Case Reports in Dermatology最新文献_第6页

Poroid Hidradenoma: Case Report and Comprehensive Review of the Literature. 息肉样Hidradenoma：病例报告和文献综述。

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Case Reports in Dermatology Pub Date : 2023-10-25 eCollection Date: 2023-01-01 DOI: 10.1159/000531052

Arrin Brooks, Mariah Morris, Jonathan Cuda, Armein Rahimpour, Semeret Munie

引用次数: 0

Treatment of Cutaneous Neurofibromas in Patients with Neurofibromatosis Type 1. 1型神经纤维瘤病患者皮肤神经纤维瘤的治疗。

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Case Reports in Dermatology Pub Date : 2023-10-20 eCollection Date: 2023-01-01 DOI: 10.1159/000534270

Bartosz Wozniak, Torsten Bove, Tomasz Zawada, Jacek Calik

{"title":"Treatment of Cutaneous Neurofibromas in Patients with Neurofibromatosis Type 1.","authors":"Bartosz Wozniak, Torsten Bove, Tomasz Zawada, Jacek Calik","doi":"10.1159/000534270","DOIUrl":"10.1159/000534270","url":null,"abstract":"Neurofibromatosis type 1 is a genetic disorder impacting approximately 2.5 million people worldwide, often leading to development of numerous benign yet disfiguring cutaneous neurofibromas (cNF). Removal of cNF is limited to excision or laser ablation with common post-operation complications and scarring. The current case explores a new approach to removal or reduction of cNF by a minimally invasive and pain-reduced treatment modality. A 40-year-old female patient with numerous cNF across her body underwent a single treatment using a 20 MHz dermatologically focused ultrasound device on seven selected cNF on the upper back. Each cNF was treated in a single session of 20-60 s without anesthesia due to manageable pain. Only one minimal adverse reaction in the form of dyspigmentation in a single treated tumor was noted from treatment or during the healing of a thin scab that formed on each cNF a few days after treatment. At the 12-month follow-up, four out of seven treated cNF showed full remission, two showed partial or significant reduction in tumor volume, while two did not respond to treatment. The reason for the variability is not fully understood, but speculations include difference in tissue content, e.g., due to tumor age. The method is concluded to be a promising candidate for a new safe and minimally invasive treatment that can potentially be used for single-session removal/reduction of a large number of cNF. Further research should focus on refining treatment parameters and strategies to enhance response predictability.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"15 1","pages":"194-201"},"PeriodicalIF":0.9,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Majocchi's Granuloma - The Great Mimicker: A Case Report. Majocchi氏肉芽肿——大咪咪：一例报告。

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Case Reports in Dermatology Pub Date : 2023-10-18 eCollection Date: 2023-01-01 DOI: 10.1159/000533475

Jakob Lillemoen Drivenes, Mette Ramsing, Anette Bygum

{"title":"Majocchi's Granuloma - The Great Mimicker: A Case Report.","authors":"Jakob Lillemoen Drivenes, Mette Ramsing, Anette Bygum","doi":"10.1159/000533475","DOIUrl":"10.1159/000533475","url":null,"abstract":"Fungal infections can be challenging to diagnose, but doctors of every specialty may encounter this issue. They can be mistaken for other common dermatoses such as eczema or psoriasis and inadvertently be treated with topical corticosteroids or calcineurin inhibitors. This may lead to tinea incognita, a term used to describe a fungal infection with an altered clinical appearance, which may confuse the clinician even further. This case report presents a 54-year-old previously healthy man with a 4-month history of a painful and pruritic rash in the genitoinguinal region. The patient's general practitioner had unsuccessfully attempted to treat the rash with topical terbinafine, econazole-triamcinolone, and betamethasone-fusidic acid, in addition to peroral dicloxacillin capsules. On examination, there were multiple red-bluish nodules and pustules coalescing into infiltrating erythematous plaques on both thighs and in the pubic region. Fungal cultures were negative, but the clinical features together with the history of prolonged use of combined topical steroids and antifungals raised suspicion of a deep fungal infection. Histopathological skin examination revealed deep suppurative and granulomatous folliculitis with ruptured hair follicles which was consistent with a diagnosis of Majocchi's granuloma. Treatment with itraconazole capsules was initiated, and after a 16-week course of systemic antifungal therapy, the rash resolved. In conclusion, our case report presents a case of Majocchi's granuloma, which is a great mimicker, especially for non-dermatologists. It is therefore important that the diagnosis is considered as a differential diagnosis, even though a patient has previously been treated with a topical antifungal.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"15 1","pages":"190-193"},"PeriodicalIF":0.9,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous Immunoglobulin Therapy-Induced Erythema Multiforme in a Patient with Chronic Lymphocytic Leukemia. 静脉注射免疫球蛋白治疗慢性淋巴细胞白血病患者诱发多发性红斑。

