Case Reports in Oncological Medicine最新文献

Hemophagocytic Lymphohistiocytosis (HLH) Following Immune Checkpoint Therapy (ICT). 免疫检查点治疗（ICT）后的噬血细胞淋巴组织细胞病（HLH）。

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Case Reports in Oncological Medicine Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.1155/crom/5582848

Saivaroon Gajagowni, Emily Wang, Jianbo Wang, Matthew T Campbell, Bilal A Siddiqui

引用次数: 0

Atypical Femur Fracture in a Teenager on Chronic Imatinib Therapy. 慢性伊马替尼治疗的青少年非典型股骨骨折。

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Case Reports in Oncological Medicine Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.1155/crom/2081905

Ana C Belzarena, James L Cook

引用次数: 0

Digital Papillary Adenocarcinoma at the Site of 5 Years of Recurrent Paronychia: Case Report and Literature Review. 5年复发甲沟炎部位的指状乳头腺癌：1例报告及文献复习。

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Case Reports in Oncological Medicine Pub Date : 2024-12-23 eCollection Date: 2024-01-01 DOI: 10.1155/crom/9910470

Ethan Bernstein, Carter Bernal, Brandon Bol, Jacob Hershenhouse, Matthew Bernstein

{"title":"Digital Papillary Adenocarcinoma at the Site of 5 Years of Recurrent Paronychia: Case Report and Literature Review.","authors":"Ethan Bernstein, Carter Bernal, Brandon Bol, Jacob Hershenhouse, Matthew Bernstein","doi":"10.1155/crom/9910470","DOIUrl":"10.1155/crom/9910470","url":null,"abstract":"Digital papillary adenocarcinoma (DPA) is a rare malignant eccrine tumor often misdiagnosed as a benign condition. A 57-year-old Caucasian male with recurrent paronychia and a subcutaneous mass on the distal phalanx of the right fourth digit was diagnosed with DPA after seeking hand surgery evaluation 5 years following onset. A marginal excisional biopsy was positive for Staphylococcus aureus infection and DPA, leading to surgical excision with transmiddle phalangeal amputation for negative margins. DPA, while rare, often presents insidiously, leading to delayed diagnosis and increased risk of metastasis. This tumor has high rates of recurrence and metastasis, most commonly to pulmonary and lymphatic sites. Accurate diagnosis of DPA is challenging due to its resemblance to multiple benign cutaneous conditions. Current treatments focus on surgical excision, with an emphasis on negative margins. Sentinel lymph node biopsy is not routinely performed, although guidelines are difficult to establish due to the rarity of DPA. Diagnosing and treating DPA minimizes metastasis and recurrence. DPA should be considered in patients presenting with recalcitrant or recurring cutaneous lesions. Surgical management remains the primary treatment strategy, with ongoing research needed to optimize treatment protocols and follow-up care.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"9910470"},"PeriodicalIF":0.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Germline TP53 Variant Detected After Radiotherapy-Induced Angiosarcoma of the Chest Wall in a Previously Treated Breast Cancer Patient: A Case Report and Review of Li-Fraumeni Syndrome and Radiotherapy-Induced Sarcoma. 在先前治疗过的乳腺癌患者胸壁血管肉瘤后检测到新的种系TP53变异：Li-Fraumeni综合征和放疗性肉瘤的病例报告和回顾

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Case Reports in Oncological Medicine Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI: 10.1155/crom/6640468

Bruna Bianca Lopes David, Sávio Solon Alves Silva, Vanessa Dinoa, Tadeu Diniz, Emilio Pereira, Carolina Bustamante, Bernardo Garicochea

{"title":"New Germline TP53 Variant Detected After Radiotherapy-Induced Angiosarcoma of the Chest Wall in a Previously Treated Breast Cancer Patient: A Case Report and Review of Li-Fraumeni Syndrome and Radiotherapy-Induced Sarcoma.","authors":"Bruna Bianca Lopes David, Sávio Solon Alves Silva, Vanessa Dinoa, Tadeu Diniz, Emilio Pereira, Carolina Bustamante, Bernardo Garicochea","doi":"10.1155/crom/6640468","DOIUrl":"10.1155/crom/6640468","url":null,"abstract":"Li-Fraumeni syndrome (LFS) is one of the most common hereditary cancer predisposition syndromes in Brazil. The high frequency of the syndrome is due to a founding variant (R337H) in the country. LFS is characterized by a wide variety of malignant phenotypes. Despite the great epidemiological importance of the R337H variant, the frequency of other types of pathogenic variants is like other populations, with the majority of these being missense variants. There is strong evidence that radiotherapy is associated with secondary sarcomas, including angiosarcomas, and this finding is especially true for LFS patients. Angiosarcoma is not described as overrepresented in individuals with LFS, except in patients submitted to radiotherapy. Germline testing in all breast cancer patients under 65 will reveal many germline mutations in TP53 without a family history of cancers associated with the syndrome. We present a case of a previously undescribed pathogenic variant in TP53 (c788del, pAns263llefs⁣∗82) in a patient with no family history of cancer, with a previous diagnosis of breast carcinoma treated with radiotherapy, who developed angiosarcoma after a few years leading to germline testing. The presence of angiosarcoma in a radiotherapy bed should raise suspicion for LFS. The recent recommendation of testing breast cancer patients under the age of 65, even without any family history, can be a source of discoveries of new mutations and assist in therapeutic decisions.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"6640468"},"PeriodicalIF":0.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcoidosis-Like Reaction in Melanoma Patients Receiving Immunotherapy or Targeted Therapy. 接受免疫治疗或靶向治疗的黑色素瘤患者的结节病样反应

