Case Reports in Oncology最新文献_第3页

Concurrent Monkeypox, HHV8, and Other Opportunistic Infections in a Human Immunodeficiency Virus Patient with Disseminated Kaposi Sarcoma: A Case Report. 猴痘、HHV8和其他机会性感染并发人类免疫缺陷病毒患者弥散性卡波西肉瘤：一例报告

IF 0.7

Case Reports in Oncology Pub Date : 2026-01-27 eCollection Date: 2026-01-01 DOI: 10.1159/000550746

Maggie H Zhou, Jeffrey A Thomas, Shari R Lipner, Igor Matushansky

{"title":"Concurrent Monkeypox, HHV8, and Other Opportunistic Infections in a Human Immunodeficiency Virus Patient with Disseminated Kaposi Sarcoma: A Case Report.","authors":"Maggie H Zhou, Jeffrey A Thomas, Shari R Lipner, Igor Matushansky","doi":"10.1159/000550746","DOIUrl":"10.1159/000550746","url":null,"abstract":"Introduction: Human immunodeficiency virus (HIV) infection predisposes patients to opportunistic infections. Kaposi sarcoma (KS) is a soft tissue sarcoma caused by human herpesvirus-8 (HHV8). Patients with high HHV8 and HIV viremia can develop KS inflammatory cytokine storm (KICS), a rare condition characterized by severe sepsis-like symptoms and high mortality.Case presentation: We present a patient with poorly controlled HIV and 2 weeks of fevers, dyspnea, abdominal pain, weight loss, and tender umbilicated plaques on the face, trunk, and extremities. Along with HIV, concomitant infections included HHV8, herpes simplex virus, cytomegalovirus, methicillin-resistant Staphylococcus aureus, adenovirus, and rhinovirus/enterovirus. The skin biopsy was positive for monkeypox. Lymph node biopsy was positive for monkeypox and HHV8, and morphologically consistent with KS. The patient also had pancytopenia with multiple increased inflammatory markers.Conclusion: This case highlights a diagnostic challenge. While numerous infections can cause inflammatory presentations with skin lesions and lymphadenopathy, only HHV8 is characterized by hypergammaglobulinemia. Further, in the setting of KS, HHV8 viremia is concerning for KICS. Recognizing this distinction is essential, as it shifts management from targeting infection to controlling the underlying inflammatory response.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"327-333"},"PeriodicalIF":0.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transformation of Castleman Disease into Angioimmunoblastic T-Cell Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review. Castleman病转化为血管免疫母细胞t细胞淋巴瘤并发噬血细胞性淋巴组织细胞增多症1例报告及文献复习。

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Case Reports in Oncology Pub Date : 2026-01-24 eCollection Date: 2026-01-01 DOI: 10.1159/000550691

Guangqiang Meng, Min Yang, Qian Liu, Yan Wang, Saran Feng

引用次数: 0

Necrosis of a Metastatic Axillary Lymph Node in Breast Cancer Possibly Induced by Fine-Needle Aspiration Cytology: A Case Report. 可能由细针穿刺细胞学诱发的乳腺癌转移性腋窝淋巴结坏死1例报告。

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Case Reports in Oncology Pub Date : 2026-01-23 eCollection Date: 2026-01-01 DOI: 10.1159/000550529

Yoshiko Masuda, Mikiko Aoki, Masumi Tanaka, Yukari Koga, Kyoko Eto, Yasuteru Yoshinaga, Toshihiko Sato

