Case Reports in Oncology最新文献

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Potential Influence of Duchenne Muscular Dystrophy Carrier on Breast Cancer Treatment-Related Cardiomyopathy: A Case Report. 杜氏肌营养不良携带者对乳腺癌治疗相关心肌病的潜在影响1例
IF 0.7
Case Reports in Oncology Pub Date : 2026-04-24 eCollection Date: 2026-01-01 DOI: 10.1159/000552006
Shivali Desai, Patrick Dillon
{"title":"Potential Influence of Duchenne Muscular Dystrophy Carrier on Breast Cancer Treatment-Related Cardiomyopathy: A Case Report.","authors":"Shivali Desai, Patrick Dillon","doi":"10.1159/000552006","DOIUrl":"10.1159/000552006","url":null,"abstract":"<p><strong>Introduction: </strong>Carriers of Duchenne muscular dystrophy (DMD) and other inherited myopathies are at risk of cardiomyopathy, and HER2-targeted therapies for breast cancer are also associated with cardiotoxicity. The coexistence of these conditions presents a novel clinical challenge. Standard baseline cardiac evaluations prior to HER2-targeted therapy do not routinely detect inherited cardiomyopathies, and genetic risk is not currently incorporated into pretreatment assessment.</p><p><strong>Case report: </strong>We report the case of a woman in her 30s with HER2-positive breast cancer with baseline borderline low global longitudinal strain who was incidentally identified as a carrier of a DMD gene mutation after her son was diagnosed with DMD and developed an asymptomatic decline in left ventricular ejection fraction during treatment.</p><p><strong>Conclusion: </strong>This case highlights the potential role of increased cardiac surveillance and consideration of cardioprotective medications and genetic screening in patients with baseline abnormal echocardiograms prior to receiving cardiotoxic cancer therapies.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"738-742"},"PeriodicalIF":0.7,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13282110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Next-Generation Sequencing for Highly Endocrine-Sensitive Metastatic Breast Cancer to Inform Late-Phase Treatments with Sustained Response: A Case Report. 使用新一代测序对高度内分泌敏感的转移性乳腺癌进行持续反应的晚期治疗:一个病例报告。
IF 0.7
Case Reports in Oncology Pub Date : 2026-04-21 eCollection Date: 2026-01-01 DOI: 10.1159/000552044
Leyla Bayat, Margaret McCabe, Sergey Cherneykin, Nancy E Mills
{"title":"Use of Next-Generation Sequencing for Highly Endocrine-Sensitive Metastatic Breast Cancer to Inform Late-Phase Treatments with Sustained Response: A Case Report.","authors":"Leyla Bayat, Margaret McCabe, Sergey Cherneykin, Nancy E Mills","doi":"10.1159/000552044","DOIUrl":"10.1159/000552044","url":null,"abstract":"<p><strong>Introduction: </strong>Biomarker profiling has long been a cornerstone in the treatment of both early-stage and metastatic breast cancer. Immunohistochemical staining for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression continues to form the foundation of our understanding of breast cancer prognosis and optimal treatment. Over the past decade, next-generation sequencing (NGS) has expanded our capacity to prevent disease progression through new mutational targets.</p><p><strong>Case presentation: </strong>We present the case of a postmenopausal woman who, 12 years after initial diagnosis with locally advanced ER+, PR+, and HER-2- breast cancer, developed recurrent metastatic disease. Control of disease progression over the following 15 years was attained through her cancer's uniquely prolonged sensitivity to endocrine therapy and, later in her disease course, by the discovery of multiple targetable mutations through NGS. She had a sustained response to both the inhibition of PIK3CA and, later, the inhibition of ESR1. Repeat NGS late in her treatment revealed new NRG1 NTRK fusion and KRAS G12C mutations. Our patient succumbed to her disease before subsequent targeted therapy could be initiated.</p><p><strong>Conclusion: </strong>Our patient's treatment course was significantly influenced by repetitive NGS informing her treatment with novel targeted therapies, with detection of emerging actionable mutations rarely seen in breast cancer toward the end of her life. This observation highlights the potential clinical benefit of repeating NGS even in late stages of breast cancer treatment. Furthermore, NGS may expand our ability to utilize targeted agents in not only early phase but also later phase breast cancer treatment.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"777-784"},"PeriodicalIF":0.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant Mid-Esophageal Leiomyoma in a Young Adult Managed by Video-Assisted Thoracoscopic Enucleation: A Case Report. 视频胸腔镜下摘除巨大食管中部平滑肌瘤1例。
