Case Reports in Oncological Medicine最新文献_第3页

Sarcoidosis-Like Reaction in Melanoma Patients Receiving Immunotherapy or Targeted Therapy. 接受免疫治疗或靶向治疗的黑色素瘤患者的结节病样反应

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Case Reports in Oncological Medicine Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1155/crom/8947861

Giulia Murgia, Luca Valtellini, Gianluca Nazzaro, Emanuela Passoni, Federica Scarfì, Francesca Boggio, Angelo V Marzano, Ornella Garrone, Nerina Denaro

{"title":"Sarcoidosis-Like Reaction in Melanoma Patients Receiving Immunotherapy or Targeted Therapy.","authors":"Giulia Murgia, Luca Valtellini, Gianluca Nazzaro, Emanuela Passoni, Federica Scarfì, Francesca Boggio, Angelo V Marzano, Ornella Garrone, Nerina Denaro","doi":"10.1155/crom/8947861","DOIUrl":"10.1155/crom/8947861","url":null,"abstract":"This case series highlights the complexity of sarcoidosis-like reactions (SLRs) during cancer treatment, specifically in patients receiving immunotherapy or targeted therapies for melanoma. SLRs can either mimic disease progression or present as part of the clinical manifestation, making diagnosis and treatment challenging. Our study reviewed the medical records of 31 patients who were candidates for postoperative treatment between June 2022 and June 2024. Out of these, three patients developed SLRs during their treatment. A 55-year-old woman with Stage IIIb cutaneous melanoma, receiving adjuvant therapy with anti-PD-1, after seven cycles of pembrolizumab, developed mediastinal node enlargement and skin hypodermic nodes. A biopsy of the hypodermic node revealed granulomatous infiltrates with sparse lymphocytes, consistent with sarcoidosis. A low dose of steroids was administered, resulting in a dramatic improvement. A 48-year-old woman with Stage IIIb BRAF wild-type melanoma, receiving nivolumab every 4 weeks, developed systemic sarcoidosis after seven cycles, primarily affecting extrapulmonary sites. Despite the immune-induced sarcoidosis, her treatment was not stopped, as decided by the multidisciplinary team (MDT). A 65-year-old man with Stage IIIb BRAF-mutant melanoma, receiving dabrafenib and trametinib, developed lung and cutaneous sarcoidosis, presenting with symptoms that led to emergency department admission. In all cases, the MDT played a crucial role in determining the course of treatment and balancing the risks of continuing or suspending cancer therapies while managing SLRs. National and international guidelines were consulted, but tailored decisions by the MDT were essential for optimizing patient care.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"8947861"},"PeriodicalIF":0.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphangitic Carcinomatosis Presenting as Cough: A Case of Occult Metastatic Prostate Adenocarcinoma. 以咳嗽为表现的淋巴管瘤病：一例隐匿转移性前列腺腺癌病例

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Case Reports in Oncological Medicine Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9915126

Sharanya Kumar, Allen Seylani, Rahul Tuli, Eric Abedi, Keerti Khandelwal

{"title":"Lymphangitic Carcinomatosis Presenting as Cough: A Case of Occult Metastatic Prostate Adenocarcinoma.","authors":"Sharanya Kumar, Allen Seylani, Rahul Tuli, Eric Abedi, Keerti Khandelwal","doi":"10.1155/2024/9915126","DOIUrl":"10.1155/2024/9915126","url":null,"abstract":"Background: Lymphangitic carcinomatosis (LC), a hallmark of advanced metastatic cancer with a poor prognosis, primarily impacts the lymphatic system of the lungs, manifesting as progressive breathlessness, cough, or hemoptysis. While prostate cancer commonly metastasizes to bones and regional lymph nodes, lung involvement is rare. This case features a patient in generally good health who presented with an insidious dry cough, leading to a diagnosis of Stage 4 prostatic adenocarcinoma with rare lymphangitic spread to the lungs. Case Presentation: A 70-year-old male in good health presented with chest tightness, a dry cough, and sudden left testicular swelling. Imaging revealed interstitial lung markings, severe left hydronephrosis, and prostatomegaly. A prostate biopsy confirmed adenocarcinoma. A PET-CT scan raised significant concern for LC, prompting the initiation of urgent inpatient chemotherapy with docetaxel. Conclusion: LC is a metastatic pattern commonly associated with solid tumors, particularly breast, gastric, and lung cancers. Its occurrence in prostate cancer is exceptionally rare. This condition is typically linked with advanced disease and a poor prognosis, often serving as a critical indicator of an underlying malignancy that may otherwise go undetected.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"9915126"},"PeriodicalIF":0.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Split-Course High-Dose Palliative Radiotherapy Regimen for Locally Advanced Sinonasal Cancer: A Case Report. 治疗局部晚期鼻窦癌的新型分次高剂量姑息放疗方案：病例报告。