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Case Reports in Oncological Medicine Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1155/crom/8947861

Giulia Murgia, Luca Valtellini, Gianluca Nazzaro, Emanuela Passoni, Federica Scarfì, Francesca Boggio, Angelo V Marzano, Ornella Garrone, Nerina Denaro

{"title":"Sarcoidosis-Like Reaction in Melanoma Patients Receiving Immunotherapy or Targeted Therapy.","authors":"Giulia Murgia, Luca Valtellini, Gianluca Nazzaro, Emanuela Passoni, Federica Scarfì, Francesca Boggio, Angelo V Marzano, Ornella Garrone, Nerina Denaro","doi":"10.1155/crom/8947861","DOIUrl":"10.1155/crom/8947861","url":null,"abstract":"This case series highlights the complexity of sarcoidosis-like reactions (SLRs) during cancer treatment, specifically in patients receiving immunotherapy or targeted therapies for melanoma. SLRs can either mimic disease progression or present as part of the clinical manifestation, making diagnosis and treatment challenging. Our study reviewed the medical records of 31 patients who were candidates for postoperative treatment between June 2022 and June 2024. Out of these, three patients developed SLRs during their treatment. A 55-year-old woman with Stage IIIb cutaneous melanoma, receiving adjuvant therapy with anti-PD-1, after seven cycles of pembrolizumab, developed mediastinal node enlargement and skin hypodermic nodes. A biopsy of the hypodermic node revealed granulomatous infiltrates with sparse lymphocytes, consistent with sarcoidosis. A low dose of steroids was administered, resulting in a dramatic improvement. A 48-year-old woman with Stage IIIb BRAF wild-type melanoma, receiving nivolumab every 4 weeks, developed systemic sarcoidosis after seven cycles, primarily affecting extrapulmonary sites. Despite the immune-induced sarcoidosis, her treatment was not stopped, as decided by the multidisciplinary team (MDT). A 65-year-old man with Stage IIIb BRAF-mutant melanoma, receiving dabrafenib and trametinib, developed lung and cutaneous sarcoidosis, presenting with symptoms that led to emergency department admission. In all cases, the MDT played a crucial role in determining the course of treatment and balancing the risks of continuing or suspending cancer therapies while managing SLRs. National and international guidelines were consulted, but tailored decisions by the MDT were essential for optimizing patient care.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"8947861"},"PeriodicalIF":0.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphangitic Carcinomatosis Presenting as Cough: A Case of Occult Metastatic Prostate Adenocarcinoma. 以咳嗽为表现的淋巴管瘤病：一例隐匿转移性前列腺腺癌病例

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Case Reports in Oncological Medicine Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9915126

Sharanya Kumar, Allen Seylani, Rahul Tuli, Eric Abedi, Keerti Khandelwal

{"title":"Lymphangitic Carcinomatosis Presenting as Cough: A Case of Occult Metastatic Prostate Adenocarcinoma.","authors":"Sharanya Kumar, Allen Seylani, Rahul Tuli, Eric Abedi, Keerti Khandelwal","doi":"10.1155/2024/9915126","DOIUrl":"10.1155/2024/9915126","url":null,"abstract":"Background: Lymphangitic carcinomatosis (LC), a hallmark of advanced metastatic cancer with a poor prognosis, primarily impacts the lymphatic system of the lungs, manifesting as progressive breathlessness, cough, or hemoptysis. While prostate cancer commonly metastasizes to bones and regional lymph nodes, lung involvement is rare. This case features a patient in generally good health who presented with an insidious dry cough, leading to a diagnosis of Stage 4 prostatic adenocarcinoma with rare lymphangitic spread to the lungs. Case Presentation: A 70-year-old male in good health presented with chest tightness, a dry cough, and sudden left testicular swelling. Imaging revealed interstitial lung markings, severe left hydronephrosis, and prostatomegaly. A prostate biopsy confirmed adenocarcinoma. A PET-CT scan raised significant concern for LC, prompting the initiation of urgent inpatient chemotherapy with docetaxel. Conclusion: LC is a metastatic pattern commonly associated with solid tumors, particularly breast, gastric, and lung cancers. Its occurrence in prostate cancer is exceptionally rare. This condition is typically linked with advanced disease and a poor prognosis, often serving as a critical indicator of an underlying malignancy that may otherwise go undetected.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"9915126"},"PeriodicalIF":0.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Split-Course High-Dose Palliative Radiotherapy Regimen for Locally Advanced Sinonasal Cancer: A Case Report. 治疗局部晚期鼻窦癌的新型分次高剂量姑息放疗方案：病例报告。