IF 0.7
Case Reports in Oncology Pub Date : 2026-04-18 eCollection Date: 2026-01-01 DOI: 10.1159/000552097
Mohammad Alaa Aldakak, Youssef Abbas, Yamama Abo Dakka, Yousef Al Jabban, Asmaa Dandashy, Hussain Chaban
{"title":"Giant Mid-Esophageal Leiomyoma in a Young Adult Managed by Video-Assisted Thoracoscopic Enucleation: A Case Report.","authors":"Mohammad Alaa Aldakak, Youssef Abbas, Yamama Abo Dakka, Yousef Al Jabban, Asmaa Dandashy, Hussain Chaban","doi":"10.1159/000552097","DOIUrl":"10.1159/000552097","url":null,"abstract":"<p><strong>Introduction: </strong>Esophageal leiomyomas are rare benign smooth-muscle tumors, usually small and incidentally detected; giant lesions in young adults are uncommon and may mimic malignant disease when symptomatic. This case highlights the unusual presentation of a giant mid-esophageal leiomyoma in a young adult and the diagnostic challenge of distinguishing large benign intramural tumors from malignant disease.</p><p><strong>Case presentation: </strong>A 22-year-old male Syrian patient with celiac disease presented with an 18-month history of progressive dysphagia, worsening over the preceding 6 months, with associated unintentional weight loss. Upper gastrointestinal endoscopy showed a submucosal lesion at 25 cm from the incisors with intact mucosa. Contrast-enhanced chest CT demonstrated a heterogeneous intramural mid-esophageal mass at the level of the carina, extending approximately 11 cm, causing mild luminal narrowing without evidence of metastatic disease. The patient underwent elective right-sided video-assisted thoracoscopic enucleation through three ports. The mass was successfully enucleated from the mid-esophageal wall, and a chest drain was placed. Histopathology revealed an encapsulated spindle-cell neoplasm without atypia or mitotic activity; immunohistochemistry supported leiomyoma and excluded malignancy.</p><p><strong>Conclusion: </strong>VATS enucleation achieved definitive diagnosis and symptom resolution with an uncomplicated 3-month outcome. The key message is that giant esophageal leiomyoma, even in young adults, can be effectively managed with minimally invasive esophageal-preserving surgery after careful evaluation.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"720-728"},"PeriodicalIF":0.7,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13278729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metaplastic Thymoma Underwent Open Thymectomy: A Rare Case Report of Biphasic Thymic Tumor. 开放性胸腺切除术后的化脓性胸腺瘤:罕见的双期胸腺肿瘤一例。
IF 0.7
Case Reports in Oncology Pub Date : 2026-04-14 eCollection Date: 2026-01-01 DOI: 10.1159/000551928
Eihab A Subahi, Muna Abuhejleh, Farah J N Assaf, Abdalla Fadul, Abdul Qadir, Amjad Salman, Mohamed Subahi, Issam Al Bozom, Mamunul Islam
{"title":"Metaplastic Thymoma Underwent Open Thymectomy: A Rare Case Report of Biphasic Thymic Tumor.","authors":"Eihab A Subahi, Muna Abuhejleh, Farah J N Assaf, Abdalla Fadul, Abdul Qadir, Amjad Salman, Mohamed Subahi, Issam Al Bozom, Mamunul Islam","doi":"10.1159/000551928","DOIUrl":"10.1159/000551928","url":null,"abstract":"<p><strong>Introduction: </strong>Metaplastic thymoma is a rare thymic epithelial tumor characterized by a distinctive biphasic pattern of epithelial and spindle cell components. It typically follows an indolent course and is associated with a favorable prognosis, distinguishing it from other more aggressive thymic neoplasms.