Case Reports in Oncological Medicine最新文献_第2页

Synchronous Primary Malignancies: Incidental Detection of Ascending Colon Adenocarcinoma During Staging of Invasive Ductal Carcinoma of the Breast. 同步原发恶性肿瘤：在乳腺浸润性导管癌分期中偶然发现升结肠腺癌。

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.1155/crom/7164628

Salif Balde, Ulrich Igor Mbessoh Kengne, Jaafar Ibn Abou Talib Thiam, Joël Gabin Konlack Mekontso, Sokhna Diop Niang, Amacoumba Fall, Mamadou Ndiaye, Gorgui Sarr, Etienne Tossou Zoure, Mamadou Sow, Sidy Ka

{"title":"Synchronous Primary Malignancies: Incidental Detection of Ascending Colon Adenocarcinoma During Staging of Invasive Ductal Carcinoma of the Breast.","authors":"Salif Balde, Ulrich Igor Mbessoh Kengne, Jaafar Ibn Abou Talib Thiam, Joël Gabin Konlack Mekontso, Sokhna Diop Niang, Amacoumba Fall, Mamadou Ndiaye, Gorgui Sarr, Etienne Tossou Zoure, Mamadou Sow, Sidy Ka","doi":"10.1155/crom/7164628","DOIUrl":"https://doi.org/10.1155/crom/7164628","url":null,"abstract":"Multiple primary malignant neoplasms (MPMNs) are defined as two or more distinct tumors in the same individual. Synchronous breast and colon cancers are infrequent and present management challenges due to the lack of standardized guidelines. We report a 73-year-old woman presenting with a right breast mass, subsequently diagnosed as Grade 2 invasive ductal carcinoma. Staging CT incidentally revealed right colon wall thickening, and colonoscopy with biopsy confirmed moderately differentiated invasive adenocarcinoma. Following neoadjuvant chemotherapy, she underwent simultaneous radical mastectomy with axillary lymph node dissection and right hemicolectomy. Postoperative recovery was uneventful. Adjuvant chemoradiation was administered per multidisciplinary team (MDT) recommendation. Synchronous breast and colon cancers pose unique diagnostic and treatment planning challenges. MDT collaboration is crucial for personalized treatment strategies and optimized outcomes in these complex cases.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2025 ","pages":"7164628"},"PeriodicalIF":0.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune Checkpoint Inhibitor-Mediated Aseptic Meningitis and Hypophysitis. 免疫检查点抑制剂介导的无菌性脑膜炎和垂体炎。

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2025-03-08 eCollection Date: 2025-01-01 DOI: 10.1155/crom/3517328

Pavel Bleik, Panisara Fangsaard, Nataliya Yuklyaeva

引用次数: 0

Remarkable Antitumor Effects and Serious Multiple Immune-Related Adverse Events in Malignant Pleural Mesothelioma: Two Case Reports. 恶性胸膜间皮瘤的显著抗肿瘤作用和严重的多重免疫相关不良事件2例报告

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2025-03-03 eCollection Date: 2025-01-01 DOI: 10.1155/crom/8768823

Koharu Harada, Hidehiro Irie, Akifumi Mitsuishi, Takahiro Fukui, Nao Takada, Ryosuke Nagaoka, Yohei Funatsu, Hidefumi Koh

引用次数: 0

Intraoperative Cortical Sensorimotor Mapping During Glioma Resection Monitored With Drum Playing During Awake Craniotomy: A Case Report. 清醒开颅术中鼓声监测脑胶质瘤切除术中皮层感觉运动映射：1例报告。

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1155/crom/4625899

Priscella Asman, Israt Tasnim, Matthew Muir, Mathew Hall, Kyle Noll, Sarah Prinsloo, Giuseppe Pellizzer, Shreyas Bhavsar, Sudhakar Tummala, Nuri Ince, Sujit Prabhu

