Case Reports in Oncology最新文献_第7页

Dissenting an Uncommon Diagnosis at Unusual Origin: A Case Report of Teratocarcinosarcoma of Sinonasal Cavity - A Rare Malignancy. 不寻常来源的不寻常诊断：一种罕见的恶性肿瘤——鼻腔畸胎瘤肉瘤1例报告。

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Case Reports in Oncology Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI: 10.1159/000546502

Shahzaib Maqbool, Muhammad Ibrahim, Abdullah Munir Ahmed, Hassaan Tahir, Ammna Kouser, Muhammad Amin Abbas, Abdur Rehman, Imran Khan, Javed Iqbal

{"title":"Dissenting an Uncommon Diagnosis at Unusual Origin: A Case Report of Teratocarcinosarcoma of Sinonasal Cavity - A Rare Malignancy.","authors":"Shahzaib Maqbool, Muhammad Ibrahim, Abdullah Munir Ahmed, Hassaan Tahir, Ammna Kouser, Muhammad Amin Abbas, Abdur Rehman, Imran Khan, Javed Iqbal","doi":"10.1159/000546502","DOIUrl":"10.1159/000546502","url":null,"abstract":"Introduction: Teratocarcinosarcoma is an extremely rare and aggressive malignancy of the nasal cavity and paranasal sinuses, comprising epithelial, mesenchymal, and neuroectodermal components. Due to its aggressive behavior, early diagnosis and a multimodal treatment approach are essential for improving outcomes.Case presentation: We report the case of a 55-year-old male who presented with bilateral nasal discharge, recurrent epistaxis, progressive nasal swelling, and left-sided epiphora over several months. Clinical examination revealed a grade III reddish, polypoidal mass with nasal obstruction and palpable cervical lymph nodes. Imaging showed a destructive mass involving the nasal cavity and adjacent sinuses. Histopathology and immunohistochemistry confirmed the diagnosis of teratocarcinosarcoma. Surgical resection via lateral rhinotomy and medial maxillectomy, followed by radiotherapy and chemotherapy, led to significant regression of the tumor.Conclusion: This case underscores the importance of timely diagnosis and a multidisciplinary treatment approach in managing aggressive sinonasal malignancies like teratocarcinosarcoma.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"872-877"},"PeriodicalIF":0.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidermal Growth Factor Receptor Kinase Domain Duplication in Lung Adenocarcinoma with Response to Osimertinib: A Case Report and Literature Review. 表皮生长因子受体激酶结构域复制在肺腺癌中对奥西替尼的反应：一个病例报告和文献综述。

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Case Reports in Oncology Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.1159/000545543

Jenny D Gong, Ankit Mangla, Matthew M Mirsky

{"title":"Epidermal Growth Factor Receptor Kinase Domain Duplication in Lung Adenocarcinoma with Response to Osimertinib: A Case Report and Literature Review.","authors":"Jenny D Gong, Ankit Mangla, Matthew M Mirsky","doi":"10.1159/000545543","DOIUrl":"10.1159/000545543","url":null,"abstract":"Introduction: Liquid and tissue next-generation sequencing (NGS) are both important in oncological care. We report a case of metastatic non-small cell lung adenocarcinoma (NSCLC) with a rare epidermal growth factor receptor kinase domain duplication (EGFR-KDD) identified on liquid biomarker testing which led to sustained targeted treatment.Case presentation: A 54-year-old male was diagnosed with metastatic NSCLC and progressed on multiple lines of therapies: carboplatin-pemetrexed-pembrolizumab, cisplatin-docetaxel, and durvalumab-tremelimumab over a 6-month period. Liquid NGS identified a rare EGFR-KDD mutation that was treated with osimertinib leading to 5 months of progression-free survival and significant clinical improvement before ultimately opting for hospice due to intolerance with osimertinib.Conclusion: Liquid and tissue NGS should be used in combination to guide treatment and monitor treatment response. Osimertinib may be particularly effective in metastatic NSCLC with EGFR-KDD mutations.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"756-762"},"PeriodicalIF":0.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of Spontaneous Bladder Rupture: An Uncommon Cause of Ascites. 自发性膀胱破裂1例：一种罕见的腹水原因。

