pks+大肠杆菌黏附素——善与恶的界限

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-01-08 DOI:10.1016/j.chom.2024.12.007

Chi Chun Wong, Jun Yu

引用次数: 0

摘要

肠道细菌可通过产生基因毒素促进结直肠癌的发生。在最近一期的《自然》杂志上，Jans等人发现细菌粘附是产生大肠杆菌素的大肠杆菌在结肠上皮上的基因毒性活性的另一个决定因素，可以靶向减轻细菌相关的DNA损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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pks+ E. coli adhesins—The fine line between good and evil

Gut bacteria could promote colorectal cancer by generating genotoxins. In a recent issue of Nature, Jans et al. identified bacterial adhesion as an additional determinant for the genotoxic activity of colibactin-producing E. coli on the colon epithelium, which could be targeted to mitigate bacteria-associated DNA damage.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.