Yordan Krastev, Rostislav Manev, Georgi Todorov, Nikolay Conev
{"title":"Tracheal Chondrosarcoma: A Case Report and Discussion.","authors":"Yordan Krastev, Rostislav Manev, Georgi Todorov, Nikolay Conev","doi":"10.1159/000548086","DOIUrl":"https://doi.org/10.1159/000548086","url":null,"abstract":"<p><strong>Introduction: </strong>Tracheal chondrosarcoma is an exceedingly rare malignant tumor arising from the cartilage parts of the trachea, with less than 40 cases described in the English literature. We aim to explore the current literature on the topic and present 1 more case of tracheal chondrosarcoma in a 69-year-old male.</p><p><strong>Case presentation: </strong>A 69-year-old male presented with upper airway obstruction and difficulty breathing. He also reported recent unintentional weight loss and night sweats. A computed tomography (CT) scan upon hospitalization revealed a large tumor formation that was obstructing the tracheal lumen and an interventional bronchoscopy for tumor debulking was performed. The histological examination determined it was a case of a high grade (G3) chondrosarcoma of the trachea. Later on, the patient underwent tracheal resection and reconstruction after which he was referred to radiation oncology for radiotherapy. Three months after concluding radiotherapy, a PET/CT scan showed no evidence of local recurrence or distant metastasis. On the fifth month post-radiation due to complaints of purulent discharge from the tracheostomy, a new biopsy was performed which determined there was local recurrence of the tumor. The patient was started on first-line chemotherapy with paclitaxel monotherapy. Restaging with CT scan was done after the fourth and sixth cycles, with inconclusive data for progression. Currently, he is scheduled to receive 4 more cycles' paclitaxel monotherapy and then be reevaluated.</p><p><strong>Conclusion: </strong>The literature on the topic is still scarce and more cases reported are needed in order to optimize the treatment of our patients and achieve the best outcome.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1262-1268"},"PeriodicalIF":0.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rare Presentation of Spontaneous Transomental Hernia in an Elderly Oncology Patient: Diagnostic Vigilance and Surgical Management.","authors":"Rudrakshi Mahaldar, Saurabh Raj, Anindya Halder, Vijay Kannaujiya, Dhiraj Mallik, Banyeswar Pal, Bishal Saha, Subhra Banerjee, Shafayat Anjum, Subinay Mandal, Vinesh B, Shreya Chopra","doi":"10.1159/000548259","DOIUrl":"https://doi.org/10.1159/000548259","url":null,"abstract":"<p><strong>Background: </strong>Transomental hernia (TOH) is a rare internal hernia, representing approximately 1-4% of all internal hernia cases. The spontaneous form, occurring in patients without a history of abdominal surgery or trauma, is exceptionally uncommon and presents a significant diagnostic challenge due to its nonspecific clinical features. TOH typically involves herniation of small bowel loops through a defect in the greater omentum.</p><p><strong>Case presentation: </strong>We report a case of spontaneous TOH in a 76-year-old male undergoing chemotherapy for synchronous primary malignancies - left lung adenocarcinoma and right renal cell carcinoma - who presented with features of intestinal obstruction. Contrast-enhanced computed tomography suggested internal herniation with ischemia. Intraoperative findings confirmed approximately 100 cm of small bowel incarcerated through a 3-cm defect in the right side of the greater omentum. Age-related omental atrophy, along with chemotherapy-induced mesenteric fibrosis, microvascular injury, and impaired regenerative capacity, likely contributed to the defect formation. An emergency midline laparotomy was performed, involving resection of the gangrenous bowel and the creation of a double-barrel enterostomy. Postoperatively, distal enteral refeeding was critical in electrolyte correction, nutritional support, and early recovery.</p><p><strong>Discussion: </strong>TOH carries a high risk of strangulation and should be considered in elderly patients with bowel obstruction, even with no history of prior abdominal surgery, especially those receiving platinum-based chemotherapy.</p><p><strong>Conclusion: </strong>Although rare, TOH should be included in the differential diagnosis of acute abdomen in elderly oncology patients, even without previous abdominal surgery. Timely surgical intervention is vital to reduce morbidity and optimize outcomes.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1307-1313"},"PeriodicalIF":0.7,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omran Janoud, Ibrahim Abd Alrahem Jaber, Kinan Jafar, Alaa Jlailati, Ahmad Al-Bitar, Souheb Al-Mahasna
