Case Reports in Oncological Medicine最新文献_第10页

Malignant Gastrointestinal Neuroectodermal Tumor (GNET) with Prolonged Disease-Free Survival after Platinum-Based Chemotherapy. 恶性胃肠道神经外胚层肿瘤(GNET)在铂基化疗后延长无病生存期。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-06-30 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8880202

Daulath Singh, Mohammed K Atieh, Mark A Russell, Muaiad Kittaneh

引用次数: 6

Peripheral Medulloepithelioma: A Rare Entity to Know. 外周髓样上皮瘤:一种罕见的肿瘤。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-06-26 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6817407

W Matrane, S Cherkaoui, M Regragui, N Bennani Guebessi, M Karkouri, S Salam, A Madani, A Quessar, N Khoubila

引用次数: 1

Clinical Significance of Pain in Differential Diagnosis between Spinal Meningioma and Schwannoma. 疼痛在脊髓脑膜瘤和神经鞘瘤鉴别诊断中的临床意义。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-06-26 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7947242

Dorota Olex-Zarychta

引用次数: 2

Response to Ipilimumab/Nivolumab Rechallenge and BRAF Inhibitor/MEK Inhibitor Rechallenge in a Patient with Advanced Metastatic Melanoma Previously Treated with BRAF Targeted Therapy and Immunotherapy. 曾接受 BRAF 靶向疗法和免疫疗法治疗的晚期转移性黑色素瘤患者对伊匹单抗/尼伐单抗再挑战和 BRAF 抑制剂/MEK 抑制剂再挑战的反应。

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2020-06-25 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4392562

Caitlyn N Myrdal, Srinath Sundararajan

{"title":"Response to Ipilimumab/Nivolumab Rechallenge and BRAF Inhibitor/MEK Inhibitor Rechallenge in a Patient with Advanced Metastatic Melanoma Previously Treated with BRAF Targeted Therapy and Immunotherapy.","authors":"Caitlyn N Myrdal, Srinath Sundararajan","doi":"10.1155/2020/4392562","DOIUrl":"10.1155/2020/4392562","url":null,"abstract":"Little is known about the optimal sequencing of targeted therapy and immunotherapy in the treatment of patients with BRAFV600-mutated metastatic melanoma. BRAF/MEK inhibition often has the benefit of rapid disease regression; however, resistance is frequently seen with long-term use. Treatment with immune checkpoint inhibitors offers the potential for long-term response but displays a lower rate of objective response. The benefit of synergy between therapies is apparent; however, there is limited data regarding optimal sequencing in the treatment of advanced melanoma. We present the case of a 62-year-old gentleman with advanced BRAFV600-mutated melanoma who followed an unconventional treatment path. After progressing on single-agent vemurafenib, he had response to multiple modalities of immunotherapy before progression. After, he had a substantial response to multiple BRAF/MEK inhibitor rechallenges before developing resistance. The patient is now stable after a retrial of combination immunotherapy. Our case illustrates that with the right sequencing of therapy, meaningful clinical responses can be elicited with rechallenging of targeted therapy and immunotherapy in metastatic melanoma.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2020 ","pages":"4392562"},"PeriodicalIF":0.6,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38156899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer. 奥沙利铂诱导的胃癌Lhermitte征象

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-06-24 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8826657

Takeshi Okamoto, Koichi Takagi, Katsuyuki Fukuda

引用次数: 3

Readministration of Cancer Drugs in a Patient with Chemorefractory Metastatic Colorectal Cancer. 一名化疗难治性转移性结直肠癌患者的抗癌药再用药。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-06-23 eCollection Date: 2020-01-01 DOI: 10.1155/2020/2351810

Tetsuro Kawagoe, Go Ikeda, Yu Oshiro, Yuta Maruki, Keiko Kaneko, Katsuhiko Iwakiri

{"title":"Readministration of Cancer Drugs in a Patient with Chemorefractory Metastatic Colorectal Cancer.","authors":"Tetsuro Kawagoe, Go Ikeda, Yu Oshiro, Yuta Maruki, Keiko Kaneko, Katsuhiko Iwakiri","doi":"10.1155/2020/2351810","DOIUrl":"https://doi.org/10.1155/2020/2351810","url":null,"abstract":"A 63-year-old woman was admitted to our institution for severe pain in her right lower abdomen caused by the perforation of cecal cancer. She underwent emergency surgery, from which she was diagnosed with cecal carcinoma with liver, lung, and lymph node metastases. As she was taking aspirin to prevent cerebral infarction, anti-vascular endothelial growth factor (receptor) antibody and regorafenib therapy were not used. Thus, we started a modified FOLFOX 6+cetuximab regimen. This first-line treatment initially achieved a partial response (PR), but she then developed progressive disease (PD) after 14 months. We changed the regimen to FOLFIRI, followed by trifluridine/tipiracil, but her progression-free survival periods were 2.7 months and 1 month, respectively. Although we cycled through the available array of standard cancer drugs, the patient showed a good performance status, and some benefit from treatment still seemed plausible. We readministered the 5-fluorouracil oral preparation S-1, which maintained stable disease (SD) for 7 months. After PD emerged, we readministered the anti-epidermal growth factor receptor (EGFR) antibody panitumumab for 7.5 months of SD. Finally, 39 months after her diagnosis, she died from rapidly progressing disease. However, her relatively long survival implies that readministering drugs similar to those used in previous regimens might benefit patients with metastatic colorectal cancer.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2020 ","pages":"2351810"},"PeriodicalIF":0.9,"publicationDate":"2020-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/2351810","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38144448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Leiomyosarcoma of the Gallbladder. 原发性胆囊平滑肌肉瘤。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-06-22 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3603689