{"title":"Intraoperative Cortical Sensorimotor Mapping During Glioma Resection Monitored With Drum Playing During Awake Craniotomy: A Case Report.","authors":"Priscella Asman, Israt Tasnim, Matthew Muir, Mathew Hall, Kyle Noll, Sarah Prinsloo, Giuseppe Pellizzer, Shreyas Bhavsar, Sudhakar Tummala, Nuri Ince, Sujit Prabhu","doi":"10.1155/crom/4625899","DOIUrl":"10.1155/crom/4625899","url":null,"abstract":"Background: Tumors infiltrating the precentral gyrus remain a unique operative challenge. In this study, we explored a novel approach for awake craniotomy involving a patient playing a drum pad during resection of low-grade glioma, with the use of preoperative navigated transcranial magnetic stimulation (nTMS)-generated diffusion tensor imaging (DTI) and high-density real-time electrocorticography (ECoG). Observation: A 36-year-old left-handed male with a low-grade glioma in the left hemisphere hand knob region had a grand mal seizure. We combined preoperative nTMS-DTI with intraoperative passive functional mapping using high-density real-time ECoG. During an awake craniotomy, the patient played a drum pad while we assessed somatosensory-evoked potentials (SSEPs) using a 64-channel ECoG grid. This confirmed the absence of motor-evoked potentials (MEPs) over the tumor area, consistent with nTMS findings. Continuous monitoring of the patient's drum pad performance during the resection allowed for a gross total resection (GTR) of the tumor. Following the resection, he experienced some weakness in the intrinsic muscles of his right hand, which returned to full normal function at 6 months. At the end of 1 year, he remained seizure-free. Conclusion: A multimodal mapping strategy combined with awake monitoring of drum playing enabled preservation of function while achieving GTR in a patient with a motor-eloquent glioma.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2025 ","pages":"4625899"},"PeriodicalIF":0.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Data From Patients Who Received Pembrolizumab in Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma. 局部晚期或转移性皮肤鳞状细胞癌患者接受派姆单抗治疗的长期数据

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2025-02-23 eCollection Date: 2025-01-01 DOI: 10.1155/crom/7038584

Katrine Elsner Melgaard, Camilla Kjaer Lonkvist, Anni Linnet Nielsen, Dorte Lisbet Nielsen, Rikke Løvendahl Eefsen

{"title":"Long-Term Data From Patients Who Received Pembrolizumab in Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma.","authors":"Katrine Elsner Melgaard, Camilla Kjaer Lonkvist, Anni Linnet Nielsen, Dorte Lisbet Nielsen, Rikke Løvendahl Eefsen","doi":"10.1155/crom/7038584","DOIUrl":"10.1155/crom/7038584","url":null,"abstract":"Nonmelanoma skin cancer (NMSC) is one of the most common cancers worldwide and cutaneous squamous cell carcinoma (CSCC) is the second most prevalent type of the NMSCs. Most often, the prognosis is good when treated with surgery with or without additional radiotherapy; however, in about 1% of patients, the disease is inoperable or advanced with no curative potential. We present four cases in which the immune checkpoint inhibitor pembrolizumab was given to patients with advanced CSCC. Three patients obtained complete response (CR) with an ongoing duration of response with a follow-up time of 60, 78, and 79 months and one who achieved stable disease (SD) as the best response. Two of the patients discontinued treatment after eight cycles of pembrolizumab due to side effects. Immunotherapy with a programmed death protein 1 (PD-1) inhibitor is an approved therapy for these patients today. The successful treatment with long-term duration of response of these three out of four patients supports the use of a PD-1 inhibitor as a primary treatment for locally advanced and metastatic CSCC.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2025 ","pages":"7038584"},"PeriodicalIF":0.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric T-Cell/Histiocyte-Rich Large B-Cell Lymphoma (THRLBC) in an 8-Year-Old Male Child: A Case Report. 儿童t细胞/组织细胞丰富的大b细胞淋巴瘤（THRLBC） 1例8岁男童

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2025-02-22 eCollection Date: 2025-01-01 DOI: 10.1155/crom/8869045

Gashaw Arega, Haileyesus Adam, Alemayehu Girma, Galgaloo Diida, Eden Beresa, Leul Adane, Michael A Negussie, Fadil Nuredin Abrar, Mesfin Asefa

