Case Reports in Oncology最新文献_第2页

Masson's Tumor Mimicking Mesenchymal Neoplasia: A Case Report of Intravascular Papillary Endothelial Hyperplasia in the Deltoid Muscle. 模拟间质瘤的马松瘤：三角肌血管内乳头状内皮增生1例报告。

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Case Reports in Oncology Pub Date : 2026-02-09 eCollection Date: 2026-01-01 DOI: 10.1159/000550884

Cristina Peralta Rivera, Miguel Ángel Monroy Ramírez, Diana Ximena Morán Bernal, Camila Dennys Arteaga González, Saúl Iván Gómez López, Saided Solano Vargas, Rafael Silva Flores

{"title":"Masson's Tumor Mimicking Mesenchymal Neoplasia: A Case Report of Intravascular Papillary Endothelial Hyperplasia in the Deltoid Muscle.","authors":"Cristina Peralta Rivera, Miguel Ángel Monroy Ramírez, Diana Ximena Morán Bernal, Camila Dennys Arteaga González, Saúl Iván Gómez López, Saided Solano Vargas, Rafael Silva Flores","doi":"10.1159/000550884","DOIUrl":"10.1159/000550884","url":null,"abstract":"Introduction: Intravascular papillary endothelial hyperplasia (IPEH), or Masson's tumor, is a benign endothelial proliferation that typically arises in soft tissues and lacks cytological atypia. It is often identified during the exclusion of malignant vascular neoplasms, particularly angiosarcoma. Deltoid involvement is exceptionally rare and usually associated with underlying vascular malformations.Case presentation: A 19-year-old woman presented with a painless, progressively enlarging swelling in the right shoulder, without a history of trauma. Magnetic resonance imaging revealed a well-defined intramuscular lesion suggestive of mesenchymal neoplasia. A complete surgical excision was performed. Histopathological analysis revealed a vascular lesion composed of multiple papillary structures lined with bland endothelial cells, consistent with IPEH. No atypia or malignancy was identified. The patient remained recurrence-free at 12-month follow-up.Conclusion: Masson's tumor invariably requires surgical excision to establish a definitive diagnosis and to exclude malignant vascular neoplasms, particularly angiosarcoma. This case highlights the diagnostic challenges posed by IPEH in atypical locations and underscores the importance of histopathological confirmation. A review of previously reported cases confirmed an indolent course and a low recurrence rate. Early detection of this tumor in young patients is essential to prevent unnecessary aggressive interventions.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"427-436"},"PeriodicalIF":0.7,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13030905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thiamine Deficiency in a Patient with Gastric Adenocarcinoma: A Case Report. 胃腺癌患者硫胺素缺乏1例报告。

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Case Reports in Oncology Pub Date : 2026-02-07 eCollection Date: 2026-01-01 DOI: 10.1159/000550936

Ahmad Al-Bitar, Ayla Kouli, Hussain Almosli, Carol Baghdan, Nisreen Khazeam

{"title":"Thiamine Deficiency in a Patient with Gastric Adenocarcinoma: A Case Report.","authors":"Ahmad Al-Bitar, Ayla Kouli, Hussain Almosli, Carol Baghdan, Nisreen Khazeam","doi":"10.1159/000550936","DOIUrl":"https://doi.org/10.1159/000550936","url":null,"abstract":"Introduction: Thiamine deficiency (TD), arising from inadequate intake or increased metabolic demand, is an underrecognized complication in oncology. While commonly associated with Wernicke encephalopathy (WE), its subclinical form often precedes overt neurological symptoms. Gastric cancer (GC) patients are at high risk due to malnutrition and cachexia. This case highlights the critical importance of proactive TD screening in malnourished cancer patients to prevent irreversible neurological sequelae.Case presentation: A 58-year-old nonalcoholic female with a smoking history presented with hematemesis. Endoscopy and biopsy confirmed gastric adenocarcinoma (signet ring cell type). She initially declined treatment. One month later, she returned with rapid clinical deterioration: 17 kg weight loss and profound anorexia, but no neurological deficits. Informed by a family history of malignancy with neuropsychiatric symptoms, serum thiamine was tested and revealed severe deficiency (21 ng/mL; normal 30-70). Intravenous thiamine replacement was initiated.Conclusion: This case underscores that overt neurological signs are not a prerequisite for significant TD in high-risk oncology patients. A low threshold for screening - based on nutritional status and rapid weight loss - is essential, particularly in resource-limited settings where advanced diagnostic tools are scarce. Proactive thiamine replacement can prevent the development of full-blown WE, potentially improving a patient's candidacy for and tolerance of anticancer therapies. Integrating nutritional deficiency screening into standard oncological workup is a simple, cost-effective measure to reduce morbidity.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"444-449"},"PeriodicalIF":0.7,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BRCA1-Mutant Ovarian Cancer with an Unusual Presentation of Leptomeningeal Disease Early in the Course of Treatment: A Case Report. brca1突变卵巢癌在治疗过程中早期出现不寻常的轻脑膜疾病：1例报告