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Case Reports in Oncological Medicine Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9340657

Saif Aljabab, Amna Mohaimeed, Firas AlMomen, Abdullah AlSwailem, Yasir Alayed

{"title":"A Novel Split-Course High-Dose Palliative Radiotherapy Regimen for Locally Advanced Sinonasal Cancer: A Case Report.","authors":"Saif Aljabab, Amna Mohaimeed, Firas AlMomen, Abdullah AlSwailem, Yasir Alayed","doi":"10.1155/2024/9340657","DOIUrl":"10.1155/2024/9340657","url":null,"abstract":"Sinonasal malignancies (SNMs) are rare heterogeneous malignancies that frequently present with locally advanced disease. The prognosis is poor when the disease is considered extensive and unresectable. In such cases, a high-dose palliative radiotherapy regimen is often required, but the ideal dose and fractionation have not been established. We detail a 33-year-old male who initially presented with a progressively growing mass over the right cheek. A biopsy of the lesion revealed squamous cell carcinoma (SCC). Imaging revealed a very advanced and unresectable disease with the involvement of several head and neck subsites. He progressed further after receiving induction chemotherapy from an outside institution. The patient requested prompt tumor and symptom control to travel back to his home country. We offered him high-dose split-course palliative radiotherapy in the form of a quad Shot of 14.80 Gy in four fractions twice daily, followed by 30 Gy in five fractions every other day with a 2-week interval. Treatment resulted in excellent clinical response with symptomatic relief in a short time, and the patient could travel back home safely.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"9340657"},"PeriodicalIF":0.6,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supraglottic Neuroendocrine Carcinoma: A Case Report and Literature Review. 声门上神经内分泌癌：病例报告和文献综述。

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Case Reports in Oncological Medicine Pub Date : 2024-10-01 eCollection Date: 2024-01-01 DOI: 10.1155/2024/6844193

Renda Alhabib, Chaker Zaidi, Abdulrahman Alfryyan, Hanan Albenayyan, Ibrahim Alotain

引用次数: 0

Case Report: An Extremely Rare Case of Epitheloid Type Leiomyoma. 病例报告：极罕见的上皮样子宫肌瘤病例

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Case Reports in Oncological Medicine Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2259872

Mokhamad Zhaffal, Shazia Tariq, Anastasia Salame

{"title":"Case Report: An Extremely Rare Case of Epitheloid Type Leiomyoma.","authors":"Mokhamad Zhaffal, Shazia Tariq, Anastasia Salame","doi":"10.1155/2024/2259872","DOIUrl":"10.1155/2024/2259872","url":null,"abstract":"Introduction: Uterine leiomyomas are a frequent finding in women of reproductive age. However, rare, unusual growth patterns exist, such as atypical, cellular, mitotically active, myxoid, and epithelioid leiomyomas, and present a major concern as they mimic highly malignant uterine tumors such as uterine leiomyosarcomas. An example of such cases is the epithelial type leiomyoma which is the subject of our report in a 35-year-old female. Case: A 35-year-old, nulliparous lady presented with abnormal uterine bleeding to the emergency department. Workup revealed a suspicious uterine mass that was extending from the intramural part of the fundus down the cervical os. The patient was managed by open myomectomy without complications. The final pathology report revealed an extremely rare benign epithelial type leiomyoma, no malignancy, areas with minimal atypia and low mitotic activity (< 5/10 high power fields), and areas of focal necroses (possibly ischemic type) were seen. No coagulative tumor necrosis was noted. Conclusion: Uterine leiomyomas are a common pathology of the uterus that can be confused with malignant tumors, especially in the setting of unusual growth patterns such as the epitheloid leiomyomas. Definitive management involves myomectomies with regular follow-up with favourable prognosis. It is important to properly manage these cases to avoid the overdiagnosis and mistreatment not to mention the repercussion of false diagnoses on the patient's mental health and well-being.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"2259872"},"PeriodicalIF":0.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and Management of a Patient With Chronic Lymphocytic Leukemia and a Concurrent Plasmacytoma. 慢性淋巴细胞白血病和浆细胞瘤并发症患者的诊断和治疗。