{"title":"Pediatric T-Cell/Histiocyte-Rich Large B-Cell Lymphoma (THRLBC) in an 8-Year-Old Male Child: A Case Report.","authors":"Gashaw Arega, Haileyesus Adam, Alemayehu Girma, Galgaloo Diida, Eden Beresa, Leul Adane, Michael A Negussie, Fadil Nuredin Abrar, Mesfin Asefa","doi":"10.1155/crom/8869045","DOIUrl":"https://doi.org/10.1155/crom/8869045","url":null,"abstract":"T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare and aggressive subtype of diffuse large B-cell lymphoma (DLBCL) that is uncommon in children. Here, we present the case of an 8-year-old male with a 3-month history of low-grade intermittent fever, significant weight loss, loss of appetite, and progressive abdominal swelling. Examination revealed splenomegaly and a palpable midabdominal mass, with laboratory findings showing bicytopenia. Imaging demonstrated hepatosplenomegaly, diffuse hypodense liver and spleen lesions, and mesenteric and retroperitoneal lymphadenopathy. A core-needle biopsy of the mesenteric mass confirmed the diagnosis, with histopathology revealing scattered large mononuclear and binucleate cells in a background of small lymphocytes and histiocytes. Immunohistochemistry showed positivity for CD45, CD20, and EMA and negativity for CD30, CD15, and Bcl-2, excluding alternative diagnoses such as nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and classical Hodgkin lymphoma (cHL). The patient was initially stabilized with a prephase regimen of cyclophosphamide, vincristine, and prednisone (COP), followed by induction and consolidation with R-COPADM (rituximab, cyclophosphamide, vincristine, prednisone, and methotrexate). Posttreatment imaging revealed significant resolution of lymphadenopathy and hepatosplenomegaly, with no residual or recurrent disease. At follow-up, the patient remains in clinical remission with no signs of progression. This case highlights the importance of early recognition, detailed histopathological evaluation, and the role of immunohistochemistry in accurately diagnosing THRLBCL in children, ensuring timely initiation of effective therapy and improving outcomes in this rare pediatric malignancy.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2025 ","pages":"8869045"},"PeriodicalIF":0.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Detection of Krukenberg Tumors Utilizing ctDNA Testing and CEA Monitoring. 利用ctDNA检测和CEA监测早期检测Krukenberg肿瘤。

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI: 10.1155/crom/5335858

Angela M DeRidder, Corrine M Check, Paul R Kunk, Christina Martin

{"title":"Early Detection of Krukenberg Tumors Utilizing ctDNA Testing and CEA Monitoring.","authors":"Angela M DeRidder, Corrine M Check, Paul R Kunk, Christina Martin","doi":"10.1155/crom/5335858","DOIUrl":"https://doi.org/10.1155/crom/5335858","url":null,"abstract":"Krukenberg tumors are rare cancers involving metastatic disease in the ovaries but classically originate from gastrointestinal malignancies, and often present diagnostic challenges due to their nonspecific symptoms and advanced stage at detection. Traditional imaging techniques like ultrasound, CT, and MRI are common methods of cancer monitoring but are limited in detecting micrometastatic disease and early-stage metastases. Circulating tumor DNA (ctDNA) testing, a noninvasive liquid biopsy method, offers a promising alternative to traditional screening methods, enabling earlier detection and precise molecular profiling of metastatic tumors. We present a case study involving a female patient who initially presented with stage IV colon cancer with oligometastatic disease to a single mesenteric lymph node. Despite neoadjuvant chemotherapy and resection of known disease, postresection ctDNA returned positive. Imaging after metastectomy failed to reveal any sites of ongoing disease, although did show a small, 2.4-cm hypodensity in the right ovary interpreted by radiology as likely an ovarian follicle. Given her ctDNA positivity, she was started on capecitabine. ctDNA levels improved, but her serum carcinoembryonic antigen (CEA) tumor marker continued to rise, and imaging subsequently revealed increased bilateral ovarian masses. She underwent bilateral salpingo-oophorectomy and total abdominal hysterectomy, with pathology confirming metastatic colon adenocarcinoma, and subsequent normalization of her CEA and ctDNA levels. Our findings underscore ctDNA's potential to complement imaging, particularly for high-risk patients, for disease monitoring and to refine therapeutic management when treating Krukenberg tumors.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2025 ","pages":"5335858"},"PeriodicalIF":0.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epithelioid Hemangioendothelioma (EHE) Mimicking Mesothelioma: Case Presentation and Review. 上皮样血管内皮瘤（EHE）模拟间皮瘤：病例报告和回顾。

