Active on demand: A precision prodrug strategy against drug-resistant Gram-negative pathogens

IF 18.7 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-08-13 DOI:10.1016/j.chom.2025.07.013

Seyed Majed Modaresi, Melis N. Anahtar, Aarti Krishnan

引用次数: 0

Abstract

In a recent issue of Science Translational Medicine, Xie et al. introduce a host defense peptide-mimicking prodrug that activates selectively at acidic infection sites, clearing Gram-negative pathogens and biofilms without inducing resistance—advancing precision antibiotic therapy.

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主动按需：针对耐药革兰氏阴性病原体的精确前药策略

在最近一期的《科学转化医学》杂志上，Xie等人介绍了一种模拟宿主防御肽的前药，该前药在酸性感染部位选择性激活，清除革兰氏阴性病原体和生物膜，而不诱导耐药的精确抗生素治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.