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Case Reports in Oncology Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.1159/000546581

Caio Heleno, Helena Miranda, Nico Gotera, Goetz Kloecker

{"title":"A Case Report of Spontaneous Bladder Rupture: An Uncommon Cause of Ascites.","authors":"Caio Heleno, Helena Miranda, Nico Gotera, Goetz Kloecker","doi":"10.1159/000546581","DOIUrl":"10.1159/000546581","url":null,"abstract":"Introduction: Spontaneous bladder rupture (SBR) is a rare cause of ascites. A systematic review identified only 351 reported cases in the literature. This condition is frequently misdiagnosed due to vague symptom presentation and failure to promptly link SBR to its common risk factors, such as pelvic irradiation and alcohol intoxication. Its presentation is not different from the most common causes of ascites, and the differential diagnosis is essential.Case presentation: Here, we present a case of a male with liver disease with portal hypertension, a previous history of cancer, and prior surgery with an artificial urinary sphincter placement who developed acute recurrent ascites and rapidly progressing acute kidney failure requiring dialysis. Extensive workup revealed that the kidney failure was caused by SBR, resulting in urinary ascites. The bladder rupture was treated by surgery, leading to complete resolution of the patient's symptoms.Conclusion: The diagnosis of SBR requires a high level of suspicion due to its rarity and nonspecific symptoms. Here, we present an extensive review of differential diagnoses of ascites and the pathway for the final diagnosis of SBR.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"845-855"},"PeriodicalIF":0.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12201938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Presentation of Ruptured Pineal Region Teratoma with Postoperative Aseptic Meningitis. 一例罕见的松果体区畸胎瘤破裂并发术后无菌性脑膜炎。

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Case Reports in Oncology Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.1159/000546099

Keisuke Fuji, Takumi Yamanaka, Manato Sakamoto, Ichita Taniyama, Yoshinobu Takahashi, Kazunori Tatsuzawa, Naoya Hashimoto

{"title":"A Rare Presentation of Ruptured Pineal Region Teratoma with Postoperative Aseptic Meningitis.","authors":"Keisuke Fuji, Takumi Yamanaka, Manato Sakamoto, Ichita Taniyama, Yoshinobu Takahashi, Kazunori Tatsuzawa, Naoya Hashimoto","doi":"10.1159/000546099","DOIUrl":"10.1159/000546099","url":null,"abstract":"Introduction: Mature teratomas are germ cell tumors composed of tissues derived from all three germ layers. These tumors are rare in the central nervous system, primarily occurring in the suprasellar and pineal regions. Rupture of intracranial teratomas is an exceptionally rare phenomenon, typically presenting on imaging as disseminated fatty droplets and occasionally associated with aseptic meningitis. We describe a case of a ruptured cystic teratoma in the pineal region, manifesting postoperatively with severe neurological symptoms consistent with aseptic meningitis.Case presentation: A 15-year-old boy presented with a 2-month history of persistent headaches. Computed tomography revealed a calcified mass lesion in the pineal region with low-density areas in the lateral ventricles. Magnetic resonance imaging (MRI) demonstrated a complex lesion in the pineal region and high T1 signal intensity bilaterally in the anterior horns of the lateral ventricles, suggestive of a ruptured teratoma. The patient underwent surgical resection. Postoperatively, he developed mild fever, severe headache, ocular pain, decreased vision, diplopia, and neck rigidity. Contrast-enhanced MRI revealed faint meningeal enhancement, consistent with aseptic meningitis. Symptoms gradually improved with steroid therapy.Conclusion: This case underscores the importance of recognizing rupture as a potential complication of intracranial teratomas, which may result in severe postoperative aseptic meningitis. Intraoperative measures, such as meticulous irrigation, are critical to mitigate this rare but serious complication.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"817-823"},"PeriodicalIF":0.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late Recurrence of Mucinous Adenocarcinoma after Lung Transplantation: A Case Report and Literature Review. 肺移植术后粘液腺癌晚期复发1例并文献复习。