{"title":"Necrosis of a Metastatic Axillary Lymph Node in Breast Cancer Possibly Induced by Fine-Needle Aspiration Cytology: A Case Report.","authors":"Yoshiko Masuda, Mikiko Aoki, Masumi Tanaka, Yukari Koga, Kyoko Eto, Yasuteru Yoshinaga, Toshihiko Sato","doi":"10.1159/000550529","DOIUrl":"https://doi.org/10.1159/000550529","url":null,"abstract":"Introduction: Axillary lymph node metastasis is a major prognostic factor for breast cancer. In rare cases, metastatic lesions may undergo necrosis.Case presentation: A 69-year-old woman with a history of rheumatoid arthritis and ovarian tumor surgery was diagnosed with right-sided breast cancer (cT1N1M0) following abnormal screening mammography. Core needle biopsy revealed invasive ductal carcinoma (estrogen receptor: >95%, progesterone receptor: <1%, human epidermal growth factor receptor 2: 2+ [fluorescence in situ hybridization-negative], MIB-1: 18%). Fine-needle aspiration (FNA) cytology of an enlarged axillary lymph node confirmed metastasis. Mastectomy and axillary dissection were performed approximately 3 months after the FNA procedure without preoperative treatment, suggesting a temporal relationship between aspiration and subsequent necrosis. Histopathological analysis revealed no viable cancer cells in the lymph nodes but uniform eosinophilic necrosis with partial epithelial-like structures in one node. Immunohistochemistry showed positivity for epithelial membrane antigen, AE1/AE3, estrogen receptor, and GATA3, and histiocytes surrounding the necrotic area were positive for cluster of differentiation 68 and 163. These findings suggested that the metastatic carcinoma had undergone necrosis, likely triggered by FNA. The Oncotype DX score was 33; however, the patient chose endocrine therapy alone. No recurrence has been observed at the time of writing, 18 months after surgery.Conclusion: This case highlights a rare instance of necrosis in a metastatic lymph node, possibly induced by FNA. Immunohistochemistry is essential to confirm the diagnosis and avoid misinterpretation as a granulomatous or infectious process.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"349-355"},"PeriodicalIF":0.7,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain Metastasis in Nasopharyngeal Carcinoma: A Case Report. 鼻咽癌脑转移1例。

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Case Reports in Oncology Pub Date : 2026-01-23 eCollection Date: 2026-01-01 DOI: 10.1159/000548859

David Khie Siong Hii, Kum Thong Wong, John Seng Hooi Low

引用次数: 0

Utilization and Outcomes of High-Dose Methotrexate in CNS Lymphoma Patients on Hemodialysis: A Report of 2 Cases. 大剂量甲氨蝶呤在中枢神经系统淋巴瘤血液透析患者中的应用及疗效：附2例报告。

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Case Reports in Oncology Pub Date : 2026-01-22 eCollection Date: 2026-01-01 DOI: 10.1159/000550253

Aneeqa Zafar, Hanna Yakubi, Benjamin Moskoff, Kathryn Alvarez, Amber Tang, Joseph Tuscano, Aaron Rosenberg

引用次数: 0

Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma Occurring in Spleen of a Patient after Chemotherapy for Lung Carcinoma: A Case Report. 肺癌化疗后脾脏发生eb病毒阳性炎性滤泡树突状细胞肉瘤1例报告

IF 0.7

Case Reports in Oncology Pub Date : 2026-01-22 eCollection Date: 2026-01-01 DOI: 10.1159/000550533

Takushi Morishige, Katsutoshi Hirazawa, Akira Tanaka, Hisayuki Osoreda, Takashi Sato, Eiji Ikeda