{"title":"Deep Venous Thrombosis as the Sentinel Event Unmasking a Uterine Leiomyosarcoma in a Postmenopausal Woman: A Case Report and Review of the Literature.","authors":"Omran Janoud, Ibrahim Abd Alrahem Jaber, Kinan Jafar, Alaa Jlailati, Ahmad Al-Bitar, Souheb Al-Mahasna","doi":"10.1159/000548265","DOIUrl":"https://doi.org/10.1159/000548265","url":null,"abstract":"<p><strong>Introduction: </strong>Uterine tumors are classified as benign or malignant, with leiomyomas being the most common benign type and leiomyosarcomas (LMSs) being a rare but aggressive form of uterine sarcoma. The clinical similarity between these two tumor types often makes preoperative differentiation challenging, necessitating surgery for a definitive diagnosis. LMSs are highly aggressive with a poor prognosis. We present the case of a 60-year-old woman whose uterine LMS was initially diagnosed as a benign myoma, with deep venous thrombosis (DVT) serving as an atypical presenting sign of her underlying malignancy.</p><p><strong>Case presentation: </strong>A 60-year-old postmenopausal woman presented with a large, progressively enlarging abdominal mass, which had been identified 5 years prior as a probable leiomyoma. She initially declined surgery but was readmitted 1 month later with a DVT in her left leg, which was attributed to the compressive effect of the large pelvic mass. The patient underwent a total abdominal hysterectomy. Histopathological and immunohistochemical analysis of the 21-cm uterine tumor confirmed a high-grade LMS. Subsequent staging scans revealed Stage IVB metastatic disease in her lungs, liver, and bones. The patient was transitioned to palliative care and passed away 6 weeks after her surgery.</p><p><strong>Conclusion: </strong>Uterine LMSs can deceptively mimic benign leiomyomas, which may lead to significant diagnostic delays and contribute to poor outcomes. This case highlights that an atypical presentation, such as an idiopathic deep vein thrombosis, should heighten clinical suspicion for an underlying pelvic malignancy, even in the absence of typical gynecological symptoms. Accurate and timely diagnosis is critical and ultimately depends on definitive histopathological evaluation, underscoring the highly aggressive nature and significant mortality associated with this rare cancer.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1297-1306"},"PeriodicalIF":0.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary Surgical Resection of Localized Hepatoblastoma in an Adolescent.","authors":"Ahmad Al-Bitar, Mohammad Alkari, Rafat Horoub","doi":"10.1159/000548192","DOIUrl":"https://doi.org/10.1159/000548192","url":null,"abstract":"<p><strong>Introduction: </strong>Hepatoblastoma (HB) is the most common pediatric primary liver malignancy, but it is exceptionally rare in adolescents. Older patients often face delayed diagnosis and poorer prognoses compared to infants.</p><p><strong>Case presentation: </strong>A 14-year-old Arab male presented with progressive abdominal distension and mild right upper quadrant pain. Examination revealed a large, firm abdominal mass. Serum alpha-fetoprotein (AFP) was markedly elevated (33,500 ng/mL), while liver function tests were normal. Contrast-enhanced CT showed a 15 × 12 × 10 cm heterogeneous mass involving right hepatic segments (5-8) and medial left segments (4a/b), without vascular invasion or metastasis. Based on characteristic imaging and elevated AFP, an <i>extended right hepatectomy</i> (resecting segments 4a, 4b, 5-8) was performed without preoperative biopsy or chemotherapy. Histopathology confirmed HB. Recovery was uneventful; AFP normalized postoperatively. At the 12-month follow-up, the patient remains disease-free with normal activity.</p><p><strong>Conclusion: </strong>Primary surgical resection is a viable strategy for <i>localized</i> HB in adolescents, even with large tumors, when vascular invasion and metastasis are absent. Prompt diagnosis using AFP and imaging, coupled with curative-intent surgery, can achieve excellent outcomes in this rare population.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1281-1288"},"PeriodicalIF":0.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomás San Martín, Jaime González-Montero, Alberto Espino, Carlos Rojas, Mauricio Burotto
{"title":"Immunotherapy-Related Pancreatitis: A Case Series of 8 Patients from a High-Volume Oncology Centre.","authors":"Tomás San Martín, Jaime González-Montero, Alberto Espino, Carlos Rojas, Mauricio Burotto","doi":"10.1159/000548016","DOIUrl":"https://doi.org/10.1159/000548016","url":null,"abstract":"<p><strong>Introduction: </strong>Immune checkpoint inhibitors (ICIs) may lead to immune-related adverse events (irAEs), including the rare complication of immune-related acute pancreatitis (irAP). Current knowledge about irAP is limited to case reports and retrospective studies.