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Case Reports in Oncology Pub Date : 2026-02-05 eCollection Date: 2026-01-01 DOI: 10.1159/000550838

Jodie Pollard, Jane Parry, Tim Wilkinson, Gerard Thompson, Kate Connolly

{"title":"BRCA1-Mutant Ovarian Cancer with an Unusual Presentation of Leptomeningeal Disease Early in the Course of Treatment: A Case Report.","authors":"Jodie Pollard, Jane Parry, Tim Wilkinson, Gerard Thompson, Kate Connolly","doi":"10.1159/000550838","DOIUrl":"https://doi.org/10.1159/000550838","url":null,"abstract":"Introduction: Leptomeningeal disease is a rare and devastating complication of ovarian cancer which typically occurs in patients with advanced relapsed disease. It is challenging to treat and associated with a very poor prognosis.Case presentation: A 48-year-old patient with BRCA1-mutant high-grade serous ovarian cancer underwent neoadjuvant chemotherapy followed by hysterectomy, bilateral salpingo-oophorectomy and omentectomy. There was no macroscopic residual disease after surgery and CA125 normalised. Back pain was reported postoperatively and at 3 months post-surgery, the patient presented with worsening headaches, vomiting, and photophobia. After extensive investigations including imaging which was initially reported as normal and multiple lumbar punctures with no malignant cells detected, she was diagnosed with leptomeningeal disease. A trial of the PARP inhibitor niraparib was initiated, but the patient deteriorated rapidly and died 6 weeks after presenting with headache.Conclusion: The development of leptomeningeal disease in an ovarian cancer patient early in her treatment pathway with apparent good response to systemic therapy is exceedingly unusual. This case posed challenges both in diagnosis and in management, with limited evidence available to guide choice of therapy. Unfortunately, the response to PARP inhibitor in this patient could not be assessed due to her rapid deterioration.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"499-507"},"PeriodicalIF":0.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sister Mary Joseph's Nodule Presenting with an Ulcerated Umbilicus as an External Diagnostic Clue Revealing a Deeply Situated Pancreatic Tail Cancer. 玛丽·约瑟夫修女的结节以溃疡的脐为外部诊断线索，揭示了胰腺癌的深层位置。

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Case Reports in Oncology Pub Date : 2026-02-03 eCollection Date: 2026-01-01 DOI: 10.1159/000550841

Hiroaki Shibahara, Atsufumi Takeuchi, Yasuko Fujii, Yoriko Yamashita

{"title":"Sister Mary Joseph's Nodule Presenting with an Ulcerated Umbilicus as an External Diagnostic Clue Revealing a Deeply Situated Pancreatic Tail Cancer.","authors":"Hiroaki Shibahara, Atsufumi Takeuchi, Yasuko Fujii, Yoriko Yamashita","doi":"10.1159/000550841","DOIUrl":"https://doi.org/10.1159/000550841","url":null,"abstract":"Case presentation: An 84-year-old female patient presented with umbilical hemorrhage. A central depressed lesion with reddish and multinodular change was exhibited in the umbilicus, showing with an ulcerated, infiltrative appearance. The patient was strongly suspected of having Sister Mary Joseph's nodule (SMJN). Referring to the tertiary care hospital, laboratory tests revealed an elevated CA19-9 level of 15,366 U/mL, and a computed tomography scan showed a pancreatic tail tumor and the umbilical mass. Biopsy of the umbilical lesion revealed adenocarcinoma cells infiltrated in the skin, with immunohistochemical staining positive for CK7 and CA19-9 but negative for CK20. Therefore, the umbilical lesion was consequently diagnosed as metastasis from pancreatic tail cancer, representing SMJN. The patient died 2 months after the initial presentation.Conclusions: Ulcerated umbilical lesions should warrant clinical consideration of SMJN, as they can serve as a critical diagnostic clue to a deeply situated pancreatic tail cancer.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"366-372"},"PeriodicalIF":0.7,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Use of Epcoritamab in Refractory Diffuse Large B-Cell Lymphoma with Central Nervous System Involvement: A Case Report. Epcoritamab成功治疗难治性弥漫性大b细胞淋巴瘤累及中枢神经系统1例。

