Case Reports in Oncology最新文献_第6页

The Role of SIX-EYA Complex in Branchiootorenal Syndrome and Glioblastoma: A Case Report and Review of Literature. 6 - eya复合物在鳃裂肾综合征和胶质母细胞瘤中的作用：1例报告及文献复习。

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Case Reports in Oncology Pub Date : 2025-01-07 eCollection Date: 2025-01-01 DOI: 10.1159/000541677

Jacqueline Boyle, William Miller, Andrew Tsung

引用次数: 0

Long-Term and Sustained Remission of Advanced Triple-Negative Breast Cancer with Large Chest Wall Lesions after Transient Chemoimmunotherapy: A Case Report. 短暂化疗免疫治疗后晚期三阴性乳腺癌伴大胸壁病变的长期持续缓解：1例报告。

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Case Reports in Oncology Pub Date : 2025-01-07 eCollection Date: 2025-01-01 DOI: 10.1159/000543292

Chanjuan Chen, Xiaonan Pang, Mingjun Zhang, Fanfan Li, Wanying Zhang, Wei Chen

{"title":"Long-Term and Sustained Remission of Advanced Triple-Negative Breast Cancer with Large Chest Wall Lesions after Transient Chemoimmunotherapy: A Case Report.","authors":"Chanjuan Chen, Xiaonan Pang, Mingjun Zhang, Fanfan Li, Wanying Zhang, Wei Chen","doi":"10.1159/000543292","DOIUrl":"10.1159/000543292","url":null,"abstract":"Introduction: We report a case of advanced triple-negative breast cancer (TNBC) with special clinical manifestations, in which a durable remission was achieved after short-term administration of toripalimab combined with chemotherapy. The progress, advantages, and unique experience of chemoimmunotherapy in TNBC were examined.Case presentation: A patient with TNBC with local recurrence 2 years following surgery, with inoperable large chest wall lesions and positive PD-L1 as the main manifestations, was treated with toripalimab plus paclitaxel (albumin-bound) for 5 months and achieved a partial remission. Twenty-five months after the discontinuation of treatment, the chest wall lesions exhibited a slow but continuous decline, until they achieved a nearly complete remission; however, the patient eventually died from cancer progression.Conclusion: Typically, chest wall recurrence in TNBC has a poor prognosis; however, recurrence was rapidly controlled, sustained remission was achieved after immunotherapy combined with chemotherapy, and the curative effect continued after drug withdrawal, which is a rare occurrence. Thus, the tailing effect of immune checkpoint inhibitors was confirmed in the treatment of TNBC.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"198-205"},"PeriodicalIF":0.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraneoplastic Neurologic Syndrome Associated with Fallopian Tube Cancer: A Case Report. 副肿瘤神经综合征与输卵管癌：1例报告。

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Case Reports in Oncology Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.1159/000542885

YingXiang Wang, HaoTian Wu, Jian Gu, Jia Wang

引用次数: 0

Next-Generation Sequencing: Key for Diagnosing Angiomyolipoma - A Case Report. 新一代测序：诊断血管平滑肌脂肪瘤的关键- 1例报告。

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Case Reports in Oncology Pub Date : 2025-01-03 eCollection Date: 2025-01-01 DOI: 10.1159/000542960

José Revilla López, Rainer Enciso Chancahuana, Sayuri Meza Cruzado, Francisco Meléndez Ríos, Yashira L Negrón Abril, Daniel Sumarriva, Timothy Samec, Yasser Sullcahuaman Allende, Ivan Chávez Passiuri, Luis Casanova Marquez, Carlos Carracedo Gonzáles

