Case Reports in Oncological Medicine最新文献_第10页

PD-1 Inhibitor Therapy in a Patient with Preexisting P-ANCA Vasculitis: A Case Report and Review of the Literature. PD-1抑制剂治疗先前存在的P-ANCA血管炎患者:1例报告和文献回顾。

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Case Reports in Oncological Medicine Pub Date : 2020-08-31 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3428945

Amanda Ramos, Marcela Del Carmen, Oladapo Yeku

{"title":"PD-1 Inhibitor Therapy in a Patient with Preexisting P-ANCA Vasculitis: A Case Report and Review of the Literature.","authors":"Amanda Ramos, Marcela Del Carmen, Oladapo Yeku","doi":"10.1155/2020/3428945","DOIUrl":"https://doi.org/10.1155/2020/3428945","url":null,"abstract":"Background: Recurrent endometrial cancer after definitive therapy is a lethal disease. Recently, immune checkpoint inhibitors (ICI) have improved the management of mismatch repair-deficient (MSI-H) endometrial cancer. Autoimmune side effects are known to occur with ICI. As a result, patients with preexisting autoimmune diseases are excluded from studies involving these drugs. This has led to challenges in clinical practice regarding the use of ICI in otherwise eligible patients with underlying autoimmune disease. Case Presentation. We present the case of an 81-year-old woman with an underlying autoimmune vasculitis and recurrent, metastatic endometrial adenocarcinoma with microsatellite instability, who was treated with an immune checkpoint inhibitor. This patient received pembrolizumab, an immune checkpoint inhibitor that targets the programmed cell death-1 immune checkpoint. Ultimately, she was treated for 4 months with pembrolizumab and benefited from stable disease during this period. She remained asymptomatic from her underlying autoimmune P-ANCA vasculitis. A review of the scientific literature reveals several cases of the successful use of immune checkpoint inhibitors in patients with autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease.Conclusion: This is one of the first reports of a patient with an underlying autoimmune vasculitis successfully treated with an immune checkpoint inhibitor without exacerbating her underlying autoimmune condition. Carefully selected patients with underlying autoimmune vasculitis can be safely treated with ICI.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3428945","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38483725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Inflammatory Myeloradiculitis Secondary to Pembrolizumab: A Case Report and Literature Review. 派姆单抗继发炎性髓根炎1例报告及文献回顾

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Case Reports in Oncological Medicine Pub Date : 2020-08-18 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8819296

M L Vickers, B Seidl, K Bigby, B Chern, L Eriksson, G Hartnett, C Gericke, R Chew

引用次数: 6

A Rare Case of Metastatic Primary Peritoneal Ependymoma: A Case Report and Literature Review. 一例罕见的转移性原发性腹膜室管膜瘤:1例报告并文献复习。

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Case Reports in Oncological Medicine Pub Date : 2020-08-14 eCollection Date: 2020-01-01 DOI: 10.1155/2020/9805847

Ben Man Fei Cheung, Johnny Kin Sang Lau, Anthony W I Lo, Mai-Yee Luk, Kwok Keung Yuen

{"title":"A Rare Case of Metastatic Primary Peritoneal Ependymoma: A Case Report and Literature Review.","authors":"Ben Man Fei Cheung, Johnny Kin Sang Lau, Anthony W I Lo, Mai-Yee Luk, Kwok Keung Yuen","doi":"10.1155/2020/9805847","DOIUrl":"https://doi.org/10.1155/2020/9805847","url":null,"abstract":"Background Primary peritoneal ependymoma is an exceedingly rare tumour with only four cases reported in the literature. It typically follows an indolent disease course. We describe a rare case of metastatic primary peritoneal ependymoma which was treated with chemotherapy and radiotherapy resulting in prolonged survival to date for 10 years. Case Presentation. The patient was a 23-year-old female on presentation. She presented with right upper quadrant pain associated with an abdominal mass. Computed tomography demonstrated a large mass displacing the liver. Debulking surgery was done revealing a tumour arising from the peritoneum as well as multiple metastatic pleural and peritoneal nodules. Pathology was consistent with primary peritoneal ependymoma. The patient was then treated with multiple lines of chemotherapy containing etoposide as the backbone. She also received palliative radiotherapy to the thoracic metastases with good and durable response. Conclusion We reported a rare case of metastatic primary peritoneal ependymoma. Etoposide containing the chemotherapy regimen is effective in the treatment of peritoneal ependymoma. Radiotherapy is also effective for palliation of local symptoms with durable response.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9805847","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38339330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Metastatic Syringocystadenocarcinoma Papilliferum: A Case Report, Tumor Genomic Profiling, and Literature Review. 转移性浆液性乳头状瘤：病例报告、肿瘤基因组图谱分析和文献综述。

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Case Reports in Oncological Medicine Pub Date : 2020-08-08 eCollection Date: 2020-01-01 DOI: 10.1155/2020/9056209