</p><p><strong>Case presentation: </strong>We report the case of a 44-year-old woman who presented with a persistent productive cough. Chest X-ray and subsequent CT imaging revealed a 6.5 × 4.5 cm anterior mediastinal mass. A CT-guided biopsy suggested metaplastic thymoma, which was confirmed postoperatively following an open thymectomy. Histopathological examination demonstrated a biphasic tumor with islands of epithelial cells (positive for pan-cytokeratin, P63, P40) and spindle cells (positive for vimentin, EMA), with a low Ki-67 index. Next-generation sequencing identified a YAP1-MAML2 rearrangement. The patient recovered uneventfully, and follow-up imaging at 6 months showed no recurrence.</p><p><strong>Conclusion: </strong>This case highlights the importance of integrating clinical, radiological, and histopathological findings for the accurate diagnosis of metaplastic thymoma. Complete surgical resection remains the treatment of choice and is associated with excellent long-term outcomes.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"712-719"},"PeriodicalIF":0.7,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13275057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated Angioinvasive Fusarium Infection following Chimeric Antigen Receptor T-Cell Therapy in Refractory Diffuse Large B-Cell Lymphoma: A Case Report. 嵌合抗原受体t细胞治疗难治性弥漫性大b细胞淋巴瘤后弥散性血管侵袭性镰刀菌感染1例报告。
IF 0.7
Case Reports in Oncology Pub Date : 2026-04-13 eCollection Date: 2026-01-01 DOI: 10.1159/000552005
Mary V Lang, Alicia Hou, Matthew Kornas, Valandrea Merilan, Ryan Skelly, Ricky Buckshaw
{"title":"Disseminated Angioinvasive <i>Fusarium</i> Infection following Chimeric Antigen Receptor T-Cell Therapy in Refractory Diffuse Large B-Cell Lymphoma: A Case Report.","authors":"Mary V Lang, Alicia Hou, Matthew Kornas, Valandrea Merilan, Ryan Skelly, Ricky Buckshaw","doi":"10.1159/000552005","DOIUrl":"10.1159/000552005","url":null,"abstract":"<p><strong>Introduction: </strong>Patients receiving immune-directed chimeric antigen receptor T-cell (CAR-T) therapy experience profound, prolonged immunosuppression, predisposing them to opportunistic infections. Disseminated angioinvasive <i>Fusarium</i> infections are uncommon but carry high morbidity and mortality in this population.</p><p><strong>Case presentation: </strong>We describe a rare case of disseminated angioinvasive <i>Fusarium</i> infection in a patient with refractory diffuse large B-cell lymphoma following CD19-directed CAR-T-cell therapy. The patient developed progressive cutaneous lesions due to <i>Fusarium keratoplasticum</i> complex, confirmed by tissue culture and histopathology. She ultimately expired due to septic shock complicated by multifactorial cardiotoxicity.</p><p><strong>Conclusion: </strong>This case highlights the heightened susceptibility to refractory opportunistic mold infections and potential cardiac complications in patients after CAR-T therapy. New skin lesions in the post-CAR-T period should prompt early biopsy and skin culture with prompt mold coverage.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"751-757"},"PeriodicalIF":0.7,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13282104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Duodenal Obstruction Secondary to Diffuse Large B-Cell Lymphoma in the Setting of Familial Mediterranean Fever: A Case Report. 家族性地中海热并发弥漫性大b细胞淋巴瘤继发十二指肠梗阻1例。
IF 0.7
Case Reports in Oncology Pub Date : 2026-04-11 eCollection Date: 2026-01-01 DOI: 10.1159/000551640
Jacob Terry Harris, Chand K Nandani, Cory Richard Fraser, Kevin Ranum, Seema Jain
{"title":"Duodenal Obstruction Secondary to Diffuse Large B-Cell Lymphoma in the Setting of Familial Mediterranean Fever: A Case Report.","authors":"Jacob Terry Harris, Chand K Nandani, Cory Richard Fraser, Kevin Ranum, Seema Jain","doi":"10.1159/000551640","DOIUrl":"10.1159/000551640","url":null,"abstract":"<p><strong>Introduction: </strong>Diffuse large B-cell lymphoma (DLBCL) and familial Mediterranean fever (FMF) can both rarely present with small bowel obstruction (SBO), with their gastrointestinal symptoms sometimes overlapping. Clinicians should be aware not only of the signs and symptoms of potential malignancy but also how such malignancy can present in patients with FMF. Distinguishing the presentation of both DLBCL and FMF will improve patient centered care and the workup and management of each individual condition. Since no known cases exist of a patient with concomitant FMF and DLBCL as acting possible drivers of SBO, this case highlights the importance of keeping broad differentials in cases of diagnostic uncertainty and when patients provide rare presentations without clear consensus on best practices regarding management or diagnosis.