{"title":"Next-Generation Sequencing: Key for Diagnosing Angiomyolipoma - A Case Report.","authors":"José Revilla López, Rainer Enciso Chancahuana, Sayuri Meza Cruzado, Francisco Meléndez Ríos, Yashira L Negrón Abril, Daniel Sumarriva, Timothy Samec, Yasser Sullcahuaman Allende, Ivan Chávez Passiuri, Luis Casanova Marquez, Carlos Carracedo Gonzáles","doi":"10.1159/000542960","DOIUrl":"10.1159/000542960","url":null,"abstract":"Introduction: Renal angiomyolipomas (AMLs) are rare tumors categorized within the perivascular epithelioid cell tumor (PEComa) family, most of which are benign, except for epithelioid AMLs (EAML) with malignant potential. EAML develops sporadically or as part of the tuberous sclerosis complex (TSC), where mutations of the TSC1/2 genes result in increased activation of the mammalian target of the rapamycin (mTOR) signaling pathway.Case presentation: A 52-year-old female patient experienced dyspnea and abdominal pain, leading to the discovery of a retroperitoneal tumor confirmed by tomography. She was initially diagnosed with a retroperitoneal liposarcoma with lung metastasis. Following a first-line anthracycline-based chemotherapy, the patient achieved a complete clinical and tomographic response. Subsequent surgical resection of the primary tumor and a course of ifosfamide monotherapy yielded a 36-month progression-free survival to date. Comprehensive molecular profiling of the primary tumor by whole exome sequencing revealed pathogenic mutations in TSC2 and the absence of amplifications in MDM2 and CDK4, raising the need to consider a differential diagnosis in PEComas, and contemplate the potential use of AKT/Pi3K/mTOR pathway inhibitors. Pathological re-evaluation confirmed the diagnosis of a metastatic retroperitoneal AML with complete response and no evidence of disease.Conclusion: This case underscores the invaluable role of next-generation sequencing testing in the differential diagnosis of retroperitoneal tumors, as well as the ability to identify precise therapeutic targets for the treatment of rare soft tissue cancer types within the realm of precision medicine.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"247-254"},"PeriodicalIF":0.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Hypomagnesemia in a Patient Treated Using Carboplatin Co-Administered with Vonoprazan. 卡铂联合伏诺哌赞治疗的严重低镁血症患者

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Case Reports in Oncology Pub Date : 2025-01-03 eCollection Date: 2025-01-01 DOI: 10.1159/000542906

Osamu Taniguchi, Yoshitaka Saito, Yuka Yamaguchi, Midori Sakai, Yasuyuki Ikezawa, Jun Sakakibara-Konishi, Mina Eguchi, Yoh Takekuma, Mitsuru Sugawara

{"title":"Severe Hypomagnesemia in a Patient Treated Using Carboplatin Co-Administered with Vonoprazan.","authors":"Osamu Taniguchi, Yoshitaka Saito, Yuka Yamaguchi, Midori Sakai, Yasuyuki Ikezawa, Jun Sakakibara-Konishi, Mina Eguchi, Yoh Takekuma, Mitsuru Sugawara","doi":"10.1159/000542906","DOIUrl":"10.1159/000542906","url":null,"abstract":"Introduction: We describe a case of severe hypomagnesemia that occurred during treatment with carboplatin (CBDCA) and nanoparticle albumin-bound paclitaxel (nab-PTX) for lung adenocarcinoma when co-administered with vonoprazan.Case presentation: A man in his 70s was diagnosed with stage IIIA lung adenocarcinoma and received CBDCA and nab-PTX as the first-line treatment. The patient had been taking omeprazole 10 mg once daily (for >3 years) for gastroesophageal reflux disease, but it was switched to lansoprazole 15 mg because of hospital's adopted medication. During the first treatment cycle, his serum creatinine levels increased from 1.0 to 1.5 mg/dL, suggesting CBDCA-associated renal impairment. Because of gastric discomfort on day 15 of the second cycle, lansoprazole was switched to vonoprazan 10 mg once daily. On day 23 of the second cycle, he developed torsades de pointes and was hospitalized; severe hypomagnesemia (0.4 mg/dL) was detected to be causing the symptoms. Discontinuation of vonoprazan and a single intravenous infusion of 60 mEq magnesium sulfate raised serum magnesium levels to 3.7 mg/dL, and the arrhythmia disappeared. Mild hypomagnesemia (1.4 mg/dL) reappeared 5 days later, and an additional intravenous infusion of 20 mEq magnesium sulfate with subsequent oral magnesium oxide (1,980 mg/day) resolved the symptoms. CBDCA was discontinued and nab-PTX monotherapy was continued. Vonoprazan was resumed owing to gastric discomfort relapse; however, grade ≥2 hypomagnesemia did not reappear later.Conclusions: This case highlights the risk of severe hypomagnesemia in patients with CBDCA and vonoprazan co-administration; therefore, regular monitoring of serum magnesium levels during the treatment is crucial.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"151-158"},"PeriodicalIF":0.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Tibiofemoral Ewing's Sarcoma Recurrence with Lung Metastasis 27 Years after Initial Diagnosis. 罕见的胫骨股部尤因肉瘤27年后复发并肺转移1例。

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Case Reports in Oncology Pub Date : 2024-12-26 eCollection Date: 2025-01-01 DOI: 10.1159/000542167