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Case Reports in Oncology Pub Date : 2026-02-03 eCollection Date: 2026-01-01 DOI: 10.1159/000550769

Yoshiki Uemura, Kazuto Togitani, Junko Nakashima

{"title":"Successful Use of Epcoritamab in Refractory Diffuse Large B-Cell Lymphoma with Central Nervous System Involvement: A Case Report.","authors":"Yoshiki Uemura, Kazuto Togitani, Junko Nakashima","doi":"10.1159/000550769","DOIUrl":"https://doi.org/10.1159/000550769","url":null,"abstract":"Introduction: Diffuse large B-cell lymphoma (DLBCL) with central nervous system (CNS) involvement carries an extremely poor prognosis, particularly in patients' refractory to standard immunochemotherapy. Although bispecific antibodies are generally considered to have limited efficacy in CNS disease, this case suggests a potential clinical benefit of epcoritamab in refractory DLBCL with CNS involvement.Case presentation: We describe the case of a 71-year-old man with primary bone marrow DLBCL refractory to dose-adjusted EPOCH-R. Despite treatment with high-dose methotrexate and intrathecal chemotherapy, the disease progressed rapidly, with involvement of the CNS. Given the limited efficacy of standard salvage regimens and the urgent need for disease control, epcoritamab, a CD20×CD3 bispecific antibody, was initiated along with the bridging therapy. Bispecific antibodies are generally considered ineffective in CNS disease because of poor blood-brain barrier penetration, and such patients are typically excluded from clinical trials. However, epcoritamab induced a rapid systemic response along with partial neurological improvement.Conclusion: This case highlights the potential role of bispecific antibody therapy in refractory DLBCL with CNS involvement, an area of significant unmet clinical need.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"356-365"},"PeriodicalIF":0.7,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abscopal Effect following Stereotactic Radiation Therapy to the Brain and Spleen in Metastatic Endometrial Cancer: A Case Report. 脑脾立体定向放射治疗转移性子宫内膜癌的体外效应：1例报告。

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Case Reports in Oncology Pub Date : 2026-02-02 eCollection Date: 2026-01-01 DOI: 10.1159/000550790

Yukiko Fukuda, Masahiro Kawahara, Keiko Akahane, Machi Nakagawa, Masashi Endo, Kazunari Ogawa, Michiko Nakamura, Daisuke Irie, Satoru Takahashi, Noriko Oyama-Manabe, Hiroyoshi Ko, Kenro Chikazawa, Tomoyuki Kuwata, Katsuyuki Shirai

{"title":"Abscopal Effect following Stereotactic Radiation Therapy to the Brain and Spleen in Metastatic Endometrial Cancer: A Case Report.","authors":"Yukiko Fukuda, Masahiro Kawahara, Keiko Akahane, Machi Nakagawa, Masashi Endo, Kazunari Ogawa, Michiko Nakamura, Daisuke Irie, Satoru Takahashi, Noriko Oyama-Manabe, Hiroyoshi Ko, Kenro Chikazawa, Tomoyuki Kuwata, Katsuyuki Shirai","doi":"10.1159/000550790","DOIUrl":"10.1159/000550790","url":null,"abstract":"Introduction: The abscopal effect of radiation therapy is a rare phenomenon in which immune activation induces the regression of distant, nonirradiated tumors. Recent studies have increasingly suggested that combining radiation therapy with immunotherapy may increase the occurrence rate of the abscopal effect.Case presentation: We report the case of a 72-year-old woman with stage IA endometrial cancer. After surgery and adjuvant pelvic radiation therapy, oligometastases develop in the spleen and lungs. Subsequently, stereotactic body radiation therapy was initiated for the spleen; nonetheless, it was discontinued because of new brain metastases that caused neurological symptoms. Following brain-fractionated stereotactic radiosurgery, her symptoms improved, and imaging demonstrated a reduction in both brain and splenic lesions. The lung metastases, which had not been irradiated, initially grew but then regressed after 6 months of radiation therapy to the spleen and brain, suggesting an abscopal effect. Of particular interest is the observation that while splenic metastasis increased 8 months after radiation, the multiple lung metastases maintained their reduction.Conclusion: This case highlights that a delayed abscopal effect can develop following stereotactic radiation therapy, even without the use of immune checkpoint inhibitors.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"393-399"},"PeriodicalIF":0.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perianal Rhabdomyosarcoma Mimicking Perianal Abscess: Case Report and Literature Review. 模拟肛周脓肿的横纹肌肉瘤：1例报告及文献复习。