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Case Reports in Oncology Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.1159/000545190

Eveline Claeys, Nico De Crem, Pierre Van Mol, Arno Vanstapel, Laurens Joseph Ceulemans, Dirk Van Raemdonck, Christophe Dooms, Walter De Wever, Christophe Michel Deroose, Isabelle Vanden Bempt, Birgit Weynand, Robin Vos, Els Wauters

{"title":"Late Recurrence of Mucinous Adenocarcinoma after Lung Transplantation: A Case Report and Literature Review.","authors":"Eveline Claeys, Nico De Crem, Pierre Van Mol, Arno Vanstapel, Laurens Joseph Ceulemans, Dirk Van Raemdonck, Christophe Dooms, Walter De Wever, Christophe Michel Deroose, Isabelle Vanden Bempt, Birgit Weynand, Robin Vos, Els Wauters","doi":"10.1159/000545190","DOIUrl":"10.1159/000545190","url":null,"abstract":"Introduction: Invasive mucinous adenocarcinoma (IMA) of the lung has a less aggressive behavior than other adenocarcinoma subtypes. Overall, the propensity for nodal and distant metastases is low, but spread throughout the lungs is frequent. The radiographic \"ground glass\" presentation makes differentiation between infectious and inflammatory consolidations challenging, and the diagnosis of malignancy is often unexpected.Case presentation: A 50-year-old patient underwent double lung transplantation (LTx) in July 2018 for progressive fibrosing interstitial lung disease (ILD). IMA was unexpectedly found in the explant lungs. Pre-transplant PET-CT scans suggested inflammatory ILD without malignancy. Endobronchial ultrasound-guided transbronchial fine needle aspiration of the enlarged mediastinal lymph nodes demonstrated no evidence of malignancy. Post-transplant pathology confirmed stage IVA IMA with a KRAS G12D mutation. After 3 years, recurrent IMA was detected. The asymptomatic patient remains under close surveillance with stable lung function, and tailored treatment will be considered if progression occurs.Conclusion: IMA is currently rarely considered an indication for LTx. The risk of recurrence after transplantation is substantial, and recurrence negatively impacts long-term post-transplant prognosis. Incidental adenocarcinoma in explant lungs will remain a complication of imperfect transplant recipient selection. A high index of suspicion of disease recurrence in the donor lungs should be maintained in these patients. Further research is required to understand the optimal screening, treatment, and follow-up of these patients.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"646-652"},"PeriodicalIF":0.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuron-Specific Enolase as a Biomarker in Ifosfamide-Induced Encephalopathy: A Case Report. 神经元特异性烯醇化酶作为异环磷酰胺诱导脑病的生物标志物：一例报告。

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Case Reports in Oncology Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.1159/000546305

Arthur Claessens, Agathe Manchart, Mahira Boufraine, Ariane Guignard, Audrène Bergeot, Anne Kieffer, Aurélien Lambert