</p><p><strong>Case presentation: </strong>A 65-year-old man with a history of FMF presented with bilateral upper quadrant abdominal pain for 12 days, abdominal fullness/distention, decreased appetite, constipation with decreased stool caliber, bilious emesis, and unintentional weight loss over 6 months. An abdominal mass was discovered and DLBCL was diagnosed.</p><p><strong>Conclusion: </strong>While DLBCL proved to be the cause of obstruction in this patient, it is critical that clinicians maintain broad differentials in settings of diagnostic uncertainty. Since these diseases are not regularly encountered by many clinicians, their presentation and management are valuable to review, especially in the setting of an entity as common to inpatient medicine as bowel obstruction. The review of DLBCL and FMF, as well as the maintaining of broad differential diagnoses, will greatly improve the care clinicians provide to their patients.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"729-737"},"PeriodicalIF":0.7,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13278725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed Postoperative Wound Healing during Alectinib Therapy for Poorly Differentiated Lung Adenocarcinoma: A Case Report. 阿勒替尼治疗低分化肺腺癌术后伤口愈合延迟1例报告。
IF 0.7
Case Reports in Oncology Pub Date : 2026-04-10 eCollection Date: 2026-01-01 DOI: 10.1159/000551911
Yanhua He, Gongdan Xu, Xue Yang, Lu Li, Mingying Tan
{"title":"Delayed Postoperative Wound Healing during Alectinib Therapy for Poorly Differentiated Lung Adenocarcinoma: A Case Report.","authors":"Yanhua He, Gongdan Xu, Xue Yang, Lu Li, Mingying Tan","doi":"10.1159/000551911","DOIUrl":"10.1159/000551911","url":null,"abstract":"<p><strong>Introduction: </strong>Anaplastic lymphoma kinase (ALK) rearrangement is a key oncogenic driver in non-small cell lung cancer. Alectinib, a highly selective second-generation ALK inhibitor, has demonstrated remarkable clinical efficacy; however, its potential influence on postoperative wound healing remains unclear.</p><p><strong>Case presentation: </strong>We report the case of a 42-year-old male with ALK-positive poorly differentiated lung adenocarcinoma who underwent right lower lobectomy following significant tumor regression with alectinib therapy. Postoperatively, the patient developed delayed wound healing complicated by <i>Staphylococcus aureus</i> infection. After temporary discontinuation of alectinib combined with repeated debridement, negative pressure wound therapy, and wound closure, the lesion achieved complete healing.</p><p><strong>Conclusion: </strong>This case highlights the possibility that alectinib may impair postoperative wound repair. Comprehensive perioperative drug evaluation, multidisciplinary collaboration, and carefully monitored treatment interruption are recommended to maintain the balance between oncologic control and effective tissue healing.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"679-684"},"PeriodicalIF":0.7,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenocortical Carcinoma in Pregnancy: The First Case Report in Mexico and Review of the Literature. 妊娠期肾上腺皮质癌:墨西哥首例报告及文献回顾。
IF 0.7
Case Reports in Oncology Pub Date : 2026-04-10 eCollection Date: 2026-01-01 DOI: 10.1159/000551907
Jose Manuel Torres-Zazuetal, Ricardo Fernández-Ferreira, Eunice Vite-Martínez, Alejandra Revelles-Martínez, Mariana Hernández-Ramírez, Mauricio-Svein Rodríguez-Mar, Josué-Farid Elías-Delgado, Abel-Antonio Ricárdez-Espinosa, Juan-Pablo Santos-Uscanga, Ximena Flores-Rangel
