双侧卵巢恶性勃勒纳瘤。

IF 0.7 Q4 ONCOLOGY
Case Reports in Oncology Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI:10.1159/000546358
Ahmad Al-Bitar, Ayla Kouli, Ibrahim Dabbour, Luna A AlMardini, Abdalkarim H Alnaser
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引用次数: 0

摘要

勃勒纳瘤(BTs)是一种罕见的卵巢肿瘤,恶性变异占病例的1-5%。恶性bt通常发生在50-70岁的女性中,通常表现为非特异性症状,如腹痛和体重减轻。其病因尚不清楚,明确的诊断需要组织病理学证实。病例介绍:54岁阿拉伯女性,长期吸烟者,腹痛、体重减轻和腹胀3个月。影像学显示双侧附件肿块(左:14cm;右:13 cm)伴有囊性变性,而肿瘤标志物(CA-125, CEA)保持正常。剖腹探查发现双侧卵巢肿瘤及大网膜转移。组织病理学证实为高度恶性BT,免疫组织化学支持。患者接受了全子宫切除术、双侧输卵管-卵巢切除术、大网膜切除术和6个周期的卡铂-紫杉醇化疗。8个月监测影像学未见复发。结论:由于非特异性症状、正常肿瘤标志物和影像学限制,本病例说明了恶性脑转移瘤的诊断复杂性。双侧受累虽不常见,但强调肿瘤侵袭性。标准的手术细胞减少和铂基化疗取得了有利的中期结果,与上皮性卵巢癌方案一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bilateral Malignant Brenner Tumor of the Ovary.

Introduction: Brenner tumors (BTs) are rare ovarian neoplasms, with malignant variants constituting 1-5% of cases. Typically occurring in women aged 50-70 years, malignant BTs often manifest with nonspecific symptoms such as abdominal pain and weight loss. Their etiology remains unclear, and a definitive diagnosis requires histopathological confirmation.

Case presentation: A 54-year-old Arab woman, a long-term smoker, presented with a 3-month history of abdominal pain, weight loss, and distension. Imaging revealed bilateral adnexal masses (left: 14 cm; right: 13 cm) with cystic degeneration, while tumor markers (CA-125, CEA) remained normal. Exploratory laparotomy identified bilateral ovarian tumors and omental metastasis. Histopathology confirmed a high-grade malignant BT, supported by immunohistochemistry. The patient underwent total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and six cycles of carboplatin-paclitaxel chemotherapy. Surveillance imaging at 8 months showed no recurrence.

Conclusion: This case illustrates the diagnostic complexity of malignant BTs due to nonspecific symptoms, normal tumor markers, and imaging limitations. Bilateral involvement, though uncommon, underscores tumor aggressiveness. Standard surgical cytoreduction and platinum-based chemotherapy achieved a favorable interim outcome, aligning with epithelial ovarian cancer protocols.

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来源期刊
CiteScore
1.40
自引率
12.50%
发文量
151
审稿时长
7 weeks
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