{"title":"Neuron-Specific Enolase as a Biomarker in Ifosfamide-Induced Encephalopathy: A Case Report.","authors":"Arthur Claessens, Agathe Manchart, Mahira Boufraine, Ariane Guignard, Audrène Bergeot, Anne Kieffer, Aurélien Lambert","doi":"10.1159/000546305","DOIUrl":"10.1159/000546305","url":null,"abstract":"Introduction: Ifosfamide, an alkylating agent, is used in treatment of various malignancies and may cause encephalopathies. The pathophysiology of this treatment adverse event is well documented, complex, and multifactorial, and involves the production of drug-related metabolites interfering with the normal functionality of neuronal synapses. Risk factors associated with the development of ifosfamide-induced encephalopathy have been identified including concurrent cisplatin administration and female gender. The clinical symptoms vary, ranging from simple confusion to seizure or coma. To date, no biomarkers have been evaluated in ifosfamide-induced encephalopathy. Neuron-specific enolase (NSE) elevation has already been correlated within toxic or metabolic encephalopathies regardless of the underlying etiology.Case presentation: We report the case of a 56-year-old woman who received adjuvant chemotherapy for high-grade osteosarcoma including cisplatin, doxorubicin, and ifosfamide. The patient experienced ifosfamide-induced encephalopathy the day after completion of the ifosfamide infusion protocol. Treatment with methylene blue was initiated as soon as confusion developed. The patient presented behavioral problems, cognitive impairment, agitation, and aphasia, which resolved within few days, with persistent fatigue. NSE levels were assessed after every electroencephalogram (EEG). The kinetics of NSE levels from 20.41 to 7.69 µg/L and EEG toxic pattern improving from grade 2 to normal were consistent with recovery from clinical encephalopathy in this patient.Conclusion: Although increased levels of NSE in peripheral blood have been correlated with other etiologies of encephalopathy, its use as a companion biomarker for ifosfamide-induced encephalopathy warrants further investigation.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"800-808"},"PeriodicalIF":0.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Intrauterine Case of Explosive Growth of Neurofibromatosis during Pregnancy with Fetal Death in Mid-Pregnancy: A Case Report. 妊娠期神经纤维瘤病宫内爆发性生长伴妊娠中期胎儿死亡1例。

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Case Reports in Oncology Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.1159/000545803

Xiyan Ouyang, Yanli Li, Xin Li, Lingna Chai, Jie Shi, Han Gao

引用次数: 0

Adenoid Cystic Carcinoma of the Sinonasal Cavity: A Case Report and Literature Review. 鼻窦腺样囊性癌1例报告及文献复习。

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Case Reports in Oncology Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.1159/000546446

Ahmad Al-Bitar, Bishr A Al-Abdulrazzak, Ruba Alahmar

{"title":"Adenoid Cystic Carcinoma of the Sinonasal Cavity: A Case Report and Literature Review.","authors":"Ahmad Al-Bitar, Bishr A Al-Abdulrazzak, Ruba Alahmar","doi":"10.1159/000546446","DOIUrl":"10.1159/000546446","url":null,"abstract":"Introduction: Adenoid cystic carcinoma (ACC), a rare, aggressive malignancy of secretory epithelia, is often present with nonspecific symptoms, delaying diagnosis.Case presentation: A 67-year-old male reported 10 months of nasal obstruction, mouth breathing, and sleep disturbances. The initial evaluation for foreign body obstruction revealed septal deviation and low-density sinonasal tissue on CT. MRI identified a 7 × 4.5 × 7 cm heterogeneous lesion invading nasal structures, paranasal sinuses, and nasopharynx with diffusion restriction. Tru-cut biopsy confirmed ACC via cribriform, tubular, and solid basaloid cell patterns, pseudocystic spaces, biphasic ductal-myoepithelial cells, and perineural invasion. Immunohistochemistry (CK7, CD117, p63, S100) supported the diagnosis, with tumor-free margins and no metastases. Multimodal therapy (30 VMAT sessions, 4 cisplatin-vinorelbine cycles) improved symptoms.Conclusion: This case illustrates ACC's diagnostic complexity, requiring advanced imaging and histopathology to exclude mimics. Despite indolent early progression, ACC's neurotropic spread and late-stage detection demand aggressive treatment. While surgery with adjuvant radiotherapy remains standard, the absence of metastases here underscores its variable behavior.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"809-816"},"PeriodicalIF":0.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential Myelomatous Pleural and Pericardial Effusions in Multiple Myeloma: A Case Report Demonstrating Extended Survival with Teclistamab. 多发性骨髓瘤的序贯骨髓瘤性胸膜和心包积液：一例报告证明Teclistamab延长了生存期。

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Case Reports in Oncology Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.1159/000545930

Deena Mudawi, Abdulrahman F Al-Mashdali, Ahmad Tawalbeh, Lajos Szabados, Dina Sameh Soliman, Shehab Fareed

