Case Reports in Oncology最新文献_第8页

Stereotactic Body Radiotherapy in a Transplanted Lung for a Primary Lung Cancer: Case Report. 原发性肺癌移植肺立体定向放射治疗一例报告。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-16 eCollection Date: 2025-01-01 DOI: 10.1159/000542713

Pedro Ferreira, Dionísio Maia, Miriam Abdulrehman

{"title":"Stereotactic Body Radiotherapy in a Transplanted Lung for a Primary Lung Cancer: Case Report.","authors":"Pedro Ferreira, Dionísio Maia, Miriam Abdulrehman","doi":"10.1159/000542713","DOIUrl":"10.1159/000542713","url":null,"abstract":"Introduction: Lung cancer in the transplanted organ is an extremely rare occurrence with very few cases reported. The use of stereotactic body radiotherapy (SBRT) for medically inoperable early stage non-small cell lung cancer is an option to treat an early stage lung adenocarcinoma on a transplanted lung.Case presentation: We report the case of a 63-year-old woman with a history of hypersensitivity pneumonitis, who underwent a right lung transplant in 2010 and developed pulmonary adenocarcinoma, stage IA2, in 2023. The patient was ineligible for surgical management and was referred for SBRT. The treatment was administered with a total dose of 48 Gy in 4 fractions in December 2023. The nodule remained stable at 9-month follow-up, with post-radiogenic pneumonitis observed. Pulmonary function remained stable after treatment.Conclusions: This case shows that SBRT on a transplanted lung cancer seems to be safe, even maintaining a standard SBRT fractionation, with good early local control. Careful consideration of dose, fractionation, and potential toxicities is essential in managing these complex cases, always in close cooperation with the transplant medical team.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"85-91"},"PeriodicalIF":0.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraperitoneal Bleeding Induced by a Ruptured Inferior Epigastric Artery Pseudoaneurysm following Interval Debulking Surgery for Ovarian Cancer: A Case Report. 卵巢癌间歇减压手术后腹壁下动脉假性动脉瘤破裂致腹腔内出血1例。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-13 eCollection Date: 2025-01-01 DOI: 10.1159/000543127

Shota Higami, Yasuyuki Kinjo, Mao Sekimata, Yuta Yoshimatsu, Yu Murakami, Tomoko Kurita, Kiyoshi Yoshino

{"title":"Intraperitoneal Bleeding Induced by a Ruptured Inferior Epigastric Artery Pseudoaneurysm following Interval Debulking Surgery for Ovarian Cancer: A Case Report.","authors":"Shota Higami, Yasuyuki Kinjo, Mao Sekimata, Yuta Yoshimatsu, Yu Murakami, Tomoko Kurita, Kiyoshi Yoshino","doi":"10.1159/000543127","DOIUrl":"10.1159/000543127","url":null,"abstract":"Introduction: Pseudoaneurysm following gynecologic cancer surgery is a rare complication that can become fatal when it ruptures. Common sites of pseudoaneurysms are the external iliac artery, hypogastric artery, and aorta, which are located around the lymphadenectomy site. There are no previous reports of ruptured inferior epigastric (IEA) artery pseudoaneurysms after gynecologic cancer surgery. We report a case of intraperitoneal bleeding induced by a ruptured IEA pseudoaneurysm following interval debulking surgery for stage IVB ovarian cancer.Case presentation: The patient underwent total abdominal simple hysterectomy, bilateral salpingo-oophorectomy, omentectomy, ileocolic resection, and peritonectomy around the ileocecal area after 5 cycles of neoadjuvant chemotherapy. The patient suddenly presented with loss of consciousness and reduced blood pressure on postoperative day 20. Her blood hemoglobin levels also decreased. Contrast-enhanced computed tomography revealed a pseudoaneurysm in the right IEA. There were no signs of extravasation from the pseudoaneurysm; however, bloody ascites was observed in the abdominal cavity. A ruptured IEA pseudoaneurysm was suspected, and coil embolization was immediately performed. Her symptoms abated soon after coil embolization, and she remained symptom-free during the 8 months of postoperative follow-up.Conclusion: Awareness of this rare complication is clinically important for its early detection and treatment.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"137-143"},"PeriodicalIF":0.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Diagnosing Rare Retroperitoneal Tumors: A Case Report of Extrarenal Giant Angiomyolipoma. 诊断罕见腹膜后肿瘤的挑战：肾外巨大血管平滑肌脂肪瘤1例报告。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-11 eCollection Date: 2025-01-01 DOI: 10.1159/000543128

