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Metastatic Ovarian Serous Adenocarcinoma Clinically Presenting as Inflammatory Breast Cancer 临床表现为炎症性乳腺癌的转移性卵巢浆液性腺癌
IF 0.9
Case Reports in Oncological Medicine Pub Date : 2024-01-10 DOI: 10.1155/2024/4756335
Lingling Xian, Rachel Hunter, Emily Smith, Rasha Mohammed, C. Madelaire, Guillermo A. Herrera, Rodney E. Shackelford
{"title":"Metastatic Ovarian Serous Adenocarcinoma Clinically Presenting as Inflammatory Breast Cancer","authors":"Lingling Xian, Rachel Hunter, Emily Smith, Rasha Mohammed, C. Madelaire, Guillermo A. Herrera, Rodney E. Shackelford","doi":"10.1155/2024/4756335","DOIUrl":"https://doi.org/10.1155/2024/4756335","url":null,"abstract":"Metastatic disease to the breast is a rare event, accounting for 0.5-2% of all breast cancers. Outside of metastases from the contralateral breast, malignant ovarian epithelial tumors are the most common origin of these metastases. Here, we present a very rare case of a high-grade ovarian serous adenocarcinoma presenting clinically as inflammatory breast cancer in a 70-year-old woman.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"6 8","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Case of Nasal Sarcoma with BCOR Internal Tandem Duplication Showing Complete Pathologic Response to the VDC-IE Chemotherapy Protocol. 一例罕见的鼻肉瘤 BCOR 内部串联重复病例对 VDC-IE 化疗方案显示出完全病理反应。
IF 0.9
Case Reports in Oncological Medicine Pub Date : 2023-12-26 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5546323
Samer Salah, Maher A Sughayer, Omar Jaber, Nebras Abu Abed, Fatena Ajlouni, Wisam Al Gargaz, Ramiz Abu Hijlih, Fawzi Abuhijla, Akram Al-Ibraheem, Farah Alul, Walid Naser
{"title":"A Rare Case of Nasal Sarcoma with BCOR Internal Tandem Duplication Showing Complete Pathologic Response to the VDC-IE Chemotherapy Protocol.","authors":"Samer Salah, Maher A Sughayer, Omar Jaber, Nebras Abu Abed, Fatena Ajlouni, Wisam Al Gargaz, Ramiz Abu Hijlih, Fawzi Abuhijla, Akram Al-Ibraheem, Farah Alul, Walid Naser","doi":"10.1155/2023/5546323","DOIUrl":"10.1155/2023/5546323","url":null,"abstract":"<p><p>Sarcoma with <i>BCOR</i> genetic alteration is an exceptionally rare and emerging subtype of sarcoma. It is categorized into two types: <i>BCOR</i>-related gene fusions such as <i>BCOR::CCNB3</i> sarcomas and other <i>BCOR</i>-rearranged sarcoma and sarcomas with internal tandem duplication of <i>BCOR</i> genes such as infantile undifferentiated round cell sarcomas and primitive myxoid mesenchymal tumors of infancy. <i>BCOR::CCNB3</i> sarcomas predominantly arise in bone rather than soft tissue and exhibit a higher occurrence in children and adolescent males, whereas sarcomas with <i>BCOR</i> internal tandem duplication show a wider age range but usually arise in the first year of life. Due to their rarity, there is ongoing debate and uncertainty regarding the best treatment approach, with a lack of specific clinical trials addressing these tumors. In this report, we present a unique case of sarcoma with internal tandem duplication of <i>BCOR</i> gene originating in the nasal region. The tumor was successfully and completely resected using the standard VDC-IE chemotherapy protocol, resulting in an unprecedented 100 percent tumor necrosis. The patient has completed the protocol and remains recurrence-free 13 months after diagnosis. This case suggests potential efficacy of the standard VDC-IE protocol in achieving remarkable responses in <i>BCOR</i> rearrangement sarcomas, including the internal tandem duplication subtype. However, further studies are needed to determine the optimal treatment strategies for this disease.</p>","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2023 ","pages":"5546323"},"PeriodicalIF":0.9,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report of Probable DRESS Syndrome Associated with Ribociclib. 可能与利博西尼相关的DRESS综合征病例报告。
IF 0.9
Case Reports in Oncological Medicine Pub Date : 2023-11-23 eCollection Date: 2023-01-01 DOI: 10.1155/2023/7904950
Florian Carneiro, Marine Bove, Frédérique Beau-Salinas, Tevy San, Pierre Combe
