Neurofibromatosis Type 1 with Relapsed/Refractory Precursor B-Lymphoblastic Lymphoma: Case Report and Literature Review.

IF 0.7 Q4 ONCOLOGY

Case Reports in Oncology Pub Date : 2025-06-19 eCollection Date: 2025-01-01 DOI:10.1159/000546996

Hongjuan Li, Yanli Leng, Yan Gu, Yan Han, Yuqi Zhao, Guoyu Ding, Hongmei Wang

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Abstract

Introduction: Concomitant occurrence of B-lymphoblastic lymphoma (B-LBL) and neurofibromatosis type 1 (NF1) is rare.

Case presentation: We diagnosed and treated a child presenting with NF1 and relapsed B-LBL and reviewed the relevant literature through the last 8 years. Stage IV precursor B-LBL with central nervous system 3 was identified in this patient, with pain and activity abnormalities in both lower limbs. NF1 was diagnosed based on physical examination, brain magnetic resonance imaging, genetic testing, and family history. The patient relapsed after chemotherapy and was given blinatumomab. After 1 week of blinatumomab treatment, the lower limb pain was relieved. The child underwent umbilical cord blood transplantation after completing two sessions of blinatumomab therapy and is still disease-free to date.

Conclusion: The findings from this study will offer valuable empirical references for peers treating NF1 associated with refractory/relapsed B-LBL.

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1型神经纤维瘤病合并复发/难治性前体b淋巴母细胞淋巴瘤：病例报告及文献复习。

b淋巴母细胞淋巴瘤（B-LBL）和1型神经纤维瘤病（NF1）同时发生是罕见的。病例介绍：我们诊断并治疗了一名患有NF1和复发B-LBL的儿童，并回顾了过去8年的相关文献。该患者伴有中枢神经系统3的IV期前体B-LBL，双下肢疼痛和活动异常。NF1的诊断基于体格检查、脑磁共振成像、基因检测和家族史。患者化疗后复发，给予布利纳单抗治疗。布利纳单抗治疗1周后，患者下肢疼痛缓解。该儿童在完成两次blinatumumab治疗后接受了脐带血移植，至今仍无疾病。结论：本研究结果将为同行治疗NF1合并难治性/复发性B-LBL提供有价值的经验参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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