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Case Reports in Oncological Medicine Pub Date : 2024-09-24 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8870681

Danielle C Thor, Rohan Umrani, Jack Bergal, Charles Yang, Richard Gordon

引用次数: 0

A Case of Rapidly Progressive De Novo Metastatic Small-Cell Neuroendocrine Prostate Cancer. 一例进展迅速的新发转移性小细胞神经内分泌前列腺癌。

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Case Reports in Oncological Medicine Pub Date : 2024-09-17 eCollection Date: 2024-01-01 DOI: 10.1155/2024/7998149

Aryan Dalal, Sean Clark-Garvey, Andrew Gdowski, Sophia Zhang, Sara E Wobker, Steven P Rowe, Ersan Altun, Himisha Beltran, Matthew I Milowsky

{"title":"A Case of Rapidly Progressive De Novo Metastatic Small-Cell Neuroendocrine Prostate Cancer.","authors":"Aryan Dalal, Sean Clark-Garvey, Andrew Gdowski, Sophia Zhang, Sara E Wobker, Steven P Rowe, Ersan Altun, Himisha Beltran, Matthew I Milowsky","doi":"10.1155/2024/7998149","DOIUrl":"10.1155/2024/7998149","url":null,"abstract":"Introduction: Neuroendocrine/small-cell prostate cancer (NEPC) is a rare and aggressive subtype of prostate cancer, which typically develops after prolonged treatment for metastatic castration-resistant disease, but can, less commonly, occur de novo. Case Presentation: We describe a case of de novo NEPC in a tumor with mixed pathology including acinar adenocarcinoma and neuroendocrine/small-cell carcinoma with rapid progression of metastatic disease. Despite initiation of treatment with androgen deprivation therapy (ADT) and chemotherapy, the patient continued to exhibit progression leading to multiple complications including a large bowel obstruction and ultimately progressive hepatic metastases resulting in liver failure. Conclusion: This case illustrates the clinical presentation and highly aggressive nature of de novo NEPC. Recognizing atypical clinical progression in prostate cancer is critical for the detection of NEPC; however, despite early identification and initiation of treatment, the prognosis remains poor, thus highlighting the need for further study into NEPC biology and novel therapeutic approaches.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"7998149"},"PeriodicalIF":0.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Preoperative Radiotherapy for Neglected Shoulder Liposarcoma: A Retrospective Case Report. 被忽视的肩部脂肪肉瘤术前放疗成功：回顾性病例报告

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Case Reports in Oncological Medicine Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5782352

Camilla Linhart, Craig MacLeod

{"title":"Successful Preoperative Radiotherapy for Neglected Shoulder Liposarcoma: A Retrospective Case Report.","authors":"Camilla Linhart, Craig MacLeod","doi":"10.1155/2024/5782352","DOIUrl":"10.1155/2024/5782352","url":null,"abstract":"This study examines a unique case of a 61-year-old male with a 5-year history of a progressively growing mass above his right shoulder, diagnosed as a dedifferentiated pleomorphic liposarcoma. Using computerized tomography-guided core needle biopsy, the tumour was identified as intermediate to high grade. Surgical removal required preoperative radiotherapy to reduce the size of the tumour. Several unique characteristics set apart this particular case of liposarcoma: its substantial size, its unpredictable growth pattern, its absence of metastasis, and notably, its prolonged period of being untreated. This case report outlines the clinical background, diagnostic procedures, and treatment modalities employed in managing this condition, emphasizing a localized dual therapy approach combining radiotherapy and surgery. Emphasis is placed on distinguishing liposarcoma from lipoblastoma, a benign adipocyte tumour, to facilitate accurate diagnosis and appropriate treatment selection. The positive result achieved in this case could provide valuable insights for the future treatment and management of similarly sized aggressive tumours.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"5782352"},"PeriodicalIF":0.6,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Small Intestinal Cancer With Uterine Metastasis After Surgery for Ovarian Metastasis, Diagnosed Using Immunostaining. 利用免疫染色法诊断卵巢转移手术后伴有子宫转移的小肠癌罕见病例