{"title":"Case Report of Probable DRESS Syndrome Associated with Ribociclib.","authors":"Florian Carneiro, Marine Bove, Frédérique Beau-Salinas, Tevy San, Pierre Combe","doi":"10.1155/2023/7904950","DOIUrl":"10.1155/2023/7904950","url":null,"abstract":"<p><p>Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but known and potentially severe side effect of drugs. The recent development of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, such as ribociclib, has considerably improved the management of hormone receptor positive (HR+) and HER2 negative (HER2-) advanced breast cancer. Here, we present the case of an 83-year-old patient who developed a probable DRESS syndrome induced by ribociclib, presenting with fever, eosinophilia, rash, and hepatic cytolysis. The RegiSCAR score was 4. The symptomatology evolved favorably with topical and systemic corticosteroids, without any sequel. Another CDK4/6 inhibitor, palbociclib, was introduced later without any cross-toxicity and with an excellent therapeutic response for more than 3 years.</p>","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2023 ","pages":"7904950"},"PeriodicalIF":0.9,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138476850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature 1例青壮年急性髓系白血病及文献回顾
Case Reports in Oncological Medicine Pub Date : 2023-11-11 DOI: 10.1155/2023/6628492
Carlee Blakemore, Sudarshawn Damodharan, Diane Puccetti
{"title":"Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature","authors":"Carlee Blakemore, Sudarshawn Damodharan, Diane Puccetti","doi":"10.1155/2023/6628492","DOIUrl":"https://doi.org/10.1155/2023/6628492","url":null,"abstract":"Acute myeloid leukemia (AML) with the high-risk variant inv(3)/t(3;3) or t(3;3)(q21;26.2) is rarely seen in the pediatric and young adult population. It is associated with poor outcomes with ineffective therapeutic options. Here, we present a case of an 18-year-old female with treatment refractory inv(3) AML in whom remission was unable to be obtained. Better treatment options are needed given the increased resistance to traditional therapy this subtype portrays. Here, we review the literature on pediatric and young adult inv(3) AML along with newer therapeutic options.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"41 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135041975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome. 产生ACTH的神经内分泌肝癌伴库欣综合征。
IF 0.9
Case Reports in Oncological Medicine Pub Date : 2023-09-26 eCollection Date: 2023-01-01 DOI: 10.1155/2023/9946271
Mudassar Sandozi, Saagar Pamulapati, Aniqa Zaidi, Zuzanna Stuart, Sneha Pamulapati, Ajay Doniparthi
{"title":"ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome.","authors":"Mudassar Sandozi,&nbsp;Saagar Pamulapati,&nbsp;Aniqa Zaidi,&nbsp;Zuzanna Stuart,&nbsp;Sneha Pamulapati,&nbsp;Ajay Doniparthi","doi":"10.1155/2023/9946271","DOIUrl":"https://doi.org/10.1155/2023/9946271","url":null,"abstract":"<p><p>Paraneoplastic Cushing's syndrome arises when neuroendocrine tumors cause excess glucocorticoid production. We report a case of ectopic ACTH-producing liver neuroendocrine tumor. A 71 y.o. female with a history of rectal squamous carcinoma presented with fatigue and diffuse swelling. Liver biopsy revealed metastatic neuroendocrine carcinoma. Workup revealed markedly elevated morning cortisol and ACTH. Overnight dexamethasone suppression testing and positive immunostaining for ACTH on biopsy suggested paraneoplastic Cushing's syndrome secondary to neuroendocrine hepatic tumors with bony metastasis. This explained the patient's persistent anasarca, hyperglycemia, and electrolyte abnormalities. Despite multiple interventions, the patient's clinical status declined, and she expired.</p>","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2023 ","pages":"9946271"},"PeriodicalIF":0.9,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41113057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cystic Glioblastoma: A Mimicker of Infection? A Case Report and Literature Review. 囊性胶质母细胞瘤:感染的模仿者?1例报告及文献回顾。
IF 0.9
Case Reports in Oncological Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/7348188