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Case Reports in Dermatology Pub Date : 2023-10-16 eCollection Date: 2023-01-01 DOI: 10.1159/000533987

Angelina Konovalova, Natālija Gerula, Ilona Hartmane, Ilze Upeniece, Mihails Ščerbuks, Kristīne Bernāte, Lelde Reinberga, Ingmārs Mikažāns

{"title":"Intravenous Immunoglobulin Therapy-Induced Erythema Multiforme in a Patient with Chronic Lymphocytic Leukemia.","authors":"Angelina Konovalova, Natālija Gerula, Ilona Hartmane, Ilze Upeniece, Mihails Ščerbuks, Kristīne Bernāte, Lelde Reinberga, Ingmārs Mikažāns","doi":"10.1159/000533987","DOIUrl":"10.1159/000533987","url":null,"abstract":"This case report discusses immunoglobulin-induced erythema multiforme (EM), a rare and understudied condition that requires further investigation. The report presents the case of a 69-year-old woman with a history of chronic lymphocytic leukemia who developed an acute hypersensitivity reaction to intravenous gamma globulin medication. The patient received intravenous immunoglobulin (IVIG) to normalize and stabilize her immunoglobulin levels and reduce the risk of recurrent infections due to her immunodeficiency with predominantly antibody defects. However, after the second administration of the medication, the patient experienced an acute skin rash and was admitted to the hospital for treatment. The treatment plan included systemic desensitizing therapy, systemic antihistamine therapy, corticosteroid therapy, and local therapy. After a course of therapy, the patient's skin condition improved, and her overall well-being improved. However, due to the acute hypersensitivity reaction, the IVIG therapy was discontinued. The multidisciplinary team of specialists concluded that the patient had developed EM. The discussion provides an overview of EM, including its causes, clinical presentation, diagnostic tools, and therapy principles. The discussion also describes the use of human IVIG preparations in treating various immunodeficient and inflammatory diseases, highlighting the importance of monitoring patients for adverse effects. The case of this patient underscores the potential risks associated with immunoglobulin therapy and emphasizes the need for healthcare providers to remain vigilant for adverse reactions. By promptly diagnosing and treating EM, healthcare providers can minimize its impact on patients' overall well-being.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"15 1","pages":"182-189"},"PeriodicalIF":0.9,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinal Dysraphism Presenting as Neuropathic Ulcers: A Case Report of a Delayed Diagnosis. 以神经性溃疡表现的脊髓闭合障碍：一例延迟诊断的病例报告。

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Case Reports in Dermatology Pub Date : 2023-09-12 eCollection Date: 2023-01-01 DOI: 10.1159/000533517

Razan S Al-Luhaibi, Shahad T Khayyat, Suha H Al-Sayed, Waseem K Alhawsawi, Khalid A Al Hawsawi