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Case Reports in Oncological Medicine Pub Date : 2024-08-10 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8551816

Sachiko Nagao, Motoki Matsuura, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Tsuyoshi Saito

{"title":"A Rare Case of Small Intestinal Cancer With Uterine Metastasis After Surgery for Ovarian Metastasis, Diagnosed Using Immunostaining.","authors":"Sachiko Nagao, Motoki Matsuura, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Tsuyoshi Saito","doi":"10.1155/2024/8551816","DOIUrl":"10.1155/2024/8551816","url":null,"abstract":"Uterine metastases from extragenital sites are rare. We present a case of a woman who had undergone surgery for small intestinal cancer and subsequently developed metastases in her left ovary and uterus. A nulliparous woman in her 50s underwent laparoscopic partial small bowel resection with lymph node dissection for small intestinal cancer. Five months later, computed tomography (CT) revealed a left ovarian tumor and ascites. She underwent bilateral adnexectomy and adjuvant chemotherapy, and the ovarian tumor was diagnosed as a small intestinal cancer metastasis. Two years after the small intestinal cancer surgery, a positron emission tomography (PET)-CT scan revealed a uterine accumulation. Cervical cytology was negative for intraepithelial lesion or malignancy. Endometrial histology showed an adenocarcinoma of the uterus. The patient underwent total abdominal hysterectomy followed by adjuvant chemotherapy. Histopathology and immunohistochemistry of the uterine tumor revealed that it was a metastasis of small intestinal cancer (Cytokeratin 7 [CK7] [-], Cytokeratin 20 [CK20] [+], Special AT-Rich Sequence-Binding Protein 2 [SATB2] [+], Paired Box Gene 2 [PAX2] [-], and estrogen receptor [ER] [-]). In patients with cancer, histopathology and immunohistochemistry are important for distinguishing between primary and metastatic tumors and for guiding the choice of treatment.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"8551816"},"PeriodicalIF":0.6,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11330332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Description of the Clinical Activity of Avapritinib in Sporadic Mesenteric Desmoid Tumor. 首次描述阿伐替尼对散发性肠系膜蝶形细胞瘤的临床活性

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Case Reports in Oncological Medicine Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8684418

Rebecca Ganzon, Wei Chen, Gabriel Tinoco

{"title":"First Description of the Clinical Activity of Avapritinib in Sporadic Mesenteric Desmoid Tumor.","authors":"Rebecca Ganzon, Wei Chen, Gabriel Tinoco","doi":"10.1155/2024/8684418","DOIUrl":"10.1155/2024/8684418","url":null,"abstract":"Desmoid tumors (DTs) are rare and locally aggressive with a high rate of local recurrence even with optimal surgical resection. Systemic treatments are often utilized for desmoid cases with high risk of surgical morbidity or for local and symptomatic control of recurrent disease. However, the systemic treatment options for DTs are limited with limited responses. Avapritinib is a tyrosine kinase inhibitor (TKI) approved in 2020 for adults with unresectable or metastatic gastrointestinal (GI) stromal tumors (GISTs) harboring a platelet-derived growth factor receptor alpha (PDGFRA) Exon 18 mutation, including D842V mutations. In this case report, we describe a 55-year-old man with a history of D842V-mutant gastric GIST who presented several years after complete resection of the GIST with an enlarging soft tissue mass in the small intestine. After a nondiagnostic biopsy, the patient was started on avapritinib due to concerns for recurrent D842V-mutant GIST. The tumor had a partial response to treatment by RECIST 1.1 criteria, and the patient underwent surgical resection. The final pathology report revealed a sporadic DT. To our knowledge, this is the first known description of the activity of avapritinib in the treatment of a sporadic mesenteric DT, which is relevant given the limited treatment options for patients with this diagnosis. This clinical finding may be worth exploring in a dedicated clinical trial.","PeriodicalId":9636,"journal":{"name":"Case Reports in Oncological Medicine","volume":"2024 ","pages":"8684418"},"PeriodicalIF":0.6,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0