Darío Sebastián López Delgado, Andres Ricaurte-Fajardo, Carlos Stiven Mueses-Tulcán, Omar Eduardo Benavides Ayala, Yeison Harvey Carlosama-Rosero

{"title":"Challenges in Diagnosing Rare Retroperitoneal Tumors: A Case Report of Extrarenal Giant Angiomyolipoma.","authors":"Darío Sebastián López Delgado, Andres Ricaurte-Fajardo, Carlos Stiven Mueses-Tulcán, Omar Eduardo Benavides Ayala, Yeison Harvey Carlosama-Rosero","doi":"10.1159/000543128","DOIUrl":"10.1159/000543128","url":null,"abstract":"Introduction: Extrarenal angiomyolipomas are extremely rare tumors, with only isolated reports in the literature. Their diagnosis is challenging as these lesions are often misdiagnosed as more common retroperitoneal tumors. This report presents a case of a retroperitoneal extrarenal angiomyolipoma, emphasizing its clinical, imaging, and histopathological features to facilitate accurate diagnosis and avoid errors.Case presentation: A 58-year-old male with a history of benign prostatic hyperplasia presented with progressive abdominal distension and weight gain. Imaging studies revealed a giant retroperitoneal mass displacing the left kidney and abdominal aorta. A core needle biopsy initially suggested a well-differentiated liposarcoma T4N0M0, leading to neoadjuvant chemotherapy with doxorubicin and ifosfamide. Surgical resection of a 20 × 30 × 25-cm mass was performed. Histopathological and immunohistochemical analysis of the specimen confirmed the diagnosis of retroperitoneal extrarenal angiomyolipoma. Chemotherapy was discontinued, and the patient remains stable under follow-up.Discussion and conclusion: Retroperitoneal extrarenal angiomyolipomas are rare, presenting significant diagnostic challenges due to their resemblance to other retroperitoneal neoplasms such as liposarcomas. This case highlights the importance of comprehensive imaging, histopathological examination, and immunohistochemical studies for accurate diagnosis. Increased awareness of this entity can help clinicians avoid unnecessary treatments and ensure appropriate management of similar cases.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"113-119"},"PeriodicalIF":0.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Mediastinal Synovial Sarcoma with Pericardial Involvement: A Case Report. 原发纵隔滑膜肉瘤伴心包受累1例。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-11 eCollection Date: 2025-01-01 DOI: 10.1159/000542680

Kenan C Michaels, Sean C Dougherty, Brett R Kurpiel, Michael G Douvas

{"title":"Primary Mediastinal Synovial Sarcoma with Pericardial Involvement: A Case Report.","authors":"Kenan C Michaels, Sean C Dougherty, Brett R Kurpiel, Michael G Douvas","doi":"10.1159/000542680","DOIUrl":"10.1159/000542680","url":null,"abstract":"Introduction: Synovial sarcoma is a rare, malignant neoplasm accounting for approximately 5-10% of all soft tissue sarcomas. Synovial sarcomas generally occur in the extremities of adolescent or young adult (AYA)-aged patients; however, they have been reported to affect virtually every organ system. The mediastinum is an exceptionally rare location for synovial sarcoma and malignant pericardial effusions occurring secondary to synovial sarcoma can occur.Case presentation: This case describes a 29-year-old male who presented with 3 weeks of dyspnea and leg swelling. An echocardiogram demonstrated a large pericardial effusion with early tamponade physiology. A subsequent pericardiocentesis returned a lymphocytic predominance with negative flow cytometry and cytology. Cross-sectional imaging with computed tomography (CT) scans of the chest, abdomen, and pelvis was negative for lymphadenopathy or detectable mass. He was discharged where repeat echocardiogram demonstrated recurrence of the effusion, but his symptoms had improved. Ultimately, he was readmitted with refractory dyspnea and edema where cardiac magnetic resonance imaging demonstrated a large mediastinal mass invading the pericardium. The biopsy demonstrated a high-grade spindle cell malignancy positive for a rearrangement of the SS18 gene, a finding diagnostic of synovial sarcoma. He passed away after one round of doxorubicin due to septic and obstructive shock (tamponade).Conclusion: Mediastinal synovial sarcomas are rare, aggressive, and highly morbid neoplasms. In some cases, they may present insidiously due to their sole presenting clinical manifestation being pericardial effusion. Particular care should be taken to rule out malignancy with MRI or PET-guided imaging in the AYA-aged population when idiopathic, recurrent pericardial effusion is found.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"76-84"},"PeriodicalIF":0.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinoblastoma and Persistent Fetal Vasculature in the Same Eye: Case Report. 视网膜母细胞瘤和胎儿血管在同只眼睛：1例报告。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-10 eCollection Date: 2025-01-01 DOI: 10.1159/000542987