Amal Miqdadi, Saadia Ayach, Hanane Boulmane, Malika Çaoui

引用次数: 0

Unusual Metastatic Lymph Node to Retro-Scapular Area in Occult Breast Cancer: A Case Report. 隐匿性乳腺癌肩胛骨后异常转移淋巴结1例报告。

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Case Reports in Oncology Pub Date : 2024-12-26 eCollection Date: 2025-01-01 DOI: 10.1159/000543346

Lina Wahbeh, Abdulla Alzibdeh, Shatha Abutaha, Issa Mohamad, Ramiz Abuhijlih, Hussam Haddad, Hikmat Abdel-Razeq, Fawzi Abuhijla

{"title":"Unusual Metastatic Lymph Node to Retro-Scapular Area in Occult Breast Cancer: A Case Report.","authors":"Lina Wahbeh, Abdulla Alzibdeh, Shatha Abutaha, Issa Mohamad, Ramiz Abuhijlih, Hussam Haddad, Hikmat Abdel-Razeq, Fawzi Abuhijla","doi":"10.1159/000543346","DOIUrl":"10.1159/000543346","url":null,"abstract":"Introduction: Breast cancer typically metastasizes to axillary, internal mammary and supraclavicular lymph node chains. In contrast, occult breast cancer (OBC), a rare form of breast cancer, usually presents as axillary lymphadenopathy and rarely metastasizes regionally or distally.Case presentation: In this case report, we present a 45-year-old female patient with unusual presentation of breast cancer initially as axillary lymphadenopathy without breast mass. She was diagnosed by magnetic resonance imaging as OBC and later presented with a rare pathological spread to the ipsilateral subscapular region. The retro-scapular nodal disease was first detected via follow-up computed tomography scan and confirmed by positron emission tomography after 18 months of her initial diagnoses. This occurred following completion of OBC management, which included neoadjuvant chemotherapy, axillary lymph node dissection, without mastectomy, followed by adjuvant radiation treatment to regional lymph nodes and ipsilateral whole breast. Her recurrent nodal disease was subsequently managed by surgical resection followed by radiation therapy to surgical bed.Conclusion: This case report emphasizes the diverse locations where metastatic breast cancer can manifest and underscores the advancements in diagnostic tools that have enhanced the detection of these metastatic sites.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"239-245"},"PeriodicalIF":0.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Metastatic Iris Tumor from Adenocarcinoma of the Cecum Diagnosed by Combined Tumor Markers in Aqueous Humor and Fine Needle Aspiration Cytology. 用房水肿瘤标志物和细针穿刺细胞学联合诊断盲肠腺癌转移性虹膜肿瘤1例。

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Case Reports in Oncology Pub Date : 2024-12-24 eCollection Date: 2025-01-01 DOI: 10.1159/000542905

Mizuho Mitamura, Satoru Kase, Yuka Suimon, Yamato Hashimoto, Ryoko Watanabe, Yoshihiro Matsuno, Susumu Ishida

{"title":"A Case of Metastatic Iris Tumor from Adenocarcinoma of the Cecum Diagnosed by Combined Tumor Markers in Aqueous Humor and Fine Needle Aspiration Cytology.","authors":"Mizuho Mitamura, Satoru Kase, Yuka Suimon, Yamato Hashimoto, Ryoko Watanabe, Yoshihiro Matsuno, Susumu Ishida","doi":"10.1159/000542905","DOIUrl":"10.1159/000542905","url":null,"abstract":"Introduction: The diagnosis of metastatic iris tumor is made by a fine-needle aspiration biopsy of part of the solid component of the tumor and tumor cells seeded in the anterior chamber; however, sometimes the diagnosis is not made due to insufficient sample volumes. We report a case of metastatic iris tumor in which measurement of tumor marker levels in the aqueous humor together with fine needle aspiration cytology contributed to the diagnosis.Case report: An 80-year-old Japanese woman was referred to our hospital because of an iris mass. Six months before the initial visit, the patient was diagnosed with adenocarcinoma of the cecum. Slit-lamp microscopy revealed an elevated iris mass. Fine-needle aspiration cytology suggested adenocarcinoma. The carcinoembryonic antigen (CEA) level in the anterior chamber was 5,716.1 ng/mL, and serum CEA level measured on the same day were 678.5 ng/mL. These data indicated CEA levels synchronously elevated in both anterior chamber and serum. Based on aspiration cytology and high CEA levels of anterior chamber, she was diagnosed with metastatic iris tumor derived from adenocarcinoma of the cecum. One month after the initial visit, right eye irradiation was performed for metastatic iris tumor.Conclusions: Measurement of tumor marker levels in the aqueous humor, together with fine needle aspiration cytology of the tumor, contributes to the diagnosis of metastatic iris tumors.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"29-34"},"PeriodicalIF":0.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trastuzumab Deruxtecan for HER2-Positive Breast Cancer with Central Nervous System Metastasis. 曲妥珠单抗德鲁西替康治疗her2阳性乳腺癌伴中枢神经系统转移。