{"title":"Adrenocortical Carcinoma in Pregnancy: The First Case Report in Mexico and Review of the Literature.","authors":"Jose Manuel Torres-Zazuetal, Ricardo Fernández-Ferreira, Eunice Vite-Martínez, Alejandra Revelles-Martínez, Mariana Hernández-Ramírez, Mauricio-Svein Rodríguez-Mar, Josué-Farid Elías-Delgado, Abel-Antonio Ricárdez-Espinosa, Juan-Pablo Santos-Uscanga, Ximena Flores-Rangel","doi":"10.1159/000551907","DOIUrl":"10.1159/000551907","url":null,"abstract":"<p><strong>Introduction: </strong>Adrenocortical carcinoma (ACC) in pregnancy is very rare, with fewer than 20 cases reported in the world literature.</p><p><strong>Case presentation: </strong>A 21-year-old woman with ACC during pregnancy, diagnosed incidentally, presented with preeclampsia and underwent a left laparoscopic adrenalectomy with significant clinical improvement.</p><p><strong>Discussion: </strong>The most common form of diagnosis of ACC is incidental, occurring during imaging studies. However, in pregnancy, gestational hypertension or preeclampsia is one of the signs frequently associated with functional ACC, particularly with cortisol secretion. Histological diagnosis is the gold standard, and in early stages, surgery is the treatment of choice. The prognosis for ACC is extremely poor, but pregnancy-associated ACC is associated with even shorter survival periods.</p><p><strong>Conclusion: </strong>This type of presentation represents a clinical challenge and requires multidisciplinary management to improve the patient's survival.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"549-560"},"PeriodicalIF":0.7,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13183367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemo- and Immunotherapy in a Patient with Anti-TIF1γ-Positive Paraneoplastic Dermatomyositis in Adenocarcinoma of Unknown Primary Origin: A Challenging Path from Diagnosis to Treatment - A Case Report. 1例原发性不明原因腺癌中抗tif1 γ阳性的副肿瘤性皮肌炎患者的化疗和免疫治疗:从诊断到治疗的挑战之路- 1例报告
IF 0.7
Case Reports in Oncology Pub Date : 2026-04-10 eCollection Date: 2026-01-01 DOI: 10.1159/000551635
Jeanine Ischi, Matthias Walther
{"title":"Chemo- and Immunotherapy in a Patient with Anti-TIF1γ-Positive Paraneoplastic Dermatomyositis in Adenocarcinoma of Unknown Primary Origin: A Challenging Path from Diagnosis to Treatment - A Case Report.","authors":"Jeanine Ischi, Matthias Walther","doi":"10.1159/000551635","DOIUrl":"10.1159/000551635","url":null,"abstract":"<p><strong>Introduction: </strong>A 35-year-old female patient presenting with photosensitive erythema initially consulted a general practitioner. After a dermatological evaluation, she was diagnosed with anti-TIF1γ-positive dermatomyositis (DM).</p><p><strong>Case presentation: </strong>Due to a painful axillary lymph node, further ultrasound investigation led to the diagnosis of adenocarcinoma of unknown primary origin with paraneoplastic DM, initiating a complex, interdisciplinary treatment approach. A novel approach was initiating an immunotherapy due to cancer despite a paraneoplastic autoimmune disease, which adds to the literature that immunotherapy is not generally contraindicated in these patients. The treatment protocol was found in a combination of dose-dense corticosteroids, chemotherapy, immunotherapy, surgery, and radiotherapy.</p><p><strong>Conclusion: </strong>The treatment protocol led to a complete remission of both DM and neoplastic disease. This case underlines the importance of an individual and careful interdisciplinary treatment protocol with regularly evaluating the therapeutic outcome of symptoms and adverse effects.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"743-750"},"PeriodicalIF":0.7,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13282109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum. 勘误表。
IF 0.7
Case Reports in Oncology Pub Date : 2026-04-08 eCollection Date: 2026-01-01 DOI: 10.1159/000551297
{"title":"Erratum.","authors":"","doi":"10.1159/000551297","DOIUrl":"10.1159/000551297","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1159/000547815.].</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"458"},"PeriodicalIF":0.7,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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