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.1155/crom/9459565

Kabir Grewal, Saivaroon Gajagowni, Elyse Lopez, Kayanaat Grewal, Son Viet Nguyen

引用次数: 0

Coexistence of T-Cell Lymphoblastic Lymphoma and Ichthyosis Vulgaris: A Case Report. t细胞淋巴母细胞淋巴瘤与寻常性鱼鳞病共存1例。

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI: 10.1155/crom/5023552

Şule Çalışkan Kamış, Begül Yağcı

{"title":"Coexistence of T-Cell Lymphoblastic Lymphoma and Ichthyosis Vulgaris: A Case Report.","authors":"Şule Çalışkan Kamış, Begül Yağcı","doi":"10.1155/crom/5023552","DOIUrl":"10.1155/crom/5023552","url":null,"abstract":"Ichthyosis vulgaris (IV) is an inherited disorder characterized by the scaling of the skin. It is caused by mutations in the filaggrin gene. IV is a reactive skin manifestation that may be associated with malignant hematological disease. Its association with neoplastic diseases such as Hodgkin lymphoma, anaplastic large-cell lymphoma, and mycosis fungoides has been reported. T-cell non-Hodgkin lymphoma (T-NHL) with ichthyosis has been rarely reported in the literature. Here, we report a case of T-cell lymphoma with congenital IV caused by a desmoglein 1 (DSG1) gene mutation associated with hyper-IgE syndrome (HIES). A 7-year-old male patient with a diagnosis of congenital IV had a biopsy performed at an external center due to multiple lymphadenopathies, which revealed T-cell lymphoblastic lymphoma. A homozygous variant in the DSG1 gene was detected through whole-exome sequencing. The diagnosis of HIES was confirmed through clinical evaluation, including elevated serum IgE levels and associated symptoms. Skin findings, growth retardation, and HIES overlap with Online Mendelian Inheritance in Man (OMIM) #615508, and parental carrier status was confirmed. The association between ichthyosis and lymphoma was determined based on the presence of lymphoma in a patient with congenital ichthyosis and the identification of a genetic mutation in DSG1. In conclusion, the coexistence of lymphoma and IV is rare. The mechanisms of their formation are different, and they can occur independently. Rare genetic syndromes or inherited diseases can cause different health problems, such as lymphoma and ichthyosis, to occur together.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2025 ","pages":"5023552"},"PeriodicalIF":0.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Mitral Regurgitation-Induced Acute Heart Failure due to Nonbacterial Thrombotic Endocarditis in a Patient With Urothelial Carcinoma Recurrence. 尿路上皮癌复发患者非细菌性血栓性心内膜炎所致严重二尖瓣反流致急性心力衰竭。

IF 0.6

Case Reports in Oncological Medicine Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI: 10.1155/crom/9938933

Catarina Santos Reis, Francisco Dias, Bárbara Granja, Maria Inês Matos, Ana Ribeiro, Fernando Friões

{"title":"Severe Mitral Regurgitation-Induced Acute Heart Failure due to Nonbacterial Thrombotic Endocarditis in a Patient With Urothelial Carcinoma Recurrence.","authors":"Catarina Santos Reis, Francisco Dias, Bárbara Granja, Maria Inês Matos, Ana Ribeiro, Fernando Friões","doi":"10.1155/crom/9938933","DOIUrl":"10.1155/crom/9938933","url":null,"abstract":"Nonbacterial thrombotic endocarditis is a rare condition characterized by the formation of noninfectious vegetations on the heart valves. It is related with systemic embolic phenomena occurring predominantly in advanced cancer stages, particularly adenocarcinomas. It is a diagnosis of exclusion based on the clinical context, echocardiographic findings of a vegetation, and negative blood cultures, and distinction between infective endocarditis is challenging. We report a case of a 66-year-old woman, with history of previously treated breast and urothelial carcinoma, presenting with constitutional syndrome and pulmonary thromboembolism. Computed tomography scan revealed systemic embolic phenomena and retroperitoneal lymphadenopathies. A vegetation in the mitral valve constituted a finding on echocardiography, causing severe mitral regurgitation, which led to severe acute heart failure and culminated in patient's death. Subsequent results of immunohistochemistry of the lymph node biopsy yielded the recurrence of urothelial carcinoma.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2025 ","pages":"9938933"},"PeriodicalIF":0.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0