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Case Reports in Oncology Pub Date : 2026-01-30 eCollection Date: 2026-01-01 DOI: 10.1159/000550387

Mohammadsadra Shamohammadi, Behnoush Mohammadtaheri, Armaghan Abbasi Garavand, Ahmad Madankan, Seyed Hamzeh Mousavie, Mahshid Panahi

{"title":"Perianal Rhabdomyosarcoma Mimicking Perianal Abscess: Case Report and Literature Review.","authors":"Mohammadsadra Shamohammadi, Behnoush Mohammadtaheri, Armaghan Abbasi Garavand, Ahmad Madankan, Seyed Hamzeh Mousavie, Mahshid Panahi","doi":"10.1159/000550387","DOIUrl":"10.1159/000550387","url":null,"abstract":"Introduction: Perianal rhabdomyosarcoma is an exceedingly rare and aggressive soft tissue malignancy that can mimic benign conditions, such as perianal abscesses, which complicates its diagnosis and treatment. This study reports a case of perianal RMS and discusses the management approach and the challenges in diagnosis.Presentation of case: A 26-year-old woman with a past medical history of breast cancer, treated with partial mastectomy, chemotherapy, and radiation therapy, presented with a recurrent perianal mass initially drained multiple times for presumed abscesses. Upon further evaluation, physical examination revealed a 7-cm perianal wound with purulent and bloody discharge. Imaging studies revealed a lobulated mass in the perineal area with involvement of the anus. Biopsy confirmed the diagnosis of alveolar RMS. The patient was treated with six cycles of neoadjuvant chemotherapy, followed by excisional biopsy. The tumor was resected with clear margins and immunohistochemical analysis confirmed the diagnosis. Adjuvant chemotherapy was initiated, and the patient remains asymptomatic at 6-month follow-up.Conclusion: Rhabdomyosarcoma should be considered in the differential diagnosis of perianal masses, especially in cases with recurrence or unusual clinical presentation. Early recognition and appropriate multidisciplinary management, including chemotherapy and surgical excision, are essential for favorable outcomes.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"379-392"},"PeriodicalIF":0.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13008405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Dual Pathology of Papillary Thyroid Carcinoma with Incidental Unicentric Castleman's Disease: Case Report and Literature Review. 罕见的甲状腺乳头状癌伴偶发单中心Castleman病双重病理：1例报告及文献复习。

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Case Reports in Oncology Pub Date : 2026-01-29 eCollection Date: 2026-01-01 DOI: 10.1159/000550666

Rola Ghasoub, Maria Benkhadra, Rajen Goyal, Abdelkareem Alhyari, Sarah A Elkourashy

{"title":"A Rare Dual Pathology of Papillary Thyroid Carcinoma with Incidental Unicentric Castleman's Disease: Case Report and Literature Review.","authors":"Rola Ghasoub, Maria Benkhadra, Rajen Goyal, Abdelkareem Alhyari, Sarah A Elkourashy","doi":"10.1159/000550666","DOIUrl":"10.1159/000550666","url":null,"abstract":"Background: Papillary thyroid carcinoma (PTC) is the most common form of thyroid malignancy, often presenting with regional lymph node involvement. Castleman's disease is a rare, non-clonal lymphoproliferative disorder, typically presenting as unicentric or multicentric disease. The incidental coexistence of PTC and Castleman's disease is exceptionally rare and can complicate the diagnostic and therapeutic approach, especially when lymphadenopathy is involved.Case presentation: We report the case of a 36-year-old male who presented with a left-sided neck mass and was diagnosed with multifocal classic and diffuse sclerosing variants of PTC, with cervical lymph node metastases. Surgical pathology following total thyroidectomy and lymph node dissection unexpectedly revealed features of unicentric hyaline-vascular variant Castleman's disease in a non-metastatic lymph node. Immunohistochemical staining confirmed the diagnosis. The patient was asymptomatic with regard to Castleman's disease and was managed conservatively. PTC was managed with surgery and suppressive levothyroxine therapy, with plans for adjuvant radioactive iodine therapy.Conclusion: This case illustrates a rare dual pathology of PTC with incidental unicentric Castleman's disease. It highlights the importance of thorough histopathological evaluation in lymphadenopathy associated with thyroid carcinoma and suggests a potential need for increased awareness of concurrent benign lymphoproliferative disorders in oncologic surgery. Further studies are needed to understand the clinical significance and possible pathophysiological link between these two conditions.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"400-409"},"PeriodicalIF":0.7,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Adenoid Cystic Breast Cancer: A Case Report and Literature Review. 罕见腺样囊性乳腺癌1例报告及文献复习。