Felipe Baccega, Laura Goldfarb Cyrino, Patricia Picciarelli, Paulo Vigga Alves E Silva, Maria Teresa Brizzi Chizzotti Bonanomi

{"title":"Retinoblastoma and Persistent Fetal Vasculature in the Same Eye: Case Report.","authors":"Felipe Baccega, Laura Goldfarb Cyrino, Patricia Picciarelli, Paulo Vigga Alves E Silva, Maria Teresa Brizzi Chizzotti Bonanomi","doi":"10.1159/000542987","DOIUrl":"10.1159/000542987","url":null,"abstract":"Introduction: Retinoblastoma is the most prevalent intraocular tumor in children, commonly manifesting as leukocoria. Persistent fetal vasculature (PFV) is another cause of leukocoria, resulting from the incomplete regression of fetal eye blood vessels. The simultaneous occurrence of retinoblastoma and PFV in the same eye is extremely uncommon and presents significant diagnostic difficulties.Case presentation: We present a case involving a 2-year-old girl with leukocoria and esotropia in her left eye. Clinical assessments, including biomicroscopy, ocular ultrasound, and magnetic resonance imaging, identified a retrolental mass with calcifications and a hyperechoic tubular structure, indicating the presence of both retinoblastoma and PFV. Enucleation followed by histopathological analysis confirmed these diagnoses. The histopathology revealed retinoblastoma with Homer-Wright and Flexner-Wintersteiner rosettes and signs of PFV, with persistent large vessels in the retrolental region.Conclusion: The coexistence of retinoblastoma and PFV in a single eye is rare and complicates the diagnosis of leukocoria. Comprehensive multimodal imaging is crucial for accurate diagnosis and effective management, tailored to the distinct needs of each condition. This case highlights the importance of detailed evaluation in pediatric patients with leukocoria to ensure correct diagnosis and appropriate treatment.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"55-60"},"PeriodicalIF":0.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Splenic Irradiation Preceding Allogeneic Hematopoietic Stem Cell Transplantation as a Possible Risk Factor of Sinusoidal Obstruction Syndrome: A Report of Three Cases. 同种异体造血干细胞移植前脾照射可能是窦道阻塞综合征的危险因素：附3例报告

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Case Reports in Oncology Pub Date : 2024-12-09 eCollection Date: 2025-01-01 DOI: 10.1159/000542608

Shuichi Shirane, Hajime Yasuda, Ayana Uchimura, Yosuke Mori, Tadaaki Inano, Miyuki Tsutsui, Yasuharu Hamano, Miki Ando

{"title":"Splenic Irradiation Preceding Allogeneic Hematopoietic Stem Cell Transplantation as a Possible Risk Factor of Sinusoidal Obstruction Syndrome: A Report of Three Cases.","authors":"Shuichi Shirane, Hajime Yasuda, Ayana Uchimura, Yosuke Mori, Tadaaki Inano, Miyuki Tsutsui, Yasuharu Hamano, Miki Ando","doi":"10.1159/000542608","DOIUrl":"10.1159/000542608","url":null,"abstract":"Introduction: Splenomegaly is frequently encountered in patients with myeloproliferative neoplasms. Splenomegaly is associated with an increased incidence of engraftment failure during allogeneic hematopoietic stem cell transplantation (allo-HSCT), and some centers perform prior low-dose splenic irradiation (LDSI) which has been reported to be both safe and effective. However, we report conflicting results by presenting three allo-HSCT patients undergoing LDSI that subsequently developed sinusoidal obstruction syndrome (SOS).Case presentation: The underlying diseases of the presented cases were atypical chronic myeloid leukemia, secondary myelofibrosis following essential thrombocythemia, and acute myeloid leukemia transforming from myeloproliferative neoplasm, unclassifiable. Endothelial Activation and Stress Index (EASIX) scores of the 3 patients were 0.40, 3.82, and 4.40, respectively.Conclusion: SOS is a potentially fatal complication of allo-HSCT, and the mortality rates of severe cases are reported to be above 80%. LDSI has not been recognized as a risk factor of SOS to date. Alternative management methods of splenomegaly during allo-HSCT such as ruxolitinib administration may be safer compared to LDSI.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1-6"},"PeriodicalIF":0.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-Grade Adenosquamous Carcinoma of the Breast: A Case Report. 低级别乳腺腺鳞癌1例报告。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-09 eCollection Date: 2025-01-01 DOI: 10.1159/000542764

