Case Reports in Oncology最新文献_第10页

Integrated Imaging-Pathologic Diagnosis and Treatment Overview of Mucinous Tubular and Spindle Cell Renal Cell Carcinoma: A Case Report and Systematic Review of the Literature. 粘液管状和梭形细胞肾细胞癌影像学病理综合诊断与治疗综述：1例报告及文献系统复习。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-18 eCollection Date: 2025-01-01 DOI: 10.1159/000543004

Yu Zhang, Yu Long, Jie Wang

{"title":"Integrated Imaging-Pathologic Diagnosis and Treatment Overview of Mucinous Tubular and Spindle Cell Renal Cell Carcinoma: A Case Report and Systematic Review of the Literature.","authors":"Yu Zhang, Yu Long, Jie Wang","doi":"10.1159/000543004","DOIUrl":"10.1159/000543004","url":null,"abstract":"Introduction: Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a rare, low-grade renal epithelial tumor with a unique histopathological profile. This case report aimed to highlight the clinical, imaging, and immunohistochemical features of MTSCC, facilitating its differentiation from other renal tumors and providing insight into effective management strategies.Case presentation: A 52-year-old female presented with left-sided abdominal pain. Imaging studies, including CT and ultrasound, revealed a low-density mass in the left kidney. The patient subsequently underwent laparoscopic radical nephrectomy. Pathological examination identified spindle and cuboidal epithelial cells forming elongated tubules with mild atypia within a mucinous stroma. Immunohistochemical staining showed positivity for CK7, P504S, and PAX8, confirming the diagnosis of MTSCC. Postoperatively, the patient was managed conservatively without chemotherapy or radiotherapy and received only symptomatic treatment. During a 24-month follow-up, she demonstrated favorable recovery with no signs of recurrence or metastasis.Conclusion: This case underscores the critical role of imaging, histopathology, and immunohistochemistry in accurately diagnosing MTSCC. Early detection and timely surgical intervention can lead to positive outcomes, as illustrated by this patient's recovery. Further research is needed to explore the molecular mechanisms of MTSCC and establish robust guidelines for its management.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"346-352"},"PeriodicalIF":0.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacologic Management of Obesity in Neuro-Oncology: A Case Report. 神经肿瘤肥胖症的药物治疗：1例报告。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-17 eCollection Date: 2025-01-01 DOI: 10.1159/000543178

Alexandra Lardieri, Vidhu Thaker, Kate Citron-Zafrin, James H Garvin, Stergios Zacharoulis, Elena J Ladas

{"title":"Pharmacologic Management of Obesity in Neuro-Oncology: A Case Report.","authors":"Alexandra Lardieri, Vidhu Thaker, Kate Citron-Zafrin, James H Garvin, Stergios Zacharoulis, Elena J Ladas","doi":"10.1159/000543178","DOIUrl":"10.1159/000543178","url":null,"abstract":"Introduction: Brain tumors are the most common solid tumors in pediatric oncology. Advances in the treatment of childhood brain tumors have led to increased survival; however, treatment-related morbidity remains high. The risk of developing overweight/obesity or significant weight gain is commonly observed in children with a brain tumor often due to hypothalamic damage as a result of radiation therapy, surgery, or the tumor itself. This may be accompanied by endocrinopathies such as diabetes insipidus and central precocious puberty in survivors of a childhood brain tumor. Lifestyle intervention strategies are often ineffective in preventing and managing obesity. Patients have difficulty with adherence to dietary interventions due to prolonged exposure to high-dose steroids, compromised physical health due to the disease process, or limitations in mobility as a result of excessive weight gain or the sequelae of the tumor management. There are no effective interventions to prevent or manage obesity in this patient population.Case presentation: We describe a case report of a 11-year-old female who underwent treatment for a ganglioglioma, WHO grade 1, and simultaneously experienced nearly 100-kg weight gain. After several unsuccessful attempts at lifestyle interventions, she was referred to endocrinology and prescribed a GLP-1 receptor agonist, semaglutide. Following treatment with semaglutide, significant weight loss was observed. Importantly, the patient reported enhanced quality of life and social activity.Conclusion: Anti-obesity medications are promising treatment options for this vulnerable patient group. Additional research is warranted to examine their use for the prevention and treatment of obesity in children with a brain tumor.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"169-173"},"PeriodicalIF":0.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-17 eCollection Date: 2025-01-01 DOI: 10.1159/000541722