{"title":"Sequential Myelomatous Pleural and Pericardial Effusions in Multiple Myeloma: A Case Report Demonstrating Extended Survival with Teclistamab.","authors":"Deena Mudawi, Abdulrahman F Al-Mashdali, Ahmad Tawalbeh, Lajos Szabados, Dina Sameh Soliman, Shehab Fareed","doi":"10.1159/000545930","DOIUrl":"10.1159/000545930","url":null,"abstract":"Introduction: Myelomatous pleural effusion (MPE) and pericardial involvement are rare manifestations of multiple myeloma (MM), occurring in less than 1% of cases and carrying historically poor prognoses. We present a unique case where both these rare serous cavity manifestations occurred sequentially in the same patient, demonstrating the evolving treatment landscape with novel targeted therapies.Case presentation: A 42-year-old Asian female presented with left shoulder pain and swelling, leading to the diagnosis of IgG lambda MM with extensive extramedullary disease. After initial partial response to D-VRD therapy, she developed MPE with complete left lung collapse. Following failure of second-line KPD-PACE therapy, she received teclistamab, achieving complete metabolic and morphological response documented by PET-CT. After maintaining remission for 10 months, she experienced relapse with pericardial involvement presenting as cardiac tamponade.Conclusion: The patient demonstrated an unprecedented response to BCMA-targeted therapy with teclistamab, achieving complete remission that lasted 10 months - more than doubling the historical median survival of 4 months for MPE. Flow cytometry proved instrumental in rapid diagnosis, showing 11% lambda monotypic plasma cells in the pleural fluid. The subsequent pericardial involvement after initial complete response highlighted the persistent challenges in managing extramedullary disease. This case represents the first documented instance of sequential MPE and pericardial involvement in MM, demonstrating the potential of novel targeted therapies, particularly BCMA-directed approaches, in extending survival and improving outcomes in these rare but aggressive disease manifestations.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"620-629"},"PeriodicalIF":0.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mammary Paget's Disease of the Nipple: A Case Report. 乳头乳腺佩吉特病1例报告

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Case Reports in Oncology Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.1159/000546289

Loubna Slama, Hafsa Taheri, Nadir Miry, Amal Bennani, Zainab Chatbi, Ibtissam Bellajdel, Hanane Saadi, Ahmed Mimouni

{"title":"Mammary Paget's Disease of the Nipple: A Case Report.","authors":"Loubna Slama, Hafsa Taheri, Nadir Miry, Amal Bennani, Zainab Chatbi, Ibtissam Bellajdel, Hanane Saadi, Ahmed Mimouni","doi":"10.1159/000546289","DOIUrl":"10.1159/000546289","url":null,"abstract":"Introduction: Tumors of the nipple-areolar complex are relatively uncommon, and Paget's disease is an uncommon presentation involving epidermal invasion of the nipple by a carcinoma in situ. Mammary Paget's disease (MPD) presents a diagnostic challenge, especially in the absence of a palpable breast mass, which often leads to delayed diagnosis and treatment.Case report: We present the case of a 64-year-old woman with persistent skin erosion of the left nipple that was unresponsive to multiple topical treatments. Diagnostic evaluation, including mammography and MRI, revealed no invasive malignancy. Nipple biopsy confirmed MPD with underlying in situ ductal carcinoma. The patient underwent lumpectomy with removal of the nipple-areolar complex, followed by radiotherapy, resulting in a favorable outcome.Discussion: Diagnosis of MPD can be challenging because of its resemblance to benign dermatological conditions. Imaging, particularly mammography and MRI, is essential for assessing the underlying malignancy and surgical planning. Treatment typically involves surgical excision, with breast-conserving therapy considered for localized disease. Early detection significantly improves the prognosis, particularly in the absence of invasive cancer.Conclusion: MPD should be considered in patients with persistent eczematous nipple lesions resistant to topical treatments. Early diagnosis and appropriate surgical management are crucial to achieve favorable outcomes.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"780-785"},"PeriodicalIF":0.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0