{"title":"Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma Occurring in Spleen of a Patient after Chemotherapy for Lung Carcinoma: A Case Report.","authors":"Takushi Morishige, Katsutoshi Hirazawa, Akira Tanaka, Hisayuki Osoreda, Takashi Sato, Eiji Ikeda","doi":"10.1159/000550533","DOIUrl":"https://doi.org/10.1159/000550533","url":null,"abstract":"Introduction: Epstein-Barr virus (EBV)-positive inflammatory follicular dendritic cell sarcoma (EBV+ inflammatory FDCS) is a rare neoplasm that occurs almost exclusively in the spleen and liver. Although EBV+ inflammatory FDCS is recognized to show indolent behavior, its pathophysiology including the pathogenesis remains unclear.Case presentation: We present an EBV+ inflammatory FDCS, which occurred in the spleen of a patient under the follow-up for chemotherapy against lung carcinoma. Sequential CT examinations reveal that a splenic lesion was first detectable 5 years after chemotherapy and has grown for another 3 years to form a mass of 4 cm in diameter. Splenectomy was performed. Histologically, a well-circumscribed lesion in the spleen exhibited the significant infiltration of lymphocytes and plasma cells in the background of hyalinized fibrous tissue, and large oval-shaped cells were intermingled with lymphocytes and plasma cells. Large oval-shaped cells were found to express CD21 and CD23, and they were shown to be positive for EBV-encoded small RNA in situ hybridization. Based on these findings, the splenic lesion was diagnosed as EBV+ inflammatory FDCS.Conclusion: The present case might provide information to discuss the possible pathogenesis of EBV+ inflammatory FDCS in the context of immunosuppression.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"293-301"},"PeriodicalIF":0.7,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Statement: Paper by William Makis, Ilyes Baghli, and Pierrick Martinez entitled "Fenbendazole as an Anticancer Agent? A Case Series of Self-Administration in Three Patients" [Case Rep Oncol. 2025;18:856-863; https://doi.org/10.1159/000546362]. 撤回声明：由William Makis， Ilyes Baghli和Pierrick Martinez发表的题为“芬苯达唑作为抗癌剂？”3例患者自我给药的病例系列分析[j] .中华医学杂志，2025;18:856-863；https://doi.org/10.1159/000546362]。

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Case Reports in Oncology Pub Date : 2026-01-21 eCollection Date: 2026-01-01 DOI: 10.1159/000549387

引用次数: 0

Complete Pathological Response to Neoadjuvant Cisplatin, Etoposide, and Pembrolizumab in Small Cell Breast Carcinoma: A Case Report and Review of the Literature. 新辅助顺铂、依托泊苷和派姆单抗在小细胞乳腺癌中的完全病理反应：一例报告和文献回顾。

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Case Reports in Oncology Pub Date : 2026-01-20 eCollection Date: 2026-01-01 DOI: 10.1159/000550080

Huei Ti Soh, Samriti Sood, Frederick Ho, Kelly Mok, Wei Chua, Udit Nindra

{"title":"Complete Pathological Response to Neoadjuvant Cisplatin, Etoposide, and Pembrolizumab in Small Cell Breast Carcinoma: A Case Report and Review of the Literature.","authors":"Huei Ti Soh, Samriti Sood, Frederick Ho, Kelly Mok, Wei Chua, Udit Nindra","doi":"10.1159/000550080","DOIUrl":"10.1159/000550080","url":null,"abstract":"Background: Small cell breast carcinoma (SCBC) is a rare, aggressive neuroendocrine breast cancer subtype comprising less than 1% of all breast malignancies. With no standardized treatment guidelines, management is typically extrapolated from small cell lung cancer (SCLC) or triple-negative breast cancer (TNBC) protocols. Immune checkpoint inhibitors (ICIs) have shown promise in both TNBC and SCLC, but their role in SCBC remains undefined.Case presentation: We report the case of a 65-year-old woman diagnosed with early-stage, triple-negative SCBC, exhibiting high-grade features and a Ki-67 index >90%. She received neoadjuvant cisplatin and etoposide with pembrolizumab, followed by breast-conserving surgery and adjuvant pembrolizumab. Histopathology demonstrated a complete pathological response. The patient tolerated treatment well and remains disease-free on follow-up.Conclusion: This is the first reported case of SCBC successfully treated with neoadjuvant chemoimmunotherapy, achieving complete pathological remission. It highlights the potential role of ICIs in SCBC and supports future research into biomarker-driven strategies for this rare and aggressive.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"136-143"},"PeriodicalIF":0.7,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Neurotoxicity following a Single Dose of Brentuximab in a Patient with Epstein Bar Virus Driven Lymphoma: A Case Report. Epstein Bar病毒驱动淋巴瘤患者单剂量Brentuximab后的早期神经毒性：1例报告

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Case Reports in Oncology Pub Date : 2026-01-19 eCollection Date: 2026-01-01 DOI: 10.1159/000549767