</p><p><strong>Case presentations: </strong>We retrospectively reviewed 8 patients diagnosed with irAP at a high-volume tertiary cancer centre in Chile between 2021 and 2025. Data were collected on cancer type, immunotherapy regimen, symptoms, enzyme levels, imaging, and treatment. The irAP diagnosis was established according to the American Gastroenterological Association criteria. Adverse reactions were graded using CTCAE v5.0. Of the 8 included patients, 4 had melanoma, 2 had breast cancer, and 2 prostate cancer. Seven received PD-1/CTLA-4 combination therapy, and 1 received anti-PD-1 monotherapy. The median time to the irAP diagnosis was 5 months. Seven patients presented with gastrointestinal symptoms. Enzyme elevations and imaging findings were variable. All patients were treated with systemic corticosteroids, and 3 required hospitalisation. Four patients were rechallenged with ICIs. Other grade ≥2 irAEs were observed in 6 patients. No deaths were directly attributable to irAP.</p><p><strong>Conclusion: </strong>As demonstrated, these manifestations can diverge substantially from those of classical pancreatitis, so establishing an irAP diagnosis requires a comprehensive assessment. Corticosteroids are an effective treatment in most cases, and ICI rechallenge may be feasible in selected patients. This case series adds 8 new reports to the limited literature on irAP, underscoring its clinical heterogeneity and the need for tailored management. Further research and detailed case reporting are essential to improve diagnosis and treatment of this rare toxicity.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1269-1279"},"PeriodicalIF":0.7,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Al-Bitar, Mhd Ammar Zalzaleh, Muhammad Reda Al Sous, Hussein Al Helbawi
{"title":"Lung Adenocarcinoma with Bilateral Renal Metastases.","authors":"Ahmad Al-Bitar, Mhd Ammar Zalzaleh, Muhammad Reda Al Sous, Hussein Al Helbawi","doi":"10.1159/000548014","DOIUrl":"https://doi.org/10.1159/000548014","url":null,"abstract":"<p><strong>Introduction: </strong>Lung adenocarcinoma, the most common subtype of non-small cell lung cancer (NSCLC), is typically characterized by positive immunohistochemical (IHC) staining for thyroid transcription factor-1 (TTF-1) and Napsin A. However, a small subset of these tumors is negative for both markers, posing a significant diagnostic challenge and carrying distinct prognostic implications. Renal metastases from lung cancer are uncommon and are rarely detected at initial diagnosis.</p><p><strong>Case presentation: </strong>We report the case of a 42-year-old male who presented with nonspecific constitutional symptoms of diffuse pain and weight loss. Comprehensive imaging revealed a large primary mediastinal mass with extensive stage IVB metastatic disease involving the bilateral adrenal glands, bones, iliac lymph nodes, and bilateral kidneys. A CT-guided biopsy of the mediastinal mass confirmed a poorly differentiated invasive adenocarcinoma. The tumor's immunoprofile was notably negative for both TTF-1 and Napsin A, but positive for cytokeratin 7, necessitating a broad IHC workup to exclude other primary sites. The patient was initiated on palliative chemotherapy with carboplatin and paclitaxel, demonstrating a significant clinical and partial radiological response.</p><p><strong>Conclusion: </strong>This case highlights the clinical and pathological features of a TTF-1-/Napsin A-negative lung adenocarcinoma. It underscores the systematic diagnostic workup required to confirm a lung primary in this challenging context, illustrates the correlation between this specific tumor phenotype and its aggressive clinical behavior with widespread metastases, and emphasizes the central role of comprehensive biomarker testing in the modern management of advanced NSCLC.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1289-1296"},"PeriodicalIF":0.7,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Al-Bitar, Yasmine Al Bidewi, Karam Alsawaf, Obada Abdin, Maha Manachi
{"title":"Severe Hypercalcemia in a Patient with Chronic Lymphocytic Leukemia following Treatment Disruption.","authors":"Ahmad Al-Bitar, Yasmine Al Bidewi, Karam Alsawaf, Obada Abdin, Maha Manachi","doi":"10.1159/000548015","DOIUrl":"https://doi.org/10.1159/000548015","url":null,"abstract":"<p><strong>Introduction: </strong>Hypercalcemia is a common paraneoplastic syndrome rarely seen in chronic lymphocytic leukemia (CLL). When it occurs, it often signals disease progression or Richter transformation. Disruption of cancer care in conflict zones may contribute to worsening clinical outcomes.</p><p><strong>Case presentation: </strong>We report a 63-year-old Arab female with a 3-year history of CLL, previously treated with chlorambucil and rituximab, who developed severe hypercalcemia (total calcium 19.9 mg/dL) after an 8-month interruption of chemotherapy due to transportation barriers amid regional conflict. She presented with confusion, weakness, polyuria, and polydipsia. Laboratory evaluation showed suppressed parathyroid hormone, normal vitamin D, renal impairment, and no evidence of lytic bone lesions. Treatment with intravenous fluids, calcitonin, and zoledronic acid effectively lowered calcium levels. Despite reinitiation of chemotherapy, she later developed fatal febrile neutropenia and septic shock.