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Case Reports in Oncology Pub Date : 2024-12-23 eCollection Date: 2025-01-01 DOI: 10.1159/000542761

Hiroaki Yamane, Tomoko Itagaki, Keiko Kajitani

{"title":"Trastuzumab Deruxtecan for HER2-Positive Breast Cancer with Central Nervous System Metastasis.","authors":"Hiroaki Yamane, Tomoko Itagaki, Keiko Kajitani","doi":"10.1159/000542761","DOIUrl":"10.1159/000542761","url":null,"abstract":"Introduction: Metastasis to the central nervous system (CNS) is frequently observed in human epidermal growth factor receptor (HER2)-positive breast cancer, leading to reduced quality of life and poor prognosis. Brain metastases (BMs) are common, whereas spinal cord metastases are rare and no standardized treatment approach has been reported for their management. Herein, we report the outcomes of treatment with trastuzumab deruxtecan (T-DXd) in a patient with BMs and intramedullary spinal cord metastasis (ISCM) and another patient with BMs.Case presentation: The first patient was a woman in her 30s. After the surgery for HER2-positive right breast cancer, T-DXd was used as fourth-line treatment for multiple BMs and ISCM. Both the BMs and ISCM reduced, and partial response was maintained for 12 months. Grade 1 fatigue was the only adverse event observed in this patient. The second patient was a woman in her 40 s with multiple BMs after primary treatment for HER2-positive right breast cancer, as well as multiple bone and lymphoid node metastases. T-DXd was administered as second-line treatment. The multiple BMs have now shrunk, and the primary tumor and bone/lymph node metastases have not shown significant changes; the patient has maintained partial response for 6 months.Conclusion: Metastasis to the CNS has a very poor prognosis and limited therapeutic response because it is difficult for drugs to cross the blood-brain barrier. However, T-DXd has yielded positive results for BMs in clinical trials. Additionally, a therapeutic effect of T-DXd on ISCM and BMs was observed in the reported cases.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"22-28"},"PeriodicalIF":0.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic Colonic Adenocarcinoma Mimicking Acute Bowel Perforation: Hiccups and Vomiting as Unusual Initial Symptoms: A Case Report. 模拟急性肠穿孔的转移性结肠腺癌：打嗝和呕吐为不寻常的初始症状：1例报告。

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Case Reports in Oncology Pub Date : 2024-12-20 eCollection Date: 2025-01-01 DOI: 10.1159/000542603

Abdul Qadir, Hafsah Iqbal, Ayesha Sabir, Osama Bin Khalid, Jamal Sajid

{"title":"Metastatic Colonic Adenocarcinoma Mimicking Acute Bowel Perforation: Hiccups and Vomiting as Unusual Initial Symptoms: A Case Report.","authors":"Abdul Qadir, Hafsah Iqbal, Ayesha Sabir, Osama Bin Khalid, Jamal Sajid","doi":"10.1159/000542603","DOIUrl":"10.1159/000542603","url":null,"abstract":"Introduction: Colorectal cancer (CRC), the third most prevalent malignancy globally, can present with complications such as bleeding, obstruction, and, less commonly, perforation. These complications are associated with significant morbidity and mortality, demanding timely recognition and intervention. Unusual initial symptoms can obscure the clinical picture, delaying diagnosis, and treatment.Case presentation: We report a 50-year-old male with a history of rectosigmoid adenocarcinoma treated with surgery and chemoradiotherapy, presenting with atypical symptoms of intractable hiccups, watery diarrhea, and vomiting. Initial imaging indicated an ileostomy site perforation with signs of ischemic colitis. Exploratory laparotomy revealed a perforation at the splenic flexure, ischemic colitis, and a stenosing rectosigmoid tumor. A total colectomy with end ileostomy was performed, leading to resolution of symptoms and stabilization of the patient.Conclusion: This case emphasizes the importance of recognizing atypical presentations of CRC and its complications. Prompt and comprehensive diagnostic evaluations followed by appropriate surgical intervention can improve outcomes and prevent further deterioration. Early recognition of unusual symptoms is critical in guiding effective management.","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"15-21"},"PeriodicalIF":0.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0