Alexandra E Richards, Anuj Maniyar, Richard Howrey, Gretchen Eames, Anish Ray

{"title":"Early Neurotoxicity following a Single Dose of Brentuximab in a Patient with Epstein Bar Virus Driven Lymphoma: A Case Report.","authors":"Alexandra E Richards, Anuj Maniyar, Richard Howrey, Gretchen Eames, Anish Ray","doi":"10.1159/000549767","DOIUrl":"https://doi.org/10.1159/000549767","url":null,"abstract":"Background: Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) present unique challenges in immunocompromised patients. Neurotoxic complications typically arise after prolonged exposure and tend to manifest as peripheral neuropathy. This case describes acute encephalopathy shortly after a brief course, an uncommon and severe adverse effect.Case report: We describe a 17-year-old Hispanic male with EBV-associated LPD in the setting of complex autoimmune vasculitis and immunosuppression. Disease was unresponsive to multiple therapies, but eventually responded to a course of SMILE (steroid-dexamethasone, methotrexate, ifosfamide, L-asparaginase, etoposide). Brentuximab vedotin maintenance was initiated to secure remission. However, 7 days post-initiation, he developed culture-negative sepsis which progressed to acute encephalopathy and multi-organ failure. Infectious work-up along with neurological evaluation, including imaging and cerebrospinal fluid analysis, did not identify an alternative etiology.Conclusion: This case highlights a rare instance of early brentuximab vedotin-induced encephalopathy and underscores the need for close neurological monitoring in high-risk patients.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"270-275"},"PeriodicalIF":0.7,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12928715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vulvar Metastasis from Breast Cancer Treated with Abemaciclib plus Fulvestrant: A Case Report. 阿贝马昔单抗联合氟维司汀治疗乳腺癌外阴转移1例。

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Case Reports in Oncology Pub Date : 2026-01-19 eCollection Date: 2026-01-01 DOI: 10.1159/000550564

Clémence Vanden Berghe, Andoni Laka Antxustegi, Nicole Nicaise, Thierry Vander Borght, Lionel D'Hondt, Jacques Moerman, Matthieu de Codt

{"title":"Vulvar Metastasis from Breast Cancer Treated with Abemaciclib plus Fulvestrant: A Case Report.","authors":"Clémence Vanden Berghe, Andoni Laka Antxustegi, Nicole Nicaise, Thierry Vander Borght, Lionel D'Hondt, Jacques Moerman, Matthieu de Codt","doi":"10.1159/000550564","DOIUrl":"https://doi.org/10.1159/000550564","url":null,"abstract":"Introduction: Breast cancer is the most common malignant tumor in women, affecting approximately 1 in 9 women worldwide. In contrast, vulvar cancer remains rare, accounting for <1% of all cancers among women. Metastatic vulvar tumors are even rarer, constituting only 5-8% of all vulvar cancers. In some cases, breast cancer may metastasize to the vulva or vulvar tumors can arise from ectopic breast tissue.Case report: We report the case of a 78-year-old woman with vulvar metastasis of breast origin occurring 17 years after the diagnosis of primary breast cancer. The recurrence was identified by a PET scan concurrent with the patient reporting episodes of vaginal bleeding. Diagnosis was confirmed by clinical examination and biopsy. The proposed treatment was combined cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor abemaciclib and anti-estrogen agent fulvestrant. The patient demonstrated a good response, with a favorable clinical outcome as she is still in complete remission.Conclusion: This case underscores the importance of long-term follow-up of hormone-sensitive breast cancer, including thorough clinical examinations. To the best of our knowledge, this is the first reported case of vulvar metastasis from breast cancer that was successfully treated with the combination of abemaciclib and fulvestrant, leading to a complete response. The use of CDK4/6 inhibitors for the treatment of vulvar metastases of breast origin represents a significant advance, offering a less invasive and potentially more effective alternative to current treatment protocols.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"19 1","pages":"276-283"},"PeriodicalIF":0.7,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0