</p><p><strong>Conclusion: </strong>This case highlights a rare but serious complication of CLL and underscores the detrimental impact of healthcare disruption on disease progression and outcomes. Clinicians should maintain vigilance for hypercalcemia in hematologic malignancies, even during remission, and prioritize continuity of care in vulnerable populations.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1256-1261"},"PeriodicalIF":0.7,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Longitudinal EAT-10 Score Pattern in Specific Biopsychosocial Factors in a Patient with Sporadic Neoplastic Mechanical Dysphagia of the Oesophagus: A Case Report.","authors":"Amos Mapesa Washika, Javan Lukandu, Walter Abila Akello, Denis Gachigi Kinuthia","doi":"10.1159/000547735","DOIUrl":"https://doi.org/10.1159/000547735","url":null,"abstract":"<p><strong>Introduction: </strong>Mechanical dysphagia is due to oesophageal structural alteration and presents a major nutritional concern among neoplastic oesophageal patients. The biopsychosocial factors still do influence residual physiological swallowing mechanisms in the setting of oesophageal neoplasms. Eating Assessment Tool (EAT-10) has traditionally been used cross-sectionally by clinicians to screen for dysphagic patients (EAT-10 ≥3) and identify aspiration at-risk dysphagic patients (EAT-10 ≥15). In this case report, EAT-10 has been longitudinally used as a patient-reported outcome of various biopsychosocial settings on a sporadically occurring dysphagia.</p><p><strong>Case presentation: </strong>This case report is on the patterns of longitudinally taken post-prandial EAT-10 score in a patient in his 70s presenting with sporadic neoplastic dysphagia of the oesophagus. The scores were taken after meals of the same amount and consistency, but in different settings, i.e., meals taken post-fasting, in isolation, at social gatherings, before and after the first as well as the last induction chemotherapy. The observations for each setting were taken serially for 20 days.</p><p><strong>Conclusion: </strong>EAT-10 scores in social gathering, before initiation, and at the end of induction chemotherapy were high while meals served in isolation, post-fasting, and soon after initiation of induction chemotherapy had low EAT-10 scores, indicating the likelihood of biopsychosocial modulation on residual swallowing mechanisms. EAT-10 score influenced by modifiable biopsychosocial factors aided in delivering instructions tailored on how to improve oral food intake, body nutrition, and response to treatment.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1228-1238"},"PeriodicalIF":0.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bilateral Pheochromocytoma in a BRCA2 Carrier: Coincidence or Emerging Association?","authors":"Poovarasan S, Shahrukh Memon, Rudrakshi Mahaldar, Saurabh Raj","doi":"10.1159/000547815","DOIUrl":"https://doi.org/10.1159/000547815","url":null,"abstract":"<p><strong>Introduction: </strong>Pheochromocytomas are rare catecholamine-secreting tumours of adrenal origin. Bilateral pheochromocytomas (BPs) occur more commonly in familial or syndromic contexts such as MEN2, VHL, or SDHx mutations. However, association with BRCA2 mutations has not been widely reported.</p><p><strong>Case presentation: </strong>We present a 55-year-old hypertensive male with persistent palpitations and sweating. Despite antihypertensive therapy, symptoms persisted. Biochemical analysis revealed elevated 24-h urinary metanephrines (1,705 µg/day), while serum cortisol and aldosterone were normal. Imaging (CECT and MRI) revealed bilateral adrenal masses suggestive of adenomas. GA68 DOTATATE PET confirmed somatostatin receptor (SSTR)-avid bilateral adrenal lesions. A bilateral adrenalectomy was performed, and histopathology confirmed pheochromocytoma. Genetic testing via whole-exome sequencing identified a BRCA2 variant of uncertain significance (VUS) on chromosome 13. Postoperatively, the patient remains normotensive on single-agent antihypertensive therapy and is on lifelong steroid replacement.</p><p><strong>Discussion: </strong>While pheochromocytoma is often linked with mutations in RET, VHL, and SDHx genes, BRCA2 is primarily associated with breast and ovarian malignancies. Emerging evidence suggests a potential role of BRCA2 mutations in adrenal tumorigenesis. This case may represent the first reported BP associated with a BRCA2 VUS. While causality cannot be established, the finding warrants further investigation into potential genotype-phenotype correlations.</p><p><strong>Conclusion: </strong>Our report expands the phenotypic spectrum of BRCA2 variants and underscores the importance of genetic screening in bilateral adrenal tumours. Recognition of such rare associations is critical for genetic counselling, surveillance, and tailored management.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1247-1255"},"PeriodicalIF":0.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}