{"title":"Spinal Dysraphism Presenting as Neuropathic Ulcers: A Case Report of a Delayed Diagnosis.","authors":"Razan S Al-Luhaibi, Shahad T Khayyat, Suha H Al-Sayed, Waseem K Alhawsawi, Khalid A Al Hawsawi","doi":"10.1159/000533517","DOIUrl":"https://doi.org/10.1159/000533517","url":null,"abstract":"Spinal dysraphism (SD) refers to the abnormal fusion of dorsal midline structures during embryogenesis. It encompasses a variety of congenital spinal defects, ranging from an overt defect in which neural tissue is exposed with no overlying skin (open SD) such as myelomeningoceles to skin-covered malformations (closed or occult SD). A 13-year-old boy presented with recurrent multiple painless ulcers and erosions over the tips of the toes, mainly involving the right foot with hemorrhagic crusts for 5 years. A review of systems revealed back pain, urine incontinence, and numbness in his right knee. He was diagnosed with peripheral neuropathic ulcers and tethered cord syndrome secondary to SD and confirmed by MRI. He underwent cord detethering and lipoma resection as well as expectant therapy with satisfying outcomes. Physicians should consider early diagnosis of SD to avoid later neurological complications of SD (traction and/or pressure on the spinal cord) when infants are presented with such anomalies: MRI, close follow-up, and neurosurgical intervention may be recommended.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"15 1","pages":"177-181"},"PeriodicalIF":0.9,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Cutaneous Marginal Zone Lymphoma following Repeated Inflammation Caused by Hair Dyeing. 染发引起反复炎症后的原发性皮肤边缘区淋巴瘤。

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Case Reports in Dermatology Pub Date : 2023-09-06 eCollection Date: 2023-01-01 DOI: 10.1159/000533516

Jun Hyo Lee, Ui Hyeon Jo, Tae Min Kim, Dae Hun Suh

引用次数: 0

Exclusive and Solitary Facial Porokeratosis: Pathogenesis and Literature Reappraisal of a Rare Entity. 排他性和孤立性面部毛孔扩张症：一种罕见实体的发病机制和文献再评价。

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Case Reports in Dermatology Pub Date : 2023-09-05 eCollection Date: 2023-01-01 DOI: 10.1159/000530936

Giovanni Paolino, Matteo Riccardo Di Nicola, Marina Yarygina, Carlo Mattozzi, Eduardo Quaranta, Vittoria Giulia Bianchi, Michele Donati, Santo Raffaele Mercuri

{"title":"Exclusive and Solitary Facial Porokeratosis: Pathogenesis and Literature Reappraisal of a Rare Entity.","authors":"Giovanni Paolino, Matteo Riccardo Di Nicola, Marina Yarygina, Carlo Mattozzi, Eduardo Quaranta, Vittoria Giulia Bianchi, Michele Donati, Santo Raffaele Mercuri","doi":"10.1159/000530936","DOIUrl":"https://doi.org/10.1159/000530936","url":null,"abstract":"Porokeratosis is a group of well-known clinically distinct entities, characterised by different clinical aspects, but sharing a single common histological aspect, namely the cornoid lamella. Usually, porokeratosis occurs in the limbs and trunk, while it rarely involves the face, especially as an exclusive, single, and solitary lesion. We report the case of a 52-year-old Caucasian woman, with an 11-month history of a 2-cm slowly growing solitary, keratotic lesion on her left cheekbone. The patient did not present other cutaneous lesions on the face, as well as in other body sites. A cutaneous biopsy showed epidermal hyperplasia with multiple, sharply defined cornoid lamella, associated with an underlying attenuation of the granular layer and scattered dyskeratotic cells in the spinous layer. The superficial dermis underneath showed a mild lymphocytic infiltrate and fibrosis with remodelled collagen bundles. A final diagnosis of solitary facial porokeratosis was made.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"15 1","pages":"147-151"},"PeriodicalIF":0.9,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bullous Lichen Planus of the Nails: A Case Report and Review of the Literature. 大疱性指甲扁平苔藓一例报告并文献复习。

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Case Reports in Dermatology Pub Date : 2023-09-04 eCollection Date: 2023-01-01 DOI: 10.1159/000533386