Rikako Ogawa, Hiroshi Sugiura, Yukari Hato, Hikaru Kawahara, Norio Shiraki, Yukashi Ito, Yoshiaki Ando, Misao Ishikawa

{"title":"Low-Grade Adenosquamous Carcinoma of the Breast: A Case Report.","authors":"Rikako Ogawa, Hiroshi Sugiura, Yukari Hato, Hikaru Kawahara, Norio Shiraki, Yukashi Ito, Yoshiaki Ando, Misao Ishikawa","doi":"10.1159/000542764","DOIUrl":"10.1159/000542764","url":null,"abstract":"Introduction: Low-grade adenosquamous carcinoma (LGASC) is categorized as a metaplastic carcinoma but differs from other types of metaplastic carcinoma in having a more favorable prognosis. Due to its rarity and unusual and inconsistent presentation, there is little information available regarding its characteristics, making correct diagnosis a challenge.Case presentation: We report herein the case of a 54-year-old Japanese woman who presented with a lump in her left breast. She was found to have a benign lesion which continually relapsed, necessitating repeated excisions, ultimately leading to the diagnosis of LGASC after the third excision. Guidelines for the treatment of LGASC emphasize complete tumor excision, with adjuvant therapies only considered in cases with positive lymph node metastasis. Consequently, the patient underwent total mastectomy but postoperative chemotherapy was not administered, and the patient was followed up with regular observation. By 20 months postoperatively, there was no sign of recurrence.Conclusion: LGASC has distinctive pathological features of the intimate admixture of well-developed glands and solid squamous cell nests within a fibrotic or cellular spindle stroma. It is difficult to determine preoperatively with cytology or needle biopsy because LGASC mimics benign tumors. It is typically triple-negative, but it has an indolent behavior. Adjuvant therapy after surgery is considered unnecessary for triple-negative status, but there is no clear evidence. We aimed to provide more data on the disease characteristics, presentation, and treatment outcome. Accumulation of further evidence is warranted to refine diagnostic and therapeutic strategies of LGASC.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"92-99"},"PeriodicalIF":0.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Survival after Stereotactic Radiotherapy Combined with Immunotherapy in a Patient with Recurrent Oral Cancer. 立体定向放疗联合免疫治疗复发口腔癌患者的长期生存率。

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Case Reports in Oncology Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI: 10.1159/000542321

Paweł Polanowski, Marlena Howorus, Aleksandra Nasiek, Anna Kozub, Agnieszka Pietruszka, Katarzyna Drosik-Rutowicz, Katarzyna Polanowska, Krzysztof Składowski

{"title":"Long-Term Survival after Stereotactic Radiotherapy Combined with Immunotherapy in a Patient with Recurrent Oral Cancer.","authors":"Paweł Polanowski, Marlena Howorus, Aleksandra Nasiek, Anna Kozub, Agnieszka Pietruszka, Katarzyna Drosik-Rutowicz, Katarzyna Polanowska, Krzysztof Składowski","doi":"10.1159/000542321","DOIUrl":"10.1159/000542321","url":null,"abstract":"Introduction: Recurrent oral squamous cell carcinoma (SCC) poses significant challenges in treatment, requiring a multifaceted approach for effective management.Case presentation: We present the case of a 68-year-old patient with a history of keratonizing SCC of the mandibular gingiva, treated with surgical resection, adjuvant radiotherapy (RT) to a total dose of 60 Gy in 30 fractions and 6 cycles of concurrent chemotherapy. After 6 years of follow-up, the patient experienced a local late recurrence in clinical stage rT4N0M0 requiring palliative chemotherapy (6 cycles of PF regimen). Due to progression, nivolumab-based immunotherapy was administered. After the 11th cycle of immunotherapy, high-dose re-irradiation (18 Gy in 3 fractions) was applied due to subsequent progression. The addition of stereotactic RT to the immunotherapy allowed nivolumab to be continued until cycle 64, ensuring long-term disease stabilization with acceptable tolerability. Consecutive palliative chemotherapy included paclitaxel and methotrexate.Conclusion: This case highlights the complex management of recurrent oral SCC, emphasizing the role of combining stereotactic RT with nivolumab in prolonging the administration of immunotherapy.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"17 1","pages":"1366-1373"},"PeriodicalIF":0.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasopharyngeal Metastasis from Lung Adenocarcinoma: A Case Report and Literature Review. 肺腺癌鼻咽转移一例报告及文献复习。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI: 10.1159/000539018

