GWASs) identified maternal genetic loci (e.g., ADAMTS8, NPR1, and COTL1) associated with HMM implicated with asthma and atopy, notably Lawsonella and alpha-diversity. Thus, our study elucidates the role of host genomics on the HMM and its potential impact on childhood asthma and atopy.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"6 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species- and strain-level diversity and evolution 对大量人类肠道类杆菌培养物进行综合分析，揭示物种和菌株层面的多样性与进化

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-09-17 DOI: 10.1016/j.chom.2024.08.016

Zhenrun J. Zhang, Cody G. Cole, Michael J. Coyne, Huaiying Lin, Nicholas Dylla, Rita C. Smith, Téa E. Pappas, Shannon A. Townson, Nina Laliwala, Emily Waligurski, Ramanujam Ramaswamy, Che Woodson, Victoria Burgo, Jessica C. Little, David Moran, Amber Rose, Mary McMillin, Emma McSpadden, Anitha Sundararajan, Ashley M. Sidebottom, Laurie E. Comstock

{"title":"Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species- and strain-level diversity and evolution","authors":"Zhenrun J. Zhang, Cody G. Cole, Michael J. Coyne, Huaiying Lin, Nicholas Dylla, Rita C. Smith, Téa E. Pappas, Shannon A. Townson, Nina Laliwala, Emily Waligurski, Ramanujam Ramaswamy, Che Woodson, Victoria Burgo, Jessica C. Little, David Moran, Amber Rose, Mary McMillin, Emma McSpadden, Anitha Sundararajan, Ashley M. Sidebottom, Laurie E. Comstock","doi":"10.1016/j.chom.2024.08.016","DOIUrl":"https://doi.org/10.1016/j.chom.2024.08.016","url":null,"abstract":"Species of the Bacteroidales order are among the most abundant and stable bacterial members of the human gut microbiome, with diverse impacts on human health. We cultured and sequenced the genomes of 408 Bacteroidales isolates from healthy human donors representing nine genera and 35 species and performed comparative genomic, gene-specific, metabolomic, and horizontal gene transfer analyses. Families, genera, and species could be grouped based on many distinctive features. We also observed extensive DNA transfer between diverse families, allowing for shared traits and strain evolution. Inter- and intra-species diversity is also apparent in the metabolomic profiling studies. This highly characterized and diverse Bacteroidales culture collection with strain-resolved genomic and metabolomic analyses represents a valuable resource to facilitate informed selection of strains for microbiome reconstitution.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"30 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salmonella Typhimurium screen identifies shifts in mixed-acid fermentation during gut colonization 伤寒沙门氏菌筛选确定肠道定植过程中混合酸发酵的变化

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-09-17 DOI: 10.1016/j.chom.2024.08.015

Bidong D. Nguyen, Anna Sintsova, Christopher Schubert, Andreas Sichert, Clio Scheidegger, Jana Näf, Julien Huttman, Verena Lentsch, Tim Keys, Christoph Rutschmann, Philipp Christen, Patrick Kiefer, Philipp Keller, Manja Barthel, Miguelangel Cuenca, Beat Christen, Uwe Sauer, Emma Slack, Julia A. Vorholt, Shinichi Sunagawa, Wolf-Dietrich Hardt

{"title":"Salmonella Typhimurium screen identifies shifts in mixed-acid fermentation during gut colonization","authors":"Bidong D. Nguyen, Anna Sintsova, Christopher Schubert, Andreas Sichert, Clio Scheidegger, Jana Näf, Julien Huttman, Verena Lentsch, Tim Keys, Christoph Rutschmann, Philipp Christen, Patrick Kiefer, Philipp Keller, Manja Barthel, Miguelangel Cuenca, Beat Christen, Uwe Sauer, Emma Slack, Julia A. Vorholt, Shinichi Sunagawa, Wolf-Dietrich Hardt","doi":"10.1016/j.chom.2024.08.015","DOIUrl":"https://doi.org/10.1016/j.chom.2024.08.015","url":null,"abstract":"How enteric pathogens adapt their metabolism to a dynamic gut environment is not yet fully understood. To investigate how Salmonella enterica Typhimurium (S.Tm) colonizes the gut, we conducted an in vivo transposon mutagenesis screen in a gnotobiotic mouse model. Our data implicate mixed-acid fermentation in efficient gut-luminal growth and energy conservation throughout infection. During initial growth, the pathogen utilizes acetate fermentation and fumarate respiration. After the onset of gut inflammation, hexoses appear to become limiting, as indicated by carbohydrate analytics and the increased need for gluconeogenesis. In response, S.Tm adapts by ramping up ethanol fermentation for redox balancing and supplying the TCA cycle with α-ketoglutarate for additional energy. Our findings illustrate how S.Tm flexibly adapts mixed fermentation and its use of the TCA cycle to thrive in the changing gut environment. Similar metabolic wiring in other pathogenic Enterobacteriaceae may suggest a broadly conserved mechanism for gut colonization.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"8 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular condensates as roadblocks in plant defense 分子凝聚物是植物防御的路障

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-09-11 DOI: 10.1016/j.chom.2024.07.022

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There and back again: Discovering antiviral and antiphage defenses using deep homology 去而复返：利用深度同源性发现抗病毒和抗蚜虫防御系统

IF 30.3 1区医学

Cell host & microbe Pub Date : 2024-09-11 DOI: 10.1016/j.chom.2024.08.006

Edward M. Culbertson, Tera C. Levin

引用次数: 0

Conversation between host and gut microbiota unveils a “silver bullet” therapeutic option for chemotherapy 宿主与肠道微生物群之间的对话揭示了化疗的 "银弹 "治疗方案

IF 30.3 1区医学