Jonathan K Hwang, Cynthia M Magro, Shari R Lipner

{"title":"Bullous Lichen Planus of the Nails: A Case Report and Review of the Literature.","authors":"Jonathan K Hwang, Cynthia M Magro, Shari R Lipner","doi":"10.1159/000533386","DOIUrl":"https://doi.org/10.1159/000533386","url":null,"abstract":"Lichen planus is a chronic inflammatory disorder that may affect the skin, nails, and/or oral mucosa. Bullous lichen planus is a rare variant of lichen planus, which is even less common in the nails. We present a case of nail bullous lichen planus, in a 48-year-old male presenting with a 10-month history of onychodystrophy of all ten fingernails. A longitudinal excision of the left thumbnail was performed, with histopathology consistent with lichen planus with focal transition to bullous lichen planus. He was treated with intralesional triamcinolone injections to the fingernails monthly, with improvements noted after three treatments. Our patient's nail bullous lichen planus manifested with longitudinal ridging, white-yellow discoloration, onycholysis, subungual hyperkeratosis, and v-shaped nicking. Histopathological findings included classical lichen planus changes, as well as formation of subepidermal bullae, colloid bodies, and extensive inflammatory infiltrate. Increased awareness and high index of suspicion for this condition are necessary, given the often late diagnosis reported in previously published cases.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"15 1","pages":"133-141"},"PeriodicalIF":0.9,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71478347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Lip Psoriasis in a 14-Year-Old Boy Successfully Treated with Adalimumab. 阿达木单抗成功治疗一例14岁男孩唇银屑病。

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Case Reports in Dermatology Pub Date : 2023-09-04 eCollection Date: 2023-01-01 DOI: 10.1159/000532103

Francesca Caroppo, Laura Gnesotto, Maria Ludovica Deotto, Roberto Salmaso, Anna Belloni Fortina

引用次数: 0

A Case of Lamina Lucida-Type Linear IgA Disease Complicated by Colon Polyposis and Rectal Adenocarcinoma. 椎板Lucida型线性IgA病并发结肠息肉病和直肠腺癌1例。

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Case Reports in Dermatology Pub Date : 2023-09-01 eCollection Date: 2023-01-01 DOI: 10.1159/000532104

Akiko Miyazaki, Saori Itoi-Ochi, Mami Hayashi, Asako Ota, Kengo Nagai, Shinya Inoue, Naohiro Tomita, Hidetaka Eguchi, Yasushi Okazaki, Hideyuki Ishida, Takashi Hashimoto

{"title":"A Case of Lamina Lucida-Type Linear IgA Disease Complicated by Colon Polyposis and Rectal Adenocarcinoma.","authors":"Akiko Miyazaki, Saori Itoi-Ochi, Mami Hayashi, Asako Ota, Kengo Nagai, Shinya Inoue, Naohiro Tomita, Hidetaka Eguchi, Yasushi Okazaki, Hideyuki Ishida, Takashi Hashimoto","doi":"10.1159/000532104","DOIUrl":"10.1159/000532104","url":null,"abstract":"Linear IgA disease (LAD) is a rare autoimmune bullous disease characterized by IgA deposition in the basement membrane zone (BMZ). A 66-year-old male was treated for myelodysplastic syndrome at our hospital for 5 years, during which his condition remained stable. He visited our department because of erythema with itching, which appeared 1 year ago and gradually exacerbated with the development of blisters and erosions. During the first visit, multiple erythemas with erosions and crusts on their periphery were observed on the trunk and lower limbs. Histopathological examination revealed subepidermal blisters with inflammatory cell infiltration, mainly constituting of neutrophils, eosinophils, and lymphocytes. Direct and indirect immunofluorescence showed linear IgA deposits in the BMZ and IgA anti-BMZ antibodies, respectively, while immunoblotting using a concentrated culture supernatant of HaCaT cells detected IgA antibodies reactive to 120-kDa LAD-1. Accordingly, the patient was diagnosed with lamina lucida-type LAD. Subsequent colonoscopy revealed multiple colorectal polyps and rectal adenocarcinoma (Tis, N0, and M0). Multigene panel test showed an ATM variant of unknown significance but did not detect any pathogenic variants associated with intestinal polyposis syndrome. The skin lesions quickly resolved with oral diaphenylsulfone 50 mg/day and resection of the colorectal polyps and adenocarcinoma. To our knowledge, this is the first reported case of LAD associated with multiple colorectal polyps and rectal adenocarcinoma. Additionally, we also analyzed reported cases of LAD associated with malignancy from the literature.","PeriodicalId":9619,"journal":{"name":"Case Reports in Dermatology","volume":"15 1","pages":"126-132"},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0