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Case Reports in Oncology Pub Date : 2026-01-29 eCollection Date: 2026-01-01 DOI: 10.1159/000550251

Elie Bterrani, Doha Houcheimy, David Karam, Lynn Mansour, Francois Georges Kamar

{"title":"A Rare Case of Adenoid Cystic Breast Cancer: A Case Report and Literature Review.","authors":"Elie Bterrani, Doha Houcheimy, David Karam, Lynn Mansour, Francois Georges Kamar","doi":"10.1159/000550251","DOIUrl":"https://doi.org/10.1159/000550251","url":null,"abstract":"Introduction: Adenoid cystic carcinoma (AdCC) of the breast is an exceptionally rare malignancy, representing less than 0.1% of all breast cancers. Despite its triple-negative receptor profile, it typically follows an indolent course with excellent prognosis, distinct from the aggressive behavior usually seen in triple-negative breast cancers (TNBCs).Case presentation: We report the case of a 48-year-old woman with a significant familial history of cancer who was diagnosed with breast AdCC. Imaging revealed a suspicious lesion in the left breast, and biopsy confirmed AdCC. Surgical resection showed a 58-mm, pT3, pN0(sn) triple-negative tumor with a low proliferative index. Genetic testing revealed a BRIP1 variant of uncertain significance (VUS). No adjuvant chemotherapy was given, and the patient remains in remission under surveillance.Discussion: This case highlights the diagnostic challenges of AdCC, including its resemblance to benign lesions on imaging and its overlap with high-grade TNBC histologically. While most AdCC cases are sporadic, the presence of a BRIP1 VUS in a patient with strong family history raises questions about possible hereditary implications. Management was based on current best practices, emphasizing surgical resection and selective use of radiotherapy.Conclusion: Breast AdCC, though rare, requires heightened clinical awareness for accurate diagnosis and management. This case underscores the potential role of genetic evaluation in rare breast cancer subtypes and the importance of continued case reporting to guide future recommendations.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"373-378"},"PeriodicalIF":0.7,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abrupt Onset of Septic Cardiomyopathy in a Cancer Patient Initiated on Chemotherapy: A Case Report and Literature Review. 化脓性心肌病在化疗开始的癌症患者突然发作：1例报告和文献复习。

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Case Reports in Oncology Pub Date : 2026-01-29 eCollection Date: 2026-01-01 DOI: 10.1159/000550294

Vinay Vaman Venkatesh, Vinod K Ramani, Sajjad Munaf, Adithya Krishna, Abderahman Belfakih, Radheshyam Naik

{"title":"Abrupt Onset of Septic Cardiomyopathy in a Cancer Patient Initiated on Chemotherapy: A Case Report and Literature Review.","authors":"Vinay Vaman Venkatesh, Vinod K Ramani, Sajjad Munaf, Adithya Krishna, Abderahman Belfakih, Radheshyam Naik","doi":"10.1159/000550294","DOIUrl":"https://doi.org/10.1159/000550294","url":null,"abstract":"Introduction: Sepsis-induced cardiomyopathy (SICM) develops in 18-65% cases of sepsis, and its presence in septic shock increases the mortality rate by 70% to 90%. The hallmark of SICM includes global hypokinesia which causes increased LV end-diastolic volume and reduced left ventricular ejection fraction (LVEF), and is reversible by 7 to 10 days provided the patient survives. Among cancer patients, assessing the baseline cardiac morbidity assumes importance as much as the optimization of the dose of chemotherapy infusion and the effective management of complications.Case presentation: In this report, we discuss a case of myocardial dysfunction occurring in neutropenic sepsis eventually leading to ventricular arrhythmia which proved fatal. The clinical finding in this 39-year-old male cancer patient (without preexisting heart disease) was consistent with SICM triggered by chemotherapy-induced neutropenic sepsis. His ECHO findings were characteristic with left ventricular changes of reduced EF, global hypokinesia, and ventricular dilation on the second/final day of admission. The discourse encompasses issues associated with maintaining hemodynamic stability in the concerned scenario, as well as distinguishing SICM from other cardiac diseases.Conclusions: LVEF as a diagnostic tool is reported as a poor measure of SICM prognosis and needs to be replaced with a sensitive and specific measure such as global longitudinal strain. The management of cardiac complications includes optimizing the strategies such as treating the underlying infection, supportive care measures such as fluid replacement, oxygen therapy, and medications for improving the functioning of heart (vasopressors and inotropes).","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"302-317"},"PeriodicalIF":0.7,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0