恶性胸膜间皮瘤的显著抗肿瘤作用和严重的多重免疫相关不良事件2例报告

IF 0.6 Q4 ONCOLOGY

Case Reports in Oncological Medicine Pub Date : 2025-03-03 eCollection Date: 2025-01-01 DOI:10.1155/crom/8768823

Koharu Harada, Hidehiro Irie, Akifumi Mitsuishi, Takahiro Fukui, Nao Takada, Ryosuke Nagaoka, Yohei Funatsu, Hidefumi Koh

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引用次数: 0

摘要

我们描述了两例经历了严重的多重免疫相关不良事件（irAEs）、治疗中断和类固醇治疗的患者。尽管存在这些挑战，但它们取得了超出预期的显著抗肿瘤效果。多种肿瘤显示免疫检查点抑制剂的抗肿瘤作用可能与irae的强度相关，但对恶性胸膜间皮瘤（MPM）的研究很少报道。我们的两个病例表现出比平常更强的irae。这两个病例仍然表现出完全缓解（CR）或接近CR部分缓解，表明irAEs与MPM抗肿瘤作用之间存在相关性。

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Remarkable Antitumor Effects and Serious Multiple Immune-Related Adverse Events in Malignant Pleural Mesothelioma: Two Case Reports.

We describe two patients who experienced serious multiple immune-related adverse events (irAEs), treatment interruption, and steroid administration. Despite these challenges, they achieved a remarkable antitumor effect beyond the expected. Various carcinomas demonstrated a possible correlation between the antitumor effect of immune checkpoint inhibitors and the intensity of irAEs, but few studies report on malignant pleural mesothelioma (MPM). Our two cases exhibited much stronger irAEs than usual. These two cases still demonstrated a complete response (CR) or near CR partial response, indicating a correlation between irAEs and the antitumor effect in MPM.

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来源期刊

Case Reports in Oncological Medicine ONCOLOGY-

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Case Reports in Oncological Medicine is a peer-reviewed, Open Access journal that publishes case reports and case series related to breast cancer, lung cancer, gastrointestinal cancer, skin cancer, head and neck cancer, paediatric oncology, neurooncology as well as genitourinary cancer.