Erdem Altunel, Aleksandr Perepletchikov, Olga Kozyreva

{"title":"Metastatic Syringocystadenocarcinoma Papilliferum: A Case Report, Tumor Genomic Profiling, and Literature Review.","authors":"Erdem Altunel, Aleksandr Perepletchikov, Olga Kozyreva","doi":"10.1155/2020/9056209","DOIUrl":"10.1155/2020/9056209","url":null,"abstract":"Syringocystadenocarcinoma papilliferum (SCACP) is an extremely rare cutaneous neoplasm of the apocrine or eccrine sweat glands. Solid and cystic glandular structures with cribriform and tubular architecture along with CK5/6, pankeratin and p63 immuno-profile set apart SCACP from other cutaneous malignancies. Wide local excision (WLE) has been the mainstay treatment for localized SCACP; however, no standard treatment has yet been established for unresectable or metastatic disease. Herein, we report a 74-year-old male with SCACP, who initially presented with a painful nodule on the upper back and later developed metastatic disease. He was treated with carboplatin and paclitaxel with concurrent intensity-modulated radiation therapy (IMRT), which resulted in disease stabilization for 12 months. Next generation sequencing (NGS) revealed a total of 18 genomic alterations associated with potential benefit from targeted therapeutics. PD-L1 expression was identified in 70% of tumor cells. These findings suggest that the opportunity of targeted therapeutics and immunotherapy exist as for metastatic SCACP. Reporting molecular profile of the rare tumors with no established standard treatment options should be encouraged.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38313181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pituitary Metastatic Composite Tumors: A Case Report with Next-Generation Sequencing and Review of the Literature. 垂体转移性复合肿瘤:1例新一代测序报告及文献回顾。

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Case Reports in Oncological Medicine Pub Date : 2020-07-21 eCollection Date: 2020-01-01 DOI: 10.1155/2020/5073236

Matthew Helton, Muhammad Abu-Rmaileh, Kevin Thomas, Murat Gokden, Alissa Kanaan, Analiz Rodriguez

{"title":"Pituitary Metastatic Composite Tumors: A Case Report with Next-Generation Sequencing and Review of the Literature.","authors":"Matthew Helton, Muhammad Abu-Rmaileh, Kevin Thomas, Murat Gokden, Alissa Kanaan, Analiz Rodriguez","doi":"10.1155/2020/5073236","DOIUrl":"https://doi.org/10.1155/2020/5073236","url":null,"abstract":"Background: While pituitary tumors are well understood, little research has been done on metastasis from primary tumors into pituitary adenomas, also known as composite tumors. Because only 34 cases of composite tumors have been reported to date, we hope to better characterize these tumors by reviewing cases reported in the literature and reviewed our own documented case, which includes next-generation sequencing. Case Presentation. A 74-year-old man presented to the emergency department with left vision loss for 3 months. He had a history of colon cancer treated with colectomy and clear cell renal carcinoma treated with left nephrectomy. A preoperative MRI demonstrated growth of a peripherally enhancing, centrally necrotic mass with sellar expansion measuring 5.7 × 3.1 × 3.0 cm. Given these findings, an endoscopic endonasal transsphenoidal resection was performed. Histological assessment revealed a composite tumor: one neoplasm was a nonfunctioning pituitary adenoma, and another neoplasm was a clear cell carcinoma. Next-generation sequencing demonstrated that the tumors shared mutations in VHL and Notch2. The patient died 2 months later from systemic metastatic cancer.Conclusion: From our literature review, most metastatic lesions in these composite tumors originated from neoplasms of the lung and kidney. Approximately 63% patients presented with ophthalmoplegia as the initial symptom while 23% displayed hormonal abnormalities. Postoperative mortality had a median of 3.5 months. In our patient, the presence of VHL and Notch2 mutations in both tumors highlights the possibility of using next-generation sequencing to help identify therapeutic targets even in complex composite neoplasms.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5073236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38246915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil. 罕见的与5-氟尿嘧啶相关的心脏毒性。

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Case Reports in Oncological Medicine Pub Date : 2020-07-20 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4151474

Mariam Charkviani, Natia Murvelashvili, Francisco Barrera, Alisha Sharma, Randa Sharag Eldin, Nur Un Nisa Nabil

{"title":"Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil.","authors":"Mariam Charkviani, Natia Murvelashvili, Francisco Barrera, Alisha Sharma, Randa Sharag Eldin, Nur Un Nisa Nabil","doi":"10.1155/2020/4151474","DOIUrl":"https://doi.org/10.1155/2020/4151474","url":null,"abstract":"5-Fluorouracil (5-FU) is a chemotherapeutic agent frequently used for the treatment of solid tumors. In a few cases, 5-FU can be associated with coronary vasospasm, cardiac ischemia, or life-threatening arrhythmias. Recognition of 5-FU cardiotoxicity is clinically important as after the rapid sensation of therapy, cardiotoxicity can be completely reversible, and on the other hand, readministration may lead to serious damage of the heart and even death. A 70-year-old male came to the emergency department (ED) with chest pain which started while receiving an infusion of 5-FU. The patient did not have a personal history or risk factors of coronary artery disease and his electrocardiogram (ECG) before starting chemotherapy was completely normal. In the ED, his ECG had ischemic changes, troponin was elevated, and echocardiogram showed anterior wall hypokinesis. However, emergent coronary angiogram did not reveal any acute coronary occlusion. 5-FU-induced cardiotoxicity was suspected; the patient was admitted to a progressive care unit for close monitoring and infusion of calcium channel blockers was initiated. The patient's symptoms and ECG findings gradually resolved, and two days later on discharge, patient was chest pain free and ECG was normal. This case supports the vasospastic hypothesis of 5-FU cardiac toxicity, describes its clinical course, and emphasizes the importance of better awareness and early recognition of the rare side effect as it may allow physicians to reduce the risk of life-threatening complications.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4151474","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38246914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Inflammatory Myofibroblastic Tumor: A Rare Presentation and an Effective Treatment with Crizotinib. 炎性肌纤维母细胞瘤：罕见的表现形式和克唑替尼的有效治疗方法