Chen Zhu, Jian Su, Zhenhua Jin, Lin Yuan, Yunfei Wei, Yan Xu

引用次数: 0

Stereotactic Body Radiotherapy in a Transplanted Lung for a Primary Lung Cancer: Case Report. 原发性肺癌移植肺立体定向放射治疗一例报告。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-16 eCollection Date: 2025-01-01 DOI: 10.1159/000542713

Pedro Ferreira, Dionísio Maia, Miriam Abdulrehman

{"title":"Stereotactic Body Radiotherapy in a Transplanted Lung for a Primary Lung Cancer: Case Report.","authors":"Pedro Ferreira, Dionísio Maia, Miriam Abdulrehman","doi":"10.1159/000542713","DOIUrl":"10.1159/000542713","url":null,"abstract":"Introduction: Lung cancer in the transplanted organ is an extremely rare occurrence with very few cases reported. The use of stereotactic body radiotherapy (SBRT) for medically inoperable early stage non-small cell lung cancer is an option to treat an early stage lung adenocarcinoma on a transplanted lung.Case presentation: We report the case of a 63-year-old woman with a history of hypersensitivity pneumonitis, who underwent a right lung transplant in 2010 and developed pulmonary adenocarcinoma, stage IA2, in 2023. The patient was ineligible for surgical management and was referred for SBRT. The treatment was administered with a total dose of 48 Gy in 4 fractions in December 2023. The nodule remained stable at 9-month follow-up, with post-radiogenic pneumonitis observed. Pulmonary function remained stable after treatment.Conclusions: This case shows that SBRT on a transplanted lung cancer seems to be safe, even maintaining a standard SBRT fractionation, with good early local control. Careful consideration of dose, fractionation, and potential toxicities is essential in managing these complex cases, always in close cooperation with the transplant medical team.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"85-91"},"PeriodicalIF":0.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraperitoneal Bleeding Induced by a Ruptured Inferior Epigastric Artery Pseudoaneurysm following Interval Debulking Surgery for Ovarian Cancer: A Case Report. 卵巢癌间歇减压手术后腹壁下动脉假性动脉瘤破裂致腹腔内出血1例。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-13 eCollection Date: 2025-01-01 DOI: 10.1159/000543127

Shota Higami, Yasuyuki Kinjo, Mao Sekimata, Yuta Yoshimatsu, Yu Murakami, Tomoko Kurita, Kiyoshi Yoshino

{"title":"Intraperitoneal Bleeding Induced by a Ruptured Inferior Epigastric Artery Pseudoaneurysm following Interval Debulking Surgery for Ovarian Cancer: A Case Report.","authors":"Shota Higami, Yasuyuki Kinjo, Mao Sekimata, Yuta Yoshimatsu, Yu Murakami, Tomoko Kurita, Kiyoshi Yoshino","doi":"10.1159/000543127","DOIUrl":"10.1159/000543127","url":null,"abstract":"Introduction: Pseudoaneurysm following gynecologic cancer surgery is a rare complication that can become fatal when it ruptures. Common sites of pseudoaneurysms are the external iliac artery, hypogastric artery, and aorta, which are located around the lymphadenectomy site. There are no previous reports of ruptured inferior epigastric (IEA) artery pseudoaneurysms after gynecologic cancer surgery. We report a case of intraperitoneal bleeding induced by a ruptured IEA pseudoaneurysm following interval debulking surgery for stage IVB ovarian cancer.Case presentation: The patient underwent total abdominal simple hysterectomy, bilateral salpingo-oophorectomy, omentectomy, ileocolic resection, and peritonectomy around the ileocecal area after 5 cycles of neoadjuvant chemotherapy. The patient suddenly presented with loss of consciousness and reduced blood pressure on postoperative day 20. Her blood hemoglobin levels also decreased. Contrast-enhanced computed tomography revealed a pseudoaneurysm in the right IEA. There were no signs of extravasation from the pseudoaneurysm; however, bloody ascites was observed in the abdominal cavity. A ruptured IEA pseudoaneurysm was suspected, and coil embolization was immediately performed. Her symptoms abated soon after coil embolization, and she remained symptom-free during the 8 months of postoperative follow-up.Conclusion: Awareness of this rare complication is clinically important for its early detection and treatment.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"137-143"},"PeriodicalIF":0.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Diagnosing Rare Retroperitoneal Tumors: A Case Report of Extrarenal Giant Angiomyolipoma. 诊断罕见腹膜后肿瘤的挑战：肾外巨大血管平滑肌脂肪瘤1例报告。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-11 eCollection Date: 2025-01-01 DOI: 10.1159/000543128