Chiara Conti, Sabrina Nucera, Giuseppe Di Grazia, Federica Martorana, Fabio Motta, Paolo Vigneri, Alfio M Di Grazia

{"title":"Nasopharyngeal Metastasis from Lung Adenocarcinoma: A Case Report and Literature Review.","authors":"Chiara Conti, Sabrina Nucera, Giuseppe Di Grazia, Federica Martorana, Fabio Motta, Paolo Vigneri, Alfio M Di Grazia","doi":"10.1159/000539018","DOIUrl":"10.1159/000539018","url":null,"abstract":"Introduction: Managing uncommon metastatic sites from different solid tumors is challenging since no available guidelines define the best therapeutic approaches for these rare clinical events. Thus, malignancies giving rise to distant metastases involving infrequent anatomical regions are often associated with a poor prognosis.Case presentation: We present the case of a 75-year-old man who developed uncontrolled epistaxis following the detection of a metachronous nasopharyngeal metastasis from a previous lung adenocarcinoma. The lesion was identified with a computed tomography scan and its origin from the earlier non-small cell lung cancer was confirmed by a biopsy. The patient was successfully treated with radiation therapy and is currently continuing his oncological follow-up. To the best of our knowledge, this is the fifth reported case of a lung malignancy spreading to the nasopharyngeal region.Conclusion: Meticulous patient monitoring and accurate radiological diagnosis followed by histological confirmation are of paramount importance for the management of uncommon metastatic sites. Likewise, a multidisciplinary approach is essential to devise the appropriate treatment strategy for each patient with locoregional interventions, such as radiation therapy, often playing a pivotal role for the management of symptomatic lesions in unusual anatomical sites.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"17 1","pages":"1358-1365"},"PeriodicalIF":0.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical Presentation of an Ovarian Yolk Sac Tumor in an 80-Year-Old Woman: A Case Report and Review of the Literature. 80岁女性卵巢卵黄囊肿瘤的不典型表现：1例报告及文献复习。

IF 0.7

Case Reports in Oncology Pub Date : 2024-12-03 eCollection Date: 2024-01-01 DOI: 10.1159/000542244

Vanessa Maldonado, María Masvidal, Vanessa Morente Laguna, Jacqueline Cimerman, Salvador Martinez Soriano

{"title":"Atypical Presentation of an Ovarian Yolk Sac Tumor in an 80-Year-Old Woman: A Case Report and Review of the Literature.","authors":"Vanessa Maldonado, María Masvidal, Vanessa Morente Laguna, Jacqueline Cimerman, Salvador Martinez Soriano","doi":"10.1159/000542244","DOIUrl":"10.1159/000542244","url":null,"abstract":"Introduction: Ovarian yolk sac tumors after the menopause are very rare.Case presentation: We report an atypical case of yolk sac tumor in an octogenarian woman, who presented to the hospital with anasarca, ascites, toxic syndrome, and an abdominal mass. Serum alpha-fetoprotein (AFP) levels were highly increased (246,720 ng/mL), and malignant cells with positive AFP immunohistochemical expression were detected in a diagnostic paracentesis. The definitive diagnosis was established by histopathological examination of the surgical specimen and immunohistochemical detection of positivity for AFP, glypican 3, cytokeratin AE1/AE3, and focal positivity for SALL4 and CK7. Adjuvant chemotherapy was refused by the patient. Postoperative AFP values decreased to normal limits. One year after surgery, she remains in good clinical condition without evidence of tumor recurrence. In a review of the literature, 11 cases of yolk sac tumors in postmenopausal women were collected. The mean age of the patients was 63.4 years (range 58-82 years). Frequent findings were FIGO stage II, cytoreductive surgery, immunohistochemical analyses of a large panel of markers, postoperative chemotherapy, and no tumor recurrence (except in 1 patient who died), although the length of follow-up was relatively short or unclearly stated.Conclusion: The present case report illustrates that yolk sac tumors in very old women may have a favorable clinical course without signs of recurrence even in the absence of radical surgical resection with curative intent and associated adjuvant chemotherapy.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"17 1","pages":"1342-1350"},"PeriodicalIF":0.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0