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Case Reports in Oncological Medicine Pub Date : 2020-07-09 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6923103

Sumaira Khalil, Tariq Ghafoor, Amna Kaneez Fatima Raja

{"title":"Inflammatory Myofibroblastic Tumor: A Rare Presentation and an Effective Treatment with Crizotinib.","authors":"Sumaira Khalil, Tariq Ghafoor, Amna Kaneez Fatima Raja","doi":"10.1155/2020/6923103","DOIUrl":"10.1155/2020/6923103","url":null,"abstract":"Inflammatory myofibroblastic tumor (IMT) is a rare entity of neoplastic origin. It usually occurs in children and adolescents and most commonly involves pulmonary and gastrointestinal sites. Here, the authors present two cases; one is the nine months old boy with a subcutaneous IMT in the left temporal region that was treated successfully with surgical resection. To the best of our knowledge, this is the first reported case of a subcutaneous IMT in this particular region. The second is an eight years old girl with an IMT of the right hemi-pelvis. The mass had complete surgical excision with clear margins and no residual disease. She was kept on regular follow-up with ultrasound abdomen. However, her disease relapsed with the appearance of lesions in right iliac fossa, right ovary, and liver. Biopsy of the relapsed abdominal mass confirmed ALK-positive IMT. She was treated with ALK inhibitor Crizotinib. She was monitored with regular blood complete picture, hepatic and renal function test, and ultrasound abdomen. Her lesions started regressing within one month, and she achieved complete remission after 6 months of treatment.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38179183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corneal Perforation during Combination Chemotherapy including Cetuximab in a Patient with a History of Herpetic Keratitis. 有疱疹性角膜炎病史患者联合化疗包括西妥昔单抗期间的角膜穿孔。

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Case Reports in Oncological Medicine Pub Date : 2020-07-07 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6802408

Keiichi Aomatsu, Koji Sugioka, Aya Kodama-Takahashi, Masahiko Fukuda, Hiroshi Mishima, Shunji Kusaka

{"title":"Corneal Perforation during Combination Chemotherapy including Cetuximab in a Patient with a History of Herpetic Keratitis.","authors":"Keiichi Aomatsu, Koji Sugioka, Aya Kodama-Takahashi, Masahiko Fukuda, Hiroshi Mishima, Shunji Kusaka","doi":"10.1155/2020/6802408","DOIUrl":"https://doi.org/10.1155/2020/6802408","url":null,"abstract":"Purpose: To report a case of corneal perforation, in a patient with a history of herpetic keratitis, during combination chemotherapy including cetuximab.Case: We report the case of a 71-year-old man who was diagnosed with a hypopharyngeal carcinoma and received radiation therapy combined with cetuximab, the epidermal growth factor receptor (EGFR) inhibitor monoclonal antibody. He was referred to us because of ocular hyperemia and corneal perforation in his left eye. In spite of conservative therapy, his corneal perforation was exacerbated, with iris incarceration into the wound site and exposure to the surface of the cornea. He therefore discontinued treatment with the combination chemotherapy and underwent lamellar keratoplasty using a preserved donor cornea. After treatment with cetuximab resumed, there was no recurrence of the corneal perforation.Conclusion: We have presented the first case of cetuximab-related corneal perforation in a patient who had a history of recurrent herpetic keratitis. EGFR inhibitors, such as cetuximab, can induce corneal perforation in cases with a history of herpetic stromal keratitis.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6802408","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38205529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Malignant Gastrointestinal Neuroectodermal Tumor (GNET) with Prolonged Disease-Free Survival after Platinum-Based Chemotherapy. 恶性胃肠道神经外胚层肿瘤(GNET)在铂基化疗后延长无病生存期。

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Case Reports in Oncological Medicine Pub Date : 2020-06-30 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8880202

Daulath Singh, Mohammed K Atieh, Mark A Russell, Muaiad Kittaneh

引用次数: 6

Peripheral Medulloepithelioma: A Rare Entity to Know. 外周髓样上皮瘤:一种罕见的肿瘤。

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Case Reports in Oncological Medicine Pub Date : 2020-06-26 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6817407

W Matrane, S Cherkaoui, M Regragui, N Bennani Guebessi, M Karkouri, S Salam, A Madani, A Quessar, N Khoubila

引用次数: 1