Ram Prakash Thirugnanasambandam, Gaudy Massiel Vanegas Silva, Alexander H Wu, Charles J Kim, Emanuela Cimpeanu, Jeremy Minkowitz, Charles Yanping Shao, Edwin Chiu
{"title":"Cystic Glioblastoma: A Mimicker of Infection? A Case Report and Literature Review.","authors":"Ram Prakash Thirugnanasambandam,&nbsp;Gaudy Massiel Vanegas Silva,&nbsp;Alexander H Wu,&nbsp;Charles J Kim,&nbsp;Emanuela Cimpeanu,&nbsp;Jeremy Minkowitz,&nbsp;Charles Yanping Shao,&nbsp;Edwin Chiu","doi":"10.1155/2023/7348188","DOIUrl":"https://doi.org/10.1155/2023/7348188","url":null,"abstract":"<p><p>Glioblastoma multiforme (GBM) is the most frequent malignant and aggressive type of glioma. Most cases of GBM present as a single solitary solid tumor; however, there are rare instances in which it may present as a cystic lesion. Here, we report an even rarer case of GBM presenting as bilateral multicystic lesions, mimicking infectious etiology. Our case highlights the importance of identifying clinical features of cystic GBM to ensure early diagnosis and treatment. A literature review was conducted in PubMed, looking at the common characteristics and treatment options for cystic GBM.</p>","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2023 ","pages":"7348188"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10619505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Central Nervous System Lymphoma: The Great Mimicker-A Single-Institution Retrospective Study. 中枢神经系统淋巴瘤:大模仿者-单机构回顾性研究。
IF 0.9
Case Reports in Oncological Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/8815502
Danielle A Bazer, Ewa Zabrocka, Nicholas Koroneos, Agnieszka Kowalska
{"title":"Central Nervous System Lymphoma: The Great Mimicker-A Single-Institution Retrospective Study.","authors":"Danielle A Bazer,&nbsp;Ewa Zabrocka,&nbsp;Nicholas Koroneos,&nbsp;Agnieszka Kowalska","doi":"10.1155/2023/8815502","DOIUrl":"https://doi.org/10.1155/2023/8815502","url":null,"abstract":"<p><strong>Background: </strong>Primary central nervous system lymphoma (PCNSL) is a rare, aggressive form of non-Hodgkin lymphoma contained in the brain and the spinal cord as well as the meninges, cranial nerves, eyes, and cerebrospinal fluid (CSF). Due to its variable presentation and lack of associated B-symptoms, it is quite challenging to diagnose PCNSL, if there is not a high level of suspicion.</p><p><strong>Methods: </strong>This is a retrospective case series examining 13 human immunodeficiency virus- (HIV-) negative patients with PCNSL and DLBCL type, with a median age of 75 years old.</p><p><strong>Results: </strong>The most common presenting symptom was altered mental status. The frontal lobes, basal ganglia, cerebellum, and corpus callosum were most affected. Prior to brain biopsy, 4/13 patients were on steroids, which did not affect biopsy results and the average time to diagnosis was 1 month. 9/13 patients who did not receive steroids had an average time to diagnosis of less than 1 month.</p><p><strong>Conclusion: </strong>Although steroid administration did not appear to diminish the yield of the biopsy, it is a best practice to withhold steroids prior to biopsy to decrease the time to diagnose PCNSL.</p>","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2023 ","pages":"8815502"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9880507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reporting a Case of Solid Pseudopapillary Neoplasm of the Pancreas in a 44-Year-Old Woman with Parallel Analysis of Literature. 报告一例44岁女性胰腺实性假乳头状肿瘤并文献平行分析。
IF 0.9
Case Reports in Oncological Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/1768926
Sargun Singh, Qing Zhao, Teviah E Sachs, Kevan Hartshorn