Darío Sebastián López Delgado, Andres Ricaurte-Fajardo, Carlos Stiven Mueses-Tulcán, Omar Eduardo Benavides Ayala, Yeison Harvey Carlosama-Rosero

{"title":"Challenges in Diagnosing Rare Retroperitoneal Tumors: A Case Report of Extrarenal Giant Angiomyolipoma.","authors":"Darío Sebastián López Delgado, Andres Ricaurte-Fajardo, Carlos Stiven Mueses-Tulcán, Omar Eduardo Benavides Ayala, Yeison Harvey Carlosama-Rosero","doi":"10.1159/000543128","DOIUrl":"10.1159/000543128","url":null,"abstract":"Introduction: Extrarenal angiomyolipomas are extremely rare tumors, with only isolated reports in the literature. Their diagnosis is challenging as these lesions are often misdiagnosed as more common retroperitoneal tumors. This report presents a case of a retroperitoneal extrarenal angiomyolipoma, emphasizing its clinical, imaging, and histopathological features to facilitate accurate diagnosis and avoid errors.Case presentation: A 58-year-old male with a history of benign prostatic hyperplasia presented with progressive abdominal distension and weight gain. Imaging studies revealed a giant retroperitoneal mass displacing the left kidney and abdominal aorta. A core needle biopsy initially suggested a well-differentiated liposarcoma T4N0M0, leading to neoadjuvant chemotherapy with doxorubicin and ifosfamide. Surgical resection of a 20 × 30 × 25-cm mass was performed. Histopathological and immunohistochemical analysis of the specimen confirmed the diagnosis of retroperitoneal extrarenal angiomyolipoma. Chemotherapy was discontinued, and the patient remains stable under follow-up.Discussion and conclusion: Retroperitoneal extrarenal angiomyolipomas are rare, presenting significant diagnostic challenges due to their resemblance to other retroperitoneal neoplasms such as liposarcomas. This case highlights the importance of comprehensive imaging, histopathological examination, and immunohistochemical studies for accurate diagnosis. Increased awareness of this entity can help clinicians avoid unnecessary treatments and ensure appropriate management of similar cases.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"113-119"},"PeriodicalIF":0.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Mediastinal Synovial Sarcoma with Pericardial Involvement: A Case Report. 原发纵隔滑膜肉瘤伴心包受累1例。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-11 eCollection Date: 2025-01-01 DOI: 10.1159/000542680