Anwar Chammout, Mike Ghabally, Christina Masri, Nour Tantak, Fadi Ward, Ghefar Omar

{"title":"Primary Leiomyosarcoma of the Gallbladder.","authors":"Anwar Chammout, Mike Ghabally, Christina Masri, Nour Tantak, Fadi Ward, Ghefar Omar","doi":"10.1155/2020/3603689","DOIUrl":"https://doi.org/10.1155/2020/3603689","url":null,"abstract":"Leiomyosarcoma (LMS) of the gallbladder is an extremely rare entity. Most reported cases were mistakenly diagnosed preoperatively as cholecystitis with or without cholelithiasis. We believe that our article demonstrates the 5th case of gallbladder LMS that was suspected preoperatively to be malignant rather than cholecystitis, which fortunately led to radical resection of the tumor instead of simple cholecystectomy. However, the definitive diagnosis relies exclusively on histological and immunohistochemical techniques. We present a case of a 62-year-old Caucasian female complaining of signs and symptoms suggestive for cholecystitis. On ultrasonography, the gallbladder appeared enlarged and filled with a necrotic mass; thus, the presence of adenocarcinoma was suspected. Multislice Computerized Tomography (MSCT) demonstrated no distant metastasis. An extensive radical cholecystectomy was performed, and histological techniques confirmed a leiomyosarcoma diagnosis. In addition, adjuvant chemotherapy of doxorubicin and ifosfamide was administrated. The patient was on follow-up for 2 years and is doing well till date. The discrimination of gallbladder sarcoma preoperatively remains a clinical and radiological challenge. Although radical resection of the tumor remains the mainstay of the treatment, we believe that adjuvant chemotherapy should be administrated in such cases. However, further studies are required in this field.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2020 ","pages":"3603689"},"PeriodicalIF":0.9,"publicationDate":"2020-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3603689","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38156898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer. 贝伐单抗治疗卵巢癌患者中性粒细胞减少性小肠结肠炎引起的肠道穿孔。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-06-16 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7231358

Akinori Sasaki, Kenichi Harano, Takahiro Kogawa, Nobuaki Matsubara, Yoichi Naito, Ako Hosono, Hirofumi Mukai, Takayuki Yoshino, Toru Mukohara

引用次数: 1

Localized Chronic Form of Langerhans Cell Histiocytosis in the Femur of a 16-Year-Old Male Successfully Treated with Radiofrequency Ablation. 16岁男性股骨局部慢性朗格汉斯细胞组织细胞增多症经射频消融术成功治疗。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-06-16 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4052034

Kyriakos Papavasiliou, Antonia Bintoudi, Apostolos Vlahodimos, Eleftherios Tsiridis, Prodromos Hytiroglou, Ioannis Tsitouridis, Fares Sayegh

引用次数: 1

Peripheral Cytotoxic T Cell Lymphoma of the Appendix Presenting as Acute Appendicitis. 阑尾周围细胞毒性T细胞淋巴瘤表现为急性阑尾炎。

IF 0.9

Case Reports in Oncological Medicine Pub Date : 2020-06-16 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8569426

Negin Rahmani, Yahya Daneshbod, Hadi Mirfazaelian, Elnaz Vahidi, Sadegh Shirian

{"title":"Peripheral Cytotoxic T Cell Lymphoma of the Appendix Presenting as Acute Appendicitis.","authors":"Negin Rahmani, Yahya Daneshbod, Hadi Mirfazaelian, Elnaz Vahidi, Sadegh Shirian","doi":"10.1155/2020/8569426","DOIUrl":"https://doi.org/10.1155/2020/8569426","url":null,"abstract":"Introduction: Lymphoma of the appendix is a rare cause of acute appendicitis; however, acute appendicitis is a common first manifestation of appendiceal lymphomas. Cytotoxic peripheral T cell lymphoma (PTCL) is a type of aggressive non-Hodgkin lymphoma that portends a generally poor outcome. Cytotoxic PTCL of the appendix is extremely rare with few cases reported in the literature. Case Presentation. This is the report of a 23-year-old man who had experienced lower abdominal pain for three months before presenting to the emergency department with severe right lower abdominal pain, nausea, vomiting, and anorexia since the day prior to admission. The patient was diagnosed with acute appendicitis, and the pathology report confirmed cytotoxic PTCL of the appendix.Conclusion: Patients with appendiceal PTCL commonly present with signs and symptoms of acute appendicitis due to luminal obstruction by the tumor. Therefore, appendiceal tumors such as PTCL should be considered in the differential diagnosis of patients presenting as acute appendicitis. In addition, since there is no standard chemotherapy regimen for cytotoxic PTCL, this and other case reports hopefully help in providing the clinical evidence needed for establishing appropriate treatment guidelines.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2020 ","pages":"8569426"},"PeriodicalIF":0.9,"publicationDate":"2020-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8569426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38114953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0