{"title":"Reporting a Case of Solid Pseudopapillary Neoplasm of the Pancreas in a 44-Year-Old Woman with Parallel Analysis of Literature.","authors":"Sargun Singh,&nbsp;Qing Zhao,&nbsp;Teviah E Sachs,&nbsp;Kevan Hartshorn","doi":"10.1155/2023/1768926","DOIUrl":"https://doi.org/10.1155/2023/1768926","url":null,"abstract":"<p><p>We present a distinctive case of solid pseudopapillary neoplasm as seen in a 44-year-old woman who presented with an abdominal mass but unremarkable labs with no elevation in any of the tumor markers. Her symptomatology ranged from typical symptoms suggestive of malignancy such as weight loss, lethargy, and anorexia to complaints like abdominal pain and jaundice. Prior to presenting at our center, she was given no hope or much in terms of treatment options. She was found to have a substantial mass over the body and tail of pancreas with characteristic and typical gross as well as histological features. Subsequently, she underwent a successful surgery and has found herself in remission since.</p>","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2023 ","pages":"1768926"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9799987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
It Is All in the Genes: A Story of Unexpected Survival in a 67-Year-Old Male with Metastatic Pancreatic Cancer. 这一切都在基因:一个67岁男性转移性胰腺癌的意外生存故事。
IF 0.9
Case Reports in Oncological Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/8751205
Patsy W P Lee, Scott W Strum, Elena Tsvetkova
{"title":"It Is All in the Genes: A Story of Unexpected Survival in a 67-Year-Old Male with Metastatic Pancreatic Cancer.","authors":"Patsy W P Lee,&nbsp;Scott W Strum,&nbsp;Elena Tsvetkova","doi":"10.1155/2023/8751205","DOIUrl":"https://doi.org/10.1155/2023/8751205","url":null,"abstract":"<p><strong>Background: </strong>We describe a case report of a 67-year-old male with PDAC who experienced an exceptional survival outcome during systemic therapy and its implications in precision medicine. We hypothesize that his outcomes are attributable, in part, to a germline <i>BRCA2</i> deletion and somatic <i>GNAS</i> substitution.</p><p><strong>Methods: </strong>Retrospective single-patient chart review was performed at the London Regional Cancer Program, as well as a structured literature search spanning all years in PubMed of BRCA and GNAS mutations in pancreatic cancer.</p><p><strong>Results: </strong>The case described herein represents a 67-year-old male who survived over 27 months after third-line treatment with gemcitabine, docetaxel, and capecitabine (GTX) chemotherapy for metastatic PDAC after progression on gemcitabine and Abraxane and then on FOLFIRINOX. His survival far exceeded the median overall survival metrics. Genetic testing revealed a pathogenic heterozygous germline <i>BRCA2</i> 6643delT p.(Tyr2215Thrfs<sup>∗</sup>14) frameshift mutation and somatic GNAS 2531<i>G</i> > <i>A</i> p.(Arg844His) mutation.</p><p><strong>Conclusions: </strong>This case highlights the urgent need to expand our knowledge of cancer biology to advance personalized cancer treatment and therapy development.</p>","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2023 ","pages":"8751205"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9950614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant Melanoma Presenting as Spinal Cord and Pleural Lesions. 恶性黑色素瘤表现为脊髓和胸膜病变。
IF 0.9
Case Reports in Oncological Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/9647892
Aysha Albastaki, Sharifa Ahmed, Asher Khan, Abeer Farhan, Talal Almayman
{"title":"Malignant Melanoma Presenting as Spinal Cord and Pleural Lesions.","authors":"Aysha Albastaki,&nbsp;Sharifa Ahmed,&nbsp;Asher Khan,&nbsp;Abeer Farhan,&nbsp;Talal Almayman","doi":"10.1155/2023/9647892","DOIUrl":"https://doi.org/10.1155/2023/9647892","url":null,"abstract":"<p><p>Primary spinal cord melanoma (PSCM) and primary pleural melanoma (PPM) are extremely rare entities with scarce cases reported in the literature. We present a case of a 54-year-old male diagnosed with possible primary pleural melanoma and primary spinal melanoma, managed with partial surgical resection, postoperative radiotherapy, and chemotherapy consisting of Ipilimumab, nivolumab, and temozolomide. This leads to decreased symptoms and improved quality of life of the patient. In this case report, we review the literature on PSCM and PPM in detail, addressing the pertinent clinical aspects as well as current and upcoming therapeutic options.</p>","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2023 ","pages":"9647892"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9388609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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