Kenan C Michaels, Sean C Dougherty, Brett R Kurpiel, Michael G Douvas

{"title":"Primary Mediastinal Synovial Sarcoma with Pericardial Involvement: A Case Report.","authors":"Kenan C Michaels, Sean C Dougherty, Brett R Kurpiel, Michael G Douvas","doi":"10.1159/000542680","DOIUrl":"10.1159/000542680","url":null,"abstract":"Introduction: Synovial sarcoma is a rare, malignant neoplasm accounting for approximately 5-10% of all soft tissue sarcomas. Synovial sarcomas generally occur in the extremities of adolescent or young adult (AYA)-aged patients; however, they have been reported to affect virtually every organ system. The mediastinum is an exceptionally rare location for synovial sarcoma and malignant pericardial effusions occurring secondary to synovial sarcoma can occur.Case presentation: This case describes a 29-year-old male who presented with 3 weeks of dyspnea and leg swelling. An echocardiogram demonstrated a large pericardial effusion with early tamponade physiology. A subsequent pericardiocentesis returned a lymphocytic predominance with negative flow cytometry and cytology. Cross-sectional imaging with computed tomography (CT) scans of the chest, abdomen, and pelvis was negative for lymphadenopathy or detectable mass. He was discharged where repeat echocardiogram demonstrated recurrence of the effusion, but his symptoms had improved. Ultimately, he was readmitted with refractory dyspnea and edema where cardiac magnetic resonance imaging demonstrated a large mediastinal mass invading the pericardium. The biopsy demonstrated a high-grade spindle cell malignancy positive for a rearrangement of the SS18 gene, a finding diagnostic of synovial sarcoma. He passed away after one round of doxorubicin due to septic and obstructive shock (tamponade).Conclusion: Mediastinal synovial sarcomas are rare, aggressive, and highly morbid neoplasms. In some cases, they may present insidiously due to their sole presenting clinical manifestation being pericardial effusion. Particular care should be taken to rule out malignancy with MRI or PET-guided imaging in the AYA-aged population when idiopathic, recurrent pericardial effusion is found.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"76-84"},"PeriodicalIF":0.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinoblastoma and Persistent Fetal Vasculature in the Same Eye: Case Report. 视网膜母细胞瘤和胎儿血管在同只眼睛：1例报告。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-10 eCollection Date: 2025-01-01 DOI: 10.1159/000542987

Felipe Baccega, Laura Goldfarb Cyrino, Patricia Picciarelli, Paulo Vigga Alves E Silva, Maria Teresa Brizzi Chizzotti Bonanomi

{"title":"Retinoblastoma and Persistent Fetal Vasculature in the Same Eye: Case Report.","authors":"Felipe Baccega, Laura Goldfarb Cyrino, Patricia Picciarelli, Paulo Vigga Alves E Silva, Maria Teresa Brizzi Chizzotti Bonanomi","doi":"10.1159/000542987","DOIUrl":"10.1159/000542987","url":null,"abstract":"Introduction: Retinoblastoma is the most prevalent intraocular tumor in children, commonly manifesting as leukocoria. Persistent fetal vasculature (PFV) is another cause of leukocoria, resulting from the incomplete regression of fetal eye blood vessels. The simultaneous occurrence of retinoblastoma and PFV in the same eye is extremely uncommon and presents significant diagnostic difficulties.Case presentation: We present a case involving a 2-year-old girl with leukocoria and esotropia in her left eye. Clinical assessments, including biomicroscopy, ocular ultrasound, and magnetic resonance imaging, identified a retrolental mass with calcifications and a hyperechoic tubular structure, indicating the presence of both retinoblastoma and PFV. Enucleation followed by histopathological analysis confirmed these diagnoses. The histopathology revealed retinoblastoma with Homer-Wright and Flexner-Wintersteiner rosettes and signs of PFV, with persistent large vessels in the retrolental region.Conclusion: The coexistence of retinoblastoma and PFV in a single eye is rare and complicates the diagnosis of leukocoria. Comprehensive multimodal imaging is crucial for accurate diagnosis and effective management, tailored to the distinct needs of each condition. This case highlights the importance of detailed evaluation in pediatric patients with leukocoria to ensure correct diagnosis and appropriate treatment.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"55-60"},"PeriodicalIF":0.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Splenic Irradiation Preceding Allogeneic Hematopoietic Stem Cell Transplantation as a Possible Risk Factor of Sinusoidal Obstruction Syndrome: A Report of Three Cases. 同种异体造血干细胞移植前脾照射可能是窦道阻塞综合征的危险因素：附3例报告

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-09 eCollection Date: 2025-01-01 DOI: 10.1159/000542608

Shuichi Shirane, Hajime Yasuda, Ayana Uchimura, Yosuke Mori, Tadaaki Inano, Miyuki Tsutsui, Yasuharu Hamano, Miki Ando