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Case Reports in Oncological Medicine Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9340657

Saif Aljabab, Amna Mohaimeed, Firas AlMomen, Abdullah AlSwailem, Yasir Alayed

{"title":"A Novel Split-Course High-Dose Palliative Radiotherapy Regimen for Locally Advanced Sinonasal Cancer: A Case Report.","authors":"Saif Aljabab, Amna Mohaimeed, Firas AlMomen, Abdullah AlSwailem, Yasir Alayed","doi":"10.1155/2024/9340657","DOIUrl":"10.1155/2024/9340657","url":null,"abstract":"Sinonasal malignancies (SNMs) are rare heterogeneous malignancies that frequently present with locally advanced disease. The prognosis is poor when the disease is considered extensive and unresectable. In such cases, a high-dose palliative radiotherapy regimen is often required, but the ideal dose and fractionation have not been established. We detail a 33-year-old male who initially presented with a progressively growing mass over the right cheek. A biopsy of the lesion revealed squamous cell carcinoma (SCC). Imaging revealed a very advanced and unresectable disease with the involvement of several head and neck subsites. He progressed further after receiving induction chemotherapy from an outside institution. The patient requested prompt tumor and symptom control to travel back to his home country. We offered him high-dose split-course palliative radiotherapy in the form of a quad Shot of 14.80 Gy in four fractions twice daily, followed by 30 Gy in five fractions every other day with a 2-week interval. Treatment resulted in excellent clinical response with symptomatic relief in a short time, and the patient could travel back home safely.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"9340657"},"PeriodicalIF":0.6,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supraglottic Neuroendocrine Carcinoma: A Case Report and Literature Review. 声门上神经内分泌癌：病例报告和文献综述。

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Case Reports in Oncological Medicine Pub Date : 2024-10-01 eCollection Date: 2024-01-01 DOI: 10.1155/2024/6844193

Renda Alhabib, Chaker Zaidi, Abdulrahman Alfryyan, Hanan Albenayyan, Ibrahim Alotain

引用次数: 0

Case Report: An Extremely Rare Case of Epitheloid Type Leiomyoma. 病例报告：极罕见的上皮样子宫肌瘤病例

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Case Reports in Oncological Medicine Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2259872

Mokhamad Zhaffal, Shazia Tariq, Anastasia Salame

{"title":"Case Report: An Extremely Rare Case of Epitheloid Type Leiomyoma.","authors":"Mokhamad Zhaffal, Shazia Tariq, Anastasia Salame","doi":"10.1155/2024/2259872","DOIUrl":"10.1155/2024/2259872","url":null,"abstract":"Introduction: Uterine leiomyomas are a frequent finding in women of reproductive age. However, rare, unusual growth patterns exist, such as atypical, cellular, mitotically active, myxoid, and epithelioid leiomyomas, and present a major concern as they mimic highly malignant uterine tumors such as uterine leiomyosarcomas. An example of such cases is the epithelial type leiomyoma which is the subject of our report in a 35-year-old female. Case: A 35-year-old, nulliparous lady presented with abnormal uterine bleeding to the emergency department. Workup revealed a suspicious uterine mass that was extending from the intramural part of the fundus down the cervical os. The patient was managed by open myomectomy without complications. The final pathology report revealed an extremely rare benign epithelial type leiomyoma, no malignancy, areas with minimal atypia and low mitotic activity (< 5/10 high power fields), and areas of focal necroses (possibly ischemic type) were seen. No coagulative tumor necrosis was noted. Conclusion: Uterine leiomyomas are a common pathology of the uterus that can be confused with malignant tumors, especially in the setting of unusual growth patterns such as the epitheloid leiomyomas. Definitive management involves myomectomies with regular follow-up with favourable prognosis. It is important to properly manage these cases to avoid the overdiagnosis and mistreatment not to mention the repercussion of false diagnoses on the patient's mental health and well-being.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"2259872"},"PeriodicalIF":0.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and Management of a Patient With Chronic Lymphocytic Leukemia and a Concurrent Plasmacytoma. 慢性淋巴细胞白血病和浆细胞瘤并发症患者的诊断和治疗。

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Case Reports in Oncological Medicine Pub Date : 2024-09-24 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8870681

Danielle C Thor, Rohan Umrani, Jack Bergal, Charles Yang, Richard Gordon

引用次数: 0