{"title":"Splenic Irradiation Preceding Allogeneic Hematopoietic Stem Cell Transplantation as a Possible Risk Factor of Sinusoidal Obstruction Syndrome: A Report of Three Cases.","authors":"Shuichi Shirane, Hajime Yasuda, Ayana Uchimura, Yosuke Mori, Tadaaki Inano, Miyuki Tsutsui, Yasuharu Hamano, Miki Ando","doi":"10.1159/000542608","DOIUrl":"10.1159/000542608","url":null,"abstract":"Introduction: Splenomegaly is frequently encountered in patients with myeloproliferative neoplasms. Splenomegaly is associated with an increased incidence of engraftment failure during allogeneic hematopoietic stem cell transplantation (allo-HSCT), and some centers perform prior low-dose splenic irradiation (LDSI) which has been reported to be both safe and effective. However, we report conflicting results by presenting three allo-HSCT patients undergoing LDSI that subsequently developed sinusoidal obstruction syndrome (SOS).Case presentation: The underlying diseases of the presented cases were atypical chronic myeloid leukemia, secondary myelofibrosis following essential thrombocythemia, and acute myeloid leukemia transforming from myeloproliferative neoplasm, unclassifiable. Endothelial Activation and Stress Index (EASIX) scores of the 3 patients were 0.40, 3.82, and 4.40, respectively.Conclusion: SOS is a potentially fatal complication of allo-HSCT, and the mortality rates of severe cases are reported to be above 80%. LDSI has not been recognized as a risk factor of SOS to date. Alternative management methods of splenomegaly during allo-HSCT such as ruxolitinib administration may be safer compared to LDSI.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1-6"},"PeriodicalIF":0.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-Grade Adenosquamous Carcinoma of the Breast: A Case Report. 低级别乳腺腺鳞癌1例报告。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-09 eCollection Date: 2025-01-01 DOI: 10.1159/000542764

Rikako Ogawa, Hiroshi Sugiura, Yukari Hato, Hikaru Kawahara, Norio Shiraki, Yukashi Ito, Yoshiaki Ando, Misao Ishikawa

{"title":"Low-Grade Adenosquamous Carcinoma of the Breast: A Case Report.","authors":"Rikako Ogawa, Hiroshi Sugiura, Yukari Hato, Hikaru Kawahara, Norio Shiraki, Yukashi Ito, Yoshiaki Ando, Misao Ishikawa","doi":"10.1159/000542764","DOIUrl":"10.1159/000542764","url":null,"abstract":"Introduction: Low-grade adenosquamous carcinoma (LGASC) is categorized as a metaplastic carcinoma but differs from other types of metaplastic carcinoma in having a more favorable prognosis. Due to its rarity and unusual and inconsistent presentation, there is little information available regarding its characteristics, making correct diagnosis a challenge.Case presentation: We report herein the case of a 54-year-old Japanese woman who presented with a lump in her left breast. She was found to have a benign lesion which continually relapsed, necessitating repeated excisions, ultimately leading to the diagnosis of LGASC after the third excision. Guidelines for the treatment of LGASC emphasize complete tumor excision, with adjuvant therapies only considered in cases with positive lymph node metastasis. Consequently, the patient underwent total mastectomy but postoperative chemotherapy was not administered, and the patient was followed up with regular observation. By 20 months postoperatively, there was no sign of recurrence.Conclusion: LGASC has distinctive pathological features of the intimate admixture of well-developed glands and solid squamous cell nests within a fibrotic or cellular spindle stroma. It is difficult to determine preoperatively with cytology or needle biopsy because LGASC mimics benign tumors. It is typically triple-negative, but it has an indolent behavior. Adjuvant therapy after surgery is considered unnecessary for triple-negative status, but there is no clear evidence. We aimed to provide more data on the disease characteristics, presentation, and treatment outcome. Accumulation of further evidence is warranted to refine diagnostic and therapeutic strategies of LGASC.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"92-99"},"PeriodicalIF":0.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0